LOCUS       NM_001079858            4684 bp    mRNA    linear   PRI 25-DEC-2023
DEFINITION  Homo sapiens adhesion G protein-coupled receptor G2 (ADGRG2),
            transcript variant 1, mRNA.
ACCESSION   NM_001079858
VERSION     NM_001079858.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4684)
  AUTHORS   Wu Q, Wang P, Peng Q, Kang Z, Deng Y, Li J, Chen Y, Li J and Ge F.
  TITLE     Adhesion G Protein-Coupled Receptor G2 Promotes Hepatocellular
            Carcinoma Progression and Serves as a Neutrophil-Related Prognostic
            Biomarker
  JOURNAL   Int J Mol Sci 24 (23), 16986 (2023)
   PUBMED   38069309
  REMARK    GeneRIF: Adhesion G Protein-Coupled Receptor G2 Promotes
            Hepatocellular Carcinoma Progression and Serves as a
            Neutrophil-Related Prognostic Biomarker.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4684)
  AUTHORS   Lu Y, Xie Y, Li M, Zuo N, Ning S, Luo B, Ning M, Song J, Liang Y
            and Qin Y.
  TITLE     A novel ADGRG2 truncating variant associated with X-linked
            obstructive azoospermia in a large Chinese pedigree
  JOURNAL   J Assist Reprod Genet 40 (7), 1747-1754 (2023)
   PUBMED   37273165
  REMARK    GeneRIF: A novel ADGRG2 truncating variant associated with X-linked
            obstructive azoospermia in a large Chinese pedigree.
REFERENCE   3  (bases 1 to 4684)
  AUTHORS   Lin H, Xiao P, Bu RQ, Guo S, Yang Z, Yuan D, Zhu ZL, Zhang CX, He
            QT, Zhang C, Ping YQ, Zhao RJ, Ma CS, Liu CH, Zhang XN, Jiang D,
            Huang S, Xi YT, Zhang DL, Xue CY, Yang BS, Li JY, Lin HC, Zeng XH,
            Zhao H, Xu WM, Yi F, Liu Z, Sun JP and Yu X.
  TITLE     Structures of the ADGRG2-Gs complex in apo and ligand-bound forms
  JOURNAL   Nat Chem Biol 18 (11), 1196-1203 (2022)
   PUBMED   35982227
  REMARK    GeneRIF: Structures of the ADGRG2-Gs complex in apo and
            ligand-bound forms.
REFERENCE   4  (bases 1 to 4684)
  AUTHORS   Gad AA, Azimzadeh P and Balenga N.
  TITLE     Conserved residues in the extracellular loop 2 regulate
            Stachel-mediated activation of ADGRG2
  JOURNAL   Sci Rep 11 (1), 14060 (2021)
   PUBMED   34234254
  REMARK    GeneRIF: Conserved residues in the extracellular loop 2 regulate
            Stachel-mediated activation of ADGRG2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4684)
  AUTHORS   Teckchandani A, Toida N, Goodchild J, Henderson C, Watts J,
            Wollscheid B and Cooper JA.
  TITLE     Quantitative proteomics identifies a Dab2/integrin module
            regulating cell migration
  JOURNAL   J Cell Biol 186 (1), 99-111 (2009)
   PUBMED   19581412
REFERENCE   6  (bases 1 to 4684)
  AUTHORS   Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE and
            Yates JR.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   7  (bases 1 to 4684)
  AUTHORS   Obermann H, Samalecos A, Osterhoff C, Schroder B, Heller R and
            Kirchhoff C.
  TITLE     HE6, a two-subunit heptahelical receptor associated with apical
            membranes of efferent and epididymal duct epithelia
  JOURNAL   Mol Reprod Dev 64 (1), 13-26 (2003)
   PUBMED   12420295
REFERENCE   8  (bases 1 to 4684)
  AUTHORS   Abe J, Fukuzawa T and Hirose S.
  TITLE     Cleavage of Ig-Hepta at a 'SEA' module and at a conserved G
            protein-coupled receptor proteolytic site
  JOURNAL   J Biol Chem 277 (26), 23391-23398 (2002)
   PUBMED   11973329
REFERENCE   9  (bases 1 to 4684)
  AUTHORS   Kirchhoff C, Osterhoff C, Pera I and Schroter S.
  TITLE     Function of human epididymal proteins in sperm maturation
  JOURNAL   Andrologia 30 (4-5), 225-232 (1998)
   PUBMED   9739419
REFERENCE   10 (bases 1 to 4684)
  AUTHORS   Osterhoff C, Ivell R and Kirchhoff C.
