LOCUS       NM_170776               2609 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens adhesion G protein-coupled receptor G3 (ADGRG3),
            transcript variant 1, mRNA.
ACCESSION   NM_170776 XM_936582
VERSION     NM_170776.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2609)
  AUTHORS   Chu,T.Y., Zheng-Gerard,C., Huang,K.Y., Chang,Y.C., Chen,Y.W.,
            I,K.Y., Lo,Y.L., Chiang,N.Y., Chen,H.Y., Stacey,M., Gordon,S.,
            Tseng,W.Y., Sun,C.Y., Wu,Y.M., Pan,Y.S., Huang,C.H., Lin,C.Y.,
            Chen,T.C., El Omari,K., Antonelou,M., Henderson,S.R., Salama,A.,
            Seiradake,E. and Lin,H.H.
  TITLE     GPR97 triggers inflammatory processes in human neutrophils via a
            macromolecular complex upstream of PAR2 activation
  JOURNAL   Nat Commun 13 (1), 6385 (2022)
   PUBMED   36302784
  REMARK    GeneRIF: GPR97 triggers inflammatory processes in human neutrophils
            via a macromolecular complex upstream of PAR2 activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2609)
  AUTHORS   Harada,N., Arahori,Y., Okuyama,M., Luis,P.B., Joseph,A.I.,
            Kitakaze,T., Goshima,N., Schneider,C., Inui,H. and Yamaji,R.
  TITLE     Curcumin activates G protein-coupled receptor 97 (GPR97) in a
            manner different from glucocorticoid
  JOURNAL   Biochem Biophys Res Commun 595, 41-46 (2022)
   PUBMED   35093639
  REMARK    GeneRIF: Curcumin activates G protein-coupled receptor 97 (GPR97)
            in a manner different from glucocorticoid.
REFERENCE   3  (bases 1 to 2609)
  AUTHORS   Ping,Y.Q., Mao,C., Xiao,P., Zhao,R.J., Jiang,Y., Yang,Z., An,W.T.,
            Shen,D.D., Yang,F., Zhang,H., Qu,C., Shen,Q., Tian,C., Li,Z.J.,
            Li,S., Wang,G.Y., Tao,X., Wen,X., Zhong,Y.N., Yang,J., Yi,F.,
            Yu,X., Xu,H.E., Zhang,Y. and Sun,J.P.
  TITLE     Structures of the glucocorticoid-bound adhesion receptor GPR97-Go
            complex
  JOURNAL   Nature 589 (7843), 620-626 (2021)
   PUBMED   33408414
  REMARK    GeneRIF: Structures of the glucocorticoid-bound adhesion receptor
            GPR97-Go complex.
REFERENCE   4  (bases 1 to 2609)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2609)
  AUTHORS   Hsiao,C.C., Chu,T.Y., Wu,C.J., van den Biggelaar,M., Pabst,C.,
            Hebert,J., Kuijpers,T.W., Scicluna,B.P., I,K.Y., Chen,T.C.,
            Liebscher,I., Hamann,J. and Lin,H.H.
  TITLE     The Adhesion G Protein-Coupled Receptor GPR97/ADGRG3 Is Expressed
            in Human Granulocytes and Triggers Antimicrobial Effector Functions
  JOURNAL   Front Immunol 9, 2830 (2018)
   PUBMED   30559745
  REMARK    GeneRIF: Ligation of GPR97 increased the bacteria uptake.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2609)
  AUTHORS   Yokoyama,K., Urashima,M., Ohkido,I., Kono,T., Yoshida,T.,
            Muramatsu,M., Niu,T. and Hosoya,T.
  TITLE     L-type voltage-dependent calcium channel alpha subunit 1C is a
            novel candidate gene associated with secondary hyperparathyroidism:
            an application of haplotype-based analysis for multiple linked
            single nucleotide polymorphisms
  JOURNAL   Nephron Clin Pract 115 (4), c237-c243 (2010)
   PUBMED   20424473
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2609)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
REFERENCE   8  (bases 1 to 2609)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
REFERENCE   9  (bases 1 to 2609)
  AUTHORS   Fredriksson,R., Lagerstrom,M.C., Hoglund,P.J. and Schioth,H.B.
  TITLE     Novel human G protein-coupled receptors with long N-terminals
            containing GPS domains and Ser/Thr-rich regions
  JOURNAL   FEBS Lett 531 (3), 407-414 (2002)
   PUBMED   12435584
REFERENCE   10 (bases 1 to 2609)
  AUTHORS   Kuznicki,J., Kuznicki,L. and Drabikowski,W.
  TITLE     Ca2+-binding modulator protein in protozoa and myxomycete
  JOURNAL   Cell Biol Int Rep 3 (1), 17-23 (1979)
   PUBMED   222487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC064508.1, AC018552.6 and BE672513.1.
