LOCUS       NM_198569               6822 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens adhesion G protein-coupled receptor G6 (ADGRG6),
            transcript variant b1, mRNA.
ACCESSION   NM_198569
VERSION     NM_198569.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6822)
  AUTHORS   Kosters,P., Cazorla-Vazquez,S., Kruger,R., Daniel,C., Vonbrunn,E.,
            Amann,K. and Engel,F.B.
  TITLE     Adhesion G Protein-Coupled Receptor Gpr126 (Adgrg6) Expression
            Profiling in Diseased Mouse, Rat, and Human Kidneys
  JOURNAL   Cells 13 (10), 874 (2024)
   PUBMED   38786096
  REMARK    GeneRIF: Adhesion G Protein-Coupled Receptor Gpr126 (Adgrg6)
            Expression Profiling in Diseased Mouse, Rat, and Human Kidneys.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6822)
  AUTHORS   Soto,M.E., Fuentevilla-Alvarez,G., Koretzky,S.G.,
            Vargas-Alarcon,G., Torres-Paz,Y.E., Meza-Toledo,S.E.,
            Perez-Torres,I., Huesca-Gomez,C. and Gamboa,R.
  TITLE     Analysis of GPR126 polymorphisms and their relationship with
            scoliosis in Marfan syndrome and Marfan-like syndrome in Mexican
            patients
  JOURNAL   Biomol Biomed 23 (6), 976-983 (2023)
   PUBMED   37270806
  REMARK    GeneRIF: Analysis of GPR126 polymorphisms and their relationship
            with scoliosis in Marfan syndrome and Marfan-like syndrome in
            Mexican patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6822)
  AUTHORS   Werder,R.B., Berthiaume,K.A., Merritt,C., Gallagher,M.,
            Villacorta-Martin,C., Wang,F., Bawa,P., Malik,V., Lyons,S.M.,
            Basil,M.C., Morrisey,E.E., Kotton,D.N., Zhou,X., Cho,M.H. and
            Wilson,A.A.
  TITLE     The COPD GWAS gene ADGRG6 instructs function and injury response in
            human iPSC-derived type II alveolar epithelial cells
  JOURNAL   Am J Hum Genet 110 (10), 1735-1749 (2023)
   PUBMED   37734371
  REMARK    GeneRIF: The COPD GWAS gene ADGRG6 instructs function and injury
            response in human iPSC-derived type II alveolar epithelial cells.
REFERENCE   4  (bases 1 to 6822)
  AUTHORS   Cazorla-Vazquez,S., Kosters,P., Bertz,S., Pfister,F., Daniel,C.,
            Dedden,M., Zundler,S., Jobst-Schwan,T., Amann,K. and Engel,F.B.
  TITLE     Adhesion GPCR Gpr126 (Adgrg6) Expression Profiling in Zebrafish,
            Mouse, and Human Kidney
  JOURNAL   Cells 12 (15), 1988 (2023)
   PUBMED   37566066
  REMARK    GeneRIF: Adhesion GPCR Gpr126 (Adgrg6) Expression Profiling in
            Zebrafish, Mouse, and Human Kidney.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6822)
  AUTHORS   Lei,X., Tian,X., Wang,H., Xu,X., Li,G., Liu,W., Wang,D., Xiao,Z.,
            Zhang,M., Li,M.J., Zhang,Z., Ma,Z. and Liu,Z.
  TITLE     Noncoding SNP at rs1663689 represses ADGRG6 via interchromosomal
            interaction and reduces lung cancer progression
  JOURNAL   EMBO Rep 24 (7), e56212 (2023)
   PUBMED   37154297
  REMARK    GeneRIF: Noncoding SNP at rs1663689 represses ADGRG6 via
            interchromosomal interaction and reduces lung cancer progression.
REFERENCE   6  (bases 1 to 6822)
  AUTHORS   Kristiansen,T.Z., Bunkenborg,J., Gronborg,M., Molina,H.,
            Thuluvath,P.J., Argani,P., Goggins,M.G., Maitra,A. and Pandey,A.
