LOCUS       NM_000673               2119 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens alcohol dehydrogenase 7 (class IV), mu or sigma
            polypeptide (ADH7), transcript variant 2, mRNA.
ACCESSION   NM_000673
VERSION     NM_000673.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2119)
  AUTHORS   Kashyap,Y., He,Y., Sadhu,N., Yao,Y., Wilkie,D.J., Molokie,R.E. and
            Wang,Z.J.
  TITLE     An alcohol dehydrogenase 7 gene polymorphism associates with both
            acute and chronic pain in sickle cell disease
  JOURNAL   Pharmacogenomics 24 (12), 641-649 (2023)
   PUBMED   37712142
  REMARK    GeneRIF: An alcohol dehydrogenase 7 gene polymorphism associates
            with both acute and chronic pain in sickle cell disease.
REFERENCE   2  (bases 1 to 2119)
  AUTHORS   Zeng,K., Li,Y., Gao,M., Liu,Y.P., Xu,F.L., Xia,X., Yao,J. and
            Wang,B.J.
  TITLE     Association of ADH7 Gene Polymorphism with Schizophrenia in the Han
            Population of Northern China: a Case-Control Study
  JOURNAL   J Mol Neurosci 70 (11), 1851-1857 (2020)
   PUBMED   32388801
  REMARK    GeneRIF: Association of ADH7 Gene Polymorphism with Schizophrenia
            in the Han Population of Northern China: a Case-Control Study.
REFERENCE   3  (bases 1 to 2119)
  AUTHORS   Latta,L., Nordstrom,K., Stachon,T., Langenbucher,A., Fries,F.N.,
            Szentmary,N., Seitz,B. and Kasmann-Kellner,B.
  TITLE     Expression of retinoic acid signaling components ADH7 and ALDH1A1
            is reduced in aniridia limbal epithelial cells and a siRNA primary
            cell based aniridia model
  JOURNAL   Exp Eye Res 179, 8-17 (2019)
   PUBMED   30292490
  REMARK    GeneRIF: These results provide evidence that PAX6 might drive
            corneal epithelial differentiation by direct or indirect control of
            retinoic acid signaling processes through ADH7 and ALDH1A1.
REFERENCE   4  (bases 1 to 2119)
  AUTHORS   Pastorino,R., Iuliano,L., Vecchioni,A., Arzani,D., Milic,M.,
            Annunziata,F., Zerbinati,C., Capoluongo,E., Bonassi,S., McKay,J.D.
            and Boccia,S.
  TITLE     Effect of alcohol dehydrogenase-1B and -7 polymorphisms on blood
            ethanol and acetaldehyde concentrations in healthy subjects with a
            history of moderate alcohol consumption
  JOURNAL   Drug Test Anal 10 (3), 488-495 (2018)
   PUBMED   28731573
  REMARK    GeneRIF: The results of the study do not support our hypothesis
            that ADH1B and ADH7 genotypes affect blood ethanol, and
            acetaldehyde concentration.
REFERENCE   5  (bases 1 to 2119)
  AUTHORS   Norden-Krichmar,T.M., Gizer,I.R., Wilhelmsen,K.C., Schork,N.J. and
            Ehlers,C.L.
  TITLE     Protective variant associated with alcohol dependence in a Mexican
            American cohort
  JOURNAL   BMC Med Genet 15, 136 (2014)
   PUBMED   25527893
  REMARK    GeneRIF: These results suggest that variants near ADH7 may play a
            role in protection from alcohol dependence in this Mexican American
            cohort.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2119)
  AUTHORS   Zgombic-Knight,M., Foglio,M.H. and Duester,G.
  TITLE     Genomic structure and expression of the ADH7 gene encoding human
            class IV alcohol dehydrogenase, the form most efficient for retinol
            metabolism in vitro
  JOURNAL   J Biol Chem 270 (9), 4305-4311 (1995)
   PUBMED   7876191
REFERENCE   7  (bases 1 to 2119)
  AUTHORS   Kedishvili,N.Y., Bosron,W.F., Stone,C.L., Hurley,T.D., Peggs,C.F.,
            Thomasson,H.R., Popov,K.M., Carr,L.G., Edenberg,H.J. and Li,T.K.
