LOCUS       NM_032787               3128 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens adhesion G protein-coupled receptor G7 (ADGRG7),
            transcript variant 1, mRNA.
ACCESSION   NM_032787
VERSION     NM_032787.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3128)
  AUTHORS   Zackova,S., Pavova,M., Trylcova,J., Chalupova,J., Priss,A.,
            Luksan,O. and Weber,J.
  TITLE     Upregulation of mRNA Expression of ADGRD1/GPR133 and ADGRG7/GPR128
            in SARS-CoV-2-Infected Lung Adenocarcinoma Calu-3 Cells
  JOURNAL   Cells 13 (10), 791 (2024)
   PUBMED   38786015
  REMARK    GeneRIF: Upregulation of mRNA Expression of ADGRD1/GPR133 and
            ADGRG7/GPR128 in SARS-CoV-2-Infected Lung Adenocarcinoma Calu-3
            Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3128)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3128)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3128)
  AUTHORS   Hamann,J., Aust,G., Arac,D., Engel,F.B., Formstone,C.,
            Fredriksson,R., Hall,R.A., Harty,B.L., Kirchhoff,C., Knapp,B.,
            Krishnan,A., Liebscher,I., Lin,H.H., Martinelli,D.C., Monk,K.R.,
            Peeters,M.C., Piao,X., Promel,S., Schoneberg,T., Schwartz,T.W.,
            Singer,K., Stacey,M., Ushkaryov,Y.A., Vallon,M., Wolfrum,U.,
            Wright,M.W., Xu,L., Langenhan,T. and Schioth,H.B.
  TITLE     International Union of Basic and Clinical Pharmacology. XCIV.
            Adhesion G protein-coupled receptors
  JOURNAL   Pharmacol Rev 67 (2), 338-367 (2015)
   PUBMED   25713288
  REMARK    Review article
REFERENCE   5  (bases 1 to 3128)
  AUTHORS   Chase,A., Ernst,T., Fiebig,A., Collins,A., Grand,F., Erben,P.,
            Reiter,A., Schreiber,S. and Cross,N.C.
  TITLE     TFG, a target of chromosome translocations in lymphoma and soft
            tissue tumors, fuses to GPR128 in healthy individuals
  JOURNAL   Haematologica 95 (1), 20-26 (2010)
   PUBMED   19797732
  REMARK    GeneRIF: An expressed in-frame TRK-fused gene-G-protein-coupled
            receptor GPR128 is identified in healthy individuals and in
            patients with myeloproliferative neoplasms.
REFERENCE   6  (bases 1 to 3128)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
REFERENCE   7  (bases 1 to 3128)
  AUTHORS   Fredriksson,R., Gloriam,D.E., Hoglund,P.J., Lagerstrom,M.C. and
            Schioth,H.B.
  TITLE     There exist at least 30 human G-protein-coupled receptors with long
            Ser/Thr-rich N-termini
  JOURNAL   Biochem Biophys Res Commun 301 (3), 725-734 (2003)
   PUBMED   12565841
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK027360.1, AC069223.15 and AK172769.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032787.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027360.1, BC113451.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273352.8/ ENSP00000273352.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-706               AK027360.1         1-706
            707-707             AC069223.15        132762-132762       c
            708-3070            AK027360.1         708-3070
            3071-3128           AK172769.1         2325-2382
FEATURES             Location/Qualifiers
     source          1..3128
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q12.2"
     gene            1..3128
                     /gene="ADGRG7"
                     /gene_synonym="GPR128"
                     /note="adhesion G protein-coupled receptor G7"
                     /db_xref="GeneID:84873"
                     /db_xref="HGNC:HGNC:19241"
                     /db_xref="MIM:612307"
     exon            1..371
                     /gene="ADGRG7"
                     /gene_synonym="GPR128"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..2650
                     /gene="ADGRG7"
                     /gene_synonym="GPR128"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; G-protein coupled receptor 128"
                     /codon_start=1
                     /product="adhesion G-protein coupled receptor G7 isoform 1
