LOCUS       NM_001366006            7432 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens adhesion G protein-coupled receptor L2 (ADGRL2),
            transcript variant 12, mRNA.
ACCESSION   NM_001366006
VERSION     NM_001366006.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7432)
  AUTHORS   Tanaka,K., Chen,M., Prendergast,A., Zhuang,Z., Nasiri,A., Joshi,D.,
            Hintzen,J., Chung,M., Kumar,A., Mani,A., Koleske,A., Crawford,J.,
            Nicoli,S. and Schwartz,M.A.
  TITLE     Latrophilin-2 mediates fluid shear stress mechanotransduction at
            endothelial junctions
  JOURNAL   EMBO J 43 (15), 3175-3191 (2024)
   PUBMED   38886581
  REMARK    GeneRIF: Latrophilin-2 mediates fluid shear stress
            mechanotransduction at endothelial junctions.
REFERENCE   2  (bases 1 to 7432)
  AUTHORS   Camillo,C., Facchinello,N., Villari,G., Mana,G., Gioelli,N.,
            Sandri,C., Astone,M., Tortarolo,D., Clapero,F., Gays,D.,
            Oberkersch,R.E., Arese,M., Tamagnone,L., Valdembri,D., Santoro,M.M.
            and Serini,G.
  TITLE     LPHN2 inhibits vascular permeability by differential control of
            endothelial cell adhesion
  JOURNAL   J Cell Biol 220 (11) (2021)
   PUBMED   34581723
  REMARK    GeneRIF: LPHN2 inhibits vascular permeability by differential
            control of endothelial cell adhesion.
REFERENCE   3  (bases 1 to 7432)
  AUTHORS   Lee,C.S., Cho,H.J., Lee,J.W., Son,H., Chai,J. and Kim,H.S.
  TITLE     Adhesion GPCR Latrophilin-2 Specifies Cardiac Lineage Commitment
            through CDK5, Src, and P38MAPK
  JOURNAL   Stem Cell Reports 16 (4), 868-882 (2021)
   PUBMED   33798451
  REMARK    GeneRIF: Adhesion GPCR Latrophilin-2 Specifies Cardiac Lineage
            Commitment through CDK5, Src, and P38MAPK.
REFERENCE   4  (bases 1 to 7432)
  AUTHORS   Vezain,M., Lecuyer,M., Rubio,M., Dupe,V., Ratie,L., David,V.,
            Pasquier,L., Odent,S., Coutant,S., Tournier,I., Trestard,L.,
            Adle-Biassette,H., Vivien,D., Frebourg,T., Gonzalez,B.J.,
            Laquerriere,A. and Saugier-Veber,P.
  TITLE     A de novo variant in ADGRL2 suggests a novel mechanism underlying
            the previously undescribed association of extreme microcephaly with
            severely reduced sulcation and rhombencephalosynapsis
  JOURNAL   Acta Neuropathol Commun 6 (1), 109 (2018)
   PUBMED   30340542
  REMARK    GeneRIF: The results of this study suggest that this ADGRL2
            variation impedes the proper development of the cerebellum
            resulting in RES which is thought to occur when the cerebellar
            primordium develops and probably results from abnormal function of
            genes expressed during initial patterning of the
            mesencephalon-rhombencephalon
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7432)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
REFERENCE   6  (bases 1 to 7432)
  AUTHORS   Sudhof,T.C.
  TITLE     alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins
  JOURNAL   Annu Rev Neurosci 24, 933-962 (2001)
   PUBMED   11520923
  REMARK    Review article
REFERENCE   7  (bases 1 to 7432)
  AUTHORS   Kreienkamp,H.J., Zitzer,H., Gundelfinger,E.D., Richter,D. and
            Bockers,T.M.
  TITLE     The calcium-independent receptor for alpha-latrotoxin from human
            and rodent brains interacts with members of the ProSAP/SSTRIP/Shank
            family of multidomain proteins
  JOURNAL   J Biol Chem 275 (42), 32387-32390 (2000)
   PUBMED   10964907
REFERENCE   8  (bases 1 to 7432)
  AUTHORS   Hayflick,J.S.
  TITLE     A family of heptahelical receptors with adhesion-like domains: a
            marriage between two super families
  JOURNAL   J Recept Signal Transduct Res 20 (2-3), 119-131 (2000)
   PUBMED   10994649
  REMARK    Review article
REFERENCE   9  (bases 1 to 7432)
  AUTHORS   White,G.R., Varley,J.M. and Heighway,J.
