LOCUS       NM_001387552           13738 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens adhesion G protein-coupled receptor L3 (ADGRL3),
            transcript variant 37, mRNA.
ACCESSION   NM_001387552
VERSION     NM_001387552.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13738)
  AUTHORS   Bui,D.L.H., Roach,A., Li,J., Bandekar,S.J., Orput,E., Raghavan,R.,
            Arac,D. and Sando,R.C.
  TITLE     The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via
            distinct activation mechanisms
  JOURNAL   Cell Rep 42 (6), 112552 (2023)
   PUBMED   37224017
  REMARK    GeneRIF: The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins
            via distinct activation mechanisms.
REFERENCE   2  (bases 1 to 13738)
  AUTHORS   Vidal,O.M., Velez,J.I. and Arcos-Burgos,M.
  TITLE     ADGRL3 genomic variation implicated in neurogenesis and ADHD links
            functional effects to the incretin polypeptide GIP
  JOURNAL   Sci Rep 12 (1), 15922 (2022)
   PUBMED   36151371
  REMARK    GeneRIF: ADGRL3 genomic variation implicated in neurogenesis and
            ADHD links functional effects to the incretin polypeptide GIP.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 13738)
  AUTHORS   Wang,J., Xi,S.Y., Zhao,Q., Xia,Y.F., Yang,Q.Y., Cai,H.P., Wang,F.,
            Zhao,Y.Y., Hu,H.J., Yu,Z.H., Chen,F.R., Xu,P.F., Xu,R.Z., Wang,J.,
            Zhang,J., Ke,C., Zhang,X.H., Lin,F.H., Guo,C.C., Lv,Y.C., Li,C.,
            Xie,H.T., Cui,Q., Wu,H.M., Liu,Y.H., Li,Z., Su,H.K., Zeng,J.,
            Han,F., Li,Z.J., Sai,K. and Chen,Z.P.
  TITLE     Driver mutations in ADGRL3 are involved in the evolution of
            ependymoma
  JOURNAL   Lab Invest 102 (7), 702-710 (2022)
   PUBMED   35013530
  REMARK    GeneRIF: Driver mutations in ADGRL3 are involved in the evolution
            of ependymoma.
REFERENCE   4  (bases 1 to 13738)
  AUTHORS   Avila-Zozaya,M., Rodriguez-Hernandez,B., Monterrubio-Ledezma,F.,
            Cisneros,B. and Boucard,A.A.
  TITLE     Thwarting of Lphn3 Functions in Cell Motility and Signaling by
            Cancer-Related GAIN Domain Somatic Mutations
  JOURNAL   Cells 11 (12), 1913 (2022)
   PUBMED   35741042
  REMARK    GeneRIF: Thwarting of Lphn3 Functions in Cell Motility and
            Signaling by Cancer-Related GAIN Domain Somatic Mutations.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 13738)
  AUTHORS   Moreno-Salinas,A.L., Holleran,B.J., Ojeda-Muniz,E.Y.,
            Correoso-Brana,K.G., Ribalta-Mena,S., Ovando-Zambrano,J.C.,
            Leduc,R. and Boucard,A.A.
  TITLE     Convergent selective signaling impairment exposes the pathogenicity
            of latrophilin-3 missense variants linked to inheritable ADHD
            susceptibility
  JOURNAL   Mol Psychiatry 27 (5), 2425-2438 (2022)
   PUBMED   35393556
  REMARK    GeneRIF: Convergent selective signaling impairment exposes the
            pathogenicity of latrophilin-3 missense variants linked to
            inheritable ADHD susceptibility.
REFERENCE   6  (bases 1 to 13738)
  AUTHORS   Ushkaryov,Y.A., Volynski,K.E. and Ashton,A.C.
  TITLE     The multiple actions of black widow spider toxins and their
            selective use in neurosecretion studies
  JOURNAL   Toxicon 43 (5), 527-542 (2004)
   PUBMED   15066411
  REMARK    Review article
REFERENCE   7  (bases 1 to 13738)
  AUTHORS   Sudhof,T.C.
  TITLE     alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins
  JOURNAL   Annu Rev Neurosci 24, 933-962 (2001)
   PUBMED   11520923
  REMARK    Review article
REFERENCE   8  (bases 1 to 13738)
  AUTHORS   Kreienkamp,H.J., Zitzer,H., Gundelfinger,E.D., Richter,D. and
            Bockers,T.M.
  TITLE     The calcium-independent receptor for alpha-latrotoxin from human
            and rodent brains interacts with members of the ProSAP/SSTRIP/Shank
            family of multidomain proteins
  JOURNAL   J Biol Chem 275 (42), 32387-32390 (2000)
   PUBMED   10964907
REFERENCE   9  (bases 1 to 13738)
  AUTHORS   Hayflick,J.S.
