LOCUS       NM_014921               7820 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens adhesion G protein-coupled receptor L1 (ADGRL1),
            transcript variant 2, mRNA.
ACCESSION   NM_014921 NM_024679
VERSION     NM_014921.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7820)
  AUTHORS   Dietzsch,A.N., Al-Hasani,H., Altschmied,J., Bottermann,K.,
            Brendler,J., Haendeler,J., Horn,S., Kaczmarek,I., Korner,A.,
            Krause,K., Landgraf,K., Le Duc,D., Lehmann,L., Lehr,S., Pick,S.,
            Ricken,A., Schnorr,R., Schulz,A., Strnadova,M., Velluva,A.,
            Zabri,H., Schoneberg,T., Thor,D. and Promel,S.
  TITLE     Dysfunction of the adhesion G protein-coupled receptor latrophilin
            1 (ADGRL1/LPHN1) increases the risk of obesity
  JOURNAL   Signal Transduct Target Ther 9 (1), 103 (2024)
   PUBMED   38664368
  REMARK    GeneRIF: Dysfunction of the adhesion G protein-coupled receptor
            latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7820)
  AUTHORS   Vitobello,A., Mazel,B., Lelianova,V.G., Zangrandi,A., Petitto,E.,
            Suckling,J., Salpietro,V., Meyer,R., Elbracht,M., Kurth,I.,
            Eggermann,T., Benlaouer,O., Lall,G., Tonevitsky,A.G., Scott,D.A.,
            Chan,K.M., Rosenfeld,J.A., Nambot,S., Safraou,H., Bruel,A.L.,
            Denomme-Pichon,A.S., Tran Mau-Them,F., Philippe,C., Duffourd,Y.,
            Guo,H., Petersen,A.K., Granger,L., Crunk,A., Bayat,A., Striano,P.,
            Zara,F., Scala,M., Thomas,Q., Delahaye,A., de Sainte Agathe,J.M.,
            Buratti,J., Kozlov,S.V., Faivre,L., Thauvin-Robinet,C. and
            Ushkaryov,Y.
  TITLE     ADGRL1 haploinsufficiency causes a variable spectrum of
            neurodevelopmental disorders in humans and alters synaptic activity
            and behavior in a mouse model
  JOURNAL   Am J Hum Genet 109 (8), 1436-1457 (2022)
   PUBMED   35907405
  REMARK    GeneRIF: ADGRL1 haploinsufficiency causes a variable spectrum of
            neurodevelopmental disorders in humans and alters synaptic activity
            and behavior in a mouse model.
REFERENCE   3  (bases 1 to 7820)
  AUTHORS   Ovando-Zambrano,J.C., Arias-Montano,J.A. and Boucard,A.A.
  TITLE     Alternative splicing event modifying ADGRL1/latrophilin-1
            cytoplasmic tail promotes both opposing and dual cAMP signaling
            pathways
  JOURNAL   Ann N Y Acad Sci 1456 (1), 168-185 (2019)
   PUBMED   31339586
  REMARK    GeneRIF: results suggest that SSB splicing selectively affects the
            duality of LPHN1 signaling toward opposing cAMP pathways
REFERENCE   4  (bases 1 to 7820)
  AUTHORS   Vysokov,N.V., Silva,J.P., Lelianova,V.G., Suckling,J., Cassidy,J.,
            Blackburn,J.K., Yankova,N., Djamgoz,M.B., Kozlov,S.V.,
            Tonevitsky,A.G. and Ushkaryov,Y.A.
  TITLE     Proteolytically released Lasso/teneurin-2 induces axonal attraction
            by interacting with latrophilin-1 on axonal growth cones
  JOURNAL   Elife 7, e37935 (2018)
   PUBMED   30457553
  REMARK    GeneRIF: These findings reveal a novel mechanism of axonal
            pathfinding, whereby latrophilin-1 and Lasso mediate both
            short-range interaction that supports synaptogenesis, and
            long-range signaling that induces axonal attraction.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7820)
  AUTHORS   Kocibalova,Z., Guzyova,M., Imrichova,D., Sulova,Z. and Breier,A.
