LOCUS       NM_201525               4257 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens adhesion G protein-coupled receptor G1 (ADGRG1),
            transcript variant 3, mRNA.
ACCESSION   NM_201525
VERSION     NM_201525.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4257)
  AUTHORS   Palacios,D., Majhi,R.K., Szabo,E.K., Clement,D., Lachota,M.,
            Netskar,H., Penna,L., Krokeide,S.Z., Vincenti,M., Kveberg,L. and
            Malmberg,K.J.
  TITLE     The G Protein-Coupled Receptor GPR56 Is an Inhibitory Checkpoint
            for NK Cell Migration
  JOURNAL   J Immunol 213 (9), 1349-1357 (2024)
   PUBMED   39320215
  REMARK    GeneRIF: The G Protein-Coupled Receptor GPR56 Is an Inhibitory
            Checkpoint for NK Cell Migration.
REFERENCE   2  (bases 1 to 4257)
  AUTHORS   Bahabayi,A., Guan,Z., Zheng,M., Yu,H., Hasimu,A., Nie,Y., Zhao,M.,
            Zhu,Y., Ren,J., Zhao,Y., Ma,X., Li,Q., Zhang,Z., Zeng,X. and Liu,C.
  TITLE     Expression of GPR56 reflects a hypoactivated state of circulating B
            cells and is downregulated in B cell subsets in patients with
            early-stage lung adenocarcinoma
  JOURNAL   Immunology 173 (1), 172-184 (2024)
   PUBMED   38840413
  REMARK    GeneRIF: Expression of GPR56 reflects a hypoactivated state of
            circulating B cells and is downregulated in B cell subsets in
            patients with early-stage lung adenocarcinoma.
REFERENCE   3  (bases 1 to 4257)
  AUTHORS   Ren,J., Zhu,Y., Nie,Y., Zheng,M., Hasimu,A., Zhao,M., Zhao,Y.,
            Ma,X., Yuan,Z., Li,Q., Bahabayi,A., Zhang,Z., Zeng,X. and Liu,C.
  TITLE     Differential GPR56 Expression in T Cell Subpopulations for
            Early-Stage Lung Adenocarcinoma Patient Identification
  JOURNAL   Immunol Invest 53 (6), 843-856 (2024)
   PUBMED   38809082
  REMARK    GeneRIF: Differential GPR56 Expression in T Cell Subpopulations for
            Early-Stage Lung Adenocarcinoma Patient Identification.
REFERENCE   4  (bases 1 to 4257)
  AUTHORS   Faas,F., Norskov,A., Holst,P.J., Andersson,A.M., Qvortrup,K.,
            Mathiasen,S. and Rosenkilde,M.M.
  TITLE     Re-routing GPR56 signalling using Galpha12/13 G protein chimeras
  JOURNAL   Basic Clin Pharmacol Toxicol 133 (4), 378-389 (2023)
   PUBMED   37621135
  REMARK    GeneRIF: Re-routing GPR56 signalling using Galpha12/13 G protein
            chimeras.
REFERENCE   5  (bases 1 to 4257)
  AUTHORS   Little,K.D., Hemler,M.E. and Stipp,C.S.
  TITLE     Dynamic regulation of a GPCR-tetraspanin-G protein complex on
            intact cells: central role of CD81 in facilitating GPR56-Galpha
            q/11 association
  JOURNAL   Mol Biol Cell 15 (5), 2375-2387 (2004)
   PUBMED   15004227
REFERENCE   6  (bases 1 to 4257)
  AUTHORS   Piao,X., Hill,R.S., Bodell,A., Chang,B.S., Basel-Vanagaite,L.,
            Straussberg,R., Dobyns,W.B., Qasrawi,B., Winter,R.M., Innes,A.M.,
            Voit,T., Ross,M.E., Michaud,J.L., Descarie,J.C., Barkovich,A.J. and
            Walsh,C.A.
  TITLE     G protein-coupled receptor-dependent development of human frontal
            cortex
  JOURNAL   Science 303 (5666), 2033-2036 (2004)
   PUBMED   15044805
  REMARK    GeneRIF: results show that mutations in GPR56 cause a human brain
            cortical malformatin called bilateral frontoparietal polymicrogyria
            (BFPP); data suggest that GPR56 signaling plays an essential role
            in regional development of human cerebral cortex
REFERENCE   7  (bases 1 to 4257)
  AUTHORS   Piao,X., Basel-Vanagaite,L., Straussberg,R., Grant,P.E., Pugh,E.W.,
            Doheny,K., Doan,B., Hong,S.E., Shugart,Y.Y. and Walsh,C.A.
