LOCUS       NM_153834               9933 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens adhesion G protein-coupled receptor G4 (ADGRG4), mRNA.
ACCESSION   NM_153834
VERSION     NM_153834.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9933)
  AUTHORS   Sharma,M., Verma,S., Angurana,S.L., Tufail,Z., Bhagat,V.,
            Nagyal,S., Jamwal,R.S., Sharma,B., Shah,R., Bhat,A., Chander,G. and
            Kumar,R.
  TITLE     Exome sequencing identifies ADGRG4 G-protein-coupled receptors gene
            as a novel cancer biomarker in ovarian cancer patients from North
            India
  JOURNAL   J Biochem Mol Toxicol 38 (3), e23672 (2024)
   PUBMED   38462741
  REMARK    GeneRIF: Exome sequencing identifies ADGRG4 G-protein-coupled
            receptors gene as a novel cancer biomarker in ovarian cancer
            patients from North India.
REFERENCE   2  (bases 1 to 9933)
  AUTHORS   Kieslich,B., Weisse,R.H., Brendler,J., Ricken,A., Schoneberg,T. and
            Strater,N.
  TITLE     The dimerized pentraxin-like domain of the adhesion G
            protein-coupled receptor 112 (ADGRG4) suggests function in sensing
            mechanical forces
  JOURNAL   J Biol Chem 299 (12), 105356 (2023)
   PUBMED   37863265
  REMARK    GeneRIF: The dimerized pentraxin-like domain of the adhesion G
            protein-coupled receptor 112 (ADGRG4) suggests function in sensing
            mechanical forces.
REFERENCE   3  (bases 1 to 9933)
  AUTHORS   Peeters,M.C., Mos,I., Lenselink,E.B., Lucchesi,M., IJzerman,A.P.
            and Schwartz,T.W.
  TITLE     Getting from A to B-exploring the activation motifs of the class B
            adhesion G protein-coupled receptor subfamily G member 4/GPR112
  JOURNAL   FASEB J 30 (5), 1836-1848 (2016)
   PUBMED   26823453
  REMARK    GeneRIF: This study described the structure-function relationship
            of adhesion G protein-coupled receptors (ADGRs) using ADGRGr as a
            model receptor.
REFERENCE   4  (bases 1 to 9933)
  AUTHORS   Hamann,J., Aust,G., Arac,D., Engel,F.B., Formstone,C.,
            Fredriksson,R., Hall,R.A., Harty,B.L., Kirchhoff,C., Knapp,B.,
            Krishnan,A., Liebscher,I., Lin,H.H., Martinelli,D.C., Monk,K.R.,
            Peeters,M.C., Piao,X., Promel,S., Schoneberg,T., Schwartz,T.W.,
            Singer,K., Stacey,M., Ushkaryov,Y.A., Vallon,M., Wolfrum,U.,
            Wright,M.W., Xu,L., Langenhan,T. and Schioth,H.B.
  TITLE     International Union of Basic and Clinical Pharmacology. XCIV.
            Adhesion G protein-coupled receptors
  JOURNAL   Pharmacol Rev 67 (2), 338-367 (2015)
   PUBMED   25713288
  REMARK    Review article
REFERENCE   5  (bases 1 to 9933)
  AUTHORS   Leja,J., Essaghir,A., Essand,M., Wester,K., Oberg,K.,
            Totterman,T.H., Lloyd,R., Vasmatzis,G., Demoulin,J.B. and
            Giandomenico,V.
  TITLE     Novel markers for enterochromaffin cells and gastrointestinal
            neuroendocrine carcinomas
  JOURNAL   Mod Pathol 22 (2), 261-272 (2009)
   PUBMED   18953328
REFERENCE   6  (bases 1 to 9933)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
REFERENCE   7  (bases 1 to 9933)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
REFERENCE   8  (bases 1 to 9933)
  AUTHORS   Fredriksson,R., Lagerstrom,M.C., Hoglund,P.J. and Schioth,H.B.
  TITLE     Novel human G protein-coupled receptors with long N-terminals
            containing GPS domains and Ser/Thr-rich regions
  JOURNAL   FEBS Lett 531 (3), 407-414 (2002)
   PUBMED   12435584
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY882585.1, AY140954.1 and
            AL161778.19.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_153834.3.