  TITLE     A family of heptahelical receptors with adhesion-like domains: a
            marriage between two super families
  JOURNAL   J Recept Signal Transduct Res 20 (2-3), 119-131 (2000)
   PUBMED   10994649
  REMARK    Review article
REFERENCE   10 (bases 1 to 13738)
  AUTHORS   Soares,M.B., Bonaldo,M.F., Jelene,P., Su,L., Lawton,L. and
            Efstratiadis,A.
  TITLE     Construction and characterization of a normalized cDNA library
  JOURNAL   Proc Natl Acad Sci U S A 91 (20), 9228-9232 (1994)
   PUBMED   7937745
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092643.2, AC020741.4,
            AC092668.2, AC108161.4, AC096723.3, AC092663.2 and AC007511.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a member of the latrophilin subfamily of
            G-protein coupled receptors (GPCR). Latrophilins may function in
            both cell adhesion and signal transduction. In experiments with
            non-human species, endogenous proteolytic cleavage within a
            cysteine-rich GPS (G-protein-coupled-receptor proteolysis site)
            domain resulted in two subunits (a large extracellular N-terminal
            cell adhesion subunit and a subunit with substantial similarity to
            the secretin/calcitonin family of GPCRs) being non-covalently bound
            at the cell membrane. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN03465402,
                              SAMN03465403 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683033.1/ ENSP00000507980.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1440              AC092643.2         143976-145415       c
            1441-1506           AC020741.4         152356-152421       c
            1507-1734           AC020741.4         38197-38424         c
            1735-1938           AC020741.4         18027-18230         c
            1939-2152           AC092668.2         117214-117427       c
            2153-2262           AC092668.2         27719-27828         c
            2263-2277           AC108161.4         27969-27983
            2278-3078           AC108161.4         30101-30901
            3079-3159           AC096723.3         30133-30213
            3160-3462           AC096723.3         108980-109282
            3463-3566           AC096723.3         112055-112158
            3567-3752           AC092663.2         103792-103977       c
            3753-3791           AC092663.2         100780-100818       c
            3792-3975           AC092663.2         78514-78697         c
            3976-4098           AC092663.2         77492-77614         c
            4099-4307           AC092663.2         66415-66623         c
            4308-4484           AC092663.2         65261-65437         c
            4485-4694           AC092663.2         33765-33974         c
            4695-4915           AC092663.2         29934-30154         c
            4916-4982           AC092663.2         17180-17246         c
            4983-5074           AC092663.2         15272-15363         c
            5075-5101           AC007511.8         151478-151504       c
            5102-5270           AC007511.8         148749-148917       c
            5271-5396           AC007511.8         142503-142628       c
            5397-5493           AC007511.8         135810-135906       c
            5494-5511           AC007511.8         112176-112193       c
            5512-13738          AC007511.8         102024-110250       c
FEATURES             Location/Qualifiers
     source          1..13738
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.1"
     gene            1..13738
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /note="adhesion G protein-coupled receptor L3"
                     /db_xref="GeneID:23284"
