LOCUS       NM_022159               3539 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens adhesion G protein-coupled receptor L4 (ADGRL4), mRNA.
ACCESSION   NM_022159 XM_371262 XM_942048
VERSION     NM_022159.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3539)
  AUTHORS   Huang,H., Georganaki,M., Conze,L.L., Lavina,B., van Hooren,L.,
            Vemuri,K., van de Walle,T., Ramachandran,M., Zhang,L., Ponten,F.,
            Bergqvist,M., Smits,A., Betsholtz,C., Dejana,E., Magnusson,P.U.,
            He,L., Lugano,R. and Dimberg,A.
  TITLE     ELTD1 deletion reduces vascular abnormality and improves T-cell
            recruitment after PD-1 blockade in glioma
  JOURNAL   Neuro Oncol 24 (3), 398-411 (2022)
   PUBMED   34347079
  REMARK    GeneRIF: ELTD1 deletion reduces vascular abnormality and improves
            T-cell recruitment after PD-1 blockade in glioma.
REFERENCE   2  (bases 1 to 3539)
  AUTHORS   Sheldon,H., Bridges,E., Silva,I., Masiero,M., Favara,D.M., Wang,D.,
            Leek,R., Snell,C., Roxanis,I., Kreuzer,M., Gileadi,U., Buffa,F.M.,
            Banham,A. and Harris,A.L.
  TITLE     ADGRL4/ELTD1 Expression in Breast Cancer Cells Induces Vascular
            Normalization and Immune Suppression
  JOURNAL   Mol Cancer Res 19 (11), 1957-1969 (2021)
   PUBMED   34348993
  REMARK    GeneRIF: ADGRL4/ELTD1 Expression in Breast Cancer Cells Induces
            Vascular Normalization and Immune Suppression.
REFERENCE   3  (bases 1 to 3539)
  AUTHORS   Sheldon,H., Alexander,J., Bridges,E., Moreira,L., Reilly,S.,
            Ang,K.H., Wang,D., Lin,S., Haider,S., Banham,A.H. and Harris,A.L.
  TITLE     ELTD1 Activation Induces an Endothelial-EMT Transition to a
            Myofibroblast Phenotype
  JOURNAL   Int J Mol Sci 22 (20), 11293 (2021)
   PUBMED   34681953
  REMARK    GeneRIF: ELTD1 Activation Induces an Endothelial-EMT Transition to
            a Myofibroblast Phenotype.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3539)
  AUTHORS   Sun,J., Zhang,Z., Chen,J., Xue,M. and Pan,X.
  TITLE     ELTD1 promotes invasion and metastasis by activating MMP2 in
            colorectal cancer
  JOURNAL   Int J Biol Sci 17 (12), 3048-3058 (2021)
   PUBMED   34421349
  REMARK    GeneRIF: ELTD1 promotes invasion and metastasis by activating MMP2
            in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3539)
  AUTHORS   Favara,D.M., Liebscher,I., Jazayeri,A., Nambiar,M., Sheldon,H.,
            Banham,A.H. and Harris,A.L.
  TITLE     Elevated expression of the adhesion GPCR ADGRL4/ELTD1 promotes
            endothelial sprouting angiogenesis without activating canonical
            GPCR signalling
  JOURNAL   Sci Rep 11 (1), 8870 (2021)
   PUBMED   33893326
  REMARK    GeneRIF: Elevated expression of the adhesion GPCR ADGRL4/ELTD1
            promotes endothelial sprouting angiogenesis without activating
            canonical GPCR signalling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3539)
  AUTHORS   Agrawal,A., Pergadia,M.L., Saccone,S.F., Lynskey,M.T., Wang,J.C.,
            Martin,N.G., Statham,D., Henders,A., Campbell,M., Garcia,R.,
            Broms,U., Todd,R.D., Goate,A.M., Rice,J., Kaprio,J., Heath,A.C.,
            Montgomery,G.W. and Madden,P.A.
  TITLE     An autosomal linkage scan for cannabis use disorders in the
            nicotine addiction genetics project
  JOURNAL   Arch Gen Psychiatry 65 (6), 713-721 (2008)
   PUBMED   18519829
  REMARK    GeneRIF: Genes such as ELTD1 on chromosome 1, in addition to genes
            on chromosomes 4 (eg, GABRA2) and 6 (eg, CNR1), may be associated
            with the genetic risk for cannabis use disorders.