  TITLE     A proteomic analysis of human bile
  JOURNAL   Mol Cell Proteomics 3 (7), 715-728 (2004)
   PUBMED   15084671
REFERENCE   7  (bases 1 to 6822)
  AUTHORS   Fredriksson,R., Gloriam,D.E., Hoglund,P.J., Lagerstrom,M.C. and
            Schioth,H.B.
  TITLE     There exist at least 30 human G-protein-coupled receptors with long
            Ser/Thr-rich N-termini
  JOURNAL   Biochem Biophys Res Commun 301 (3), 725-734 (2003)
   PUBMED   12565841
REFERENCE   8  (bases 1 to 6822)
  AUTHORS   Xu,J., Bleecker,E.R., Jongepier,H., Howard,T.D., Koppelman,G.H.,
            Postma,D.S. and Meyers,D.A.
  TITLE     Major recessive gene(s) with considerable residual polygenic effect
            regulating adult height: confirmation of genomewide scan results
            for chromosomes 6, 9, and 12
  JOURNAL   Am J Hum Genet 71 (3), 646-650 (2002)
   PUBMED   12119602
REFERENCE   9  (bases 1 to 6822)
  AUTHORS   Hirschhorn,J.N., Lindgren,C.M., Daly,M.J., Kirby,A.,
            Schaffner,S.F., Burtt,N.P., Altshuler,D., Parker,A., Rioux,J.D.,
            Platko,J., Gaudet,D., Hudson,T.J., Groop,L.C. and Lander,E.S.
  TITLE     Genomewide linkage analysis of stature in multiple populations
            reveals several regions with evidence of linkage to adult height
  JOURNAL   Am J Hum Genet 69 (1), 106-116 (2001)
   PUBMED   11410839
REFERENCE   10 (bases 1 to 6822)
  AUTHORS   Matoba,R., Okubo,K., Hori,N., Fukushima,A. and Matsubara,K.
  TITLE     The addition of 5'-coding information to a 3'-directed cDNA library
            improves analysis of gene expression
  JOURNAL   Gene 146 (2), 199-207 (1994)
   PUBMED   8076819
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB183548.1, AL033377.2 and
            AL080079.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 18, 2019 this sequence version replaced NM_198569.2.
            
            Summary: This gene, which is upregulated in human umbilical vein
            endothelial cells, encodes a G protein-coupled receptor. Variations
            in this gene can affect a person's stature. Multiple transcript
            variants encoding different proteins have been found for this gene.
            [provided by RefSeq, Mar 2009].
            
            Transcript Variant: This variant (b1) encodes the longest isoform
            (beta 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1966682,
                              SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367609.8/ ENSP00000356581.3
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1798              AB183548.1         79-1876
            1799-1799           AL033377.2         63506-63506
            1800-3702           AB183548.1         1878-3780
            3703-3703           AL033377.2         103336-103336
            3704-6074           AB183548.1         3782-6152
            6075-6809           AB183548.1         6168-6902
            6810-6822           AL080079.1         1892-1904
FEATURES             Location/Qualifiers
     source          1..6822
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q24.2"
     gene            1..6822
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /note="adhesion G protein-coupled receptor G6"
                     /db_xref="GeneID:57211"