                     /db_xref="HGNC:HGNC:20974"
                     /db_xref="MIM:616417"
     exon            1..1440
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1506
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1734
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             1680..6311
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /note="isoform 23 precursor is encoded by transcript
                     variant 37; latrophilin homolog 3 (cow);
                     calcium-independent alpha-latrotoxin receptor 3;
                     latrophilin-3; lectomedin 3"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor L3 isoform
                     23 precursor"
                     /protein_id="NP_001374481.1"
                     /db_xref="CCDS:CCDS93538.1"
                     /db_xref="GeneID:23284"
                     /db_xref="HGNC:HGNC:20974"
                     /db_xref="MIM:616417"
                     /translation="MWPSQLLIFMMLLAPIIHGGKHSERHPALAAPLRHAERSPGGAL
                     PPRHLLQQPAAERTAAHRGQGPRGATRGVRGPGAQGAQIAAQAFSRAPIPMAVVRREL
                     SCESYPIELRCPGTDVIMIESANYGRTDDKICDSDPAQMENIRCYLPDAYKIMSQRCN
                     NRTQCAVVAGPDVFPDPCPGTYKYLEVQYECVPYKVEQKVFLCPGLLKGVYQSEHLFE
                     SDHQSGAWCKDPLQASDKIYYMPWTPYRTDTLTEYSSKDDFIAGRPTTTYKLPHRVDG
                     TGFVVYDGALFFNKERTRNIVKFDLRTRIKSGEAIIANANYHDTSPYRWGGKSDIDLA
                     VDENGLWVIYATEQNNGKIVISQLNPYTLRIEGTWDTAYDKRSASNAFMICGILYVVK
                     SVYEDDDNEATGNKIDYIYNTDQSKDSLVDVPFPNSYQYIAAVDYNPRDNLLYVWNNY
                     HVVKYSLDFGPLDSRSGQAHHGQVSYISPPIHLDSELERPSVKDISTTGPLGMGSTTT
                     STTLRTTTLSPGRSTTPSVSGRRNRSTSTPSPAVEVLDDMTTHLPSASSQIPALEESC
                     EAVEAREIMWFKTRQGQIAKQPCPAGTIGVSTYLCLAPDGIWDPQGPDLSNCSSPWVN
                     HITQKLKSGETAANIARELAEQTRNHLNAGDITYSVRAMDQLVGLLDVQLRNLTPGGK
                     DSAARSLNKLQKRERSCRAYVQAMVETVNNLLQPQALNAWRDLTTSDQLRAATMLLHT
                     VEESAFVLADNLLKTDIVRENTDNIKLEVARLSTEGNLEDLKFPENMGHGSTIQLSAN
                     TLKQNGRNGEIRVAFVLYNNLGPYLSTENASMKLGTEALSTNHSVIVNSPVITAAINK
                     EFSNKVYLADPVVFTVKHIKQSEENFNPNCSFWSYSKRTMTGYWSTQGCRLLTTNKTH
                     TTCSCNHLTNFAVLMAHVEVKHSDAVHDLLLDVITWVGILLSLVCLLICIFTFCFFRG
                     LQSDRNTIHKNLCISLFVAELLFLIGINRTDQPIACAVFAALLHFFFLAAFTWMFLEG
                     VQLYIMLVEVFESEHSRRKYFYLVGYGMPALIVAVSAAVDYRSYGTDKVCWLRLDTYF
                     IWSFIGPATLIIMLNVIFLGIALYKMFHHTAILKPESGCLDNINYEDNRPFIKSWVIG
                     AIALLCLLGLTWAFGLMYINESTVIMAYLFTIFNSLQGMFIFIFHCVLQKKVRKEYGK
                     CLRTHCCSGKSTESSIGSGKTSGSRTPGRYSTGSQSRIRRMWNDTVRKQSESSFITGD
                     INSSASLNREPYRETKGLLNNARDTSVMDTLPLNGNHGNSYSIASGEYLSNCVQIIDR
                     GYNHNETALEKKILKELTSNYIPSYLNNHERSSEQNRNLMNKLVNNLGSGREDDAIVL
                     DDATSFNHEESLGLELIHEESDAPLLPPRVYSTENHQPHHYTRRRIPQDHSESFFPLL
                     TNEHTEDLQSPHRDSLYTSMPTLAGVAATESVTTSTQTEPPPAKCGDAEDVYYKSMPN
                     LGSRNHVHQLHTYYQLGRGSSDGFIVPPNKDGTPPEGSSKGPAHLVTSL"
     exon            1735..1938
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2152
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2262
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2277
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..3078
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3079..3159
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3160..3462
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3463..3566
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3567..3752
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3753..3791
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3792..3975