REFERENCE   7  (bases 1 to 3539)
  AUTHORS   Liu,T., Qian,W.J., Gritsenko,M.A., Camp,D.G. 2nd, Monroe,M.E.,
            Moore,R.J. and Smith,R.D.
  TITLE     Human plasma N-glycoproteome analysis by immunoaffinity
            subtraction, hydrazide chemistry, and mass spectrometry
  JOURNAL   J Proteome Res 4 (6), 2070-2080 (2005)
   PUBMED   16335952
REFERENCE   8  (bases 1 to 3539)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
REFERENCE   9  (bases 1 to 3539)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 3539)
  AUTHORS   Nechiporuk,T., Urness,L.D. and Keating,M.T.
  TITLE     ETL, a novel seven-transmembrane receptor that is developmentally
            regulated in the heart. ETL is a member of the secretin family and
            belongs to the epidermal growth factor-seven-transmembrane
            subfamily
  JOURNAL   J Biol Chem 276 (6), 4150-4157 (2001)
   PUBMED   11050079
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA477962.1, AB032017.1, AK129766.1 and AC099674.2.
            
            On Nov 23, 2018 this sequence version replaced NM_022159.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358360.1, BC025721.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370742.4/ ENSP00000359778.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 DA477962.1         81-88
            9-1934              AB032017.1         50-1975
            1935-2915           AK129766.1         467-1447
            2916-3539           AC099674.2         174240-174863       c
FEATURES             Location/Qualifiers
     source          1..3539
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..3539
                     /gene="ADGRL4"
                     /gene_synonym="ELTD1; ETL; KPG_003"
                     /note="adhesion G protein-coupled receptor L4"
                     /db_xref="GeneID:64123"
                     /db_xref="HGNC:HGNC:20822"
                     /db_xref="MIM:616419"
     exon            1..98
                     /gene="ADGRL4"
                     /gene_synonym="ELTD1; ETL; KPG_003"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..2149
                     /gene="ADGRL4"
                     /gene_synonym="ELTD1; ETL; KPG_003"
                     /note="EGF-TM7-latrophilin-related protein; EGF,
                     latrophilin and seven transmembrane domain containing 1;
                     EGF, latrophilin and seven transmembrane domain-containing
                     protein 1"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor L4
                     precursor"
                     /protein_id="NP_071442.2"
                     /db_xref="CCDS:CCDS41352.1"
                     /db_xref="GeneID:64123"
                     /db_xref="HGNC:HGNC:20822"
                     /db_xref="MIM:616419"
                     /translation="MKRLPLLVVFSTLLNCSYTQNCTKTPCLPNAKCEIRNGIEACYC
                     NMGFSGNGVTICEDDNECGNLTQSCGENANCTNTEGSYYCMCVPGFRSSSNQDRFITN
                     DGTVCIENVNANCHLDNVCIAANINKTLTKIRSIKEPVALLQEVYRNSVTDLSPTDII
                     TYIEILAESSSLLGYKNNTISAKDTLSNSTLTEFVKTVNNFVQRDTFVVWDKLSVNHR
                     RTHLTKLMHTVEQATLRISQSFQKTTEFDTNSTDIALKVFFFDSYNMKHIHPHMNMDG
                     DYINIFPKRKAAYDSNGNVAVAFVYYKSIGPLLSSSDNFLLKPQNYDNSEEEERVISS
                     VISVSMSSNPPTLYELEKITFTLSHRKVTDRYRSLCAFWNYSPDTMNGSWSSEGCELT
                     YSNETHTSCRCNHLTHFAILMSSGPSIGIKDYNILTRITQLGIIISLICLAICIFTFW
                     FFSEIQSTRTTIHKNLCCSLFLAELVFLVGINTNTNKLFCSIIAGLLHYFFLAAFAWM
                     CIEGIHLYLIVVGVIYNKGFLHKNFYIFGYLSPAVVVGFSAALGYRYYGTTKVCWLST
                     ENNFIWSFIGPACLIILVNLLAFGVIIYKVFRHTAGLKPEVSCFENIRSCARGALALL
                     FLLGTTWIFGVLHVVHASVVTAYLFTVSNAFQGMFIFLFLCVLSRKIQEEYYRLFKNV