  TITLE     Genomic structure and expression profile of LPHH1, a 7TM gene
            variably expressed in breast cancer cell lines
  JOURNAL   Biochim Biophys Acta 1491 (1-3), 75-92 (2000)
   PUBMED   10760572
REFERENCE   10 (bases 1 to 7432)
  AUTHORS   White,G.R., Varley,J.M. and Heighway,J.
  TITLE     Isolation and characterization of a human homologue of the
            latrophilin gene from a region of 1p31.1 implicated in breast
            cancer
  JOURNAL   Oncogene 17 (26), 3513-3519 (1998)
   PUBMED   10030676
  REMARK    Erratum:[Oncogene 1999 Mar 25;18(12):2167]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL358939.9, AL359705.10,
            AL157903.16 and AC113949.2.
            
            On Aug 14, 2020 this sequence version replaced NM_001366006.1.
            
            Summary: This gene encodes a member of the latrophilin subfamily of
            G-protein coupled receptors. The encoded protein participates in
            the regulation of exocytosis. The proprotein is thought to be
            further cleaved within a cysteine-rich G-protein-coupled receptor
            proteolysis site into two chains that are non-covalently bound at
            the cell membrane. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (12), as well as variant 11,
            encodes isoform 7.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN03465403
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000686636.1/ ENSP00000509478.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               AL358939.9         143425-143559
            136-308             AL359705.10        21026-21198
            309-522             AL157903.16        32945-33158
            523-632             AL157903.16        62655-62764
            633-644             AL157903.16        67961-67972
            645-1445            AL157903.16        68896-69696
            1446-1739           AC113949.2         3485-3778
            1740-1843           AC113949.2         4314-4417
            1844-2029           AC113949.2         5253-5438
            2030-2068           AC113949.2         6283-6321
            2069-2252           AC113949.2         9173-9356
            2253-2378           AC113949.2         19354-19479
            2379-2584           AC113949.2         19700-19905
            2585-2758           AC113949.2         21322-21495
            2759-2968           AC113949.2         22474-22683
            2969-3189           AC113949.2         23610-23830
            3190-3256           AC113949.2         25148-25214
            3257-3348           AC113949.2         33165-33256
            3349-3517           AC113949.2         35104-35272
            3518-3646           AC113949.2         37879-38007
            3647-3743           AC113949.2         38555-38651
            3744-3872           AC113949.2         40197-40325
            3873-3890           AC113949.2         41165-41182
            3891-7432           AC113949.2         43687-47228
FEATURES             Location/Qualifiers
     source          1..7432
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..7432
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /note="adhesion G protein-coupled receptor L2"
                     /db_xref="GeneID:23266"
                     /db_xref="HGNC:HGNC:18582"
                     /db_xref="MIM:607018"
     exon            1..135
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /inference="alignment:Splign:2.1.0"
     exon            136..308
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..4645