            
            Summary: This gene encodes a G-protein coupled receptor belonging
            to a large family of diverse integral membrane proteins that
            participate in various physiological functions. Members of this
            superfamily are characterized by a signature 7-transmembrane domain
            motif. The ligand for this family member is unknown, and it is
            therefore an orphan receptor. This receptor is known to be
            expressed in normal enterochromaffin cells and in gastrointestinal
            neuroendocrine carcinoma cells, and it is therefore considered to
            be a novel biomarker or target for immunotherapy. [provided by
            RefSeq, May 2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY882585.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394143.6/ ENSP00000377699.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1118              AY882585.1         1-1118
            1119-7018           AY140954.1         636-6535
            7019-8231           AY882585.1         7019-8231
            8232-8368           AY140954.1         7194-7330
            8369-8561           AY882585.1         8369-8561
            8562-8595           AY140954.1         7521-7554
            8596-9407           AY882585.1         8596-9407
            9408-9496           AY140954.1         8259-8347
            9497-9931           AY882585.1         9497-9931
            9932-9933           AL161778.19        29430-29431
FEATURES             Location/Qualifiers
     source          1..9933
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.3"
     gene            1..9933
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /note="adhesion G protein-coupled receptor G4"
                     /db_xref="GeneID:139378"
                     /db_xref="HGNC:HGNC:18992"
                     /db_xref="MIM:301085"
     exon            1..38
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /inference="alignment:Splign:2.1.0"
     exon            39..113
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /inference="alignment:Splign:2.1.0"
     exon            114..282
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /inference="alignment:Splign:2.1.0"
     exon            283..361
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..9534
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /note="probable G-protein coupled receptor 112; G
                     protein-coupled receptor 112"
                     /codon_start=1
                     /product="adhesion G-protein coupled receptor G4
                     precursor"
                     /protein_id="NP_722576.3"
                     /db_xref="CCDS:CCDS35409.1"
                     /db_xref="GeneID:139378"
                     /db_xref="HGNC:HGNC:18992"
                     /db_xref="MIM:301085"
                     /translation="MKEHIIYQKLYGLILMSSFIFLSDTLSLKGKKLDFFGRGDTYVS
                     LIDTIPELSRFTACIDLVFMDDNSRYWMAFSYITNNALLGREDIDLGLAGDHQQLILY
                     RLGKTFSIRHHLASFQWHTICLIWDGVKGKLELFLNKERILEVTDQPHNLTPHGTLFL
                     GHFLKNESSEVKSMMRSFPGSLYYFQLWDHILENEEFMKCLDGNIVSWEEDVWLVNKI
                     IPTVDRTLRCFVPENMTIQEKSTTVSQQIDMTTPSQITGVKPQNTAHSSTLLSQSIPI
