LOCUS       NM_001102470            2802 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens alcohol dehydrogenase 6 (class V) (ADH6), transcript
            variant 1, mRNA.
ACCESSION   NM_001102470
VERSION     NM_001102470.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2802)
  AUTHORS   Ostberg,L.J., Persson,B. and Hoog,J.O.
  TITLE     Computational studies of human class V alcohol dehydrogenase - the
            odd sibling
  JOURNAL   BMC Biochem 17 (1), 16 (2016)
   PUBMED   27455956
  REMARK    GeneRIF: Local structural differences between human class V ADH and
            other human ADHs includes a for class V ADH unique and conserved
            Lys51, a position directly involved in the catalytic mechanism in
            other ADHs, and nine other class V ADH-specific residues.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2802)
  AUTHORS   Jeff,J.M., Ritchie,M.D., Denny,J.C., Kho,A.N., Ramirez,A.H.,
            Crosslin,D., Armstrong,L., Basford,M.A., Wolf,W.A., Pacheco,J.A.,
            Chisholm,R.L., Roden,D.M., Hayes,M.G. and Crawford,D.C.
  TITLE     Generalization of variants identified by genome-wide association
            studies for electrocardiographic traits in African Americans
  JOURNAL   Ann Hum Genet 77 (4), 321-332 (2013)
   PUBMED   23534349
REFERENCE   3  (bases 1 to 2802)
  AUTHORS   Zuo,L., Wang,K., Zhang,X.Y., Pan,X., Wang,G., Tan,Y., Zhong,C.,
            Krystal,J.H., State,M., Zhang,H. and Luo,X.
  TITLE     Association between common alcohol dehydrogenase gene (ADH)
            variants and schizophrenia and autism
  JOURNAL   Hum Genet 132 (7), 735-743 (2013)
   PUBMED   23468174
  REMARK    GeneRIF: common ADH variants conferred risk for both schizophrenia
            in African-Americans and autism in European-Americans.
REFERENCE   4  (bases 1 to 2802)
  AUTHORS   Park,B.L., Kim,J.W., Cheong,H.S., Kim,L.H., Lee,B.C., Seo,C.H.,
            Kang,T.C., Nam,Y.W., Kim,G.B., Shin,H.D. and Choi,I.G.
  TITLE     Extended genetic effects of ADH cluster genes on the risk of
            alcohol dependence: from GWAS to replication
  JOURNAL   Hum Genet 132 (6), 657-668 (2013)
   PUBMED   23456092
REFERENCE   5  (bases 1 to 2802)
  AUTHORS   Munoz,X., Amiano,P., Celorrio,D., Dorronsoro,M., Sanchez,M.J.,
            Huerta,J.M., Barricarte,A., Arriola,L., Navarro,C.,
            Molina-Montes,E., Chirlaque,M.D., Ardanaz,E., Rodriguez,L.,
            Duell,E.J., Hijona,E., Herreros-Villanueva,M., Sala,N. and
            Bujanda,L.
  TITLE     Association of alcohol dehydrogenase polymorphisms and life-style
            factors with excessive alcohol intake within the Spanish population
            (EPIC-Spain)
  JOURNAL   Addiction 107 (12), 2117-2127 (2012)
   PUBMED   22690706
  REMARK    GeneRIF: Results show that polymorphism of ADH6 gene leads to heavy
            drinking in women.
REFERENCE   6  (bases 1 to 2802)
  AUTHORS   Sun,H.W. and Plapp,B.V.
  TITLE     Progressive sequence alignment and molecular evolution of the
            Zn-containing alcohol dehydrogenase family
  JOURNAL   J Mol Evol 34 (6), 522-535 (1992)
   PUBMED   1593644
REFERENCE   7  (bases 1 to 2802)
  AUTHORS   Chen,C.S. and Yoshida,A.
  TITLE     Enzymatic properties of the protein encoded by newly cloned human
            alcohol dehydrogenase ADH6 gene
  JOURNAL   Biochem Biophys Res Commun 181 (2), 743-747 (1991)
   PUBMED   1755855
REFERENCE   8  (bases 1 to 2802)
  AUTHORS   Yasunami,M., Chen,C.S. and Yoshida,A.
  TITLE     A human alcohol dehydrogenase gene (ADH6) encoding an additional
            class of isozyme
  JOURNAL   Proc Natl Acad Sci U S A 88 (17), 7610-7614 (1991)
   PUBMED   1881901
REFERENCE   9  (bases 1 to 2802)
  AUTHORS   Lieber,C.S.
  TITLE     Interaction of ethanol with drugs, hepatotoxic agents, carcinogens
            and vitamins
  JOURNAL   Alcohol Alcohol 25 (2-3), 157-176 (1990)
   PUBMED   2198032
  REMARK    Review article
REFERENCE   10 (bases 1 to 2802)
  AUTHORS   Lange,L.G., Sytkowski,A.J. and Vallee,B.L.