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3976..4098
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4099..4307
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4308..4484
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4485..4694
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4695..4915
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4916..4982
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4983..5074
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     exon            5075..5101
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     exon            5102..5270
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     exon            5271..5396
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     exon            5397..5493
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     exon            5494..5511
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     exon            5512..13738
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7819..7824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /note="hexamer: AATAAA"
     polyA_site      7846
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /note="major polyA site"
     regulatory      13715..13720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /note="hexamer: AATAAA"
     polyA_site      13738
                     /gene="ADGRL3"
                     /gene_synonym="CIRL3; CL3; LEC3; LPHN3"
                     /note="major polyA site"
ORIGIN      
        1 attctggcct ccgctccggc cccggctgcg cctaccccgc gcgcaggctg cacggtcccc
       61 gcgcgcccgc gctctgaccc gctgtctgcg cgtcgccccc ctcgcctgct ggcccggcac
      121 cgctcgctcc agttcccagg agcggggatg cagatgctgc agctggtcgg ggtgggcgcc
      181 gccgccgccg ccgccgccgc tgctgctggt ttttctcgga ctgctcgttg cctccgctcc
      241 ggcagctgct gccgccgcca ccgccgcctg tgactcgccc cctccccttt ctttcttctc
      301 tttttgcctt ggtcctcttc ctacgggtgt gcgcgcgcgc gggttgcacg gtttgctttg
      361 gcaggagctc gctcgtgtgt gcgcgtgtgt gagtgtgcgt gtctggagag cgccagtgcc
      421 tcgctcgctc ttggggagtc gaagaagaga aagaaccgaa gagacagcgg cggcggcgca
      481 gagcccgggg ccgcgcgatg aagctcccac atgcccgcag ctgcccggcc cggccggcga
      541 gctaatcatc caccccacgg gctcggggtt cgccggcccc cgggacgcag ccctcggcgg
      601 ccgggcgccc gctctgtctg cgcgccccct ccgtgcaccg gggaaggagt ttgtgtggct
      661 ctcgctccgg ctgtccgcgg aggttgcggg cttgagaggg gaccctcggc tgggagagag
      721 cctcgggagg acgaagagga ggacggtttg gcggagaagc cacccctggc cctcgcggct
      781 ccccctacct attccatcgc tcccgctccg aggcggaaag gggaggacgt ggaagaagaa
      841 aaagaaagag aaggggggtg gggtgggaga actggatata aagatcggct ggggggatgg
      901 tggaagattt ttggtctctt cggcagcgtc ttttcttaag cggcggcggc agcagcagca
      961 gcaagagaag gagaagcagc cccagctatg actgccgcat gttaatagct gccgctgggt
     1021 ccctcggctg ctgctggaga cagagcctga ctccgaagtt gtgcaactgt ggactgggag
     1081 agacatttga accctctttt cttttcgctc cccttttgcc cccttggggt gtgtgaagcg
     1141 aggaacgtaa aggaaggcga acatttggct ctctttttcc ttcccctttc tccgtggctg
     1201 tgtagcggaa gaaagggaag agagactttt tgttgttgtt tccttgactg gggtctccac
     1261 cctcctgctg ctttctctgc gcttcgattc tcgttatttg ccgcgtgtgg ttgggggtgt
     1321 ctgcacaggg gccggccggt cttttgcccc gggctcaatg gctggattgt ggaaactgca
     1381 cccgccttca ggttgttgag caactgatgg gacgatctca gggaccggcg tttacgaaag
     1441 aaatgtttaa tttggtaaat tggaggaaaa aaacatggat ttttagcaat tgaagagcaa
     1501 attaaggttt cagatttggg atattggtgt ttctgttttg gagaaattat tctttttctt
     1561 tttaatttga agaaaaatca tcagtcttgg aatacagaag agaaactaga aatatacgta
     1621 ttttgtttca catttgaaca gtcattcttg aggaatactc catacctgag tagacagcca
     1681 tgtggccatc gcagctacta attttcatga tgctcttagc tccaataatt catggtggca
     1741 agcacagtga acgacatcct gcccttgctg ctccattgcg acacgctgag cgcagcccag