                     FATDYTTISYSNTTSPPLETMTAQKILKTLVDETATFAVDVLSTSSAISLPTQSISID
                     NTTNSMKKTKSPSSESTKTTKMVEAMATEIFQPPTPSNFLSTSRFTKNSVVSTTSAIK
                     SQSAVTKTTSLFSTIESTSMSTTPCLKQKSTNTGALPISTAGQEFIESTAAGTVPWFT
                     VEKTSPASTHVGTASSFPPEPVLISTAAPVDSVFPRNQTAFPLATTDMKIAFTVHSLT
                     LPTRLIETTPAPRTAETELTSTNFQDVSLPRVEDAMSTSMSKETSSKTFSFLTSFSFT
                     GTESVQTVIDAEATRTALTPEITLASTVAETMLSSTITGRVYTQNTPTADGHLLTLMS
                     TRSASTSKAPESGPTSTTDEAAHLFSSNETIWTSRPDQALLASMNTTTILTFVPNENF
                     TSAFHENTTYTEYLSATTNITPLKASPEGKGTTANDATTARYTTAVSKLTSPWFANFS
                     IVSGTTSITNMPEFKLTTLLLKTIPMSTKPANELPLTPRETVVPSVDIISTLACIQPN
                     FSTEESASETTQTEINGAIVFGGTTTPVPKSATTQRLNATVTRKEATSHYLMRKSTIA
                     AVAEVSPFSTMLEVTDESAQRVTASVTVSSFPDIEKLSTPLDNKTATTEVRESWLLTK
                     LVKTTPRSSYNEMTEMFNFNHTYVAHWTSETSEGISAGSPTSGSTHIFGEPLGASTTR
                     ISETSFSTTPTDRTATSLSDGILPPQPTAAHSSATPVPVTHMFSLPVNGSSVVAEETE
                     VTMSEPSTLARAFSTSVLSDVSNLSSTTMTTALVPPLDQTASTTIVIVPTHGDLIRTT
                     SEATVISVRKTSMAVPSLTETPFHSLRLSTPVTAKAETTLFSTSVDTVTPSTHTLVCS
                     KPPPDNIPPASSTHVISTTSTPEATQPISQVEETSTYALSFPYTFSGGGVVASLATGT
                     TETSVVDETTPSHISANKLTTSVNSHISSSATYRVHTPVSIQLVTSTSVLSSDKDQMT
                     ISLGKTPRTMEVTEMSPSKNSFISYSRGTPSLEMTDTGFPETTKISSHQTHSPSEIPL
                     GTPSDGNLASSPTSGSTQITPTLTSSNTVGVHIPEMSTSLGKTALPSQALTITTFLCP
                     EKESTSALPAYTPRTVEMIVNSTYVTHSVSYGQDTSFVDTTTSSSTRISNPMDINTTF
                     SHLHSLRTQPEVTSVASFISESTQTFPESLSLSTAGLYNDGFTVLSDRITTAFSVPNV
                     PTMLPRESSMATSTPIYQMSSLPVNVTAFTSKKVSDTPPIVITKSSKTMHPGCLKSPC
                     TATSGPMSEMSSIPVNNSAFTPATVSSDTSTRVGLFSTLLSSVTPRTTMTMQTSTLDV
                     TPVIYAGATSKNKMVSSAFTTEMIEAPSRITPTTFLSPTEPTLPFVKTVPTTIMAGIV
                     TPFVGTTAFSPLSSKSTGAISSIPKTTFSPFLSATQQSSQADEATTLGILSGITNRSL
                     STVNSGTGVALTDTYSRITVPENMLSPTHADSLHTSFNIQVSPSLTSFKSASGPTKNV
                     KTTTNCFSSNTRKMTSLLEKTSLTNYATSLNTPVSYPPWTPSSATLPSLTSFVYSPHS
                     TEAEISTPKTSPPPTSQMVEFPVLGTRMTSSNTQPLLMTSWNIPTAEGSQFPISTTIN
                     VPTSNEMETETLHLVPGPLSTFTASQTGLVSKDVMAMSSIPMSGILPNHGLSENPSLS
                     TSLRAITSTLADVKHTFEKMTTSVTPGTTLPSILSGATSGSVISKSPILTWLLSSLPS
                     GSPPATVSNAPHVMTSSTVEVSKSTFLTSDMISAHPFTNLTTLPSATMSTILTRTIPT
                     PTLGGITTGFPTSLPMSINVTDDIVYISTHPEASSRTTITANPRTVSHPSSFSRKTMS
                     PSTTDHTLSVGAMPLPSSTITSSWNRIPTASSPSTLIIPKPTLDSLLNIMTTTSTVPG
                     ASFPLISTGVTYPFTATVSSPISSFFETTWLDSTPSFLSTEASTSPTATKSTVSFYNV
                     EMSFSVFVEEPRIPITSVINEFTENSLNSIFQNSEFSLATLETQIKSRDISEEEMVMD
                     RAILEQREGQEMATISYVPYSCVCQVIIKASSSLASSELMRKIKSKIHGNFTHGNFTQ
                     DQLTLLVNCEHVAVKKLEPGNCKADETASKYKGTYKWLLTNPTETAQTRCIKNEDGNA
                     TRFCSISINTGKSQWEKPKFKQCKLLQELPDKIVDLANITISDENAEDVAEHILNLIN
                     ESPALGKEETKIIVSKISDISQCDEISMNLTHVMLQIINVVLEKQNNSASDLHEISNE
                     ILRIIERTGHKMEFSGQIANLTVAGLALAVLRGDHTFDGMAFSIHSYEEGTDPEIFLG
                     NVPVGGILASIYLPKSLTERIPLSNLQTILFNFFGQTSLFKTKNVTKALTTYVVSASI