  TITLE     Human liver alcohol dehydrogenase: purification, composition, and
            catalytic features
  JOURNAL   Biochemistry 15 (21), 4687-4693 (1976)
   PUBMED   9982
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK092768.1, BC039065.1 and
            AP002026.2.
            
            On Nov 23, 2018 this sequence version replaced NM_001102470.1.
            
            Summary: This gene encodes class V alcohol dehydrogenase, which is
            a member of the alcohol dehydrogenase family. Members of this
            family metabolize a wide variety of substrates, including ethanol,
            retinol, other aliphatic alcohols, hydroxysteroids, and lipid
            peroxidation products. This gene is expressed in the stomach as
            well as in the liver, and it contains a glucocorticoid response
            element upstream of its 5' UTR, which is a steroid hormone receptor
            binding site. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK092768.1, SRR5189664.128750.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394899.6/ ENSP00000378359.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-889               AK092768.1         1-889
            890-922             BC039065.1         879-911
            923-1881            AK092768.1         923-1881
            1882-2802           AP002026.2         128626-129546       c
FEATURES             Location/Qualifiers
     source          1..2802
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q23"
     gene            1..2802
                     /gene="ADH6"
                     /gene_synonym="ADH-5"
                     /note="alcohol dehydrogenase 6 (class V)"
                     /db_xref="GeneID:130"
                     /db_xref="HGNC:HGNC:255"
                     /db_xref="MIM:103735"
     exon            1..112
                     /gene="ADH6"
                     /gene_synonym="ADH-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1222
                     /gene="ADH6"
                     /gene_synonym="ADH-5"
                     /EC_number="1.1.1.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     aldehyde reductase"
                     /codon_start=1
                     /product="alcohol dehydrogenase 6 isoform 1"
                     /protein_id="NP_001095940.1"
                     /db_xref="CCDS:CCDS43255.1"
                     /db_xref="GeneID:130"
                     /db_xref="HGNC:HGNC:255"
                     /db_xref="MIM:103735"
                     /translation="MSTTGQVIRCKAAILWKPGAPFSIEEVEVAPPKAKEVRIKVVAT
                     GLCGTEMKVLGSKHLDLLYPTILGHEGAGIVESIGEGVSTVKPGDKVITLFLPQCGEC
                     TSCLNSEGNFCIQFKQSKTQLMSDGTSRFTCKGKSIYHFGNTSTFCEYTVIKEISVAK
                     IDAVAPLEKVCLISCGFSTGFGAAINTAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAA
                     RIIGVDVNKEKFKKAQELGATECLNPQDLKKPIQEVLFDMTDAGIDFCFEAIGNLDVL
                     AAALASCNESYGVCVVVGVLPASVQLKISGQLFFSGRSLKGSVFGGWKSRQHIPKLVA
                     DYMAEKLNLDPLITHTLNLDKINEAVELMKTGKCIRCILLL"
     exon            113..214
                     /gene="ADH6"
                     /gene_synonym="ADH-5"
                     /inference="alignment:Splign:2.1.0"
     exon            215..356
                     /gene="ADH6"
                     /gene_synonym="ADH-5"
                     /inference="alignment:Splign:2.1.0"
     exon            357..444
                     /gene="ADH6"
                     /gene_synonym="ADH-5"
                     /inference="alignment:Splign:2.1.0"
     exon            445..661
                     /gene="ADH6"
                     /gene_synonym="ADH-5"
                     /inference="alignment:Splign:2.1.0"
     exon            662..922
                     /gene="ADH6"
                     /gene_synonym="ADH-5"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1058
                     /gene="ADH6"
                     /gene_synonym="ADH-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1197
                     /gene="ADH6"