     1801 gaggcgctct tccacccaga catctgcttc agcagccagc tgcagagcgc accgctgctc
     1861 atcgtggaca agggccccgt ggagctacca gaggagttcg cggtccaggt gcccaaggag
     1921 cacagattgc agcgcaagct ttcagccgtg ccccaattcc aatggctgtg gtccgcagag
     1981 agctatcctg tgagagctat cctatagagc ttcgctgtcc aggaacagac gtcatcatga
     2041 tagaaagtgc caactatggc aggactgatg acaaaatttg tgactctgac cctgctcaga
     2101 tggagaatat ccgatgttat ctgccagatg cctataagat tatgtctcaa agatgcaata
     2161 acagaaccca gtgtgcagtg gtggcaggtc ctgatgtttt tccagacccg tgtccaggaa
     2221 cctataaata ccttgaagtg cagtatgaat gtgtccctta caaagtggaa caaaaagttt
     2281 ttctttgtcc tggactacta aaaggagtat accagagtga acatttgttt gagtccgacc
     2341 accaatctgg ggcgtggtgc aaagaccctc tgcaggcatc tgacaagatt tattatatgc
     2401 cctggactcc ctacagaact gataccctga ctgagtattc atccaaggat gacttcattg
     2461 ctggaagacc aactacaacc tacaagctcc ctcacagggt ggatggcaca ggatttgtag
     2521 tgtatgatgg agctttgttc ttcaacaaag agcgcaccag gaacatagta aagtttgatt
     2581 tgcggactag gataaagagt ggagaggcta tcatagcaaa tgccaattac catgatacct
     2641 ccccttaccg atggggaggc aaatctgaca tagacctggc agtagatgag aatgggctat
     2701 gggtaatcta tgcaacagaa caaaacaatg gtaaaattgt cattagtcaa ttgaaccctt
     2761 acaccctacg gatcgaagga acatgggata ctgcatatga taaaaggtca gcttccaatg
     2821 cctttatgat ttgtggaatt ctgtatgtgg tcaaatctgt atatgaggat gatgacaatg
     2881 aggctactgg aaataagatt gactacattt acaacactga ccaaagcaag gatagtttgg
     2941 tggatgtacc ctttcctaat tcataccagt acattgcagc tgtggattac aaccccaggg
     3001 acaacctact ttatgtatgg aataactatc acgtcgtgaa atattctttg gattttggac
     3061 ctctggatag tagatcaggg caggcacatc atggacaagt ttcatacatt tctccgccaa
     3121 ttcaccttga ctctgagcta gaaagaccct ctgttaaaga tatctctacc acaggacctc
     3181 ttggcatggg aagcactacc accagtacca cccttcggac cacaactttg agcccaggaa
     3241 ggagtaccac cccgtcagtg tcaggaagaa gaaaccggag tactagtacc ccatctccag
     3301 ctgtcgaggt acttgatgac atgaccacac accttccatc agcatcgtcc caaatcccag
     3361 ctctcgaaga gagctgtgag gctgtggaag cccgagaaat catgtggttt aagactcgtc
     3421 aaggacagat agcaaagcag ccatgccctg caggaactat aggtgtatca acttatctat
     3481 gccttgctcc tgatggaatt tgggatcccc aaggtccaga tctcagcaac tgttcttctc
     3541 cttgggtcaa tcatataaca cagaagttga aatctggtga aacagctgcc aacattgcta
     3601 gagagctggc tgaacagaca agaaatcact tgaatgctgg ggacatcacc tactctgtcc
     3661 gggccatgga ccagctggta ggcctcctag atgtacagct tcggaacttg accccaggtg
     3721 gaaaagatag tgctgcccgg agtttgaaca agcttcagaa aagagagcgc tcttgcagag
     3781 cctatgtcca ggcaatggtc gagacagtta acaacctcct tcagccacaa gctttgaatg
     3841 catggagaga cctgactacg agtgatcagc tgcgtgcggc caccatgttg cttcatactg
     3901 tggaggaaag tgcttttgtg ctggctgata accttttgaa gactgacatt gtcagggaga
     3961 atacagacaa tattaaattg gaagttgcaa gactgagcac agaaggaaac ttagaagacc
     4021 taaaatttcc agaaaacatg ggccatggaa gcactatcca gctgtctgca aataccttaa
     4081 agcaaaatgg ccgaaatgga gagatcagag tggcctttgt cctgtataac aacttgggtc
     4141 cttatttatc cacggagaat gccagtatga agttgggaac ggaagctttg tccacaaatc
     4201 attctgttat tgtcaattcc cctgttatta cggcagcaat aaacaaagag ttcagtaaca
     4261 aggtttattt ggctgatcct gtggtattta ctgttaaaca tatcaagcag tcagaggaaa
     4321 atttcaaccc taactgttca ttttggagct actccaagcg tacaatgaca ggttattggt
     4381 caacacaagg ctgtcggctc ctgacaacaa ataagacaca tactacatgc tcttgtaacc
     4441 acctaacaaa ttttgcagta ctgatggcac atgtggaagt taagcacagt gatgcggtcc
     4501 atgacctcct tctggatgtg atcacgtggg ttggaatttt gctgtccctt gtttgtctcc
     4561 tgatttgcat cttcacattt tgctttttcc gggggctcca gagtgaccgt aacaccatcc
     4621 acaagaacct ctgcatcagt ctctttgtag cagagctgct cttcctgatt gggatcaacc
     4681 gaactgacca accaattgcc tgtgctgttt tcgctgccct gttacatttc ttcttcttgg
     4741 ctgccttcac ctggatgttc ctggaggggg tgcagcttta tatcatgctg gtggaggttt