  TITLE     Overexpression of the ABCB1 drug transporter in acute myeloid
            leukemia cells is associated with downregulation of latrophilin-1
  JOURNAL   Gen Physiol Biophys 37 (3), 353-357 (2018)
   PUBMED   29938681
  REMARK    GeneRIF: alterations in latrophilin expression occur in AML cells
            expressing P-gp
REFERENCE   6  (bases 1 to 7820)
  AUTHORS   Brill,L.M., Salomon,A.R., Ficarro,S.B., Mukherji,M.,
            Stettler-Gill,M. and Peters,E.C.
  TITLE     Robust phosphoproteomic profiling of tyrosine phosphorylation sites
            from human T cells using immobilized metal affinity chromatography
            and tandem mass spectrometry
  JOURNAL   Anal Chem 76 (10), 2763-2772 (2004)
   PUBMED   15144186
REFERENCE   7  (bases 1 to 7820)
  AUTHORS   Ushkaryov,Y.A., Volynski,K.E. and Ashton,A.C.
  TITLE     The multiple actions of black widow spider toxins and their
            selective use in neurosecretion studies
  JOURNAL   Toxicon 43 (5), 527-542 (2004)
   PUBMED   15066411
  REMARK    Review article
REFERENCE   8  (bases 1 to 7820)
  AUTHORS   Sudhof,T.C.
  TITLE     alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins
  JOURNAL   Annu Rev Neurosci 24, 933-962 (2001)
   PUBMED   11520923
  REMARK    Review article
REFERENCE   9  (bases 1 to 7820)
  AUTHORS   Kreienkamp,H.J., Zitzer,H., Gundelfinger,E.D., Richter,D. and
            Bockers,T.M.
  TITLE     The calcium-independent receptor for alpha-latrotoxin from human
            and rodent brains interacts with members of the ProSAP/SSTRIP/Shank
            family of multidomain proteins
  JOURNAL   J Biol Chem 275 (42), 32387-32390 (2000)
   PUBMED   10964907
REFERENCE   10 (bases 1 to 7820)
  AUTHORS   Hayflick,J.S.
  TITLE     A family of heptahelical receptors with adhesion-like domains: a
            marriage between two super families
  JOURNAL   J Recept Signal Transduct Res 20 (2-3), 119-131 (2000)
   PUBMED   10994649
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB020628.1, AF307079.1,
            BC002974.1 and BC072445.1.
            
            On Jun 2, 2019 this sequence version replaced NM_014921.4.
            
            Summary: This gene encodes a member of the latrophilin subfamily of
            G-protein coupled receptors (GPCR). Latrophilins may function in
            both cell adhesion and signal transduction. In experiments with
            non-human species, endogenous proteolytic cleavage within a
            cysteine-rich GPS (G-protein-coupled-receptor proteolysis site)
            domain resulted in two subunits (a large extracellular N-terminal
            cell adhesion subunit and a subunit with substantial similarity to
            the secretin/calcitonin family of GPCRs) being non-covalently bound
            at the cell membrane. Latrophilin-1 has been shown to recruit the
            neurotoxin from black widow spider venom, alpha-latrotoxin, to the
            synapse plasma membrane. Alternative splicing results in multiple