                     PCCFGCLR"
     exon            99..248
                     /gene="ADGRL4"
                     /gene_synonym="ELTD1; ETL; KPG_003"
                     /inference="alignment:Splign:2.1.0"
     exon            249..401
                     /gene="ADGRL4"
                     /gene_synonym="ELTD1; ETL; KPG_003"
                     /inference="alignment:Splign:2.1.0"
     exon            402..472
                     /gene="ADGRL4"
                     /gene_synonym="ELTD1; ETL; KPG_003"
                     /inference="alignment:Splign:2.1.0"
     exon            473..652
                     /gene="ADGRL4"
                     /gene_synonym="ELTD1; ETL; KPG_003"
                     /inference="alignment:Splign:2.1.0"
     exon            653..836
                     /gene="ADGRL4"
                     /gene_synonym="ELTD1; ETL; KPG_003"
                     /inference="alignment:Splign:2.1.0"
     exon            837..953
                     /gene="ADGRL4"
                     /gene_synonym="ELTD1; ETL; KPG_003"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1159
                     /gene="ADGRL4"
                     /gene_synonym="ELTD1; ETL; KPG_003"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1333
                     /gene="ADGRL4"
                     /gene_synonym="ELTD1; ETL; KPG_003"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1537
                     /gene="ADGRL4"
                     /gene_synonym="ELTD1; ETL; KPG_003"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1758
                     /gene="ADGRL4"
                     /gene_synonym="ELTD1; ETL; KPG_003"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1825
                     /gene="ADGRL4"
                     /gene_synonym="ELTD1; ETL; KPG_003"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1917
                     /gene="ADGRL4"
                     /gene_synonym="ELTD1; ETL; KPG_003"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2086
                     /gene="ADGRL4"
                     /gene_synonym="ELTD1; ETL; KPG_003"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..3539
                     /gene="ADGRL4"
                     /gene_synonym="ELTD1; ETL; KPG_003"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2681..2686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRL4"
                     /gene_synonym="ELTD1; ETL; KPG_003"
                     /note="hexamer: AATAAA"
     polyA_site      2702
                     /gene="ADGRL4"
                     /gene_synonym="ELTD1; ETL; KPG_003"
                     /note="major polyA site"
     regulatory      3518..3523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRL4"
                     /gene_synonym="ELTD1; ETL; KPG_003"
                     /note="hexamer: AATAAA"
     polyA_site      3539
                     /gene="ADGRL4"
                     /gene_synonym="ELTD1; ETL; KPG_003"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcccggt cccgggtcca cagccgcact cactccgccg cgctctccgc caccgccacc
       61 actgcggcca ccgccaatga aacgcctccc gctcctagtg gttttttcca ctttgttgaa
      121 ttgttcctat actcaaaatt gcaccaagac accttgtctc ccaaatgcaa aatgtgaaat
      181 acgcaatgga attgaagcct gctattgcaa catgggattt tcaggaaatg gtgtcacaat
      241 ttgtgaagat gataatgaat gtggaaattt aactcagtcc tgtggcgaaa atgctaattg
      301 cactaacaca gaaggaagtt attattgtat gtgtgtacct ggcttcagat ccagcagtaa
      361 ccaagacagg tttatcacta atgatggaac cgtctgtata gaaaatgtga atgcaaactg
      421 ccatttagat aatgtctgta tagctgcaaa tattaataaa actttaacaa aaatcagatc
      481 cataaaagaa cctgtggctt tgctacaaga agtctataga aattctgtga cagatctttc
      541 accaacagat ataattacat atatagaaat attagctgaa tcatcttcat tactaggtta