            
            On Nov 23, 2018 this sequence version replaced NM_170776.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064508.1, AB049169.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333493.9/ ENSP00000332900.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1435              BC064508.1         48-1482
            1436-1436           AC018552.6         54330-54330         c
            1437-2193           BC064508.1         1484-2240
            2194-2609           BE672513.1         7-422               c
FEATURES             Location/Qualifiers
     source          1..2609
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..2609
                     /gene="ADGRG3"
                     /gene_synonym="GPR97; PB99; PGR26"
                     /note="adhesion G protein-coupled receptor G3"
                     /db_xref="GeneID:222487"
                     /db_xref="HGNC:HGNC:13728"
                     /db_xref="MIM:618441"
     exon            1..100
                     /gene="ADGRG3"
                     /gene_synonym="GPR97; PB99; PGR26"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1692
                     /gene="ADGRG3"
                     /gene_synonym="GPR97; PB99; PGR26"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; G-protein coupled receptor PGR26; probable
                     G-protein coupled receptor 97; G protein-coupled receptor
                     97"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor G3 isoform 1
                     precursor"
                     /protein_id="NP_740746.4"
                     /db_xref="CCDS:CCDS10786.1"
                     /db_xref="GeneID:222487"
                     /db_xref="HGNC:HGNC:13728"
                     /db_xref="MIM:618441"
                     /translation="MATPRGLGALLLLLLLPTSGQEKPTEGPRNTCLGSNNMYDIFNL
                     NDKALCFTKCRQSGSDSCNVENLQRYWLNYEAHLMKEGLTQKVNTPFLKALVQNLSTN
                     TAEDFYFSLEPSQVPRQVMKDEDKPPDRVRLPKSLFRSLPGNRSVVRLAVTILDIGPG
                     TLFKGPRLGLGDGSGVLNNRLVGLSVGQMHVTKLAEPLEIVFSHQRPPPNMTLTCVFW
                     DVTKGTTGDWSSEGCSTEVRPEGTVCCCDHLTFFALLLRPTLDQSTVHILTRISQAGC
                     GVSMIFLAFTIILYAFLRLSRERFKSEDAPKIHVALGGSLFLLNLAFLVNVGSGSKGS
                     DAACWARGAVFHYFLLCAFTWMGLEAFHLYLLAVRVFNTYFGHYFLKLSLVGWGLPAL
                     MVIGTGSANSYGLYTIRDRENRTSLELCWFREGTTMYALYITVHGYFLITFLFGMVVL
                     ALVVWKIFTLSRATAVKERGKNRKKVLTLLGLSSLVGVTWGLAIFTPLGLSTVYIFAL
                     FNSLQGVFICCWFTILYLPSQSTTVSSSTARLDQAHSASQE"
     exon            101..248
                     /gene="ADGRG3"
                     /gene_synonym="GPR97; PB99; PGR26"
                     /inference="alignment:Splign:2.1.0"
     exon            249..387
                     /gene="ADGRG3"
                     /gene_synonym="GPR97; PB99; PGR26"
                     /inference="alignment:Splign:2.1.0"
     exon            388..534
                     /gene="ADGRG3"
                     /gene_synonym="GPR97; PB99; PGR26"
                     /inference="alignment:Splign:2.1.0"
     exon            535..669
                     /gene="ADGRG3"
                     /gene_synonym="GPR97; PB99; PGR26"
                     /inference="alignment:Splign:2.1.0"
     exon            670..709
                     /gene="ADGRG3"
                     /gene_synonym="GPR97; PB99; PGR26"
                     /inference="alignment:Splign:2.1.0"
     exon            710..810
                     /gene="ADGRG3"
                     /gene_synonym="GPR97; PB99; PGR26"
                     /inference="alignment:Splign:2.1.0"
     exon            811..923
                     /gene="ADGRG3"
                     /gene_synonym="GPR97; PB99; PGR26"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1204
                     /gene="ADGRG3"
                     /gene_synonym="GPR97; PB99; PGR26"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1298
                     /gene="ADGRG3"