                     SDDMFIQNLADPVVITLQHIGGNQNYGQVHCAFWDFENNNGLGGWNSSGCKVKETNVN
                     YTICQCDHLTHFGVLMDLSRSTVDSVNEQILALITYTGCGISSIFLGVAVVTYIAFHK
                     LRKDYPAKILINLCTALLMLNLVFLINSWLSSFQKVGVCITAAVALHYFLLVSFTWMG
                     LEAVHMYLALVKVFNIYIPNYILKFCLVGWGIPAIMVAITVSVKKDLYGTLSPTTPFC
                     WIKDDSIFYISVVAYFCLIFLMNLSMFCTVLVQLNSVKSQIQKTRRKMILHDLKGTMS
                     LTFLLGLTWGFAFFAWGPMRNFFLYLFAIFNTLQGFFIFVFHCVMKESVREQWQIHLC
                     CGWLRLDNSSDGSSRCQIKVGYKQEGLKKIFEHKLLTPSLKSTATSSTFKSLGSAQGT
                     PSEISFPNDDFDKDPYCSSP"
     exon            362..976
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /inference="alignment:Splign:2.1.0"
     exon            977..7018
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /inference="alignment:Splign:2.1.0"
     exon            7019..7113
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /inference="alignment:Splign:2.1.0"
     exon            7114..7178
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /inference="alignment:Splign:2.1.0"
     exon            7179..7218
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /inference="alignment:Splign:2.1.0"
     exon            7219..7271
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /inference="alignment:Splign:2.1.0"
     exon            7272..7435
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /inference="alignment:Splign:2.1.0"
     exon            7436..7568
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /inference="alignment:Splign:2.1.0"
     exon            7569..7687
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /inference="alignment:Splign:2.1.0"
     exon            7688..7904
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /inference="alignment:Splign:2.1.0"
     exon            7905..8067
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /inference="alignment:Splign:2.1.0"
     exon            8068..8202
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /inference="alignment:Splign:2.1.0"
     exon            8203..8325
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /inference="alignment:Splign:2.1.0"
     exon            8326..8371
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /inference="alignment:Splign:2.1.0"
     exon            8372..8475
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /inference="alignment:Splign:2.1.0"
     exon            8476..8597
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /inference="alignment:Splign:2.1.0"
     exon            8598..8866
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /inference="alignment:Splign:2.1.0"
     exon            8867..8945
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /inference="alignment:Splign:2.1.0"
     exon            8946..9226
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /inference="alignment:Splign:2.1.0"
     exon            9227..9328
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /inference="alignment:Splign:2.1.0"
     exon            9329..9496
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /inference="alignment:Splign:2.1.0"
     exon            9497..9933
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9583..9588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /note="hexamer: AATAAA"