  TITLE     An autosomal recessive form of bilateral frontoparietal
            polymicrogyria maps to chromosome 16q12.2-21
  JOURNAL   Am J Hum Genet 70 (4), 1028-1033 (2002)
   PUBMED   11845408
REFERENCE   8  (bases 1 to 4257)
  AUTHORS   Zendman,A.J., Cornelissen,I.M., Weidle,U.H., Ruiter,D.J. and van
            Muijen,G.N.
  TITLE     TM7XN1, a novel human EGF-TM7-like cDNA, detected with mRNA
            differential display using human melanoma cell lines with different
            metastatic potential
  JOURNAL   FEBS Lett 446 (2-3), 292-298 (1999)
   PUBMED   10100861
REFERENCE   9  (bases 1 to 4257)
  AUTHORS   Liu,M., Parker,R.M., Darby,K., Eyre,H.J., Copeland,N.G.,
            Crawford,J., Gilbert,D.J., Sutherland,G.R., Jenkins,N.A. and
            Herzog,H.
  TITLE     GPR56, a novel secretin-like human G-protein-coupled receptor gene
  JOURNAL   Genomics 55 (3), 296-305 (1999)
   PUBMED   10049584
REFERENCE   10 (bases 1 to 4257)
  AUTHORS   Stutterd,C.A., Dobyns,W.B., Jansen,A., Mirzaa,G. and Leventer,R.J.
  TITLE     Polymicrogyria Overview - RETIRED CHAPTER, FOR HISTORICAL REFERENCE
            ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301504
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK312405.1, AK299110.1,
            AK075555.1, CR936747.1 and AC018552.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 1, 2019 this sequence version replaced NM_201525.3.
            
            Summary: This gene encodes a member of the G protein-coupled
            receptor family and regulates brain cortical patterning. The
            encoded protein binds specifically to transglutaminase 2, a
            component of tissue and tumor stroma implicated as an inhibitor of
            tumor progression. Mutations in this gene are associated with a
            brain malformation known as bilateral frontoparietal
            polymicrogyria. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and uses
            an alternate in-frame splice site in the coding region compared to
            variant 4. The resulting isoform (b, also known as S1) is shorter
            than isoform a. Variants 2, 3, 5, 6, and 7 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.798482.1, AK312405.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000562631.7/ ENSP00000455351.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2272              AK312405.1         241-2512
            2273-2430           AK299110.1         2221-2378
            2431-3189           AK075555.1         2490-3248
            3190-3718           CR936747.1         3122-3650
            3719-4257           AC018552.6         74543-75081         c
FEATURES             Location/Qualifiers
     source          1..4257
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..4257
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /note="adhesion G protein-coupled receptor G1"
                     /db_xref="GeneID:9289"
                     /db_xref="HGNC:HGNC:4512"
                     /db_xref="MIM:604110"
     exon            1..173
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            174..272
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..2272
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /EC_number="2.7.11.25"
                     /note="isoform b precursor is encoded by transcript
                     variant 3; 7-transmembrane protein with no EGF-like
                     N-terminal domains-1; G protein-coupled receptor 56;
                     testicular tissue protein Li 77"
                     /codon_start=1
                     /product="adhesion G-protein coupled receptor G1 isoform b
                     precursor"
                     /protein_id="NP_958933.1"
                     /db_xref="CCDS:CCDS32461.1"