            variants encoding distinct isoforms.[provided by RefSeq, Oct 2008].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon, compared to variant 1, resulting in a shorter protein
            (isoform 2) compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF307079.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361434.8/ ENSP00000355328.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-674               AB020628.1         19-692
            675-1251            AB020628.1         708-1284
            1252-5610           AF307079.1         1252-5610
            5611-5640           BC002974.1         1386-1415
            5641-5879           BC072445.1         2-240
            5880-7820           BC072445.1         253-2193
FEATURES             Location/Qualifiers
     source          1..7820
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..7820
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /note="adhesion G protein-coupled receptor L1"
                     /db_xref="GeneID:22859"
                     /db_xref="HGNC:HGNC:20973"
                     /db_xref="MIM:616416"
     exon            1..185
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /inference="alignment:Splign:2.1.0"
     exon            186..350
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..4690
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; lectomedin-2; calcium-independent
                     alpha-latrotoxin receptor 1; latrophilin-1; CIRL-1"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor L1 isoform 2
                     precursor"
                     /protein_id="NP_055736.2"
                     /db_xref="CCDS:CCDS12307.1"
                     /db_xref="GeneID:22859"
                     /db_xref="HGNC:HGNC:20973"
                     /db_xref="MIM:616416"
                     /translation="MARLAAVLWNLCVTAVLVTSATQGLSRAGLPFGLMRRELACEGY
                     PIELRCPGSDVIMVENANYGRTDDKICDADPFQMENVQCYLPDAFKIMSQRCNNRTQC
                     VVVAGSDAFPDPCPGTYKYLEVQYDCVPYIFVCPGTLQKVLEPTSTHESEHQSGAWCK
                     DPLQAGDRIYVMPWIPYRTDTLTEYASWEDYVAARHTTTYRLPNRVDGTGFVVYDGAV
                     FYNKERTRNIVKYDLRTRIKSGETVINTANYHDTSPYRWGGKTDIDLAVDENGLWVIY
                     ATEGNNGRLVVSQLNPYTLRFEGTWETGYDKRSASNAFMVCGVLYVLRSVYVDDDSEA
                     AGNRVDYAFNTNANREEPVSLTFPNPYQFISSVDYNPRDNQLYVWNNYFVVRYSLEFG
                     PPDPSAGPATSPPLSTTTTARPTPLTSTASPAATTPLRRAPLTTHPVGAINQLGPDLP
                     PATAPVPSTRRPPAPNLHVSPELFCEPREVRRVQWPATQQGMLVERPCPKGTRGIASF
                     QCLPALGLWNPRGPDLSNCTSPWVNQVAQKIKSGENAANIASELARHTRGSIYAGDVS
                     SSVKLMEQLLDILDAQLQALRPIERESAGKNYNKMHKRERTCKDYIKAVVETVDNLLR
                     PEALESWKDMNATEQVHTATMLLDVLEEGAFLLADNVREPARFLAAKENVVLEVTVLN
                     TEGQVQELVFPQEEYPRKNSIQLSAKTIKQNSRNGVVKVVFILYNNLGLFLSTENATV
                     KLAGEAGPGGPGGASLVVNSQVIAASINKESSRVFLMDPVIFTVAHLEDKNHFNANCS
                     FWNYSERSMLGYWSTQGCRLVESNKTHTTCACSHLTNFAVLMAHREIYQGRINELLLS
                     VITWVGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLCINLFLAELLFLVGIDKTQY
                     EIACPIFAGLLHYFFLAAFSWLCLEGVHLYLLLVEVFESEYSRTKYYYLGGYCFPALV
                     VGIAAAIDYRSYGTEKACWLRVDNYFIWSFIGPVSFVIVVNLVFLMVTLHKMIRSSSV
                     LKPDSSRLDNIKSWALGAIALLFLLGLTWAFGLLFINKESVVMAYLFTTFNAFQGVFI
                     FVFHCALQKKVHKEYSKCLRHSYCCIRSPPGGTHGSLKTSAMRSNTRYYTGTQSRIRR
                     MWNDTVRKQTESSFMAGDINSTPTLNRGTMGNHLLTNPVLQPRGGTSPYNTLIAESVG
                     FNPSSPPVFNSPGSYREPKHPLGGREACGMDTLPLNGNFNNSYSLRSGDFPPGDGGPE
                     PPRGRNLADAAAFEKMIISELVHNNLRGSSSAAKGPPPPEPPVPPVPGGGGEEEAGGP
                     GGADRAEIELLYKALEEPLLLPRAQSVLYQSDLDESESCTAEDGATSRPLSSPPGRDS
                     LYASGANLRDSPSYPDSSPEGPSEALPPPPPAPPGPPEIYYTSRPPALVARNPLQGYY
                     QVRRPSHEGYLAAPGLEGPGPDGDGQMQLVTSL"
     exon            351..564
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /inference="alignment:Splign:2.1.0"
     exon            565..674
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /inference="alignment:Splign:2.1.0"
     exon            675..1475
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1790
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1894
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2080
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2119
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2303
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2429
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..2644
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2815
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..3025
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3026..3246
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3247..3313
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3314..3405
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3406..3574
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3575..3703
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3704..3800
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3801..3929
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3930..3947
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3948..7820
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7799..7804
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /note="hexamer: AAGAAA"
     polyA_site      7820
                     /gene="ADGRL1"
                     /gene_synonym="CIRL1; CL1; DEDBANP; LEC2; LPHN1"
                     /note="major polyA site"
ORIGIN      
        1 ctaatttttg gtcggcggcg gtgctgggcc aggggaagga agggacacgg aggccgccct
       61 cgtcccgcca cctcctaccc gcttcccccc agccccggct ccgggagatg tgccgggcgg
      121 ggggcccggg ttcgccgagc cgcaggagag acacgctggg ccgaccccag agaggcgctg
      181 gacaggctgg tggtccaggc cgtggtgcct gccaggtgat gtggggcaaa gccccccgca
      241 caggccactg agagctccgg acacgcaccc ggctgccacc atggcccgcc tagccgcagt
      301 gctctggaat ctgtgtgtca ccgccgtcct ggtcacctcg gccacccaag gcctgagccg
      361 ggccgggctc ccgttcgggc tgatgcgccg ggagctggcg tgtgaaggct accccatcga
      421 gctgcggtgc cccggcagcg acgtcatcat ggtggagaat gccaactacg ggcgcacgga