     polyA_site      9605
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /note="major polyA site"
     regulatory      9721..9726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /note="hexamer: AATAAA"
     polyA_site      9748
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
     regulatory      9909..9914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
                     /note="hexamer: ATTAAA"
     polyA_site      9933
                     /gene="ADGRG4"
                     /gene_synonym="GPR112; PGR17; RP1-299I16"
ORIGIN      
        1 cagtttctta atccagtcta tcactgatgg acatttggat atggagagca gatggtcaac
       61 attctcctca taaccttcca gggaatggaa gatacccgtt gaagccctcc caggctgtgt
      121 gaccccacgt tggggacagg tcacaaaacc taagccttgt gcctactgga aagaagaagc
      181 agtggagtcc ttgacagaag cagtggtgct ggaacctggt gctaggcgct gggccaagca
      241 ctttacatac tgtgtgttat gtaatcttca cagcaatatg agacttagac aatgaaagaa
      301 cacatcatat atcagaagct ttatggattg attctcatgt cgagttttat ctttctctca
      361 gatacacttt cactaaaagg aaaaaagctg gatttttttg gaagaggtga cacatatgta
      421 agcctgatag ataccattcc tgaactcagc cgattcacag catgcattga tctggtattc
      481 atggatgaca actcaaggta ttggatggcc ttctcttata ttactaataa cgccctcctg
      541 ggcagagaag acatagacct tggacttgca ggagaccatc agcagctaat actatacaga
      601 ttgggaaaga ccttttctat ccgtcaccac ctggcttcat ttcaatggca tacaatatgc
      661 ttgatatggg atggtgtgaa gggcaaatta gaactcttcc tgaataaaga aaggatactg
      721 gaagtaacgg atcaaccaca caacctgaca cctcatggga ctctgttcct agggcacttt
      781 ctcaagaatg agagcagcga ggttaaaagc atgatgcgta gctttcctgg cagcttgtac
      841 tactttcaac tctgggacca catcctggaa aacgaagagt ttatgaagtg tttagatgga
      901 aatatagtta gttgggaaga agacgtctgg cttgtcaaca agatcatccc aactgttgac
      961 aggacactgc gctgctttgt tcctgaaaat atgacaattc aagaaaaaag tacaactgtt
     1021 tcacaacaga tagatatgac cactccatcc caaattactg gagtaaaacc acaaaatact
     1081 gcacattcct ctacactatt gtctcaaagc atacctatat ttgcaactga ttacacaacc
     1141 atatcatatt ccaatacaac atctccacct ctggaaacaa tgactgcaca aaaaatctta
     1201 aagacactgg tagatgagac agctacattt gcagtggatg ttttatcaac ttcatcagcc
     1261 atctctctgc ctacccagag tatatccata gacaatacta ccaattccat gaaaaaaacg
     1321 aaatctccat cttcagaaag cacaaagaca acaaaaatgg ttgaagccat ggctactgaa
     1381 atctttcaac cacctacacc ttctaatttc ctatccacat ccagatttac caagaattca
     1441 gttgtatcta caacttcagc aattaaatct cagtcggctg ttacgaagac aacatcttta
     1501 ttttcaacta ttgagtcaac atctatgtct acaacacctt gtctcaaaca aaaatccaca
     1561 aatactgggg cactccctat ctccacagct ggccaggagt tcattgaatc tacagctgcc
     1621 ggaactgtac cttggtttac agtggaaaag acttcacctg catctactca tgttgggact
     1681 gcatcatcat tcccacctga gcctgtgctc atctccacag ctgctccagt agattctgta
     1741 tttcctagaa accagacagc atttccattg gcaacaactg atatgaaaat agcatttaca
     1801 gtccattcat tgactctccc aactaggctt attgagacca cacctgcccc aaggacagct
     1861 gaaacagaat tgacatctac aaattttcag gatgtctctt tacccagagt ggaagatgcc
     1921 atgtctactt ccatgtcgaa agagacctcc tctaagacct tttctttctt aacatccttt
     1981 tcatttactg ggactgagag tgtacagaca gttattgatg ctgaagctac acgtacagcc
     2041 ttaactcctg aaatcacact tgcatctaca gtggctgaaa ctatgctttc ctccacaatc
     2101 acaggacgag tttacaccca gaatacacct acagctgatg gacacttgct tactttgatg
