LOCUS       NM_001304376            3335 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens adhesion G protein-coupled receptor G5 (ADGRG5),
            transcript variant 2, mRNA.
ACCESSION   NM_001304376 XM_005255836
VERSION     NM_001304376.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3335)
  AUTHORS   Wilde,C., Fischer,L., Lede,V., Kirchberger,J., Rothemund,S.,
            Schoneberg,T. and Liebscher,I.
  TITLE     The constitutive activity of the adhesion GPCR GPR114/ADGRG5 is
            mediated by its tethered agonist
  JOURNAL   FASEB J 30 (2), 666-673 (2016)
   PUBMED   26499266
REFERENCE   2  (bases 1 to 3335)
  AUTHORS   Hamann,J., Aust,G., Arac,D., Engel,F.B., Formstone,C.,
            Fredriksson,R., Hall,R.A., Harty,B.L., Kirchhoff,C., Knapp,B.,
            Krishnan,A., Liebscher,I., Lin,H.H., Martinelli,D.C., Monk,K.R.,
            Peeters,M.C., Piao,X., Promel,S., Schoneberg,T., Schwartz,T.W.,
            Singer,K., Stacey,M., Ushkaryov,Y.A., Vallon,M., Wolfrum,U.,
            Wright,M.W., Xu,L., Langenhan,T. and Schioth,H.B.
  TITLE     International Union of Basic and Clinical Pharmacology. XCIV.
            Adhesion G protein-coupled receptors
  JOURNAL   Pharmacol Rev 67 (2), 338-367 (2015)
   PUBMED   25713288
  REMARK    Review article
REFERENCE   3  (bases 1 to 3335)
  AUTHORS   Engelman,C.D., Meyers,K.J., Ziegler,J.T., Taylor,K.D., Palmer,N.D.,
            Haffner,S.M., Fingerlin,T.E., Wagenknecht,L.E., Rotter,J.I.,
            Bowden,D.W., Langefeld,C.D. and Norris,J.M.
  TITLE     Genome-wide association study of vitamin D concentrations in
            Hispanic Americans: the IRAS family study
  JOURNAL   J Steroid Biochem Mol Biol 122 (4), 186-192 (2010)
   PUBMED   20600896
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   4  (bases 1 to 3335)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
REFERENCE   5  (bases 1 to 3335)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   6  (bases 1 to 3335)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
REFERENCE   7  (bases 1 to 3335)
  AUTHORS   Fredriksson,R., Lagerstrom,M.C., Hoglund,P.J. and Schioth,H.B.
  TITLE     Novel human G protein-coupled receptors with long N-terminals
            containing GPS domains and Ser/Thr-rich regions
  JOURNAL   FEBS Lett 531 (3), 407-414 (2002)
   PUBMED   12435584
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM193863.1, AK292783.1,
            AY358447.1 and BC032401.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001304376.2.
            
            Summary: This gene encodes a member of the adhesion family of
            G-protein coupled receptors. Members of this family are
            characterized by long N-termini and multiple functional domains.
            They may play a role in the immune system as well as in the central
            nervous system. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358447.1, SRR1803611.63088.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000349457.8/ ENSP00000290823.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BM193863.1         8-9
            3-15                AK292783.1         1-13
            16-942              AY358447.1         1-927
            943-3335            BC032401.1         1369-3761
FEATURES             Location/Qualifiers
     source          1..3335
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..3335
                     /gene="ADGRG5"
                     /gene_synonym="GPR114; PGR27"
                     /note="adhesion G protein-coupled receptor G5"
                     /db_xref="GeneID:221188"
                     /db_xref="HGNC:HGNC:19010"
                     /db_xref="MIM:616965"
     exon            1..59
                     /gene="ADGRG5"
                     /gene_synonym="GPR114; PGR27"
                     /inference="alignment:Splign:2.1.0"
     exon            60..161