  TITLE     Expression and kinetic characterization of recombinant human
            stomach alcohol dehydrogenase. Active-site amino acid sequence
            explains substrate specificity compared with liver isozymes
  JOURNAL   J Biol Chem 270 (8), 3625-3630 (1995)
   PUBMED   7876099
REFERENCE   8  (bases 1 to 2119)
  AUTHORS   Cheung,B., Anderson,J.K., Holmes,R.S. and Beacham,I.R.
  TITLE     Human stomach class IV alcohol dehydrogenase: molecular genetic
            analysis
  JOURNAL   Alcohol Clin Exp Res 19 (1), 185-186 (1995)
   PUBMED   7771649
REFERENCE   9  (bases 1 to 2119)
  AUTHORS   Pares,X., Cederlund,E., Moreno,A., Saubi,N., Hoog,J.O. and
            Jornvall,H.
  TITLE     Class IV alcohol dehydrogenase (the gastric enzyme). Structural
            analysis of human sigma sigma-ADH reveals class IV to be variable
            and confirms the presence of a fifth mammalian alcohol
            dehydrogenase class
  JOURNAL   FEBS Lett 303 (1), 69-72 (1992)
   PUBMED   1592118
REFERENCE   10 (bases 1 to 2119)
  AUTHORS   Lange,L.G., Sytkowski,A.J. and Vallee,B.L.
  TITLE     Human liver alcohol dehydrogenase: purification, composition, and
            catalytic features
  JOURNAL   Biochemistry 15 (21), 4687-4693 (1976)
   PUBMED   9982
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001960.2.
            
            On Oct 23, 2020 this sequence version replaced NM_000673.6.
            
            Summary: This gene encodes class IV alcohol dehydrogenase 7 mu or
            sigma subunit, which is a member of the alcohol dehydrogenase
            family. Members of this family metabolize a wide variety of
            substrates, including ethanol, retinol, other aliphatic alcohols,
            hydroxysteroids, and lipid peroxidation products. The enzyme
            encoded by this gene is inefficient in ethanol oxidation, but is
            the most active as a retinol dehydrogenase; thus it may participate
            in the synthesis of retinoic acid, a hormone important for cellular
            differentiation. The expression of this gene is much more abundant
            in stomach than liver, thus differing from the other known gene
            family members. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and 5'
            coding region, compared to variant 1, resulting in an isoform (2)
            that has a distinct N-terminus and is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X76342.1, U09623.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2147975
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000437033.7/
                                                ENSP00000414254.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               AP001960.2         86823-86949
            128-229             AP001960.2         92532-92633
            230-368             AP001960.2         93535-93673
            369-456             AP001960.2         93991-94078
            457-673             AP001960.2         94176-94392
            674-934             AP001960.2         101372-101632
            935-1070            AP001960.2         103044-103179
            1071-1209           AP001960.2         106549-106687
            1210-2119           AP001960.2         108993-109902
FEATURES             Location/Qualifiers
     source          1..2119
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q23"
     gene            1..2119
                     /gene="ADH7"
                     /gene_synonym="ADH4"
                     /note="alcohol dehydrogenase 7 (class IV), mu or sigma
                     polypeptide"
                     /db_xref="GeneID:131"
                     /db_xref="HGNC:HGNC:256"
                     /db_xref="MIM:600086"
     exon            1..127
                     /gene="ADH7"
                     /gene_synonym="ADH4"
                     /inference="alignment:Splign:2.1.0"
     exon            128..229
                     /gene="ADH7"
                     /gene_synonym="ADH4"
                     /inference="alignment:Splign:2.1.0"