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /note="isoform 7 precursor is encoded by transcript
                     variant 12; latrophilin homolog 1; calcium-independent
                     alpha-latrotoxin receptor 2; lectomedin-1; latrophilin-2"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor L2 isoform 7
                     precursor"
                     /protein_id="NP_001352935.1"
                     /db_xref="CCDS:CCDS90986.1"
                     /db_xref="GeneID:23266"
                     /db_xref="HGNC:HGNC:18582"
                     /db_xref="MIM:607018"
                     /translation="MVSSGCRMRSLWFIIVISFLPNTEGFSRAALPFGLVRRELSCEG
                     YSIDLRCPGSDVIMIESANYGRTDDKICDADPFQMENTDCYLPDAFKIMTQRCNNRTQ
                     CIVVTGSDVFPDPCPGTYKYLEVQYECVPYMEQKVFVCPGTLKAIVDSPCIYEAEQKA
                     GAWCKDPLQAADKIYFMPWTPYRTDTLIEYASLEDFQNSRQTTTYKLPNRVDGTGFVV
                     YDGAVFFNKERTRNIVKFDLRTRIKSGEAIINYANYHDTSPYRWGGKTDIDLAVDENG
                     LWVIYATEQNNGMIVISQLNPYTLRFEATWETVYDKRAASNAFMICGVLYVVRSVYQD
                     NESETGKNSIDYIYNTRLNRGEYVDVPFPNQYQYIAAVDYNPRDNQLYVWNNNFILRY
                     SLEFGPPDPAQVPTTAVTITSSAELFKTIISTTSTTSQKGPMSTTVAGSQEGSKGTKP
                     PPAVSTTKIPPITNIFPLPERFCEALDSKGIKWPQTQRGMMVERPCPKGTRGTASYLC
                     MISTGTWNPKGPDLSNCTSHWVNQLAQKIRSGENAASLANELAKHTKGPVFAGDVSSS
                     VRLMEQLVDILDAQLQELKPSEKDSAGRSYNKLQKREKTCRAYLKAIVDTVDNLLRPE
                     ALESWKHMNSSEQAHTATMLLDTLEEGAFVLADNLLEPTRVSMPTENIVLEVAVLSTE
                     GQIQDFKFPLGIKGAGSSIQLSANTVKQNSRNGLAKLVFIIYRSLGQFLSTENATIKL
                     GADFIGRNSTIAVNSHVISVSINKESSRVYLTDPVLFTLPHIDPDNYFNANCSFWNYS
                     ERTMMGYWSTQGCKLVDTNKTRTTCACSHLTNFAILMAHREIAYKDGVHELLLTVITW
                     VGIVISLVCLAICIFTFCFFRGLQSDRNTIHKNLCINLFIAEFIFLIGIDKTKYAIAC
                     PIFAGLLHFFFLAAFAWMCLEGVQLYLMLVEVFESEYSRKKYYYVAGYLFPATVVGVS
                     AAIDYKSYGTEKACWLHVDNYFIWSFIGPVTFIILLNIIFLVITLCKMVKHSNTLKPD
                     SSRLENIKSWVLGAFALLCLLGLTWSFGLLFINEETIVMAYLFTIFNAFQGVFIFIFH
                     CALQKKVRKEYGKCFRHSYCCGGLPTESPHSSVKASTTRTSARYSSGTQSRIRRMWND
                     TVRKQSESSFISGDINSTSTLNQGMTGNYLLTNPLLRPHGTNNPYNTLLAETVVCNAP
                     SAPVFNSPATYRETRHSLNNARDTSAMDTLPLNGNFNNSYSLHKGDYNDSVQVVDCGL
                     SLNDTAFEKMIISELVHNNLRGSSKTHNLELTLPVKPVIGGSSSEDDAIVADASSLMH
                     SDNPGLELHHKELEAPLIPQRTHSLLYQPQKKVKSEGTDSYVSQLTAEAEDHLQSPNR
                     DSLYTSMPNLRDSPYPESSPDMEEDLSPSRRSENEDIYYKSMPNLGAGHQLQMCYQIS
                     RGNSDGYIIPINKEGCIPEGDVREGQMQLVTSL"
     exon            309..522
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /inference="alignment:Splign:2.1.0"
     exon            523..632
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /inference="alignment:Splign:2.1.0"
     exon            633..644
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /inference="alignment:Splign:2.1.0"
     exon            645..1445
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1739
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1843
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..2029
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2068
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2252
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2378
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2584
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2758
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..2968
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2969..3189