      481 cgacaagatt tgcgatgctg accctttcca gatggagaat gtgcagtgct acctgccgga
      541 cgccttcaag atcatgtcac agaggtgtaa caaccgcacc cagtgcgtgg tggtcgccgg
      601 ctcggatgcc tttcctgacc cctgtcctgg gacctacaag tacctggagg tgcagtacga
      661 ctgtgtcccc tacatcttcg tgtgcccagg gaccctgcag aaggtgctgg agcccacctc
      721 gacacacgag tcagagcacc agtctggcgc atggtgcaag gacccgctgc aggcgggtga
      781 ccgcatctac gtgatgccct ggatccccta ccgcacggac acactgactg agtatgcctc
      841 gtgggaggac tacgtggccg cccgccacac caccacctac cgcctgccca accgcgtgga
      901 tggcacaggc tttgtggtct acgatggtgc cgtcttctac aacaaggagc gcacgcgcaa
      961 catcgtcaag tatgacctac ggacgcgcat caagagcggg gagacggtca tcaataccgc
     1021 caactaccat gacacctcgc cctaccgctg gggcggaaag accgacattg acctggcggt
     1081 ggacgagaac gggctgtggg tcatctacgc cactgagggc aacaacgggc ggctggtggt
     1141 gagccagctg aacccctaca cactgcgctt tgagggcacg tgggagacgg gttacgacaa
     1201 gcgctcggca tccaacgcct tcatggtgtg tggggtcctg tacgtcctgc gttccgtgta
     1261 cgtggatgat gacagcgagg cggctggcaa ccgcgtggac tatgccttca acaccaatgc
     1321 caaccgcgag gagcctgtca gcctcacctt ccccaacccc taccagttca tctcctccgt
     1381 tgactacaac cctcgcgaca accagctgta cgtctggaac aactatttcg tggtgcgcta
     1441 cagcctggag ttcgggccgc ccgaccccag tgctggccca gccacttccc cacccctcag
     1501 cacgaccacc acagccaggc ccacgcccct caccagcaca gcctcgcccg cagccaccac
     1561 cccgctccgc cgggcacccc tcaccacgca cccagtgggt gccatcaacc agctgggacc
     1621 tgatctgcct ccagccacag ccccagtccc cagcacccgg cggcccccag ccccgaatct
     1681 acacgtgtcc cctgagctct tctgcgagcc ccgagaggta cggcgggtcc agtggccggc
     1741 cacccagcag ggcatgctgg tggagaggcc ctgccccaag gggactcgag gaattgcctc
     1801 cttccagtgt ctaccagcct tggggctctg gaacccccgg ggccctgacc tcagcaactg
     1861 cacctccccc tgggtcaacc aggtggccca gaagatcaag agtggggaga acgcggccaa
     1921 catcgccagc gagctggccc gacacacccg gggctccatc tacgcggggg acgtctcctc
     1981 ctctgtgaag ctgatggagc agctgctgga catcctggat gcccagctgc aggccctgcg
     2041 gcccatcgag cgcgagtcag ccggcaagaa ctacaacaag atgcacaagc gagagagaac
     2101 ttgtaaggat tatatcaagg ccgtggtgga gacagtggac aatctgctcc ggccagaagc
     2161 tctggagtcc tggaaggaca tgaatgccac ggagcaggtg cacacggcca ccatgctcct
     2221 cgacgtcctg gaggagggcg ccttcctgct ggccgacaat gtcagggagc ctgcccgctt
     2281 cctggctgcc aaggagaacg tggtcctgga ggtcacagtc ctgaacacag agggccaggt
     2341 gcaggagctg gtgttccccc aggaggagta cccgagaaag aactccatcc agctgtctgc
     2401 caaaaccatc aagcagaaca gccgcaatgg ggtggtcaaa gttgtcttca tcctctacaa
     2461 caacctgggc ctcttcctgt ccacggagaa tgccacagtg aagctggccg gcgaagcagg
     2521 cccgggtggc cctgggggcg cctctctagt ggtgaactca caggtcatcg cagcatccat
     2581 caacaaggag tccagccgcg tcttcctcat ggaccctgtc atcttcaccg tggcccacct
     2641 ggaggacaag aaccacttca atgctaactg ctccttctgg aactactcgg agcgttccat
     2701 gctgggctac tggtcgaccc aaggctgccg cctggtggag tccaacaaga cccataccac
     2761 gtgtgcctgc agccacctca ccaacttcgc tgtgctcatg gctcaccgtg agatctacca
     2821 gggccgcatc aacgagctgc tgctgtcggt catcacctgg gtgggcattg tgatctccct
     2881 ggtctgcttg gccatctgca tctccacctt ctgcttcctg cgggggctgc agaccgaccg