                     /db_xref="GeneID:9289"
                     /db_xref="HGNC:HGNC:4512"
                     /db_xref="MIM:604110"
                     /translation="MTPQSLLQTTLFLLSLLFLVQGAHGRGHREDFRFCSQRNQTHRS
                     SLHYKPTPDLRISIENSEEALTVHAPFPAAHPASRSFPDPRGLYHFCLYWNRHAGRLH
                     LLYGKRDFLLSDKASSLLCFQHQEESLAQGPPLLATSVTSWWSPQNISLPSAASFTFS
                     FHSPPHTAAHNASVDMCELKRDLQLLSQFLKHPQKASRRPSAAPASQQLQSLESKLTS
                     VRFMGDMVSFEEDRINATVWKLQPTAGLQDLHIHSRQEEEQSEIMEYSVLLPRTLFQR
                     TKGRSGEAEKRLLLVDFSSQALFQDKNSSQVLGEKVLGIVVQNTKVANLTEPVVLTFQ
                     HQLQPKNVTLQCVFWVEDPTLSSPGHWSSAGCETVRRETQTSCFCNHLTYFAVLMVSS
                     VEVDAVHKHYLSLLSYVGCVVSALACLVTIAAYLCSRRKPRDYTIKVHMNLLLAVFLL
                     DTSFLLSEPVALTGSEAGCRASAIFLHFSLLTCLSWMGLEGYNLYRLVVEVFGTYVPG
                     YLLKLSAMGWGFPIFLVTLVALVDVDNYGPIILAVHRTPEGVIYPSMCWIRDSLVSYI
                     TNLGLFSLVFLFNMAMLATMVVQILRLRPHTQKWSHVLTLLGLSLVLGLPWALIFFSF
                     ASGTFQLVVLYLFSIITSFQGFLIFIWYWSMRLQARGGPSPLKSNSDSARLPISSGST
                     SSSRI"
     exon            273..695
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            696..828
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            829..976
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1108
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1225
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1271
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1375
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1494
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1763
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1872
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2141
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..4257
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3686..3691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /note="hexamer: AATAAA"
     polyA_site      3718
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /note="major polyA site"
     regulatory      4233..4238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /note="hexamer: ATTAAA"
     polyA_site      4257
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
ORIGIN      
        1 gcactagctg tctgccctgc cctgccgtag gagatgggct gggagcctcc cacgctctcc
       61 agctcactcg gcaggcagcg gggaccaggg ctggcaggtt aagcctctgg gggtggatcc
      121 tgaaaggtgg tccagccgcc tggccctgcg tgggaccctc cacctggcag caggtggtga
      181 cttccaagag tgactccgtc ggaggaaaat gactccccag tcgctgctgc agacgacact
      241 gttcctgctg agtctgctct tcctggtcca aggtgcccac ggcaggggcc acagggaaga
      301 ctttcgcttc tgcagccagc ggaaccagac acacaggagc agcctccact acaaacccac
      361 accagacctg cgcatctcca tcgagaactc cgaagaggcc ctcacagtcc atgccccttt
      421 ccctgcagcc caccctgctt cccgatcctt ccctgacccc aggggcctct accacttctg
      481 cctctactgg aaccgacatg ctgggagatt acatcttctc tatggcaagc gtgacttctt
      541 gctgagtgac aaagcctcta gcctcctctg cttccagcac caggaggaga gcctggctca
      601 gggccccccg ctgttagcca cttctgtcac ctcctggtgg agccctcaga acatcagcct
      661 gcccagtgcc gccagcttca ccttctcctt ccacagtcct ccccacacgg ccgctcacaa
      721 tgcctcggtg gacatgtgcg agctcaaaag ggacctccag ctgctcagcc agttcctgaa
      781 gcatccccag aaggcctcaa ggaggccctc ggctgccccc gccagccagc agttgcagag
      841 cctggagtcg aaactgacct ctgtgagatt catgggggac atggtgtcct tcgaggagga
      901 ccggatcaac gccacggtgt ggaagctcca gcccacagcc ggcctccagg acctgcacat
      961 ccactcccgg caggaggagg agcagagcga gatcatggag tactcggtgc tgctgcctcg
     1021 aacactcttc cagaggacga aaggccggag cggggaggct gagaagagac tcctcctggt
     1081 ggacttcagc agccaagccc tgttccagga caagaattcc agccaagtcc tgggtgagaa
     1141 ggtcttgggg attgtggtac agaacaccaa agtagccaac ctcacggagc ccgtggtgct
     1201 cactttccag caccagctac agccgaagaa tgtgactctg caatgtgtgt tctgggttga
