LOCUS       NM_000669               1454 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens alcohol dehydrogenase 1C (class I), gamma polypeptide
            (ADH1C), transcript variant 1, mRNA.
ACCESSION   NM_000669
VERSION     NM_000669.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1454)
  AUTHORS   Yu,Y. and Liu,Y.
  TITLE     LncRNA LINC01339 Hinders the Development of Wilms' Tumor via
            MiR-135b-3p/ADH1C Axis
  JOURNAL   Horm Metab Res 56 (3), 244-254 (2024)
   PUBMED   37890508
  REMARK    GeneRIF: LncRNA LINC01339 Hinders the Development of Wilms' Tumor
            via MiR-135b-3p/ADH1C Axis.
REFERENCE   2  (bases 1 to 1454)
  AUTHORS   Kukowka,A., Brzuchalski,B., Kurzawski,M., Malinowski,D. and
            Bialecka,M.A.
  TITLE     ADH1B, ADH1B/C and CYP2E1 Gene Polymorphism and the Risk of Fetal
            Alcohol Spectrum Disorder
  JOURNAL   Genes (Basel) 14 (7), 1392 (2023)
   PUBMED   37510297
  REMARK    GeneRIF: ADH1B, ADH1B/C and CYP2E1 Gene Polymorphism and the Risk
            of Fetal Alcohol Spectrum Disorder.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1454)
  AUTHORS   Hoang,Y.T.T., Nguyen,Y.T., Vu,L.T., Bui,H.T.T., Nguyen,Q.V.,
            Vu,N.P., Nguyen,T.D. and Nguyen,H.H.
  TITLE     Association of ADH1B rs1229984, ADH1C rs698, and ALDH2 rs671 with
            Alcohol abuse and Alcoholic Cirrhosis in People Living in Northeast
            Vietnam
  JOURNAL   Asian Pac J Cancer Prev 24 (6), 2073-2082 (2023)
   PUBMED   37378938
  REMARK    GeneRIF: Association of ADH1B rs1229984, ADH1C rs698, and ALDH2
            rs671 with Alcohol abuse and Alcoholic Cirrhosis in People Living
            in Northeast Vietnam.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1454)
  AUTHORS   Aliyeva,G., Muslumov,G., Bayramov,B., Zeynalov,N. and Behbudov,V.
  TITLE     INVESTIGATION OF ALCOHOL DEHYDROGENASE (ADH3) GENE POLYMOPHISM IN
            PATIENTS WITH CHRONIC ALCOHOLIC PANCRATITIS IN AZERBAIJAN
            POPULATION
  JOURNAL   Georgian Med News (332), 113-117 (2022)
   PUBMED   36701787
  REMARK    GeneRIF: INVESTIGATION OF ALCOHOL DEHYDROGENASE (ADH3) GENE
            POLYMOPHISM IN PATIENTS WITH CHRONIC ALCOHOLIC PANCRATITIS IN
            AZERBAIJAN POPULATION.
REFERENCE   5  (bases 1 to 1454)
  AUTHORS   Yokoyama,S., Matsuo,Y., Rajasekharan,S. and Yokoyama,R.
  TITLE     Molecular structure of the human alcohol dehydrogenase 3 gene
  JOURNAL   Jpn J Genet 67 (2), 167-171 (1992)
   PUBMED   1524834
REFERENCE   6  (bases 1 to 1454)
  AUTHORS   Hurley,T.D., Bosron,W.F., Hamilton,J.A. and Amzel,L.M.
  TITLE     Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic
            effects of non-active-site substitutions
  JOURNAL   Proc Natl Acad Sci U S A 88 (18), 8149-8153 (1991)
   PUBMED   1896463
REFERENCE   7  (bases 1 to 1454)
  AUTHORS   Stewart,M.J., McBride,M.S., Winter,L.A. and Duester,G.