     4801 ttgagagtga acattcacgt aggaaatact tttatctggt cggctatggg atgcctgcac
     4861 tcattgtggc tgtgtcagct gcagtagact acaggagtta tggaacagat aaagtatgtt
     4921 ggctccgact tgacacctac ttcatttgga gttttatagg accagcaact ttgataatta
     4981 tgcttaatgt aatcttcctt gggattgctt tatataaaat gtttcatcat actgctatac
     5041 tgaaacctga atcaggctgt cttgataaca tcaactatga ggataacaga cccttcatca
     5101 agtcatgggt tataggtgca atagctcttc tctgcctatt aggattgacc tgggcctttg
     5161 gactcatgta tattaatgaa agcacagtca tcatggccta tctcttcacc attttcaatt
     5221 ctctacaggg aatgtttata tttattttcc attgtgtcct acagaagaag gtacgaaaag
     5281 agtatgggaa atgcctgcga acacattgct gtagtggcaa aagtacagag agttccattg
     5341 gttcagggaa aacatctggt tctcgaactc ctggacgcta ctccacaggc tcacagagcc
     5401 gaatccgtag aatgtggaat gacacggttc gaaagcagtc agagtcttcc tttattactg
     5461 gagacataaa cagttcagcg tcactcaaca gagagcccta cagagagaca aaggggcttc
     5521 tgaacaatgc cagggataca agtgtcatgg atactctacc actgaatggt aaccatggca
     5581 atagttacag cattgccagc ggcgaatacc tgagcaactg tgtgcaaatc atagaccgtg
     5641 gctataacca taacgagacc gccctagaga aaaagattct gaaggaactc acttccaact
     5701 atatcccttc ttacctgaac aaccatgagc gctccagtga acagaacagg aatctgatga
     5761 acaagctggt gaataacctt ggcagtggaa gggaagatga tgccattgtc ctggatgatg
     5821 ccacctcgtt taaccacgag gagagtttgg gcctggaact cattcatgag gaatctgatg
     5881 ctcctttgct gcccccaaga gtatactcca ccgagaacca ccagccacac cattatacca
     5941 gaaggcggat cccccaagac cacagtgaga gctttttccc tttgctaacc aacgagcaca
     6001 cagaagatct ccagtcaccc catagagact ctctctatac cagcatgccg acactggctg
     6061 gtgtggccgc cacagagagt gttaccacca gcacccagac cgaaccccca ccggccaaat
     6121 gtggtgatgc cgaagatgtt tactacaaaa gcatgccaaa cctaggctcc agaaaccacg
     6181 tccatcagct gcatacttac taccagctag gtcgcggcag cagtgatgga tttatagttc
     6241 ctccaaacaa agatgggacc cctcccgagg gaagttcaaa aggaccggct catttggtca
     6301 ctagtctata gaagatgaca cagaaattgg aaccaacaaa actgctaaca ccttgttgac
     6361 tgttctgagt tgatataagc agtggtaata atgtgtgtac tcctaaatct ttatgctgtc
     6421 ctctaaagac aaacacaaac tctcagactt tttttttttt aatgggattt ttaggtcagc
     6481 ccaggggaga aagataactg ctaaaattcc cctgtacccc atcctttctt gtcctttccc
     6541 cttcagatgg agacttcatt atgttaatga acaagatatg aagaaaatgg cactcattgt
     6601 ggccttgttg aattatgttg tgtatgtttt aacatctctg atgctgtgtt actaaaatta
     6661 caaggacctg ctttttaaaa ggccagaaca attgtctgaa attagtaaca atgctgcatc
     6721 tagattggag tgctgcacaa acaaacataa gagcaaagca aaactgtatc acatagggtt
     6781 tttggtcact cacaacctga attcaccaca gctggaatag ctgtggaaaa caaaataaaa
     6841 caacaaaatt aataatgaaa tggaggggaa ttctagaatt atatgctaaa tgcatatttt
     6901 atgatttgct gtattaactg atgataaaac taatggcaga aaaagaagtt gagcaatttc
     6961 tatgtaatgt acagatacta gcattgcaca tatagtctgc tttctgttcc tccagaattt
     7021 gagtcctgtt aatgtagtag aaaaaaaaaa aagaaatttt ctttttcttt tgtgctggtc
     7081 ttgcaagttt gtctaccagt aagagagcaa agtttccttc ctttcttctc tttcttcatt
     7141 ttcttttttt cttttttgcc ttttattcct ttaaaatttc gcctggcaaa aaataaataa
     7201 atggaactat cactttataa gaatcatttt ctagtaatgc aaacaaatta ttttttacaa
     7261 aaaaacaaaa taaataaaat tagacttcct tccctcacta tatatcttta tgcagtcaga
     7321 atatttccaa cagtgttttt tgcaaattag agcaggacaa acttttatgt ttacagggca
     7381 cgtctgttgt aatgcaaagc atatttggca agcagttcat caccaggaca ctagctatga
     7441 ttctagaagt caaaaggtgt ctatagaact agtggggctt ctgcatgtga aaaacggttt
     7501 tccataggca ttaaagtgct gaatgctcag tctgatcaac aagtgggcac ctgcactacc
     7561 actttttaga ggaaattcac tccctcgtaa gcattggaag gtcaaattat tttgaagtga
     7621 tttttttaaa aaaaagtctt ctgtttatta acaggaaaat ttatttattt gacaggattt
     7681 tgagtaatgt aggaatacaa aaggtaaatt agcagcacat ataatttttt tttaatttat
     7741 gatccatttt gtatggtctc aaagttggat gacctcatta ctaatatttg ttgtaaaagt