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3190..3256
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3257..3348
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3349..3517
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3518..3646
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3647..3743
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3744..3872
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3873..3890
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3891..7432
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5295..5300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /note="hexamer: AATACA"
     polyA_site      5317
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
     regulatory      5900..5905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /note="hexamer: AATAAA"
     polyA_site      5923
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /note="major polyA site"
     regulatory      6919..6924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /note="hexamer: AATAAA"
     polyA_site      6939
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
     regulatory      7410..7415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
                     /note="hexamer: AATAAA"
     polyA_site      7432
                     /gene="ADGRL2"
                     /gene_synonym="CIRL2; CL2; LEC1; LPHH1; LPHN2"
ORIGIN      
        1 ggccgtgcgc gcgcgtccct cgccgccacc gccgcccgga cagccctgcg gccgccccgc
       61 cggcggagcc ggggccggcc tggtcctcgg gcggctgctt ggccaccgcc accgccgtcc
      121 gaagggctcg agcccatatg aagatcaatg atgcagactg atggttttga tgaagctggg
      181 catttataac tagattcatt aaggaataca aagaaaatac ttaaagggat caataatggt
      241 gtcttctggt tgcagaatgc gaagtctgtg gtttatcatt gtaatcagct tcttaccaaa
      301 tacagaaggt ttcagcagag cagctttacc atttgggctg gtgaggcgag aattatcctg
      361 tgaaggttat tctatagatc tgcgatgccc gggcagtgat gtcatcatga ttgagagcgc
      421 taactatggt cggacggatg acaagatttg tgatgctgac ccatttcaga tggagaatac
      481 agactgctac ctccccgatg ccttcaaaat tatgactcaa aggtgcaaca atcgaacaca
      541 gtgtatagta gttactgggt cagatgtgtt tcctgatcca tgtcctggaa catacaaata
      601 ccttgaagtc caatatgaat gtgtccctta catggagcaa aaagtttttg tgtgtcctgg
      661 gaccttgaaa gcaattgtgg actcaccatg tatatatgaa gctgaacaaa aggcgggtgc
      721 ttggtgcaag gaccctcttc aggctgcaga taaaatttat ttcatgccct ggactcccta
      781 tcgtaccgat actttaatag aatatgcttc tttagaagat ttccaaaata gtcgccaaac
      841 aacaacatat aaacttccaa atcgagtaga tggtactgga tttgtggtgt atgatggtgc
      901 tgtcttcttt aacaaagaaa gaacgaggaa tattgtgaaa tttgacttga ggactagaat
      961 taagagtggc gaggccataa ttaactatgc caactaccat gatacctcac catacagatg
     1021 gggaggaaag actgatatcg acctagcagt tgatgaaaat ggtttatggg tcatttacgc
     1081 cactgaacag aacaatggaa tgatagttat tagccagctg aatccataca ctcttcgatt
     1141 tgaagcaacg tgggagactg tatacgacaa acgtgccgca tcaaatgctt ttatgatatg
     1201 cggagtcctc tatgtggtta ggtcagttta tcaagacaat gaaagtgaaa caggcaagaa
     1261 ctcaattgat tacatttata atacccgatt aaaccgagga gaatatgtag atgttccctt
     1321 ccccaaccag tatcagtata ttgctgcagt ggattacaat ccaagagata accaacttta
     1381 cgtgtggaac aataacttca ttttacgata ttctctggag tttggtccac ctgatcctgc
     1441 ccaagtgcct accacagctg tgacaataac ttcttcagct gagctgttca aaaccataat
     1501 atcaaccaca agcactactt cacagaaagg ccccatgagc acaactgtag ctggatcaca
     1561 ggaaggaagc aaagggacaa aaccacctcc agcagtttct acaaccaaaa ttccacctat
     1621 aacaaatatt tttcccctgc cagagagatt ctgtgaagca ttagactcca aggggataaa
     1681 gtggcctcag acacaaaggg gaatgatggt tgaacgacca tgccctaagg gaacaagagg