  TITLE     Promoters for the human alcohol dehydrogenase genes ADH1, ADH2, and
            ADH3: interaction of CCAAT/enhancer-binding protein with elements
            flanking the ADH2 TATA box
  JOURNAL   Gene 90 (2), 271-279 (1990)
   PUBMED   2169444
REFERENCE   8  (bases 1 to 1454)
  AUTHORS   Yasunami,M., Kikuchi,I., Sarapata,D. and Yoshida,A.
  TITLE     The human class I alcohol dehydrogenase gene cluster: three genes
            are tandemly organized in an 80-kb-long segment of the genome
  JOURNAL   Genomics 7 (2), 152-158 (1990)
   PUBMED   2347582
REFERENCE   9  (bases 1 to 1454)
  AUTHORS   Ikuta,T., Szeto,S. and Yoshida,A.
  TITLE     Three human alcohol dehydrogenase subunits: cDNA structure and
            molecular and evolutionary divergence
  JOURNAL   Proc Natl Acad Sci U S A 83 (3), 634-638 (1986)
   PUBMED   2935875
REFERENCE   10 (bases 1 to 1454)
  AUTHORS   Lange,L.G., Sytkowski,A.J. and Vallee,B.L.
  TITLE     Human liver alcohol dehydrogenase: purification, composition, and
            catalytic features
  JOURNAL   Biochemistry 15 (21), 4687-4693 (1976)
   PUBMED   9982
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA562068.1, BC074786.2 and
            CD014078.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000669.4.
            
            Summary: This gene encodes class I alcohol dehydrogenase, gamma
            subunit, which is a member of the alcohol dehydrogenase family.
            Members of this enzyme family metabolize a wide variety of
            substrates, including ethanol, retinol, other aliphatic alcohols,
            hydroxysteroids, and lipid peroxidation products. Class I alcohol
            dehydrogenase, consisting of several homo- and heterodimers of
            alpha, beta, and gamma subunits, exhibits high activity for ethanol
            oxidation to acetaldehyde, thus playing a major role in ethanol
            catabolism. Three genes encoding alpha, beta and gamma subunits are
            tandemly organized in a genomic segment as a gene cluster. An
            association between ADH1C polymorphism and alcohol dependence has
            not been established. [provided by RefSeq, Sep 2019].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.164929.1,
                                           SRR5189664.65250.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2152474
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000515683.6/ ENSP00000426083.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                DA562068.1         300-343
            45-1230             BC074786.2         1-1186
            1231-1454           CD014078.1         1187-1410
FEATURES             Location/Qualifiers
     source          1..1454
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q23"
     gene            1..1454
                     /gene="ADH1C"
                     /gene_synonym="ADH3"
                     /note="alcohol dehydrogenase 1C (class I), gamma
                     polypeptide"
                     /db_xref="GeneID:126"
                     /db_xref="HGNC:HGNC:251"
                     /db_xref="MIM:103730"
     exon            1..89
                     /gene="ADH1C"
                     /gene_synonym="ADH3"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1199
                     /gene="ADH1C"
                     /gene_synonym="ADH3"
                     /EC_number="1.1.1.1"
                     /note="ADH, gamma subunit; alcohol dehydrogenase 3 (class
                     I), gamma polypeptide; aldehyde reductase"
                     /codon_start=1
                     /product="alcohol dehydrogenase 1C"
                     /protein_id="NP_000660.1"
                     /db_xref="CCDS:CCDS54780.1"
                     /db_xref="GeneID:126"
                     /db_xref="HGNC:HGNC:251"
                     /db_xref="MIM:103730"