      601 caagaacaac actatctcag ccaaggacac cctttctaac tcaactctta ctgaatttgt
      661 aaaaaccgtg aataattttg ttcaaaggga tacatttgta gtttgggaca agttatctgt
      721 gaatcatagg agaacacatc ttacaaaact catgcacact gttgaacaag ctactttaag
      781 gatatcccag agcttccaaa agaccacaga gtttgataca aattcaacgg atatagctct
      841 caaagttttc ttttttgatt catataacat gaaacatatt catcctcata tgaatatgga
      901 tggagactac ataaatatat ttccaaagag aaaagctgca tatgattcaa atggcaatgt
      961 tgcagttgca tttgtatatt ataagagtat tggtcctttg ctttcatcat ctgacaactt
     1021 cttattgaaa cctcaaaatt atgataattc tgaagaggag gaaagagtca tatcttcagt
     1081 aatttcagtc tcaatgagct caaacccacc cacattatat gaacttgaaa aaataacatt
     1141 tacattaagt catcgaaagg tcacagatag gtataggagt ctatgtgcat tttggaatta
     1201 ctcacctgat accatgaatg gcagctggtc ttcagagggc tgtgagctga catactcaaa
     1261 tgagacccac acctcatgcc gctgtaatca cctgacacat tttgcaattt tgatgtcctc
     1321 tggtccttcc attggtatta aagattataa tattcttaca aggatcactc aactaggaat
     1381 aattatttca ctgatttgtc ttgccatatg catttttacc ttctggttct tcagtgaaat
     1441 tcaaagcacc aggacaacaa ttcacaaaaa tctttgctgt agcctatttc ttgctgaact
     1501 tgtttttctt gttgggatca atacaaatac taataagctc ttctgttcaa tcattgccgg
     1561 actgctacac tacttctttt tagctgcttt tgcatggatg tgcattgaag gcatacatct
     1621 ctatctcatt gttgtgggtg tcatctacaa caagggattt ttgcacaaga atttttatat
     1681 ctttggctat ctaagcccag ccgtggtagt tggattttcg gcagcactag gatacagata
     1741 ttatggcaca accaaagtat gttggcttag caccgaaaac aactttattt ggagttttat
     1801 aggaccagca tgcctaatca ttcttgttaa tctcttggct tttggagtca tcatatacaa
     1861 agtttttcgt cacactgcag ggttgaaacc agaagttagt tgctttgaga acataaggtc
     1921 ttgtgcaaga ggagccctcg ctcttctgtt ccttctcggc accacctgga tctttggggt
     1981 tctccatgtt gtgcacgcat cagtggttac agcttacctc ttcacagtca gcaatgcttt
     2041 ccaggggatg ttcatttttt tattcctgtg tgttttatct agaaagattc aagaagaata
     2101 ttacagattg ttcaaaaatg tcccctgttg ttttggatgt ttaaggtaaa catagagaat
     2161 ggtggataat tacaactgca caaaaataaa aattccaagc tgtggatgac caatgtataa
     2221 aaatgactca tcaaattatc caattattaa ctactagaca aaaagtattt taaatcagtt
     2281 tttctgttta tgctatagga actgtagata ataaggtaaa attatgtatc atatagatat
     2341 actatgtttt tctatgtgaa atagttctgt caaaaatagt attgcagata tttggaaagt
     2401 aattggtttc tcaggagtga tatcactgca cccaaggaaa gattttcttt ctaacacgag
     2461 aagtatatga atgtcctgaa ggaaaccact ggcttgatat ttctgtgact cgtgttgcct
     2521 ttgaaactag tcccctacca cctcggtaat gagctccatt acagaaagtg gaacataaga
     2581 gaatgaaggg gcagaatatc aaacagtgaa aagggaatga taagatgtat tttgaatgaa
     2641 ctgttttttc tgtagactag ctgagaaatt gttgacataa aataaagaat tgaagaaaca
     2701 cattttacca ttttgtgaat tgttctgaac ttaaatgtcc actaaaacaa cttagacttc
     2761 tgtttgctaa atctgtttct ttttctaata ttctaaaaaa aaaaaaaagg tttacctcca
     2821 caaattgaaa aaaaaaaagt gaaaaaaatc tgtttctaag gttagactga gatatatact
     2881 atttccttac ttatttcaca gattgtgact ttggatagtt aatcagtaaa atataaatgt
     2941 gtcaagatat aatattgttt atacctatca atgtaaaaac agtgtaataa agctgaagta
     3001 ttctattacc tttcagtgaa gtgaaagtta tactatctca ttagtatatt tgaatccttt
     3061 attattttta attttataaa tatcacagtt cacattgcaa tattcccttt aatttactat
     3121 ttttaaaggg gtattgtaaa tatgaaagta tttataaagt gaattgctat tttttctgtt
     3181 cagaaaagta cacacttaaa attgttattg ttaacaatgt gtaaacacat ttaaaattgt
     3241 tattgttaac aaagaaatca tggagaactg tagaggtttt cacagtggat ccattttctg
     3301 acagttttct actatctatt aaatcatatc tgcttaaata tatagcttct atctgtcttt
     3361 aaatcttctc attaaaatgt ataagcagtg attttgatct caaaaatagg taatttttct
     3421 ttgccgacct gtaaaagtgt gccaatacac taaatttgtg attttaaatt aattcctcca
     3481 gctgttgaaa tgaagtctgc caaatcttgc tctaacaaat aaaatgttat ctaaatgaa
//