     2941 caacaccatc cacaagaacc tgtgcatcaa cctcttcctg gctgagctgc tcttcctggt
     3001 cgggatcgac aagactcagt atgagattgc ctgccccatc ttcgccggcc tgctgcacta
     3061 tttcttcctg gctgccttct cctggctgtg cctggagggc gtgcacctct acctgctact
     3121 agtggaggtg tttgagagcg agtattcccg caccaagtac tactacctgg gtggctactg
     3181 cttcccggcc ctggtggtgg gcatcgcggc tgccattgac taccgcagct acggcaccga
     3241 gaaggcctgc tggctccgag tggacaatta cttcatctgg agtttcatcg ggccagtctc
     3301 cttcgttatc gtggtcaacc tggtgttcct catggtgacc ctgcacaaga tgatccgaag
     3361 ctcatctgtg ctcaagcccg actccagccg cctggacaac attaaatcct gggcgctggg
     3421 ggccatcgcg ctgctgttcc tgctgggcct cacctgggct ttcggcctcc tcttcatcaa
     3481 caaggagtcg gtggtcatgg cctatctctt caccaccttc aacgccttcc agggggtctt
     3541 catcttcgtc tttcactgcg ccttacagaa gaaggtgcac aaggagtaca gcaagtgcct
     3601 gcgtcactcc tactgctgca tccgctcccc acccgggggc actcacggat ccctcaagac
     3661 ctcagccatg cgaagcaaca cccgctacta cacagggacc cagagccgaa ttcggaggat
     3721 gtggaatgac actgtgagga aacagacgga gtcctccttc atggcgggtg acatcaacag
     3781 cacccccacc ctgaaccgag gtaccatggg gaaccacctg ctgaccaacc ccgtgctgca
     3841 gccccgtggg ggcaccagtc cctacaacac cctcatcgcc gagtcagtgg gcttcaatcc
     3901 ctcctcgccc cctgtcttca actccccagg gagctaccgg gaacccaagc accccttggg
     3961 aggccgggaa gcctgtggca tggacaccct gcccctgaac ggcaacttca ataacagtta
     4021 ctccttgcga agtggggatt tccctcccgg ggatgggggc cctgagccgc cccgaggccg
     4081 gaacctagcc gatgcggcgg cctttgagaa gatgatcatc tcagagctgg tgcacaacaa
     4141 cctgcggggg agcagcagcg cggccaaggg ccctccaccg cctgagcccc ctgtgccacc
     4201 tgtgccaggg ggcgggggcg aggaagaggc gggcgggccc gggggtgctg accgggccga
     4261 gattgaactt ctctataagg ccctggagga gcctctgctg ctgccccggg cccagtcggt
     4321 gctgtaccag agcgatctgg acgagtcgga gagctgcacg gccgaggacg gcgccaccag
     4381 ccggcccctc tcctcccctc ctggccggga ctccctctat gccagcgggg ccaacctgcg
     4441 ggactcaccc tcctacccgg acagcagccc tgaggggccc agtgaggccc tgcccccacc
     4501 ccctcccgca ccccccggcc cccccgaaat ctactacacc tcgcgcccgc cagccctggt
     4561 ggcccggaat cccctgcagg gctactacca ggtgcggcgt cctagccacg agggctacct
     4621 ggcagcccca ggccttgagg ggccagggcc cgatggggac gggcagatgc agctggtcac
     4681 cagtctctga gggcacctca tggaccaggg gctggtggcc caggccaggg agggaaccct
     4741 gggcagggct ctggtgggag agggagacag atggaggcag tggctggtgg gccactctct
     4801 ccaggtgccc ctcagccatg ggccctacag tcccctcagg ggactctaac ctgggggcct
     4861 gaggtgccag ggttcacaga cagggtttcc caccagccac acgcaccagc tctatttggg
     4921 ggaagtgtag tgaggaggag cccagaggac cccaggggag tgaggaggga gaacttggaa
     4981 gggtgcagcc cacttccaga ctctcccctc tcccaccctt ctaccctgtg aagggaaatg
     5041 agggctttag tttcctgggc agggaggggc agcttctgag gttgccaaag gcccccactg
     5101 gatggaacct gttagctgct cctctccgca gccagaaatg ctgccggctg cacccagagg
     5161 gagcagtgag gcaggacaga tggacaggtt cctcctgcgc tgtaattccc tgctccctgg
     5221 agactgggaa aaggccgcag ggcaggggga ctgggcggtg gtggctggtg gtttaaaggt
     5281 tgaactttct ctgaagctcc tttccccttg ctcttggtcc ctgccccgca agcaaacctg
     5341 ccccctctgc ctcccagtgc acccaatgac cccctccctt ggggcgactc ctgatgaagc