                     /translation="MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAA
                     GICRSDEHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCR
                     ICKNPESNYCLKNDLGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAK
                     IDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAA
                     RIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTM
                     MASLLCCHEACGTSVIVGVPPDSQNLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVA
                     DFMAKKFSLDALITNILPFEKINEGFDLLRSGKSIRTVLTF"
     exon            90..191
                     /gene="ADH1C"
                     /gene_synonym="ADH3"
                     /inference="alignment:Splign:2.1.0"
     exon            192..330
                     /gene="ADH1C"
                     /gene_synonym="ADH3"
                     /inference="alignment:Splign:2.1.0"
     exon            331..418
                     /gene="ADH1C"
                     /gene_synonym="ADH3"
                     /inference="alignment:Splign:2.1.0"
     exon            419..638
                     /gene="ADH1C"
                     /gene_synonym="ADH3"
                     /inference="alignment:Splign:2.1.0"
     exon            639..899
                     /gene="ADH1C"
                     /gene_synonym="ADH3"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1035
                     /gene="ADH1C"
                     /gene_synonym="ADH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1174
                     /gene="ADH1C"
                     /gene_synonym="ADH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1454
                     /gene="ADH1C"
                     /gene_synonym="ADH3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1433..1438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADH1C"
                     /gene_synonym="ADH3"
                     /note="hexamer: AATAAA"
     polyA_site      1454
                     /gene="ADH1C"
                     /gene_synonym="ADH3"
                     /note="major polyA site"
ORIGIN      
        1 atgcactcaa gcagagaaga aatccacaag tactcaccag cctcctggtc tgcagagaag
       61 acagaatcaa tatgagcaca gcaggaaaag taatcaaatg caaagcagct gtgctatggg
      121 agttaaagaa acccttttcc attgaggagg tagaggttgc acctcctaag gctcatgaag
      181 ttcgcattaa gatggtggct gcaggaatct gtcgttcaga tgagcatgtg gttagtggca
      241 acctggtgac cccccttcct gtgattttag gccatgaggc agccggcatc gtggaaagtg
      301 ttggagaagg ggtgactaca gtcaaaccag gtgataaagt catcccgctc tttactcctc
      361 agtgtggaaa atgcagaatt tgtaaaaacc cagaaagcaa ctactgcttg aaaaatgatc
      421 taggcaatcc tcgggggacc ctgcaggatg gcaccaggag gttcacctgc agcgggaagc
      481 ccatccacca cttcgtcggc gtcagcacct tctcccagta cacagtggtg gatgagaatg
      541 cagtggccaa aattgatgca gcctcgcccc tggagaaagt ctgcctcatt ggctgtggat
      601 tttcgactgg ttatgggtct gcagtcaaag ttgccaaggt caccccaggg tctacctgtg
      661 ctgtgtttgg cctgggaggg gtcggcctat ctgttgttat gggctgtaaa gcagctggag
      721 cagccagaat cattgctgtg gacatcaaca aggacaaatt tgcaaaggct aaagagttgg
      781 gtgccactga atgcatcaac cctcaagact acaagaaacc cattcaggaa gtgctaaagg
      841 aaatgactga tggaggtgtg gatttttcgt ttgaagtcat cggtcggctt gacaccatga
      901 tggcttccct gttatgttgt catgaggcat gtggcacaag tgtcattgta ggggtacctc
      961 ctgattccca gaacctctca ataaacccta tgctgctact gactggacgc acgtggaaag
     1021 gagctatttt tggaggcttt aagagtaaag aatctgtccc caaacttgtg gctgacttta
     1081 tggctaagaa gttttcactg gatgcattaa taacaaatat tttacctttt gaaaaaataa
     1141 atgaaggatt tgacctgctt cgctctggaa agagtatccg taccgtcctg acgttttgaa
     1201 acaatacaga tgccttccct tgtagcagtt ttcagcctcc tctaccctac atgatctgga
     1261 gcaacagcta ggaaatatca ttaattctgc tcttcagaga tgttaaaaat aaattacacg
     1321 tgggagcttt ccaaagaaat ggaaattgat gggaaattat ttgtcaagca aatgtttaaa
     1381 atccaaatga gaactaaata aagtgttgaa catcaactgg ggaattgaag ccaataaacc
     1441 ttccttctta acca
//