     2161 tccactagat cagcttccac atccaaggca cctgagtcag gtcccacatc cacaactgat
     2221 gaagctgccc atctgttctc cagcaatgag accatttgga cttctaggcc agaccaggcc
     2281 ctgctggcat ctatgaacac aaccaccata ctcacatttg tgcctaatga aaattttaca
     2341 tcagcatttc atgagaatac tacttataca gaatatttat ccgcaactac caatatcacc
     2401 ccactgaaag catctccaga gggcaaaggt accactgcca atgatgctac tacagccaga
     2461 tatacaacag ctgtatccaa attgacatca ccatggtttg ctaatttctc catagtttct
     2521 ggaaccacat ccataaccaa tatgcctgaa tttaaactta ccactttact actaaaaaca
     2581 atacctatgt ctacaaaacc tgcaaatgaa cttcctttga caccaaggga gactgttgtt
     2641 ccatcagtag atataatatc tactcttgct tgcattcaac caaatttttc tactgaggaa
     2701 agtgcttctg agaccacaca aacagaaata aatggtgcaa ttgtatttgg aggtacaacg
     2761 acccctgtac caaagtcagc aacaacacaa agattaaatg ccactgtgac aagaaaagaa
     2821 gcaacttccc attatcttat gagaaaatca actatagcag cagtggctga ggtttctcca
     2881 ttttcaacaa tgctggaagt gacagacgaa tcagcacaaa gggtgacagc ttctgtcact
     2941 gtttcctctt ttcctgatat agaaaagcta agtaccccat tggataataa aactgcaaca
     3001 actgaggtga gagaaagttg gcttttgaca aaattggtga aaaccacacc taggagttca
     3061 tacaatgaaa tgacagaaat gtttaatttt aaccacacct atgtagcaca ttggacttca
     3121 gagacatctg agggaatttc agctggatct cccacttctg ggagcacaca tatattcggt
     3181 gaacccctgg gtgcttctac cacaaggata tcagaaacca gtttctccac tacccctaca
     3241 gacaggacag ctacgtcctt gtctgatggt atcttacctc cacagcctac agctgctcat
     3301 tcctcagcaa cccctgtgcc tgttactcat atgttctcat tgccagttaa tggcagttct
     3361 gtggtggctg aggagactga ggttaccatg tctgagcctt ctacactggc cagggctttt
     3421 tctacatctg tgctctcaga tgtctcaaat ctatcctcaa ctacaatgac cacagcattg
     3481 gtaccacctt tggatcagac tgcttccaca accattgtta ttgtgcctac ccatggagac
     3541 ttgattcgta ccacttcaga ggccacggta atctctgtca ggaagacatc catggcagtt
     3601 ccttctctga cagaaacacc atttcattca ctgagactct ccactcctgt gacagctaag
     3661 gctgagacca cccttttctc tacctcagtt gatacagtaa ccccatctac acacactctt
     3721 gtctgctcaa aacctccccc tgacaacatt cctcctgcgt cctccactca tgtgatctca
     3781 actacgtcta caccagaagc aactcaacca atatctcaag tagaggagac ttctacctat
     3841 gctctcagct tcccatatac tttcagtggt ggtggagttg ttgccagctt ggctactggc
     3901 accacagaga cctctgttgt tgatgagacc acaccctcac acatctctgc caataagttg
     3961 actacttcag taaacagtca catttcttca tctgccacat atcgtgtaca cacaccagtg
     4021 tccatccagt tggtgactag cacctctgtc ttatcttccg acaaagacca gatgaccata
     4081 tccctgggaa aaacccctag aactatggag gtgacagaaa tgtccccatc aaagaattct
     4141 tttatttcat actcccgggg tactccatct ttggaaatga cagatacagg atttcctgag
     4201 accacaaaaa tttccagtca ccaaacacat tcgccttcag agattccact tgggactccc
     4261 tctgatggaa atttggcttc atctcccact tctggaagca cacagattac accaaccttg
     4321 acctcaagta acacagtagg tgttcacatt ccagaaatgt ctaccagtct tgggaaaaca
     4381 gctctcccct cacaagctct gacaatcacc acttttttgt gtcctgaaaa ggaaagcacg
     4441 agtgcccttc cagcatatac tcccaggact gtggaaatga tagtaaactc cacctatgtg
     4501 actcactctg tctcatatgg ccaggatact tcatttgtag ataccacaac ttccagctca
     4561 acaaggatat caaatcctat ggacatcaat acaacttttt cacacttgca ttcacttagg
     4621 acacaacctg aggtgacttc agttgcctct ttcatttctg aaagcacaca gactttccct
     4681 gagtccttgt ctctttccac agctggacta tataatgacg gttttacagt tctctccgac