                     /gene_synonym="ADH-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..2802
                     /gene="ADH6"
                     /gene_synonym="ADH-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2779..2784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADH6"
                     /gene_synonym="ADH-5"
                     /note="hexamer: AATAAA"
     polyA_site      2802
                     /gene="ADH6"
                     /gene_synonym="ADH-5"
                     /note="major polyA site"
ORIGIN      
        1 accagtcgcc tgtgtacctt tgtactttct acagtgaaag ttgctacagg atctcccttt
       61 ctcaataaat tcatctgcgg tggagaaaat cagcatgagt actacaggcc aagtcatcag
      121 atgcaaagca gccatactct ggaagcctgg tgcaccattt tctattgaag aggtagaagt
      181 ggccccacca aaggcaaagg aagttcgcat aaaggttgtg gccaccggac tgtgtggtac
      241 agagatgaaa gtgttgggga gtaaacactt ggacctcttg tatcccacca tcttgggcca
      301 tgaaggggct ggaatcgttg agagtattgg agaaggagta agcacagtga aaccaggtga
      361 caaagttatc acactctttc tgccacagtg tggagaatgt acctcttgcc tgaattctga
      421 gggcaatttt tgtatacaat tcaaacagtc aaaaacccaa ctgatgtctg atggtaccag
      481 caggtttacc tgcaagggaa aatcaatata tcactttggt aataccagca ccttctgtga
      541 atacacagtg ataaaggaaa tctcagttgc caagattgat gcagtcgctc ctctagagaa
      601 agtatgccta attagctgtg gcttttccac tgggtttggt gctgcaatca atactgccaa
      661 ggtgactcca ggttctacct gtgctgtgtt tggcctggga ggagtcggct tgtctgttgt
      721 catgggttgt aaagcagcag gagcagccag gatcattgga gtggatgtca acaaggagaa
      781 atttaagaag gcacaggaat tgggtgctac tgagtgcctc aaccctcagg acttaaagaa
      841 acccattcaa gaagttttat ttgatatgac agatgctggt atagacttct gctttgaggc
      901 cattggaaat ctggacgttc tggcagctgc cctcgcctcc tgcaatgaga gctatggggt
      961 ctgtgtggtt gttggggtgt tgcctgccag tgttcaactc aaaatcagtg gccagttgtt
     1021 cttctcagga cgttctttga agggttctgt ttttggaggc tggaagagca gacagcacat
     1081 ccctaaactg gttgctgatt atatggcaga gaagttgaat ctagatccac taattactca
     1141 tactctgaat cttgataaaa tcaatgaagc agttgaatta atgaaaactg gaaaatgtat
     1201 ccgctgtatc ctgttacttt aagtacaatg taatacatgc aagacccaaa ggatatttca
     1261 ccaactcaat ggcatttgat gtaattttca tgatttagaa gaattattca cccaatccca
     1321 tttctatatt ctgacttctg attcactccg cagtggacct atatctggct tctgacctaa
     1381 ccatttcatc aaaattgttc ttacgtaacc cagtgtcacc aaggatcagc ctccttttca
     1441 gagctagatt aaggttggct tgaatcactc aactccacat ccttcagaca taaaaggtca
     1501 atgcaagatg ctcccatttt catagttcct ctacctgtgg acctttatat tcttgtacac
     1561 tatatgtctc tctcacaggc ctagacatga aactctgcca ttttactcta aagaaacaaa
     1621 actccgcatt aatgagttta ttgaagattc aggttaacct gaatcaagtt aacccagtct
     1681 caaatgctca cttatcctat ctccttggca caaatctctc ctctcctgga ttgccaaaga
     1741 aaattcaaat tattcttcaa ttagtcagga tgatttgact atcagcagtt catagtaccc
     1801 atcttcataa ctaagccacc tagggatcca gcagaaaaaa aagggatgag gggagtcatc
     1861 atacaggagg tggatcattt agcaggatcc acacttccta caaagcggtt gtaatattaa
     1921 ataacaaaac tgttttttat tccaatcttc acataaaaca ggaataattg tatactttct
     1981 tactaatgtg ttccatggag tttttcctcc aagaagtggc ttaggggaaa atgagcccca
     2041 gtaatgcttt gtggcatcca atccttctac cccgaccctt tgactttctg ccccagcccc
     2101 tcttagttct cctagaatta ggactaaggt taagtgccct cttgggatat gacttccttc
     2161 ccttcctctt gatacaaaaa gagcctatta ccaaccctca tacacacaag agttcccttc
     2221 ctagttgcag actcttctgc tccagctgga ctcccctagc tctggactcc cactagatca
     2281 cacaggggtc cctgcatgtc agtaaacttt ggatgacctt gggagaccaa aaaatggaat
     2341 atcatttttt gatctaaaca aaatagtttc ctgatttaac actggccagg aaggtgggct
     2401 gcaccctcag tctctctctc ccatcatggt tttcacatga tatcaaagga ctctcataac
     2461 agtctgattc ttatgagttg ggcatcctgt gtttcccttt aggggcctgc ttccttcaaa
     2521 tagaggagat gggtgctatg aaacctattc actctggact tgggatggct cttctccatc
     2581 ttcccaagtc tgagctggag cctccatgcc caactctgct ctgctcttct atttcctgac
     2641 agcagctaag gcatgttcct gttctgcccc caaattgacc ttactaacag tgagaacttg
     2701 gaggagtctt cgggtcttgg gaaatccaag ttttcccgga aacgttttgt tgtaaacagt
     2761 gtccacactc tttgctccaa taaagctcgg ttccttaagc ca
//