                     /db_xref="HGNC:HGNC:13841"
                     /db_xref="MIM:612243"
     exon            1..325
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..4076
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /note="isoform beta 1 precursor is encoded by transcript
                     variant b1; G-protein coupled receptor 126;
                     developmentally regulated G-protein-coupled receptor;
                     vascular-inducible G protein-coupled receptor; HBV
                     PreS1-transactivated protein 2"
                     /codon_start=1
                     /product="adhesion G-protein coupled receptor G6 isoform
                     beta 1 precursor"
                     /protein_id="NP_940971.2"
                     /db_xref="CCDS:CCDS47489.1"
                     /db_xref="GeneID:57211"
                     /db_xref="HGNC:HGNC:13841"
                     /db_xref="MIM:612243"
                     /translation="MMFRSDRMWSCHWKWKPSPLLFLFALYIMCVPHSVWGCANCRVV
                     LSNPSGTFTSPCYPNDYPNSQACMWTLRAPTGYIIQITFNDFDIEEAPNCIYDSLSLD
                     NGESQTKFCGATAKGLSFNSSANEMHVSFSSDFSIQKKGFNASYIRVAVSLRNQKVIL
                     PQTSDAYQVSVAKSISIPELSAFTLCFEATKVGHEDSDWTAFSYSNASFTQLLSFGKA
                     KSGYFLSISDSKCLLNNALPVKEKEDIFAESFEQLCLVWNNSLGSIGVNFKRNYETVP
                     CDSTISKVIPGNGKLLLGSNQNEIVSLKGDIYNFRLWNFTMNAKILSNLSCNVKGNVV
                     DWQNDFWNIPNLALKAESNLSCGSYLIPLPAAELASCADLGTLCQATVNSPSTTPPTV
                     TTNMPVTNRIDKQRNDGIIYRISVVIQNILRHPEVKVQSKVAEWLNSTFQNWNYTVYV
                     VNISFHLSAGEDKIKVKRSLEDEPRLVLWALLVYNATNNTNLEGKIIQQKLLKNNESL
                     DEGLRLHTVNVRQLGHCLAMEEPKGYYWPSIQPSEYVLPCPDKPGFSASRICFYNATN
                     PLVTYWGPVDISNCLKEANEVANQILNLTADGQNLTSANITNIVEQVKRIVNKEENID
                     ITLGSTLMNIFSNILSSSDSDLLESSSEALKTIDELAFKIDLNSTSHVNITTRNLALS
                     VSSLLPGTNAISNFSIGLPSNNESYFQMDFESGQVDPLASVILPPNLLENLSPEDSVL
                     VRRAQFTFFNKTGLFQDVGPQRKTLVSYVMACSIGNITIQNLKDPVQIKIKHTRTQEV
                     HHPICAFWDLNKNKSFGGWNTSGCVAHRDSDASETVCLCNHFTHFGVLMDLPRSASQL
                     DARNTKVLTFISYIGCGISAIFSAATLLTYVAFEKLRRDYPSKILMNLSTALLFLNLL
                     FLLDGWITSFNVDGLCIAVAVLLHFFLLATFTWMGLEAIHMYIALVKVFNTYIRRYIL
                     KFCIIGWGLPALVVSVVLASRNNNEVYGKESYGKEKGDEFCWIQDPVIFYVTCAGYFG
                     VMFFLNIAMFIVVMVQICGRNGKRSNRTLREEVLRNLRSVVSLTFLLGMTWGFAFFAW
                     GPLNIPFMYLFSIFNSLQGLFIFIFHCAMKENVQKQWRQHLCCGRFRLADNSDWSKTA
                     TNIIKKSSDNLGKSLSSSSIGSNSTYLTSKSKSSSTTYFKRNSHTDSASMDKSLSKLA
                     HADGDQTSIIPVHQVIDKVKGYCNAHSDNFYKNIIMSDTFSHSTKF"
     exon            326..426
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            427..768
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            769..1392
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1461
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1545
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1631
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1684
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1747
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1890
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2002
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2067