     exon            230..368
                     /gene="ADH7"
                     /gene_synonym="ADH4"
                     /inference="alignment:Splign:2.1.0"
     exon            369..456
                     /gene="ADH7"
                     /gene_synonym="ADH4"
                     /inference="alignment:Splign:2.1.0"
     exon            457..673
                     /gene="ADH7"
                     /gene_synonym="ADH4"
                     /inference="alignment:Splign:2.1.0"
     exon            674..934
                     /gene="ADH7"
                     /gene_synonym="ADH4"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1070
                     /gene="ADH7"
                     /gene_synonym="ADH4"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1209
                     /gene="ADH7"
                     /gene_synonym="ADH4"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..2119
                     /gene="ADH7"
                     /gene_synonym="ADH4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2102..2107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADH7"
                     /gene_synonym="ADH4"
                     /note="hexamer: ATTAAA"
     polyA_site      2119
                     /gene="ADH7"
                     /gene_synonym="ADH4"
                     /note="major polyA site"
ORIGIN      
        1 agactatcta tgtgaaggca caagctgctg ttatatacaa cagagtgaac tgagcatcag
       61 tcagaaaaag tctatgtttg cagaaataca gatccaagac aaagacagga tgggcactgc
      121 tggaaaagtt attaaatgca aagcagctgt gctttgggag cagaagcaac ccttctccat
      181 tgaggaaata gaagttgccc caccaaagac taaagaagtt cgcattaaga ttttggccac
      241 aggaatctgt cgcacagatg accatgtgat aaaaggaaca atggtgtcca agtttccagt
      301 gattgtggga catgaggcaa ctgggattgt agagagcatt ggagaaggag tgactacagt
      361 gaaaccaggt gacaaagtca tccctctctt tctgccacaa tgtagagaat gcaatgcttg
      421 tcgcaaccca gatggcaacc tttgcattag gagcgatatt actggtcgtg gagtactggc
      481 tgatggcacc accagattta catgcaaggg caaaccagtc caccacttca tgaacaccag
      541 tacatttacc gagtacacag tggtggatga atcttctgtt gctaagattg atgatgcagc
      601 tcctcctgag aaagtctgtt taattggctg tgggttttcc actggatatg gcgctgctgt
      661 taaaactggc aaggtcaaac ctggttccac ttgcgtcgtc tttggcctgg gaggagttgg
      721 cctgtcagtc atcatgggct gtaagtcagc tggtgcatct aggatcattg ggattgacct
      781 caacaaagac aaatttgaga aggccatggc tgtaggtgcc actgagtgta tcagtcccaa
      841 ggactctacc aaacccatca gtgaggtgct gtcagaaatg acaggcaaca acgtgggata
      901 cacctttgaa gttattgggc atcttgaaac catgattgat gccctggcat cctgccacat
      961 gaactatggg accagcgtgg ttgtaggagt tcctccatca gccaagatgc tcacctatga
     1021 cccgatgttg ctcttcactg gacgcacatg gaagggatgt gtctttggag gtttgaaaag
     1081 cagagatgat gtcccaaaac tagtgactga gttcctggca aagaaatttg acctggacca
     1141 gttgataact catgttttac catttaaaaa aatcagtgaa ggatttgagc tgctcaattc
     1201 aggacaaagc attcgaacgg tcctgacgtt ttgagatcca aagtggcagg aggtctgtgt
     1261 tgtcatggtg aactggagtt tctcttgtga gagttccctc atctgaaatc atgtatctgt
     1321 ctcacaaata caagcataag tagaagattt gttgaagaca tagaaccctt ataaagaatt
     1381 attaaccttt ataaacattt aaagtcttgt gagcacctgg gaattagtat aataacaatg
     1441 ttaatatttt tgatttacat tttgtaaggc tataattgta tcttttaaga aaacatacac
     1501 ttggatttct atgttgaaat ggagattttt aagagtttta accagctgct gcagatatat
     1561 aactcaaaac agatatagcg tataaagata tagtaaatgc atctcctaga gtaatattca
     1621 cttaacacat tgaaactatt attttttaga tttgaatata aatgtatttt ttaaacactt
     1681 gttatgagtt aagttggatt acattttgaa atcagttcat tccatgatgc atattactgg
     1741 attagattaa gaaagacaga aaagattaag ggacgggcac atttttcaac gattaagaat
     1801 catcattaca taacttggtg aaactgaaaa agtatatcat atgggtacac aaggctattt
     1861 gccagcatat attaatattt tagaaaatat tccttttgta atactgaata taaacataga
     1921 gctagaatca tattatcata cttatcataa tgttcaattt gatacagtag aattgcaagt
     1981 ccctaagtcc ctattcactg tgcttagtag tgactccatt taataaaaag tgtttttagt
     2041 ttttaacaac tacactgatg tatctatata tatctataac atgttaaaaa ttcttaagaa
     2101 aattaaaaat tatataaaa
//