     4741 aggatcacta cagccttttc tgttccaaat gtacctacaa tgcttcctag agaatcctct
     4801 atggcaacgt ccactcctat ttaccagatg tcctcattgc cagttaatgt aactgccttc
     4861 acctccaaaa aagtttctga cactccccca atagtgataa ctaaatcttc taaaacaatg
     4921 catccaggtt gtttgaaaag tccctgtaca gccacttctg ggcctatgtc tgagatgtcc
     4981 tcaataccag ttaataactc tgctttcaca cctgcaacag tctcttctga cacttccaca
     5041 agagttgggt tattctctac tttattgtct tcagttaccc ccaggactac tatgaccatg
     5101 caaacatcta cattggatgt cacacctgtg atatatgctg gggctacttc aaaaaacaaa
     5161 atggtttcct ctgctttcac tacagaaatg atagaggcac cttccaggat cacacctacg
     5221 acctttctct ctccaacaga gccaactttg ccctttgtaa aaaccgttcc caccaccatt
     5281 atggctggga tagtgactcc atttgtaggc accactgcct tctctccact cagttctaag
     5341 agcactggag ctatttcctc cattccaaag accacatttt caccatttct atcagcaact
     5401 caacagtcat cacaagcaga tgaggctaca actttgggca tattatctgg gattactaac
     5461 aggtccctat ctactgtgaa cagtggtaca ggggtagctc tcacagatac ttattccaga
     5521 atcactgttc ctgaaaatat gctttcacct actcatgcag atagtctcca tacttccttc
     5581 aatattcagg tttccccatc tctgactagc tttaagagtg cttctggacc cacaaaaaat
     5641 gttaaaacaa ccaccaattg cttttcttct aatactagaa agatgacttc cttgttagaa
     5701 aagacttcct taacaaacta tgccacatct ttgaataccc ctgtttcata ccctccatgg
     5761 accccatcca gtgcaactct accctctttg acatcatttg tttattcacc tcatagtact
     5821 gaagctgaga tctctactcc aaagacctct cctcctccca catcccaaat ggttgaattt
     5881 ccagttctgg gaacaagaat gacatctagt aatacccaac ctctgcttat gacttcctgg
     5941 aacataccca cagctgaagg ttctcagttt ccaatttcca ccactattaa tgtacctaca
     6001 tccaatgaga tggaaacaga gactctacac cttgttcctg ggcctttgtc aacattcaca
     6061 gcctctcaga ctggtctagt atctaaagat gtcatggcaa tgtcatcaat tcctatgtca
     6121 ggaattcttc ctaaccatgg gctttctgag aacccttcat tatcaacatc tttaagagct
     6181 atcacttcca cattggctga cgttaagcac acatttgaga aaatgaccac atctgtaact
     6241 cctgggacca cactcccatc aattctttct ggtgccactt caggatctgt aatttcaaag
     6301 tcacccattc tgacatggct cttatctagt ctcccttctg gctcccctcc ggcaactgta
     6361 tctaatgccc ctcatgttat gacttcctct acagtagagg tgtcaaaatc aacatttctg
     6421 acatctgaca tgatatcagc gcacccattc actaacttga caacactacc ctctgctact
     6481 atgagcacca tactcacccg aaccattcct acacctacac tgggtggtat cactactggc
     6541 ttcccaactt ctctccctat gtctataaat gtcacagatg acattgtgta catttccaca
     6601 caccctgagg catcctccag aaccacaata actgccaacc ccaggactgt gtctcatcct
     6661 tcatccttca gcagaaagac tatgtcacct tctacaactg accacactct atctgttggt
     6721 gccatgcctc tgcctagctc tacaataaca tcttcatgga acagaattcc aactgcatca
     6781 tcaccctcta ctttaattat tcctaagccc acactggact cccttctaaa tataatgact
     6841 actacatcca ctgttcctgg agcctcattt ccactcatat ccactggggt gacatatcct
     6901 tttacagcaa ctgtgtcttc accaatatcg tccttttttg aaacaacttg gctggactcc
     6961 acaccttcct ttctatctac ggaagcatcg acttcgccta ctgccaccaa gtccacagtt
     7021 tccttctaca atgttgaaat gagcttctct gtctttgttg aagagccaag gatccctatt
     7081 accagtgtta taaatgaatt tacggaaaat tcgttgaatt ctatatttca gaacagtgaa
     7141 ttttctcttg ctactctgga aacccaaatt aaaagcaggg acatttcaga ggaagagatg
     7201 gtcatggatc gagctatttt ggaacagaga gaaggacaag aaatggctac aatttcctat
     7261 gtaccataca gttgtgtttg tcaggtcatc ataaaagcca gctcttcctt agcatcctct