                     /gene="ADGRG5"
                     /gene_synonym="GPR114; PGR27"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1684
                     /gene="ADGRG5"
                     /gene_synonym="GPR114; PGR27"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; probable G-protein coupled receptor 114; G
                     protein-coupled receptor PGR27; G protein-coupled receptor
                     114"
                     /codon_start=1
                     /product="adhesion G-protein coupled receptor G5 isoform 1
                     precursor"
                     /protein_id="NP_001291305.1"
                     /db_xref="CCDS:CCDS10785.1"
                     /db_xref="GeneID:221188"
                     /db_xref="HGNC:HGNC:19010"
                     /db_xref="MIM:616965"
                     /translation="MDHCGALFLCLCLLTLQNATTETWEELLSYMENMQVSRGRSSVF
                     SSRQLHQLEQMLLNTSFPGYNLTLQTPTIQSLAFKLSCDFSGLSLTSATLKRVPQAGG
                     QHARGQHAMQFPAELTRDACKTRPRELRLICIYFSNTHFFKDENNSSLLNNYVLGAQL
                     SHGHVNNLRDPVNISFWHNQSLEGYTLTCVFWKEGARKQPWGGWSPEGCRTEQPSHSQ
                     VLCRCNHLTYFAVLMQLSPALVPAELLAPLTYISLVGCSISIVASLITVLLHFHFRKQ
                     SDSLTRIHMNLHASVLLLNIAFLLSPAFAMSPVPGSACTALAAALHYALLSCLTWMAI
                     EGFNLYLLLGRVYNIYIRRYVFKLGVLGWGAPALLVLLSLSVKSSVYGPCTIPVFDSW
                     ENGTGFQNMSICWVRSPVVHSVLVMGYGGLTSLFNLVVLAWALWTLRRLRERADAPSV
                     RACHDTVTVLGLTVLLGTTWALAFFSFGVFLLPQLFLFTILNSLYGFFLFLWFCSQRC
                     RSEAEAKAQIEAFSSSQTTQ"
     exon            162..237
                     /gene="ADGRG5"
                     /gene_synonym="GPR114; PGR27"
                     /inference="alignment:Splign:2.1.0"
     exon            238..394
                     /gene="ADGRG5"
                     /gene_synonym="GPR114; PGR27"
                     /inference="alignment:Splign:2.1.0"
     exon            395..526
                     /gene="ADGRG5"
                     /gene_synonym="GPR114; PGR27"
                     /inference="alignment:Splign:2.1.0"
     exon            527..643
                     /gene="ADGRG5"
                     /gene_synonym="GPR114; PGR27"
                     /inference="alignment:Splign:2.1.0"
     exon            644..796
                     /gene="ADGRG5"
                     /gene_synonym="GPR114; PGR27"
                     /inference="alignment:Splign:2.1.0"
     exon            797..918
                     /gene="ADGRG5"
                     /gene_synonym="GPR114; PGR27"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1187
                     /gene="ADGRG5"
                     /gene_synonym="GPR114; PGR27"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1305
                     /gene="ADGRG5"
                     /gene_synonym="GPR114; PGR27"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1583
                     /gene="ADGRG5"
                     /gene_synonym="GPR114; PGR27"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..3335
                     /gene="ADGRG5"
                     /gene_synonym="GPR114; PGR27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3299..3304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRG5"
                     /gene_synonym="GPR114; PGR27"
                     /note="hexamer: AATAAA"
     polyA_site      3335
                     /gene="ADGRG5"
                     /gene_synonym="GPR114; PGR27"
                     /note="major polyA site"
ORIGIN      
        1 gcagaagcta caagacagca gccgagacag cagctgagac ggcagcggca gcttctcagg
       61 gccggagcca gttcttggag gagactctgc acagggcatg gatcactgtg gtgccctttt
      121 cctgtgcctg tgccttctga ctttgcagaa tgcaacaaca gagacatggg aagaactcct
      181 gagctacatg gagaatatgc aggtgtccag gggccggagc tcagtttttt cctctcgtca
      241 actccaccag ctggagcaga tgctactgaa caccagcttc ccaggctaca acctgacctt