     7801 gaaacttgtt tgccaaccaa taaacaactg attgagattt agaagatatt gtattgatgt
     7861 atgtactata tgattaatca gtctttttat ttttctcgcc tttctttctt tctgttttca
     7921 atacataaac tttgctaatc ctctgtggcc caaatgagcc atgcaaaaga aatcaatctg
     7981 cctagatgaa taagctaagc acaaaatcat acaggtttgc agacaaagta aaccagaaaa
     8041 atggaatggg catgtttatt ttggatgaaa tcagatgcat aacttaatgt tgagcaggtt
     8101 aacatatatg ttactatttg cttatctata aaccagctgc agtcactatg cttaccttta
     8161 aaaccagatt caatcagaga tataaatatg aaatttgggg gctgggtgag tcatattttt
     8221 tcctcctttg tacattgcat tttgatgtta gaaattcaaa ttccctcaat ttgctaaaag
     8281 ctgcaaagag aatattcatt ttataaagat ataataagac ttttattgtg tttttttctt
     8341 attctatata tgagggaaat cggaaaagat aaagaagttc tttcaaagaa actttctaga
     8401 tctctcatta ctgcagatcc tttatagcag tgtccaagta cagatcccct gttagggcaa
     8461 agctaaaagg aacctgccaa attataattt ctcctgtagt gtgttttatc tcggggtttc
     8521 ctttttcaaa aatctaaaca ctatccatct ataaatgact atcttaaatc aagtttagag
     8581 aatggccaat aatctgtata tagtttataa atacatgaca aaaaaatttc tgctgagcca
     8641 gagtgcatca taaccttcac atcacctcaa aatattttat gtctcattct tttttagtga
     8701 attggcatga atatttttta agtctacaga ttttatgtta gaggagaatc acaagcgtta
     8761 atgataatta ggttttctca caccacacta tggcaatatt agcacgtcca aggcttttaa
     8821 cccacccgat acatagaata catttggcaa taaaagaatc ctttttagat gtgtttatgg
     8881 taacttcaga aacacaaatg tggtctgtgg attatgagca cttatgcttg ttttgtcaaa
     8941 cagtaaccta catgaaagca actctatcag taagaagctg gtttcacaga aaaatgggga
     9001 aactacctca attcagcttg ctgattttct gacattgcta cctccctgcc cattattttt
     9061 gtgtttctat atggaaattt gaagcaggta gcttctcaag ctctacatag accaaactga
     9121 agaaagatca cttgaataca caaactggtg cagaagaaca ttcagcatat aaagttacta
     9181 ccaagctctt gcatcaagaa aaaagagtga gatttttgaa ctctatacat cataaatggc
     9241 atgctttcag agagacttaa gatcccaaag attataacag agagaaattt cccctgcaag
     9301 tattatgtaa ccgtaattaa aaaaaatgga taaaggagct aattttacat acatttcaat
     9361 agaaatttgc atatatctaa catattcatt ttgtcctgtt tacactagca agggttgaat
     9421 tcctgaactt gaatcttttt cttcatatac attttcttat agagctattg atgaattaat
     9481 taatgatttt ttaattgttc ttttttctac caccttttgt gactcaattt tttaagatcc
     9541 tgagacattt atgacctgct tatctgtata tttttatgtg ttcatctgaa tttccagtaa
     9601 gaagtaaatt tccgtcaaac agatgtagta taccgctata atacagctta tttagccagc
     9661 tagaagtaaa acttatgcca ccgaaacaaa caaatgatta ctttcttgtc aaataatatt
     9721 tttgtcacat ttttagactt ggttgttttt cctctttgaa atctagttca catgacactt
     9781 tatcagggac actagctaat ggacctcatg tttagttaat tctgaaactg atggattgtt
     9841 gcacagcctc tgctcctaac tgataaatat ttgcggcaaa gtccaaattt tgtgaaggag
     9901 aaattggttg gaattaaatt ttatgggcgt cccttcttgt ttccactata ttataattaa
     9961 acacactgaa gttgaataat aaattactgt gctaaaataa ttgtaataac aaaaatgaac
    10021 tgacagaaca attatcttga agtaacaata atcaggaaaa tatctaacaa aaagcacgta
    10081 agggaaatat ccttaacttc ctgtaaaaaa aattcacatt gactctaaat taagatgtag
    10141 tttatcatct gtattttaaa atatccatca taactaaaaa tgttgacata ttaaggaaag
    10201 gatctttaag atctaggttt aagattctta ttagtattaa cttaattggt atgacaaaac
    10261 ttttcataat agatataagc atataaggga attagtaaca tttataaagg acccacatat
    10321 ttaattttag gcattgtctt cagcttccct ggacccccaa cacatgttga aatgttattg
    10381 actagcttgc tttttttaag gaatgacatt aaaaatttcg actgactttc tacattactg
    10441 taaagatcaa aagggagagg aaaaatagtt tacaagtttt ctaaagatca actccagact
    10501 aatctatatc atcccctaat aatgaaaaaa caattagttt ttagaagttg tctatcagta
    10561 ctgtaccgaa gtgctactgc ttggattttt ttgttgtggt tttaaagaga tggggtcttg
    10621 ctctgtcaca aagactgaag ggcagtggca caatcccagc tcactgcagc ctcagactct
    10681 tgggctcaag tgatcctgct gtctcagcct tctgcgtagc catgatcaca ggtttgagcc