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2278
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2450
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2591
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2711
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..2757
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            2758..2864
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..2992
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3261
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            3262..3358
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            3359..3642
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            3643..3744
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            3745..3897
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            3898..6822
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6790..6795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /note="hexamer: AATAAA"
     polyA_site      6822
                     /gene="ADGRG6"
                     /gene_synonym="APG1; DREG; GPR126; LCCS9; PR126; PS1TP2;
                     STQTL1; VIGR"
                     /note="major polyA site"
ORIGIN      
        1 ccggtctcct cagcaccagc cccacgcaca ccctacttcc tcagcttctc gccctcaccc
       61 tgccaacttc cctgcgagga gggacctgcc gccagcctgc ttcctcgtcc gcaggccctg
      121 cgctgaacgc tgccgcgccc agggttcacc ttgcgccgtc gggaaagccc atgaactctc
      181 cagaaacggc gtaaaggagg gtcccgccgc ggcgcagggc tggggcgcct gggttccccc
      241 tgggtggagc agcggcagca gagcgggaaa gtggtggagg atgatcttgc ggccaaaggg
      301 gacctcggcg cagtaatgtc aacatgatgt ttcgctcaga tcgaatgtgg agctgccatt
      361 ggaaatggaa gcccagtcct ctcctgttct tatttgcttt atatatcatg tgtgttcctc
      421 actcagtgtg gggatgtgcc aactgccgag tggttttgtc caacccttct gggaccttta
      481 cttctccatg ctaccctaac gactacccaa acagccaggc ttgcatgtgg acgctccgag
      541 cccccaccgg ttatatcatt cagataacat ttaacgactt tgacattgaa gaagctccca
      601 attgcattta tgactcatta tcccttgata atggagagag ccagactaaa ttttgtggag
      661 caactgccaa aggcctatca tttaactcaa gtgcgaatga gatgcatgtg tccttttcaa
      721 gtgactttag catccagaag aaaggtttca atgccagcta catcagagtt gccgtgtcct
      781 taaggaatca aaaggtcatt ttaccccaga catcagatgc ttaccaggta tctgttgcaa
      841 aaagcatctc tattccagag ctcagtgctt tcacactctg ctttgaagca accaaagttg
      901 gccatgaaga cagtgattgg acagctttct cctactcaaa tgcatccttc acacaattgc
      961 tcagttttgg aaaggccaag agtggctact ttctatccat ttctgattca aaatgtttgt
     1021 tgaataatgc attacctgtc aaagaaaaag aagacatttt tgcagaaagc tttgaacagc
     1081 tctgccttgt ttggaataat tctttgggct ctattggtgt aaatttcaaa agaaactatg
     1141 aaacagttcc atgtgattct accattagta aagttattcc tgggaatggg aaattgttgt
     1201 tgggctccaa tcaaaatgaa attgtctctc taaaagggga catttataac tttcgacttt
     1261 ggaattttac catgaatgcc aaaatcctct ccaacctcag ctgtaatgtg aaagggaatg
     1321 tagtcgactg gcaaaatgac ttctggaata tcccaaacct agctctgaaa gctgaaagca
     1381 acctaagctg tggttcctac ctgatcccgc tcccagcagc agaactggcc agctgtgcag
     1441 acctggggac cctctgtcaa gctactgtaa actctcctag tactacacca cccactgtca
     1501 ccactaacat gcctgttact aacagaatcg ataaacaaag gaatgatgga attatctata
     1561 gaatatccgt agtgattcag aacatccttc gtcaccctga ggtaaaagta cagagcaagg
