LOCUS       NM_001370438            4228 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens adhesion G protein-coupled receptor G1 (ADGRG1),
            transcript variant 22, mRNA.
ACCESSION   NM_001370438
VERSION     NM_001370438.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4228)
  AUTHORS   Palacios,D., Majhi,R.K., Szabo,E.K., Clement,D., Lachota,M.,
            Netskar,H., Penna,L., Krokeide,S.Z., Vincenti,M., Kveberg,L. and
            Malmberg,K.J.
  TITLE     The G Protein-Coupled Receptor GPR56 Is an Inhibitory Checkpoint
            for NK Cell Migration
  JOURNAL   J Immunol 213 (9), 1349-1357 (2024)
   PUBMED   39320215
  REMARK    GeneRIF: The G Protein-Coupled Receptor GPR56 Is an Inhibitory
            Checkpoint for NK Cell Migration.
REFERENCE   2  (bases 1 to 4228)
  AUTHORS   Bahabayi,A., Guan,Z., Zheng,M., Yu,H., Hasimu,A., Nie,Y., Zhao,M.,
            Zhu,Y., Ren,J., Zhao,Y., Ma,X., Li,Q., Zhang,Z., Zeng,X. and Liu,C.
  TITLE     Expression of GPR56 reflects a hypoactivated state of circulating B
            cells and is downregulated in B cell subsets in patients with
            early-stage lung adenocarcinoma
  JOURNAL   Immunology 173 (1), 172-184 (2024)
   PUBMED   38840413
  REMARK    GeneRIF: Expression of GPR56 reflects a hypoactivated state of
            circulating B cells and is downregulated in B cell subsets in
            patients with early-stage lung adenocarcinoma.
REFERENCE   3  (bases 1 to 4228)
  AUTHORS   Ren,J., Zhu,Y., Nie,Y., Zheng,M., Hasimu,A., Zhao,M., Zhao,Y.,
            Ma,X., Yuan,Z., Li,Q., Bahabayi,A., Zhang,Z., Zeng,X. and Liu,C.
  TITLE     Differential GPR56 Expression in T Cell Subpopulations for
            Early-Stage Lung Adenocarcinoma Patient Identification
  JOURNAL   Immunol Invest 53 (6), 843-856 (2024)
   PUBMED   38809082
  REMARK    GeneRIF: Differential GPR56 Expression in T Cell Subpopulations for
            Early-Stage Lung Adenocarcinoma Patient Identification.
REFERENCE   4  (bases 1 to 4228)
  AUTHORS   Faas,F., Norskov,A., Holst,P.J., Andersson,A.M., Qvortrup,K.,
            Mathiasen,S. and Rosenkilde,M.M.
  TITLE     Re-routing GPR56 signalling using Galpha12/13 G protein chimeras
  JOURNAL   Basic Clin Pharmacol Toxicol 133 (4), 378-389 (2023)
   PUBMED   37621135
  REMARK    GeneRIF: Re-routing GPR56 signalling using Galpha12/13 G protein
            chimeras.
REFERENCE   5  (bases 1 to 4228)
  AUTHORS   Little,K.D., Hemler,M.E. and Stipp,C.S.
  TITLE     Dynamic regulation of a GPCR-tetraspanin-G protein complex on
            intact cells: central role of CD81 in facilitating GPR56-Galpha
            q/11 association
  JOURNAL   Mol Biol Cell 15 (5), 2375-2387 (2004)
   PUBMED   15004227
REFERENCE   6  (bases 1 to 4228)
  AUTHORS   Piao,X., Hill,R.S., Bodell,A., Chang,B.S., Basel-Vanagaite,L.,
            Straussberg,R., Dobyns,W.B., Qasrawi,B., Winter,R.M., Innes,A.M.,
            Voit,T., Ross,M.E., Michaud,J.L., Descarie,J.C., Barkovich,A.J. and
            Walsh,C.A.
  TITLE     G protein-coupled receptor-dependent development of human frontal
            cortex
  JOURNAL   Science 303 (5666), 2033-2036 (2004)
   PUBMED   15044805
  REMARK    GeneRIF: results show that mutations in GPR56 cause a human brain
            cortical malformatin called bilateral frontoparietal polymicrogyria
            (BFPP); data suggest that GPR56 signaling plays an essential role
            in regional development of human cerebral cortex
REFERENCE   7  (bases 1 to 4228)
  AUTHORS   Piao,X., Basel-Vanagaite,L., Straussberg,R., Grant,P.E., Pugh,E.W.,
            Doheny,K., Doan,B., Hong,S.E., Shugart,Y.Y. and Walsh,C.A.
  TITLE     An autosomal recessive form of bilateral frontoparietal
            polymicrogyria maps to chromosome 16q12.2-21
  JOURNAL   Am J Hum Genet 70 (4), 1028-1033 (2002)
   PUBMED   11845408
REFERENCE   8  (bases 1 to 4228)
  AUTHORS   Zendman,A.J., Cornelissen,I.M., Weidle,U.H., Ruiter,D.J. and van
            Muijen,G.N.
  TITLE     TM7XN1, a novel human EGF-TM7-like cDNA, detected with mRNA
            differential display using human melanoma cell lines with different
            metastatic potential
  JOURNAL   FEBS Lett 446 (2-3), 292-298 (1999)
   PUBMED   10100861
REFERENCE   9  (bases 1 to 4228)
  AUTHORS   Liu,M., Parker,R.M., Darby,K., Eyre,H.J., Copeland,N.G.,
            Crawford,J., Gilbert,D.J., Sutherland,G.R., Jenkins,N.A. and
            Herzog,H.