  TITLE     Cloning of a human epididymis-specific mRNA, HE6, encoding a novel
            member of the seven transmembrane-domain receptor superfamily
  JOURNAL   DNA Cell Biol 16 (4), 379-389 (1997)
   PUBMED   9150425
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC063315.1, AF538954.1 and
            X81892.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001079858.2.
            
            Summary: This gene encodes a member of the G protein-coupled
            receptor family described as an epididymis-specific transmembrane
            protein. The encoded protein may be proteolytically processed as it
            contains a motif shown to be a protein scission motif in some
            members of this family (PMID: 11973329). Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063315.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379869.8/ ENSP00000369198.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-380               BC063315.1         171-550
            381-677             AF538954.1         471-767
            678-1467            BC063315.1         848-1637
            1468-3854           X81892.1           1458-3844
            3855-4684           BC063315.1         4024-4853
FEATURES             Location/Qualifiers
     source          1..4684
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.13"
     gene            1..4684
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /note="adhesion G protein-coupled receptor G2"
                     /db_xref="GeneID:10149"
                     /db_xref="HGNC:HGNC:4516"
                     /db_xref="MIM:300572"
     exon            1..27
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            28..72
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            73..191
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..3127
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; G protein-coupled receptor, epididymis-specific
                     (seven transmembrane family); epididymal protein 6; G
                     protein-coupled receptor 64; human epididymis-specific
                     protein 6"
                     /codon_start=1
                     /product="adhesion G-protein coupled receptor G2 isoform 1
                     precursor"
                     /protein_id="NP_001073327.1"
                     /db_xref="CCDS:CCDS43923.1"
                     /db_xref="GeneID:10149"
                     /db_xref="HGNC:HGNC:4516"
                     /db_xref="MIM:300572"
                     /translation="MVFSVRQCGHVGRTEEVLLTFKIFLVIICLHVVLVTSLEEDTDN
                     SSLSPPPAKLSVVSFAPSSNGTPEVETTSLNDVTLSLLPSNETEKTKITIVKTFNASG
                     VKPQRNICNLSSICNDSAFFRGEIMFQYDKESTVPQNQHITNGTLTGVLSLSELKRSE
                     LNKTLQTLSETYFIMCATAEAQSTLNCTFTIKLNNTMNACAVIAALERVKIRPMEHCC
                     CSVRIPCPSSPEELEKLQCDLQDPIVCLADHPRGPPFSSSQSIPVVPRATVLSQVPKA
                     TSFAEPPDYSPVTHNVPSPIGEIQPLSPQPSAPIASSPAIDMPPQSETISSPMPQTHV
                     SGTPPPVKASFSSPTVSAPANVNTTSAPPVQTDIVNTSSISDLENQVLQMEKALSLGS
                     LEPNLAGEMINQVSRLLHSPPDMLAPLAQRLLKVVDDIGLQLNFSNTTISLTSPSLAL
                     AVIRVNASSFNTTTFVAQDPANLQVSLETQAPENSIGTITLPSSLMNNLPAHDMELAS
                     RVQFNFFETPALFQDPSLENLSLISYVISSSVANLTVRNLTRNVTVTLKHINPSQDEL
                     TVRCVFWDLGRNGGRGGWSDNGCSVKDRRLNETICTCSHLTSFGVLLDLSRTSVLPAQ
                     MMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLVFLLD
                     SWIALYKMQGLCISVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCI
                     VGWGVPAVVVTIILTISPDNYGLGSYGKFPNGSPDDFCWINNNAVFYITVVGYFCVIF
                     LLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDLRSIAGLTFLLGITWGFAFFAWGPV
                     NVTFMYLFAIFNTLQGFFIFIFYCVAKENVRKQWRRYLCCGKLRLAENSDWSKTATNG
                     LKKQTVNQGVSSSSNSLQSSSNSTNSTTLLVNNDCSVHASGNGNASTERNGVSFSVQN
                     GDVCLHDFTGKQHMFNEKEDSCNGKGRMALRRTSKRGSLHFIEQM"