     1621 tggcagaatg gctcaattca accttccaaa attggaacta cacggtttat gtcgttaata
     1681 tcagttttca cctgagtgct ggagaggaca agattaaagt caagagaagc cttgaggatg
     1741 agccaaggtt ggtgctttgg gcccttctag tttacaatgc taccaacaat actaatttgg
     1801 aaggaaaaat cattcagcag aagctcctaa aaaataatga gtccttggat gaaggcttga
     1861 ggctacatac agtgaatgtg agacaactgg gtcattgtct tgccatggag gaacccaaag
     1921 gctactactg gccatctatc caaccttctg aatacgttct tccttgtcca gacaagcctg
     1981 gcttttctgc ttctcggata tgtttttaca atgctaccaa cccattggta acctactggg
     2041 gacctgttga tatctccaac tgtttaaaag aagcaaatga agttgctaac cagattttaa
     2101 atttaactgc tgatgggcag aacttaacct cagccaatat taccaacatt gtggaacagg
     2161 tcaaaagaat tgtgaataaa gaagaaaaca ttgatataac acttggctca actctaatga
     2221 atatattttc taatatctta agcagttcag acagtgactt gcttgagtca tcttctgaag
     2281 ctttaaaaac aattgatgaa ttggccttca agatagacct aaatagcaca tcacatgtga
     2341 atattacaac tcggaacttg gctctcagcg tatcatccct gttaccaggg acaaatgcaa
     2401 tttcaaattt tagcattggt cttccaagca ataatgaatc gtatttccag atggattttg
     2461 agagtggaca agtggatcca ctggcatctg taattttgcc tccaaactta cttgagaatt
     2521 taagtccaga agattctgta ttagttagaa gagcacagtt tactttcttc aacaaaactg
     2581 gacttttcca ggatgtagga ccccaaagaa aaactttagt gagttatgtg atggcgtgca
     2641 gtattggaaa cattactatc cagaatctga aggatcctgt tcaaataaaa atcaaacata
     2701 caagaactca ggaagtgcat catcccatct gtgccttctg ggatctgaac aaaaacaaaa
     2761 gttttggagg atggaacacg tcaggatgtg ttgcacacag agattcagat gcaagtgaga
     2821 cagtctgcct gtgtaaccac ttcacacact ttggagttct gatggacctt ccaagaagtg
     2881 cctcacagtt agatgcaaga aacactaaag tcctcacttt catcagctat attgggtgtg
     2941 gaatatctgc tattttttca gcagcaactc tcctgacata tgttgctttt gagaaattgc
     3001 gaagggatta tccctccaaa atcttgatga acctgagcac agccctgctg ttcctgaatc
     3061 tcctcttcct cctagatggc tggatcacct ccttcaatgt ggatggactt tgcattgctg
     3121 ttgcagtcct gttgcatttc ttccttctgg caacctttac ctggatgggg ctagaagcaa
     3181 ttcacatgta cattgctcta gttaaagtat ttaacactta cattcgccga tacattctaa
     3241 aattctgcat cattggctgg ggtttgcctg ccttagtggt gtcagttgtt ctagcgagca
     3301 gaaacaacaa tgaagtctat ggaaaagaaa gttatgggaa agaaaaaggt gatgaattct
     3361 gttggattca agatccagtc atattttatg tgacctgtgc tgggtatttt ggagtcatgt
     3421 tttttctgaa cattgccatg ttcattgtgg taatggtgca gatctgtggg aggaatggca
     3481 agagaagcaa ccggaccctg agagaagaag tgttaaggaa cctgcgcagt gtggttagct
     3541 tgacctttct gttgggcatg acatggggtt ttgcattctt tgcctgggga cccttaaata
     3601 tccccttcat gtacctcttc tccatcttca attcattaca aggcttattt atattcatct
     3661 tccactgtgc tatgaaggag aatgttcaga aacagtggcg gcagcatctc tgctgtggta
     3721 gatttcggtt agcagataac tcagattgga gtaagacagc taccaatatc atcaagaaaa
     3781 gttctgataa tctaggaaaa tctttgtctt caagctccat tggttccaac tcaacctatc
     3841 ttacatccaa atctaaatcc agctctacca cctatttcaa aaggaatagc cacacagaca
     3901 gtgcttccat ggacaagtcc ttgtcaaaac tggcccatgc tgatggagat caaacatcaa
     3961 tcatccctgt ccatcaggtc attgataagg tcaagggtta ttgcaatgct cattcagaca
     4021 acttctataa aaatattatc atgtcagaca ccttcagcca cagcacaaag ttttaatgtc
     4081 tttaagaaaa agaaatcaat ctgcagaaat gtgaagattt gcaagcagtg taaactgcaa
     4141 ctagtgatgt aaatgtgcta ttacctaggt aactgcatat atataaggaa tgtattttgt