     1741 aactgcctca tatctctgca tgatttccac tggaacatgg aaccctaagg gccccgatct
     1801 tagcaactgt acctcacact gggtgaatca gctggctcag aagatcagaa gcggagaaaa
     1861 tgctgctagt cttgccaatg aactggctaa acataccaaa gggccagtgt ttgctgggga
     1921 tgtaagttct tcagtgagat tgatggagca gttggtggac atccttgatg cacagctgca
     1981 ggaactgaaa cctagtgaaa aagattcagc tggacggagt tataacaagc tccaaaaacg
     2041 agagaagaca tgcagggctt accttaaggc aattgttgac acagtggaca accttctgag
     2101 acccgaagct ttggaatcat ggaaacatat gaattcttct gaacaagcac atactgcaac
     2161 aatgttactc gatacattgg aagaaggagc ttttgtccta gctgacaatc ttttagaacc
     2221 aacaagggtc tcaatgccca cagaaaatat tgtcctggaa gttgccgtac tcagtacaga
     2281 aggacagatc caagacttta aatttcctct gggcatcaaa ggagcaggca gctcaatcca
     2341 actgtccgca aataccgtca aacagaacag caggaatggg cttgcaaagt tggtgttcat
     2401 catttaccgg agcctgggac agttccttag tacagaaaat gcaaccatta aactgggtgc
     2461 tgattttatt ggtcgtaata gcaccattgc agtgaactct cacgtcattt cagtttcaat
     2521 caataaagag tccagccgag tatacctgac tgatcctgtg ctttttaccc tgccacacat
     2581 tgatcctgac aattatttca atgcaaactg ctccttctgg aactactcag agagaactat
     2641 gatgggatat tggtctaccc agggctgcaa gctggttgac actaataaaa ctcgaacaac
     2701 gtgtgcatgc agccacctaa ccaattttgc aattctcatg gcccacaggg aaattgcata
     2761 taaagatggc gttcatgaat tacttcttac agtcatcacc tgggtgggaa ttgtcatttc
     2821 ccttgtttgc ctggctatct gcatcttcac cttctgcttt ttccgtggcc tacagagtga
     2881 ccgaaatact attcacaaga acctttgtat caaccttttc attgctgaat ttattttcct
     2941 aataggcatt gataagacaa aatatgcgat tgcatgccca atatttgcag gacttctaca
     3001 ctttttcttt ttggcagctt ttgcttggat gtgcctagaa ggtgtgcagc tctacctaat
     3061 gttagttgaa gtttttgaaa gtgaatattc aaggaaaaaa tattactatg ttgctggtta
     3121 cttgtttcct gccacagtgg ttggagtttc agctgctatt gactataaga gctatggaac
     3181 agaaaaagct tgctggcttc atgttgataa ctactttata tggagcttca ttggacctgt
     3241 taccttcatt attctgctaa atattatctt cttggtgatc acattgtgca aaatggtgaa
     3301 gcattcaaac actttgaaac cagattctag caggttggaa aacattaagt cttgggtgct
     3361 tggcgctttc gctcttctgt gtcttcttgg cctcacctgg tcctttgggt tgctttttat
     3421 taatgaggag actattgtga tggcatatct cttcactata tttaatgctt tccagggagt
     3481 gttcattttc atctttcact gtgctctcca aaagaaagta cgaaaagaat atggcaagtg
     3541 cttcagacac tcatactgct gtggaggcct cccaactgag agtccccaca gttcagtgaa
     3601 ggcatcaacc accagaacca gtgctcgcta ttcctctggc acacagagtc gtataagaag
     3661 aatgtggaat gatactgtga gaaaacaatc agaatcttct tttatctcag gtgacatcaa
     3721 tagcacttca acacttaatc aaggaatgac tggcaattac ctactaacaa accctcttct
     3781 tcgaccccac ggcactaaca acccctataa cacattgctc gctgaaacag ttgtatgtaa
     3841 tgccccttca gctcctgtat ttaactcacc agcaacctac agagagacaa gacattcact
     3901 gaacaatgcc agggatacaa gtgccatgga tactctaccg ctaaatggta attttaacaa
     3961 cagctactcg ctgcacaagg gtgactataa tgacagcgtg caagttgtgg actgtggact
     4021 aagtctgaat gatactgctt ttgagaaaat gatcatttca gaattagtgc acaacaactt
     4081 acggggcagc agcaagactc acaacctcga gctcacgcta ccagtcaaac ctgtgattgg
     4141 aggtagcagc agtgaagatg atgctattgt ggcagatgct tcatctttaa tgcacagcga
     4201 caacccaggg ctggagctcc atcacaaaga actcgaggca ccacttattc ctcagcggac
     4261 tcactccctt ctgtaccaac cccagaagaa agtgaagtcc gagggaactg acagctatgt
     4321 ctcccaactg acagcagagg ctgaagatca cctacagtcc cccaacagag actctcttta
     4381 tacaagcatg cccaatctta gagactctcc ctatccggag agcagccctg acatggaaga
     4441 agacctctct ccctccagga ggagtgagaa tgaggacatt tactataaaa gcatgccaaa
     4501 tcttggagct ggccatcagc ttcagatgtg ctaccagatc agcaggggca atagtgatgg