      301 gcagacaccc accatccagt ctctggcctt caagctgagc tgtgacttct ctggcctctc
      361 gctgaccagt gccactctga agcgggtgcc ccaggcagga ggtcagcatg cccggggtca
      421 gcacgccatg cagttccccg ccgagctgac ccgggacgcc tgcaagaccc gccccaggga
      481 gctgcggctc atctgtatct acttctccaa cacccacttt ttcaaggatg aaaacaactc
      541 atctctgctg aataactacg tcctgggggc ccagctgagt catgggcacg tgaacaacct
      601 cagggatcct gtgaacatca gcttctggca caaccaaagc ctggaaggct acaccctgac
      661 ctgtgtcttc tggaaggagg gagccaggaa acagccctgg gggggctgga gccctgaggg
      721 ctgtcgtaca gagcagccct cccactctca ggtgctctgc cgctgcaacc acctcaccta
      781 ctttgctgtt ctcatgcaac tctccccagc cctggtccct gcagagttgc tggcacctct
      841 tacgtacatc tccctcgtgg gctgcagcat ctccatcgtg gcctcgctga tcacagtcct
      901 gctgcacttc catttcagga agcagagtga ctccttaaca cgcatccaca tgaacctgca
      961 tgcctccgtg ctgctcctga acatcgcctt cctgctgagc cccgcattcg caatgtctcc
     1021 tgtgcccggg tcagcatgca cggctctggc cgctgccctg cactacgcgc tgctcagctg
     1081 cctcacctgg atggccatcg agggcttcaa cctctacctc ctcctcgggc gtgtctacaa
     1141 catctacatc cgcagatatg tgttcaagct tggtgtgcta ggctgggggg ccccagccct
     1201 cctggtgctg ctttccctct ctgtcaagag ctcggtatac ggaccctgca caatccccgt
     1261 cttcgacagc tgggagaatg gcacaggctt ccagaacatg tccatatgct gggtgcggag
     1321 ccccgtggtg cacagtgtcc tggtcatggg ctacggcggc ctcacgtccc tcttcaacct
     1381 ggtggtgctg gcctgggcgc tgtggaccct gcgcaggctg cgggagcggg cggatgcacc
     1441 aagtgtcagg gcctgccatg acactgtcac tgtgctgggc ctcaccgtgc tgctgggaac
     1501 cacctgggcc ttggccttct tttcttttgg cgtcttcctg ctgccccagc tgttcctctt
     1561 caccatctta aactcgctct acggtttctt ccttttcctg tggttctgct cccagcggtg
     1621 ccgctcagaa gcagaggcca aggcacagat agaggccttc agctcctccc aaacaacaca
     1681 gtagtccggg cctcctggcc tggaatcctc agcctctctg gccgccagta gcctgaggct
     1741 acggctcctg ctagagaggg tggcaggcct gctgctggac cccagaggcc actgtgaccg
     1801 ccaaggggcc ttttccactt ccacggcctc tccaggcact gaggggaagg cattgctcta
     1861 cctctccctg acattttgct ccggggcaga tccaacctta cctggggcag caaactttgt
     1921 cctggtacct gggcccagct cgccagggat gtgggcagag caccagcctg ggcatcagga
     1981 agccaagttt caaggactgt ctttgagtct gtctgtatga ccttgggcct gccacttctc
     2041 acagacccta ggtatccaca gctgtgacat gggggcaagc ggctttgttt cagcctaacc
     2101 caggagctta gtaaaaattg cataagacca gggggaagag tgtcagcgtg gggtgggaat
     2161 tcccgcggcc tccacctgct tgctaggggc aggatctcat tcaggctgcc ctggaagcac
     2221 ctgcttggcc ctgccacctt cctccagggg agggccagat ggcatcctgg cttggggcgg
     2281 gtgggaccta cccaggctct gagactttac tggcctatgc ctgaggcctc ttttccttta
     2341 actccctaaa ttatgatgac tccaagtcca agcccaccct tcccaaagat tgggaggttc
     2401 cgccgttccc agaggctcct cctgcggtgc tcccaagact tccatagacc atctggacca
     2461 gtagcccatc ccgcagtttt cttgggggca gaggaaaacg cttctttctc ctccagctga
     2521 atcagctgga tcccagtgtc ctggctgttt ggtgattggg caagattgaa tttgcccagg
     2581 taggcgtgag agtgtgggtt ttaaattcga agctcaggcc atagtttcag agaatcaccc
     2641 ttaccccaga ccttcatgag acagtgctca tgaagccagt gcgtttccca gaacgaacac
     2701 taggcggcac cgttggtcca cactcagagg cccttggcgc caagactgca tctagaatcg
     2761 ctcaaacacc tgtttgcaga ccccatgcac cagctggagg ggccgtaact gcaggactgc
     2821 gcctactgag tgacccattt cctccaggag gaaaggcaag acacgcttac acggccattt
     2881 gtctcttttc ccaatgcggc ggtgcacttt cgctcttggg ggctgcaccc cagacatagc
     2941 tggcaccaga gcagggtgct caggtggtgg gtgctcaggg ccctgcccca ggccactggg
     3001 ccgttttgat gacctcgaag gtcacaggca gaaaatagga gcaggatttc ccctggggaa
     3061 aagttctcct gggacatctt ctgctcttct gtacatttct agatgcaaat aactccttca
     3121 ccaggcagtg agtggcgtag gctctggagc caggctgcct gggctccaat gccagctctg
     3181 ccacttgcta gctgtgagac tgtggacaaa ccactcagcc tctgtgtgcc tcagttttcc
     3241 tatttgtaaa atagaggcca tagtggtacc tattttgaag actaagtaaa agaattcaaa
     3301 taaagagact tggcacagag taagtgctca gtaaa
//