     4201 taagaaggct tttgtgaaat tcagaatttt tctttttaat atatttcttc catggaagag
     4261 ttgtcatcac taaaacttca gtactgagag taacatgact cagtagccac agaagctatg
     4321 atttgtaaaa tatataattg aatcagagta atcataatgc aggggagaca ttcaaattag
     4381 agacaaggga gaagcaatgc tgaggaagac cctagataga gctcatttta ctccacctaa
     4441 tcgttatatc tggatatacc cattttctgc atcttctttc tcaacaataa aaaatgtaac
     4501 tattttgaat gcccacaaat cccattccag tgttactttc tgtgaatgca gtaccatatt
     4561 ctcattttca atgacatttc aaccacaggc agaaaagact gtttactcct tgacccaaag
     4621 attaaaaagg attttttatt attttaaata ttacaccttc agaaccataa catgcttaag
     4681 aaaactttcc caaaatgttg acctagttaa atgaggctat ataaatttct aatattttac
     4741 ttattctatt caaggcatag ggccaaagca ttaagtataa tttaatccca tacattcgag
     4801 ttaagtttag tgttgatgtt ccatcattct ggacctccca ggagttgttt aagaatgaat
     4861 ctcttacacc tctacttttg cccctctact gtatattaag cccataggct tgtgggagga
     4921 aggagaattt ccattaggca agctgtatgc agtggaattt tccttttagg agacacacaa
     4981 ttaagactct ctggttctgt ccttgctttg gagactttaa gacatttcct aaagcacaaa
     5041 taaaagcctc gtatttcccc attgagagtt ttgttccaag gaatatgaag tgagacatat
     5101 gggtgagtca taataatcaa aataatttat gaagagctgg gtctgcaata gctagtctaa
     5161 aaactacttg tgtgtcagtc ctctggttat agtatataag agcctgagga ggtctggcaa
     5221 gatagatggt gtattattta tggatcaggc tgctgcatac aaaccttgca tactattatg
     5281 cagcttacct aactctcaga ctattctgag taatgcttgc ttgctaatga atgtatagga
     5341 gaccacattg taattgttct tagatgatgg agtccatgca gtttcttaga aatcggtctc
     5401 agtgcatgct gtgctttttc acatttgctc tgggttatct gggaagtatc aggttctggg
     5461 aggcaacagc attaagtgat aagaaaagga gacattctgg caaagccaat ctgcttaaag
     5521 gcaaagtcca gaacctggaa cctagaggcc tttctctctg cacgaaaaac aggtagtttg
     5581 cagtctgaga tatgggagag cttttaggct acacagcaac ccaagggacc tctcaccttt
     5641 tgctgagctt caatcaggaa gctatttgcc tggctccagc agatgatgag ataatgaggt
     5701 agtgggtttt ttattactgt tccattttgc aacatcctgc aacaccatcc tgggagacaa
     5761 gagcattacc cagcttggct ttcacggggg agggttgtat tcagtaaaaa agaatagtaa
     5821 atataaggtc actgagattc taagtaagat agtaaatcta aggtcactga gccaaatcct
     5881 tttcaatagg catatattaa caggctgctt attttggcgg aggttacata tggatgaaaa
     5941 tgaatcttag tcactgaata ttcatataca tttcccccaa aaccttagac attcatagta
     6001 gattttaatt agttagcttt ctaactagtc agatttctgc ccaaagtgct tagtcaatag
     6061 taattaagat atagcttcaa aaatggcttt gcttttgatt tctactcata ttcgtatggc
     6121 tccagaaaaa tatttttttc atatttgaca atgtcagctc cactttagaa attttcaata
     6181 accagatgag aaaaaaatta agaaattgct caagggaaac atttgtaaat ggatttgaaa
     6241 gattgagcca aattctgttg tcagttctaa gcatgcagtt ctcacctcca tttagtcccc
     6301 catcagaaca gaggtcagga atttagctgg ggagcctaaa tttagttcag cttacctttg
     6361 agaatagcat caattcagac tctcttttca ttatgttttc ttttcttttt ccctcttttt
     6421 aaactacatt gtgttagagt catagtctag gatcctgaga gattttccat tcttgtcacc
     6481 attcacttgc attgtaaaga ttttctttgt ctgttgttgg catagattct tttgtacata
     6541 tttatttatt tgtgtttata tatgtcaatt ggtttccttt cttagcttga tattgcctag
     6601 ctttgttgtt ttaattaact ttctattaga gagactgtat atattttttc taaatacttt
     6661 gtgaaatcat ttttggtagc aatatctttg aatatgatga ataaaagtga ctgtgagtgc
     6721 aaatagaatt agcagtaaga agctactcta gctaatttgc cattttactt aaatggaaaa
     6781 tgtttttcaa ataaatactt atgttgttca tgttccaagt ta
//