     5401 acaactcccc gcagggcccc cagcccacag gggtggccat atttgggcag ttcccagtcc
     5461 tgtgggctcg gctatctggg gagcagattt tgggtctgga tctccctggg gagtgggtcc
     5521 tgggcttgga tctttcccta gggggccctc ttactccttc ctctctcctc ctccttcccc
     5581 attgctgtaa atatttcaac gaaatggaaa agaaaaaaaa aagacaaaaa aaaaaaaaaa
     5641 gaaaagaaaa aaaatctcat cacttgaagc caccgggagc ctgcggcccg ggccagcccg
     5701 ggctttctcc ggagcagagc agcgctgctg gcctggcagc caggacttct ccgtgtacgt
     5761 gcatccccag tccccgccgg ggcgggcggg ccgccagagc agctttttac aatccagaga
     5821 cagaaaacaa aatctagatg caacagcgaa acaaagaacc catttccttc ctggcaccct
     5881 cctttcctgc tccgcctgcc cggcatcatc agcccttctg gggcgtgtac ctctcactgc
     5941 ctgccccagg accagaggcc tgtctccccc ttccctcccc accggcccgg gggagacctc
     6001 ttcacaccca aagatgcttt gtcaagatgg ctgcgctgtc cctttgagtt cctgcttctt
     6061 gtatattgct ctggggactc tcgccgggga agatggggct gatttcccac ctagagaggt
     6121 tgatggcaga aggaaaatgg ggaggcactg gggttgtgga gggcatgggt atggctgagg
     6181 agggtgctgg gaacggcaag gcggtctggg ggatggggag gggcaaaggt gagagatcac
     6241 cttccctatc ctccaccttc ccgcagggaa gacgaagcca ggtgccaggg ctggggtcgg
     6301 gacacccatg ttctgggcgg cttgacccca aatcccagac cccggaagct ccaggctcgg
     6361 gatgtgtcct gagcacctgt cccggccccc tcctctccag cctgtcaggc cagcctcccc
     6421 agcccccttc cctcaactct aggggcagca tagccccagg ccaccctagc ccagcccctg
     6481 cattgccgtt tccccagagg tggcccctcc acctctgctc tgacctctcc ccatctctct
     6541 gcccctcctt ttctcacaag tgccatgagt tttcaaacat cttcgggtct cagcctgctg
     6601 ctgccatgaa ctttgttggg ttaaggggga ggggctctag gaaggaactg gggggaaggg
     6661 gacaggtagg tggctggagg gacccttttt gctgctagaa agcccctccc ttctcccggg
     6721 gagctggggc tggcttgtcc ccatcaatta ggggagaagg ggtcagacca aagatggtgg
     6781 tttgtcccgt gtaagggaac aggtgtgggg aagaggtggg gttgggttcc aactctggct
     6841 ttttctggta gaaaggccta acccattaca ccagaagacc atgggtgaag tctagatggg
     6901 gaggagaagt gaggccaggg acagtcttgc cagacgactc tgaggagggc aagggacagt
     6961 tccatggccc ttcccggact gcactaggct gggagctctg ttgtgtggag gggtggtcag
     7021 aggtctgtga agagcgggca ggaggcatga gcaggcgagg agctggcctg tcccgggaag
     7081 cagcccagcc tgtggctgcc cccgacacca ggaggagggc caggagagtt ccagggggct
     7141 gaggcacaca gagaggccaa cttcctccct gcccagcctt ccttgtatct ctccagactc
     7201 ggacaatcaa agggagagag ggtgtatcgg gtcctgttcc agccggcatc gccgggtggc
     7261 ttccaggcct cagagctgtg tggcagggcc ccctgctggg gctggacatc actgcagtcc
     7321 agtgcaaagc cgcccccaga gcccaggtgt ccccccaacc taaccagacc tggtgccttg
     7381 acgcccccac cccagctggg acggtacaga gaagggtctt ggtttcctct cctactccct
     7441 tccttaggct cctgaactcg tttgctccta aatcttgtta attctttttc tctggatttt
     7501 ggtttctttt ggctttccct tgccttcccc tttctctgtc tccaacactc tttccccatg
     7561 tctttctggc tgtctctatg ttcctcttct cttatcctca actttctgtc cattcgggcc
     7621 tcctccccac ctcccacgcc ccagcccctc cctccttggt ctccttttcg atatgccaaa
     7681 ccaattttgg gtcgagtgca tttaacgaga acaaaacaaa aggctcataa caacaagaac
     7741 gtttcagaaa aaaacaaaaa gttttaaaaa aattgttgag tcaaaaagtc aaacaataaa
     7801 gaaattaaga tttcttggaa
//