                     precursor"
                     /protein_id="NP_116176.2"
                     /db_xref="CCDS:CCDS2938.1"
                     /db_xref="GeneID:84873"
                     /db_xref="HGNC:HGNC:19241"
                     /db_xref="MIM:612307"
                     /translation="MASCRAWNLRVLVAVVCGLLTGIILGLGIWRIVIRIQRGKSTSS
                     SSTPTEFCRNGGTWENGRCICTEEWKGLRCTIANFCENSTYMGFTFARIPVGRYGPSL
                     QTCGKDTPNAGNPMAVRLCSLSLYGEIELQKVTIGNCNENLETLEKQVKDVTAPLNNI
                     SSEVQILTSDANKLTAENITSATRVVGQIFNTSRNASPEAKKVAIVTVSQLLDASEDA
                     FQRVAATANDDALTTLIEQMETYSLSLGNQSVVEPNIAIQSANFSSENAVGPSNVRFS
                     VQKGASSSLVSSSTFIHTNVDGLNPDAQTELQVLLNMTKNYTKTCGFVVYQNDKLFQS
                     KTFTAKSDFSQKIISSKTDENEQDQSASVDMVFSPKYNQKEFQLYSYACVYWNLSAKD
                     WDTYGCQKDKGTDGFLRCRCNHTTNFAVLMTFKKDYQYPKSLDILSNVGCALSVTGLA
                     LTVIFQIVTRKVRKTSVTWVLVNLCISMLIFNLLFVFGIENSNKNLQTSDGDINNIDF
                     DNNDIPRTDTINIPNPMCTAIAALLHYFLLVTFTWNALSAAQLYYLLIRTMKPLPRHF
                     ILFISLIGWGVPAIVVAITVGVIYSQNGNNPQWELDYRQEKICWLAIPEPNGVIKSPL
                     LWSFIVPVTIILISNVVMFITISIKVLWKNNQNLTSTKKVSSMKKIVSTLSVAVVFGI
                     TWILAYLMLVNDDSIRIVFSYIFCLFNTTQGLQIFILYTVRTKVFQSEASKVLMLLSS
                     IGRRKSLPSVTRPRLRVKMYNFLRSLPTLHERFRLLETSPSTEEITLSESDNAKESI"
     exon            372..485
                     /gene="ADGRG7"
                     /gene_synonym="GPR128"
                     /inference="alignment:Splign:2.1.0"
     exon            486..590
                     /gene="ADGRG7"
                     /gene_synonym="GPR128"
                     /inference="alignment:Splign:2.1.0"
     exon            591..703
                     /gene="ADGRG7"
                     /gene_synonym="GPR128"
                     /inference="alignment:Splign:2.1.0"
     exon            704..853
                     /gene="ADGRG7"
                     /gene_synonym="GPR128"
                     /inference="alignment:Splign:2.1.0"
     exon            854..954
                     /gene="ADGRG7"
                     /gene_synonym="GPR128"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1094
                     /gene="ADGRG7"
                     /gene_synonym="GPR128"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1202
                     /gene="ADGRG7"
                     /gene_synonym="GPR128"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1366
                     /gene="ADGRG7"
                     /gene_synonym="GPR128"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1522
                     /gene="ADGRG7"
                     /gene_synonym="GPR128"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1635
                     /gene="ADGRG7"
                     /gene_synonym="GPR128"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1982
                     /gene="ADGRG7"
                     /gene_synonym="GPR128"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2079
                     /gene="ADGRG7"
                     /gene_synonym="GPR128"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2235
                     /gene="ADGRG7"
                     /gene_synonym="GPR128"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2392
                     /gene="ADGRG7"
                     /gene_synonym="GPR128"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..3128
                     /gene="ADGRG7"
                     /gene_synonym="GPR128"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3052..3057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRG7"
                     /gene_synonym="GPR128"
                     /note="hexamer: ATTAAA"
     polyA_site      3072
                     /gene="ADGRG7"
                     /gene_synonym="GPR128"
                     /note="major polyA site"
     regulatory      3109..3114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRG7"
                     /gene_synonym="GPR128"
                     /note="hexamer: AATGAA"
     polyA_site      3128