     exon            192..227
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            228..275
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            276..299
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            300..335
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            336..377
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            378..431
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            432..487
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            488..543
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            544..583
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            584..621
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            622..716
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            717..783
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            784..1172
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1338
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1495
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1639
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1762
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1808
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1912
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2034
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2303
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2403
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2687
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2789
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..2942
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..4684
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4659..4664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /note="hexamer: AATAAA"
     polyA_site      4684
                     /gene="ADGRG2"
                     /gene_synonym="CBAVDX; EDDM6; GPR64; HE6; TM7LN2"
                     /note="major polyA site"
ORIGIN      
        1 agccagcccc gaggacgcga gcggcaggtg tgcacagagg ttctccactt tgttttctga
       61 actcgcggtc aggatggttt tctctgtcag gcagtgtggc catgttggca gaactgaaga
      121 agttttactg acgttcaaga tattccttgt catcatttgt cttcatgtcg ttctggtaac
      181 atccctggaa gaagatactg ataattccag tttgtcacca ccacctgcta aattatctgt
      241 tgtcagtttt gccccctcct ccaatggtac tccagaggtt gaaacaacaa gcctcaatga
      301 tgttacttta agcttactcc cttcaaacga aacagaaaaa actaaaatca ctatagtaaa
      361 aaccttcaat gcatcaggcg tcaaacccca gagaaatatc tgcaatttgt catctatttg
      421 caatgactca gcatttttta gaggtgagat catgtttcaa tatgataaag aaagcactgt
      481 tccccagaat caacatataa cgaatggcac cttaactgga gtcctgtctc taagtgaatt
      541 aaaacgctca gagctcaaca aaaccctgca aaccctaagt gagacttact ttataatgtg
      601 tgctacagca gaggcccaaa gcacattaaa ttgtacattc acaataaaac tgaataatac
      661 aatgaatgca tgtgctgtaa tagctgcttt ggaaagagta aagattcgac caatggaaca
      721 ctgctgctgt tctgtcagga taccctgccc ttcctcccca gaagagttgg aaaagcttca
      781 gtgtgacctg caggatccca ttgtctgtct tgctgaccat ccacgtggcc caccattttc
      841 ttccagccaa tccatcccag tggtgcctcg ggccactgtg ctttcccagg tccccaaagc
      901 tacctctttt gctgagcctc cagattattc acctgtgacc cacaatgttc cctctccaat
      961 aggggagatt caaccccttt caccccagcc ttcagctccc atagcttcca gccctgccat
     1021 tgacatgccc ccacagtctg aaacgatctc ttcccctatg ccccaaaccc atgtctccgg
     1081 caccccacct cctgtgaaag cctcattttc ctctcccacc gtgtctgccc ctgcgaatgt
     1141 caacactacc agcgcacctc ctgtccagac agacatcgtc aacaccagca gtatttctga
     1201 tcttgagaac caagtgttgc agatggagaa ggctctgtcc ttgggcagcc tggagcctaa
     1261 cctcgcagga gaaatgatca accaagtcag cagactcctt cattccccgc ctgacatgct
     1321 ggcccctctg gctcaaagat tgctgaaagt agtggatgac attggcctac agctgaactt
     1381 ttcaaacacg actataagtc taacctcccc ttctttggct ctggctgtga tcagagtgaa
     1441 tgccagtagt ttcaacacaa ctacctttgt ggcccaagac cctgcaaatc ttcaggtttc
     1501 tctggaaacc caagctcctg agaacagtat tggcacaatt actcttcctt catcgctgat