     1261 agaccccaca ttgagcagcc cggggcattg gagcagtgct gggtgtgaga ccgtcaggag
     1321 agaaacccaa acatcctgct tctgcaacca cttgacctac tttgcagtgc tgatggtctc
     1381 ctcggtggag gtggacgccg tgcacaagca ctacctgagc ctcctctcct acgtgggctg
     1441 tgtcgtctct gccctggcct gccttgtcac cattgccgcc tacctctgct ccaggaggaa
     1501 acctcgggac tacaccatca aggtgcacat gaacctgctg ctggccgtct tcctgctgga
     1561 cacgagcttc ctgctcagcg agccggtggc cctgacaggc tctgaggctg gctgccgagc
     1621 cagtgccatc ttcctgcact tctccctgct cacctgcctt tcctggatgg gcctcgaggg
     1681 gtacaacctc taccgactcg tggtggaggt ctttggcacc tatgtccctg gctacctact
     1741 caagctgagc gccatgggct ggggcttccc catctttctg gtgacgctgg tggccctggt
     1801 ggatgtggac aactatggcc ccatcatctt ggctgtgcat aggactccag agggcgtcat
     1861 ctacccttcc atgtgctgga tccgggactc cctggtcagc tacatcacca acctgggcct
     1921 cttcagcctg gtgtttctgt tcaacatggc catgctagcc accatggtgg tgcagatcct
     1981 gcggctgcgc ccccacaccc aaaagtggtc acatgtgctg acactgctgg gcctcagcct
     2041 ggtccttggc ctgccctggg ccttgatctt cttctccttt gcttctggca ccttccagct
     2101 tgtcgtcctc taccttttca gcatcatcac ctccttccaa ggcttcctca tcttcatctg
     2161 gtactggtcc atgcggctgc aggcccgggg tggcccctcc cctctgaaga gcaactcaga
     2221 cagcgccagg ctccccatca gctcgggcag cacctcgtcc agccgcatct aggcctccag
     2281 cccacctgcc catgtgatga agcagagatt cggcctcgtc gcacactgcc tgtggccccc
     2341 gagcccggcc cagccccagg ccagtcagcc gcagactttg gaaagcccaa cgaccatgga
     2401 gagatgggcc gttgccatgg tggacggact cccgggctgg gcttttgaat tggccttggg
     2461 gactactcgg ctctcactca gctcccacgg gactcagaag tgcgccgcca tgctgcctag
     2521 ggtactgtcc ccacatctgt cccaacccag ctggaggcct ggtctctcct tacaacccct
     2581 gggcccagcc ctcattgctg ggggccaggc cttggatctt gagggtctgg cacatcctta
     2641 atcctgtgcc cctgcctggg acagaaatgt ggctccagtt gctctgtctc tcgtggtcac
     2701 cctgagggca ctctgcatcc tctgtcattt taacctcagg tggcacccag ggcgaatggg
     2761 gcccagggca gaccttcagg gccagagccc tggcggagga gaggcccttt gccaggagca
     2821 cagcagcagc tcgcctacct ctgagcccag gccccctccc tccctcagcc ccccagtcct
     2881 ccctccatct tccctggggt tctcctcctc tcccagggcc tccttgctcc ttcgttcaca
     2941 gctgggggtc cccgattcca atgctgtttt ttggggagtg gtttccagga gctgcctggt
     3001 gtctgctgta aatgtttgtc tactgcacaa gcctcggcct gcccctgagc caggctcggt
     3061 accgatgcgt gggctgggct aggtccctct gtccatctgg gcctttgtat gagctgcatt
     3121 gcccttgctc accctgacca agcacacgcc tcagaggggc cctcagcctc tcctgaagcc
     3181 ctcttgtggc aagaactgtg gaccatgcca gtcccgtctg gtttccatcc caccactcca
     3241 aggactgaga ctgacctcct ctggtgacac tggcctaggg cctgacactc tcctaagagg
     3301 ttctctccaa gcccccaaat agctccaggc gccctcggcc gcccatcatg gttaattctg
     3361 tccaacaaac acacacgggt agattgctgg cctgttgtag gtggtaggga cacagatgac
     3421 cgacctggtc actcctcctg ccaacattca gtctggtatg tgaggcgtgc gtgaagcaag
     3481 aactcctgga gctacaggga cagggagcca tcattcctgc ctgggaatcc tggaagactt
     3541 cctgcaggag tcagcgttca atcttgacct tgaagatggg aaggatgttc tttttacgta
     3601 ccaattcttt tgtcttttga tattaaaaag aagtacatgt tcattgtaga gaatttggaa
     3661 actgtagaag agaatcaaga agaaaaataa aaatcagctg ttgtaatcac ctagcaaact
     3721 ggcgtaagca ttttgggtca tttccttctg agctttttcc tgtgcttcta ttgaaagagt
     3781 cactgatact aatacaaata ccttggggcc aatcaggaaa catgaaagag agaagagggc
     3841 tgtgtgtgaa gaaaaaaaaa aaatcgactg ctggaaacct catcaaccag ggcacagggg
     3901 aagataaatg gcaacttggt gtctgtgctg gggaggcaat ggggagtggt ggggcctgtg
     3961 gcgaactgga gactcccaac cccatgctga gagcgtggct gctcatcagc tccagctggt
     4021 cactaccttg cagggatgag ggcccatgta gccagaccac ctgcctttta tgagaaatgg
     4081 gaaatccaga ctgtggtttg acatcccctg attttaaaat tttggcgaat ccaaaacatt
     4141 ttctggccaa agagattaca gtcaaaagct gcctggtcct gggatttatg caaccagttt
     4201 actgatcact ctgcagcagg tgggctgcaa gaattaaatc actggacttc tctccca
//