     4561 ttatataatc cccattaaca aagaagggtg tattccagaa ggagatgtta gagaaggaca
     4621 aatgcagctg gttacaagtc tttaatcata cagctaagga attccaaggg ccacatgcga
     4681 gtattaataa ataaagacac cattggcctg acgcagctcc ctcaaactct gcttgaagag
     4741 atgactcttg acctgtggtt ctctggtgta aaaaagatga ctgaaccttg cagttctgtg
     4801 aatttttata aaacatacaa aaactttgta tatacacaga gtatactaaa gtgaattatt
     4861 tgttacaaag aaaagagatg ccagccaggt attttaagat tctgctgctg tttagagaaa
     4921 ttgtgaaaca agcaaaacaa aactttccag ccattttact gcagcagtct gtgaactaaa
     4981 tttgtaaata tggctgcacc atttttgtag gcctgcattg tattatatac aagacgtagg
     5041 ctttaaaatc ctgtgggaca aatttactgt accttactat tcctgacaag acttggaaaa
     5101 gcaggagaga tattctgcat cagtttgcag ttcactgcaa atcttttaca ttaaggcaaa
     5161 gattgaaaac atgcttaacc actagcaatc aagccacagg ccttatttca tatgtttcct
     5221 caactgtaca atgaactatt ctcatgaaaa atggctaaag aaattatatt ttgttctatt
     5281 gctagggtaa aataaataca tttgtgtcca actgaaatat aattgtcatt aaaataattt
     5341 taaagagtga agaaaatatt gtgaaaagct cttggttgca catgttatga aatgtttttt
     5401 cttacacttt gtcatggtaa gttctactca ttttcacttc ttttccactg tatacagtgt
     5461 tctgctttga caaagttggt ctttattact tacatttaaa tttcttattg ccaaaagaac
     5521 gtgttttatg gggagaaaca aactctttga agccagttat gtcatgcctt gcacaaaagt
     5581 gatgaaatct agaaaagatt gtgtgtcacc cctgtttatt cttgaacaga gggcaaagag
     5641 ggcactgggc acttctcaca aactttctag tgaacaaaag gtgcctattc ttttttaaaa
     5701 aaataaaata aaacataaat attactcttc catattcctt ctgcctatat ttagtaatta
     5761 atttatttta tgataaagtt ctaatgaaat gtaaattgtt tcagcaaaat tctgcttttt
     5821 tttcatccct ttgtgtaaac ctgttaataa tgagcccatc actaatatcc agtgtaaagt
     5881 ttaacacggt ttgacagtaa ataaatgtga attttttcaa gtagttaaca tgtgaacttt
     5941 tatgtatgat acataattgg ctttaacatg ttggtccatt cccaccttgg tttaagtaac
     6001 gtcataccaa agtccatgga tatatgaaag gatacaatta agttgcctgt ttgttcttta
     6061 tgctgaaagg aatatatgtc ttccaattgc ccactacata tgcacaaaat ctgctggata
     6121 agttttaaga gggatatatt ctgaaagcat ttttgtttgt tgcattgtac caggactaaa
     6181 aaaagaagga ttggaagttc tgccatcaaa tttgggtatc ataaaaagtt tttaactgat
     6241 ttttcagcag tattgggaag tttcttaaac atactttaag gattataaat atccctatag
     6301 acagctgtga ataccaatat acattaccct ggaaaagttt tactccaagt tcaaaaatca
     6361 tataattgaa tatcaagaaa tagatgtttt ctgtttgtat cataagcatt tatagaaaat
     6421 tattctaaag cttaatggtt tgctataatt ctcaaatact accactagct tataaatcac
     6481 ttttatgtgg acacacacat gcctattgaa tttaaaaagg aatgagattt aaaaattaag
     6541 tgcatatata taatatacat atatatatat atatatatat atatatattt tttttttttt
     6601 tttttttttt tttttttttg ggacagagtg tccctctgtc acccaggctg gagtgcagta
     6661 gtgtgatctc ggctcactgc aacctccgcc tcccaggttc tcaaacagat ttaacaatcc
     6721 tctgagaatg gtactcattt atttggctaa aattcttcag ggatttataa actacttgct
     6781 aaaggagggc attagataat caagtatttt taattttcca tcttgttata ctttttattt
     6841 taaatgccta aaaccataca gtattgtgtg atgtgtaatt cctagtatac aagctaccta
     6901 gagtcaggct ggttcagtaa taaatttttt taaaggcaac actgattatt cagttagtcc
     6961 tatttctttc tcttgaggca gttctcaaaa ctctaaagac atgaacactg catcgtacct
     7021 aaatggctac tgttctctaa cgtctttatc ctatggattc aatttggaag ccatcattga
     7081 tctttggcat caaaagaaaa gtcattttta aagcatttct tttcaaaaat atataaatat
     7141 tgccttaaat tccatctagg attcccttag tacaaggtag tttcttaggt ttgtaattac
     7201 taaactactg actgttttaa tgcagatgcg ttattgtatt tattaaccca gtttctttgg
     7261 gtctgcctag acttcacctg aatgtacagt tttcacattc ttgattgttt ctctttgtga
     7321 tagtcacaac tgtgaactta taaagtcaca tttttaaagt tcttcctaga gacattcact
     7381 ctgtctttat taaaaataat aataataata ataaacgtta tcttgttggc ca
//