                     /gene="ADGRG7"
                     /gene_synonym="GPR128"
ORIGIN      
        1 acttttttca tgttctcctt gagtgaagga tgaggaaatt gaaagcagag tatgcacctt
       61 ttattaggag attcaaactg catcctactg gattagcctc aaaagtccta aaatacaaag
      121 acatccatct gacagatcac tgaggggagg acttgttttt ctgttttaga atagtttccg
      181 attaaacttt ttagctcaag aagaaaagaa gctagttatt tctcacccag gagtggattt
      241 gtggtttggc ttcaccatgg cttcctgccg tgcctggaac cttagggtgc tggtggctgt
      301 cgtgtgtgga ctactgactg gcatcatttt gggactgggc atctggagga ttgtgatcag
      361 gatccaaaga ggaaaatcta cttcctcatc aagcacccct acagagttct gcaggaatgg
      421 tggaacctgg gaaaatggca gatgtatttg tacagaagag tggaaaggac tgagatgtac
      481 aattgctaat ttttgtgaaa atagtaccta tatgggtttt acttttgcca gaatcccagt
      541 gggcagatat ggaccatcct tgcaaacatg tggcaaggat actccaaatg cgggcaatcc
      601 aatggcagtc cggttgtgca gtctctctct atatggagag atagaattac aaaaagtgac
      661 aataggaaat tgcaatgaaa atctggaaac cctggaaaag caggtaaagg atgtcacagc
      721 accacttaat aacatttctt ctgaagtcca gattttaaca tctgatgcca ataaattaac
      781 tgctgagaac atcactagtg ctacgcgagt ggttggacag atattcaaca cttccagaaa
      841 tgcttcacct gaggcaaaga aagttgccat agtaacagtg agtcaactcc tagatgccag
      901 tgaagatgct tttcaaagag ttgctgctac tgctaatgat gatgccctta caacgcttat
      961 tgagcaaatg gagacttatt ccttgtcttt gggtaatcaa tcagtggtgg aacctaacat
     1021 agcaatacag tcagcaaatt tctcttcaga aaatgcggtg gggccttcaa atgttcgctt
     1081 ctctgtgcag aaaggagcta gcagttctct agtttctagt tcaacattta tacatacaaa
     1141 tgtggatggc cttaacccag atgcacagac tgagcttcag gtcttgctta atatgacgaa
     1201 aaattacacc aagacatgcg gctttgtagt ttatcaaaat gacaagcttt tccaatcaaa
     1261 aacttttaca gctaaatcgg attttagtca aaaaattatc tcaagcaaaa ctgatgaaaa
     1321 tgagcaagat cagagtgctt ctgttgacat ggtctttagt ccaaagtaca accaaaaaga
     1381 atttcaactc tattcctatg cctgtgtcta ttggaatttg tcagcgaagg actgggacac
     1441 atatggctgt caaaaagaca agggcactga tggattcctg cgctgccgct gcaaccatac
     1501 tactaatttt gctgtattaa tgactttcaa aaaggattat caatatccca aatcacttga
     1561 catattatcc aacgttggat gtgcactgtc tgttactggt ctggctctca cagttatatt
     1621 tcagattgtc accaggaaag tcagaaaaac ctcagtaacc tgggttttgg tcaatctgtg
     1681 catatcaatg ttgattttca acctcctctt tgtgtttgga attgaaaact ccaataagaa
     1741 cttgcagaca agtgatggtg acatcaataa tattgacttt gacaataatg acatacccag
     1801 gacagacacc attaacatcc cgaatcccat gtgcactgcg attgccgcct tactgcacta
     1861 ttttctgtta gtgacattta cctggaacgc actcagcgct gcacagctct attaccttct
     1921 aataaggacc atgaagcctc ttcctcggca tttcattctt ttcatctcat taattggatg
     1981 gggagtccca gctatagtag tggctataac agtgggagtt atttattctc agaatggaaa
     2041 taatccacag tgggaattag actaccggca agagaaaatc tgctggctgg caattccaga
     2101 acccaatggt gttataaaaa gtccgctgtt gtggtcattc atcgtacctg taaccattat
     2161 cctcatcagc aatgttgtta tgtttattac aatctcgatc aaagtgctgt ggaagaataa
     2221 ccagaacctg acaagcacaa aaaaagtttc atccatgaag aagattgtta gcacattatc
     2281 tgttgcagtt gtttttggaa ttacctggat tctagcatac ctgatgctag ttaatgatga
     2341 tagcatcagg atcgtcttca gctacatatt ctgccttttc aacactacac agggattgca
     2401 aatttttatc ctgtacactg ttagaacaaa agtcttccag agtgaagctt ccaaagtgtt
     2461 gatgttgcta tcgtctattg ggagaaggaa gtcattgcct tcagtgacgc ggccgaggct
     2521 gcgtgtaaag atgtataatt tcctcaggtc attgccaacc ttacatgaac gctttaggct
     2581 actggaaacc tctccgagta ctgaggaaat cacactctct gaaagtgaca atgcaaagga
     2641 aagcatctag acagtaaaac ttacctgttg tggtcttttt aatcacctcg tttgagtttt
     2701 atctgtttct ctcctttatt tcccagtcct ctcagaaagt cttcctcaat gtattttgct
     2761 caggattaag aattagataa aacctgttgt ttattattat tcggcataat ggacttggta
     2821 gtttttctat ttttcaatag atttgtactt gaataaggtg aagaatttca cacaacatac
     2881 aagagtacca ttgttcctta tatcgttaaa tctttgtgac acactttgac aaaaatgtag
     2941 aacctataac aaattctttt acaagttact ataaaggaca caaagagaaa actttacctt
     3001 ccagaacaaa atgactcctg atgaacagtg tgtggggatt tgcttgtatg tattaaactt
     3061 ttgacctctg aatattttac agtcgtatgt gcttgtactt ttatttccaa tgaagaattt
     3121 ggcaccaa
//