     1561 gaataattta ccagctcatg acatggagct agcttccagg gttcagttca atttttttga
     1621 aacacctgct ttgtttcagg atccttccct ggagaacctc tctctgatca gctacgtcat
     1681 atcatcgagt gttgcaaacc tgaccgtcag gaacttgaca agaaacgtga cagtcacatt
     1741 aaagcacatc aacccgagcc aggatgagtt aacagtgaga tgtgtatttt gggacttggg
     1801 cagaaatggt ggcagaggag gctggtcaga caatggctgc tctgtcaaag acaggagatt
     1861 gaatgaaacc atctgtacct gtagccatct aacaagcttc ggcgttctgc tggacctatc
     1921 taggacatct gtgctgcctg ctcaaatgat ggctctgacg ttcattacat atattggttg
     1981 tgggctttca tcaatttttc tgtcagtgac tcttgtaacc tacatagctt ttgaaaagat
     2041 ccggagggat tacccttcca aaatcctcat ccagctgtgt gctgctctgc ttctgctgaa
     2101 cctggtcttc ctcctggact cgtggattgc tctgtataag atgcaaggcc tctgcatctc
     2161 agtggctgta tttcttcatt attttctctt ggtctcattc acatggatgg gcctagaagc
     2221 attccatatg tacctggccc ttgtcaaagt atttaatact tacatccgaa aatacatcct
     2281 taaattctgc attgtcggtt ggggggtacc agctgtggtt gtgaccatca tcctgactat
     2341 atccccagat aactatgggc ttggatccta tgggaaattc cccaatggtt caccggatga
     2401 cttctgctgg atcaacaaca atgcagtatt ctacattacg gtggtgggat atttctgtgt
     2461 gatatttttg ctgaacgtca gcatgttcat tgtggtcctg gttcagctct gtcgaattaa
     2521 aaagaagaag caactgggag cccagcgaaa aaccagtatt caagacctca ggagtatcgc
     2581 tggccttaca tttttactgg gaataacttg gggctttgcc ttctttgcct ggggaccagt
     2641 taacgtgacc ttcatgtatc tgtttgccat ctttaatacc ttacaaggat ttttcatatt
     2701 catcttttac tgtgtggcca aagaaaatgt caggaagcaa tggaggcggt atctttgttg
     2761 tggaaagtta cggctggctg aaaattctga ctggagtaaa actgctacta atggtttaaa
     2821 gaagcagact gtaaaccaag gagtgtccag ctcttcaaat tccttacagt caagcagtaa
     2881 ctccactaac tccaccacac tgctagtgaa taatgattgc tcagtacacg caagcgggaa
     2941 tggaaatgct tctacagaga ggaatggggt ctcttttagt gttcagaatg gagatgtgtg
     3001 ccttcacgat ttcactggaa aacagcacat gtttaacgag aaggaagatt cctgcaatgg
     3061 gaaaggccgt atggctctca gaaggacttc aaagcgggga agcttacact ttattgagca
     3121 aatgtgattc ctttcttcta aaatcaaagc atgatgcttg acagtgtgaa atgtccaatt
     3181 ttacctttta cacaatgtga gatgtatgaa aatcaactca ttttattctc ggcaacatct
     3241 ggagaagcat aagctaatta agggcgatga ttattattac aagaagaaac caagacatta
     3301 caccatggtt tttagacatt tctgatttgg tttcttatct ttcattttat aagaaggttg
     3361 gttttaaaca atacactaag aatgactcct ataaagaaaa caaaaaaagg tagtgaactt
     3421 tcagctacct tttaaagagg ctaagttatc tttgataaca tcatataaag caactgttga
     3481 cttcagcctg ttggtgagtt tagttgtgca tgcctttgtt gtatataagc taaattctag
     3541 tgacccatgt gtcaaaaatc ttacttctac atttttttgt atttattttc tactgtgtaa
     3601 atgtattcct ttgtagaatc atggttgttt tgtctcacgt gataattcag aaaatccttg
     3661 ctcgttccgc aaatcctaaa gctccttttg gagatgatat aggatgtgaa atacagaaac
     3721 ctcagtgaaa tcaagaaata atgatcccag ccagactgag aaaatgtaag cagacagtgc
     3781 cacagttagc tcatacagtg cctttgagca agttaggaaa agatgccccc actgggcaga
     3841 cacagcccta tgggctcatg gtttgacaaa cagagtggag agaccatatt ttagccccac
     3901 tcaccctctt gggtgcacga cctgtacagc caaacacagc atccaatatg aatacccatc
     3961 ccctgaccgc atccccagta gtcagattat agaatctgca ccaagatgtt tagctttata
     4021 ccttggccac agagagggat gaactgtcat ccagaccatg tgtcaggaaa attgtgaacg
     4081 tagatgaggt acatacactg ccgcttctca aatccccaga gcctttagga acaggagagt
     4141 agactaggat tccttctctt aaaaaggtac atatatatgg aaaaaaatca tattgccgtt
     4201 ctttaaaagg caactgcatg gtacattgtt gattgttatg actggtacac tctggcccag
     4261 ccagagctat aattgttttt taaatgtgtc ttgaagaatg cacagtgaca aggggagtag
     4321 ctattgggaa cagggaactg tcctacactg ctattgttgc tacatgtatc gagccttgat
     4381 tgctcctagt tatatacagg gtctatcttg cttcctacct acatctgctt gagcagtgcc
     4441 tcaagtacat ccttattagg aacatttcaa acccctttta gttaagtctt tcactaaggt
     4501 tctcttgcat atatttcaag tgaatgttgg atctcagact aaccatagta ataatacaca
     4561 tttctgtgag tgctgacttg tctttgcaat atttcttttc tgatttattt aattttcttg
     4621 tatttatatg ttaaaatcaa aaatgttaaa atcaatgaaa taaatttgca gttaagatct
     4681 ttaa
//