     7321 gaattgatga gaaaaatcaa aagtaaaata catggcaact tcacacatgg aaacttcaca
     7381 caagatcaat tgacgttatt agtaaactgt gaacacgttg cagtgaaaaa actagagcct
     7441 ggaaattgca aagctgatga aacagcctct aaatacaaag ggacctataa gtggctatta
     7501 accaacccta cggagacagc ccaaaccaga tgcataaaaa atgaggatgg aaatgccaca
     7561 agattctgtt caatcagcat caacacgggc aaatctcagt gggaaaagcc aaagtttaaa
     7621 caatgcaaat tgcttcaaga acttcctgac aagattgtgg atcttgctaa tattaccata
     7681 agtgatgaga atgctgagga tgttgcagag catattttaa atttgataaa tgaatcccca
     7741 gccctgggta aagaagagac aaagattatt gtttctaaaa tatcagatat ttcacaatgt
     7801 gatgagataa gtatgaacct aactcatgtt atgttacaaa taatcaacgt tgttttggaa
     7861 aagcaaaaca attccgcctc tgatctgcat gaaataagca atgaaattct gaggataatt
     7921 gagcgtactg gtcacaagat ggagttttct gggcagatag caaatctgac ggtggccggg
     7981 ctggctttgg ctgtgctgcg gggggaccac acgtttgatg gcatggcttt cagcattcac
     8041 tcctatgaag aaggcacaga ccctgagatt ttcctaggca atgtccctgt gggagggatt
     8101 ttggcttcca tatatttgcc taaatcactg acggagagaa ttcctcttag caacttacaa
     8161 acgatcttgt ttaatttctt tggccaaact tcactcttta agaccaaaaa tgtcactaaa
     8221 gcattaacca cctatgttgt gagtgccagc atttcagatg atatgttcat tcaaaactta
     8281 gctgacccag tggttatcac tctgcagcat attggaggaa accagaatta tggtcaagtt
     8341 cactgtgcct tttgggattt tgagaataat aatgggctgg gtggatggaa ttcgtcaggc
     8401 tgtaaagtaa aggaaacaaa tgtaaattac acaatctgtc agtgtgacca cctcacccat
     8461 tttggagtct taatggattt atccaggtct acagtggatt cagtgaatga acagatatta
     8521 gcgcttataa catacaccgg atgtggaatc tcctccattt ttctgggagt tgcagtggtg
     8581 acatacatag cttttcacaa acttcgaaaa gattatcctg ccaaaattct gatcaacctg
     8641 tgcacagcac tactgatgct aaacctggta tttttgatca attcttggtt gtcatcattt
     8701 cagaaagtgg gagtttgtat cacagctgca gtggcacttc attacttcct gcttgtttct
     8761 tttacttgga tgggcctgga ggcagtccac atgtatttgg ctctagtcaa agtcttcaac
     8821 atatacattc caaattatat ccttaaattt tgtctagttg gttggggaat cccggctatc
     8881 atggtggcaa tcacagtcag tgtgaaaaaa gatctgtatg gaactctgag cccaacaact
     8941 ccgttttgtt ggattaaaga tgattctatc ttttacatct cagtggtggc ttatttttgc
     9001 ctcatatttc tcatgaatct ctccatgttc tgcactgttc ttgttcaact gaattctgtg
     9061 aaatcccaaa tccagaagac tcggcggaag atgatcctgc atgacctcaa aggcacaatg
     9121 agcctgacat tcttacttgg cctcacctgg gggtttgcat tttttgcttg gggacccatg
     9181 aggaactttt tcttgtattt gtttgccatt tttaacactt tgcaaggatt cttcattttt
     9241 gtgtttcact gtgtgatgaa ggagagtgtg cgggagcagt ggcagataca cctctgctgt
     9301 gggtggttgc gattggataa ctcttctgat gggagcagcc ggtgtcagat aaaggttgga
     9361 tataaacagg agggactaaa gaaaatcttt gagcacaaac tgttgacgcc atctctcaag
     9421 tcaactgcaa ctagctccac tttcaaatct ttaggctctg cacaaggcac accttcagaa
     9481 ataagctttc caaatgatga ctttgacaaa gatccttact gttcctctcc ttgatttgtg
     9541 aagttgtgcc taattatgta aaaagaatat aatacctgtg gaaataaaaa tgaattccaa
     9601 gtgtatactt gctcgggtga tgggtgcacc aaaatctcac aaatcaccac taaataatgt
     9661 actcatgtaa ccaaatgcta cctgttccac caaaacctat ggaaatttaa aaaaaacaaa
     9721 aataaaaagc aaaacaaaaa tcccaaaatg aattccattc acaaacagaa tttttcaata
     9781 aatcccagta gagatacttg cctcctccca acccctgatt ggggaaaagg ttgaatttgt
     9841 gaaacaatct gctccaacct tctattttaa ttattatttt gtaaggggaa gaataacatt
     9901 tgataaatat taaagtcaga ataattctcc tat
//