                     /gene_synonym="GPR97; PB99; PGR26"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1582
                     /gene="ADGRG3"
                     /gene_synonym="GPR97; PB99; PGR26"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..2609
                     /gene="ADGRG3"
                     /gene_synonym="GPR97; PB99; PGR26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2589..2594
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRG3"
                     /gene_synonym="GPR97; PB99; PGR26"
                     /note="hexamer: AATAAA"
     polyA_site      2609
                     /gene="ADGRG3"
                     /gene_synonym="GPR97; PB99; PGR26"
                     /note="major polyA site"
ORIGIN      
        1 agacagccac agagctcctg gcgtgggcaa ggctggccaa ggatggcgac gcccaggggc
       61 ctgggggccc tgctcctgct cctcctgctc ccgacctcag gtcaggaaaa gcccaccgaa
      121 gggccaagaa acacctgcct ggggagcaac aacatgtacg acatcttcaa cttgaatgac
      181 aaggctttgt gcttcaccaa gtgcaggcag tcgggcagcg actcctgcaa tgtggaaaac
      241 ttgcagagat actggctaaa ctacgaggcc catctgatga aggaaggttt gacgcagaag
      301 gtgaacacgc ctttcctgaa ggctttggtc cagaacctca gcaccaacac tgcagaagac
      361 ttctatttct ctctggagcc ctctcaggtt ccgaggcagg tgatgaagga cgaggacaag
      421 ccccctgaca gagtgcgact tcccaagagc ctttttcgat ccctgccagg caacaggtct
      481 gtggtccgct tggccgtcac cattctggac attggtccag ggactctctt caagggcccc
      541 cggctcggcc tgggagatgg cagcggcgtg ttgaacaatc gcctggtggg tttgagtgtg
      601 ggacaaatgc atgtcaccaa gctggctgag cctctggaga tcgtcttctc tcaccagcga
      661 ccgcccccta acatgaccct cacctgtgta ttctgggatg tgactaaagg gaccactgga
      721 gactggtctt ctgagggctg ctccacggag gtcagacctg aggggaccgt gtgctgctgt
      781 gaccacctga cctttttcgc cctgctcctg agacccacct tggaccagtc cacggtgcat
      841 atcctcacac gcatctccca ggcgggctgt ggggtctcca tgatcttcct ggccttcacc
      901 attattcttt atgcctttct gaggctttcc cgggagaggt tcaagtcaga agatgcccca
      961 aagatccacg tggccctggg tggcagcctg ttcctcctga atctggcctt cttggtcaat
     1021 gtggggagtg gctcaaaggg gtctgatgct gcctgctggg cccggggggc tgtcttccac
     1081 tacttcctgc tctgtgcctt cacctggatg ggccttgaag ccttccacct ctacctgctc
     1141 gctgtcaggg tcttcaacac ctacttcggg cactacttcc tgaagctgag cctggtgggc
     1201 tggggcctgc ccgccctgat ggtcatcggc actgggagtg ccaacagcta cggcctctac
     1261 accatccgtg atagggagaa ccgcacctct ctggagctat gctggttccg tgaagggaca
     1321 accatgtacg ccctctatat caccgtccac ggctacttcc tcatcacctt cctctttggc
     1381 atggtggtcc tggccctggt ggtctggaag atcttcaccc tgtcccgtgc tacagcggtc
     1441 aaggagcggg ggaagaaccg gaagaaggtg ctcaccctgc tgggcctctc gagcctggtg
     1501 ggtgtgacat gggggttggc catcttcacc ccgttgggcc tctccaccgt ctacatcttt
     1561 gcacttttca actccttgca aggtgtcttc atctgctgct ggttcaccat cctttacctc
     1621 ccaagtcaga gcaccacagt ctcctcctct actgcaagat tggaccaggc ccactccgca
     1681 tctcaagaat aggaaggcac ggccctgcaa tatggactca gctctggctc tctgtgtgac
     1741 cttgggcagc tccgtgcctc tctctgtact ccctcagttt ccttctctgt acaatgtggc
     1801 tggggaggga gaggatggga ccaggttgga ccacgtggca tcagaggtcc catccagatc
     1861 caactatagg tccaagagtc cacgtaagca ggtttgcaag gctctaaagt tcctatagtc
     1921 ctgagacccc ctgccagcaa agagtgacag tcacctccat gccctgccct cattgcaaag
     1981 ccctcactca ccttctggtc tcagcaaggg aggagagtct gttgctggca tagccctgga
     2041 aggagccccc agcctctccc ctcctcctcc ttgtcactgg cctcccacaa ctccccttct
     2101 ggctgcctgt aaccttgagg ggcattcagg aggccagcgt tccctcaggc actgggggtt
     2161 tgttttgggg ggtgggagtt gatcctccca cccagtctgc ccctggtctc tgcccatcca
     2221 atcagagccc accctcctgg aagagacccc cgtgttcaga gtgctggcag ccctgcacgt
     2281 gtccagggac actgcatttc aaagaaccac tgagtgggtg agctaccttg ggcaaacccc
     2341 ccactcctga ctctgactgc cacgtgggtg gcccgacctc tgacctgctg tcatcgtaga
     2401 ggtagaaagc aaacaatctg gggctcagca cacctggggg tgctcccact cattcagtgt
     2461 gtggggcccc tgagcagagg ctgggcattg ccactaggac ctgagctcct agagaacaag
     2521 gacctgggtg gcctcgctta ctgttccagc ccaggccaag cacagggtct ggctcgtggc
     2581 aaaccttgaa taaatatttg ttggctgaa
//