    10741 acagcacttg gcctgtgatg tattgcagag ggaaaaaaac caacactaca gaagtataat
    10801 gcatgtcaat tcagatttag agagtgtaaa aaacaaaaac ccaaagtcca actatttagt
    10861 tttgagcaaa tctgaagata ttggcatgaa tatcctttct tctctaagaa aatttttgag
    10921 ataacaatat atatgaagtt cccagtacat tgtagaccaa ggtgttaaaa tttaattagt
    10981 tcatttttag taattcataa ttttaactta ccacataaac aattactatg catttctaag
    11041 taacgttttc aatatagctt atattagatt tctgcacatc attaaattac gaagatggca
    11101 caaaagcaaa gcagcaacat tgcacaatag cttatggaag catttttgtg cgaatggatt
    11161 ttacataaga agcttttctg agctcataaa atatattcaa tggatcccaa cattaaattt
    11221 aactttgcaa tcagcaaata tgttctttat aacatcttaa aaatattaaa caattaaatt
    11281 ttcatttgta ggctagcaga acttaaatgt gttggtagtt gcttctttcc tgattaggcc
    11341 ataagaagaa actttcctat ttactaatta acactgatta cactctcttt ggtttaaaag
    11401 ggaaactttc acctgtacac atacacactc tgattccatt tatttacagc ctgcagaaga
    11461 agtagcttgt ttacgatatt taaaactttg tgatttctgc aataaaacag gtagttaata
    11521 tagtttcgca taatctcatt gaaagatatt gctattcctt ctttatttaa aaaaaaattt
    11581 aaaagtcagc acttctttca catctagcac ctataagtta ctattcaaat gtcttgattt
    11641 cagctaagtt ttgatgtttc tttttctctt aatagtatgt caaaagcatt gttctcattt
    11701 gataatttgt gtcccgttac agtatttcaa aggtaaatgc aaactaattt ttaggaaggc
    11761 ttgtgaaaga actttgattt atgtgaagaa atcaagaaag actatacatg aacaaatctc
    11821 tattgggata aacaagtctc ttcaaccaca atatgaacaa cggaagagca gaaaccaaac
    11881 aagttagcaa acttatggta aggtgacagg acctaaacta gagttacaga gaaaagtttt
    11941 ccaggaaaga ataatgaagt catttgtagt gataaaaatc ttatacacta caccaaatgt
    12001 tacagatgta ttccgaaaag taaaatggga gtttcctata ttctgatttc attctgctaa
    12061 ttccacggga aacattaaat actttaaaca ctcttgagat atttcgtatc tagctatacc
    12121 ttgtctcaag gaaacatcaa tattttataa atgtttctta aatataagta ttttgtctga
    12181 attcatcttc actctctaat ctgctggctc tattgaacac caacagagtt aatgctttta
    12241 gtagctttgt accttttaaa gctctattat gaatctttct aatacatatg aaattaatat
    12301 tatattagaa ttatgtacat tatacaaaat aattcataac caagaaatat tcatactata
    12361 gaataattta ttattatata tatgaatatt acattgagac tgaacaaata accactctgc
    12421 tccaaatatt actctcaagt tctctgcctt taattattat agtcaattca taaaattcta
    12481 catacagttg tacatggtgg gttatcaaag tactccataa tccaaatgca tctaaaagta
    12541 ttccaaatgc gcctttcatt ctagaatact aaaggaaagc gtttgaaaga agaggaaagt
    12601 aaagcagact tctaactatt taatttaaac attgccattc agattgaata atttttaaat
    12661 gatgatgctc cactctttga tctacagaca aggttacaaa agatttacaa ttagtccaaa
    12721 atcagaggat tttaaatctt aaaggagtta agtttgtctc aatgatccaa gactacaaaa
    12781 tttcttgcta cattggcaag gaaatatgtt taaagccgag aactaaaata gctttttaaa
    12841 atttaaaaat tcctctgttt cttctgaatg taaaacaggc aaaatgatcc tgacttcaaa
    12901 atgaaatata ttgattgctc tcaaaagatg tttgacaaag ttaagtcagt atcttcaatg
    12961 ctttaacagt aggtagaggt ctttggggtt ggaactcagg atacagtgac taggacagag
    13021 tgcattctta ggctaattag tgcctagtcc tctggagtat tttttaatgc cctgaatttc
    13081 aagttgtcaa actggtttac atattgaatg acattttgaa tcaataaaaa tgagaaaaaa
    13141 acatttaaat ttggttttca tgactcattt gagaataaag atttccttca tcaccctaag
    13201 taataaaagc tgatatgtct tgaaacaact atagacaatc agaatgtgtt catttataaa
    13261 gtatcactgg tttgtatatt ttaatgctga cctttgcctg tgaactagaa aatcaagatt
    13321 tgtagagtca ggttgatttg ccttcattta attcctgcaa atgcattgga agtggatgga
    13381 taacttggaa ctttttccat actgttttcc ccctcaccaa gcattaaatc taattcaaaa
    13441 tatgtctttc taaaaaacaa tagtttattt ttaaaactaa caactaattg tgttattcct
    13501 tgttgataag aaagtcactt tttagaaaca agaatatagc tattgtggct ttggtcgctt
    13561 aggattctca tatatttaca catggcatta ttcttttcat atacacctac cagatttcaa
    13621 gctattggat atttcccttg tacaaccttt acatcctttt tttttcctta aatgctctgt
    13681 acaatcacat gtaaagtcat gagctacaaa cctcaataaa aatatcagta aacaagaa
//