  TITLE     GPR56, a novel secretin-like human G-protein-coupled receptor gene
  JOURNAL   Genomics 55 (3), 296-305 (1999)
   PUBMED   10049584
REFERENCE   10 (bases 1 to 4228)
  AUTHORS   Stutterd,C.A., Dobyns,W.B., Jansen,A., Mirzaa,G. and Leventer,R.J.
  TITLE     Polymicrogyria Overview - RETIRED CHAPTER, FOR HISTORICAL REFERENCE
            ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301504
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018552.6.
            
            Summary: This gene encodes a member of the G protein-coupled
            receptor family and regulates brain cortical patterning. The
            encoded protein binds specifically to transglutaminase 2, a
            component of tissue and tumor stroma implicated as an inhibitor of
            tumor progression. Mutations in this gene are associated with a
            brain malformation known as bilateral frontoparietal
            polymicrogyria. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Feb 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1879728.1,
                                           SRR7346977.1745510.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AC018552.6         120229-120372       c
            145-243             AC018552.6         89759-89857         c
            244-666             AC018552.6         88488-88910         c
            667-799             AC018552.6         86775-86907         c
            800-947             AC018552.6         85977-86124         c
            948-1079            AC018552.6         84580-84711         c
            1080-1196           AC018552.6         84118-84234         c
            1197-1242           AC018552.6         83839-83884         c
            1243-1346           AC018552.6         83493-83596         c
            1347-1465           AC018552.6         82619-82737         c
            1466-1734           AC018552.6         80429-80697         c
            1735-1843           AC018552.6         79234-79342         c
            1844-2112           AC018552.6         78145-78413         c
            2113-4228           AC018552.6         74543-76658         c
FEATURES             Location/Qualifiers
     source          1..4228
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..4228
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /note="adhesion G protein-coupled receptor G1"
                     /db_xref="GeneID:9289"
                     /db_xref="HGNC:HGNC:4512"
                     /db_xref="MIM:604110"
     exon            1..144
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            145..243
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..2243
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /EC_number="2.7.11.25"
                     /note="isoform b precursor is encoded by transcript
                     variant 22; 7-transmembrane protein with no EGF-like
                     N-terminal domains-1; G protein-coupled receptor 56;
                     testicular tissue protein Li 77"
                     /codon_start=1
                     /product="adhesion G-protein coupled receptor G1 isoform b
                     precursor"
                     /protein_id="NP_001357367.1"
                     /db_xref="CCDS:CCDS32461.1"
                     /db_xref="GeneID:9289"
                     /db_xref="HGNC:HGNC:4512"
                     /db_xref="MIM:604110"
                     /translation="MTPQSLLQTTLFLLSLLFLVQGAHGRGHREDFRFCSQRNQTHRS
                     SLHYKPTPDLRISIENSEEALTVHAPFPAAHPASRSFPDPRGLYHFCLYWNRHAGRLH
                     LLYGKRDFLLSDKASSLLCFQHQEESLAQGPPLLATSVTSWWSPQNISLPSAASFTFS
                     FHSPPHTAAHNASVDMCELKRDLQLLSQFLKHPQKASRRPSAAPASQQLQSLESKLTS
                     VRFMGDMVSFEEDRINATVWKLQPTAGLQDLHIHSRQEEEQSEIMEYSVLLPRTLFQR
                     TKGRSGEAEKRLLLVDFSSQALFQDKNSSQVLGEKVLGIVVQNTKVANLTEPVVLTFQ
                     HQLQPKNVTLQCVFWVEDPTLSSPGHWSSAGCETVRRETQTSCFCNHLTYFAVLMVSS
                     VEVDAVHKHYLSLLSYVGCVVSALACLVTIAAYLCSRRKPRDYTIKVHMNLLLAVFLL
                     DTSFLLSEPVALTGSEAGCRASAIFLHFSLLTCLSWMGLEGYNLYRLVVEVFGTYVPG
                     YLLKLSAMGWGFPIFLVTLVALVDVDNYGPIILAVHRTPEGVIYPSMCWIRDSLVSYI
                     TNLGLFSLVFLFNMAMLATMVVQILRLRPHTQKWSHVLTLLGLSLVLGLPWALIFFSF
                     ASGTFQLVVLYLFSIITSFQGFLIFIWYWSMRLQARGGPSPLKSNSDSARLPISSGST
                     SSSRI"
     exon            244..666
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..799
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            800..947
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1079
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1196
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1242
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1346
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1465
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1734
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1843
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..2112
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..4228
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3657..3662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /note="hexamer: AATAAA"
     polyA_site      3689
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /note="major polyA site"
     regulatory      4204..4209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
                     /note="hexamer: ATTAAA"
     polyA_site      4228
                     /gene="ADGRG1"
                     /gene_synonym="BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56;
                     TM7LN4; TM7XN1"
ORIGIN      
        1 acaaagagtt ggcagatcac ggatggaggg cagcatctcc caacagcctg ggcggccgct
       61 gagacccaga gaacccaagg actcccctgg gctcatccag cagcctctgc ttcccaggag
      121 agaggtgctg aagtccacga agaggtggtg acttccaaga gtgactccgt cggaggaaaa
      181 tgactcccca gtcgctgctg cagacgacac tgttcctgct gagtctgctc ttcctggtcc
      241 aaggtgccca cggcaggggc cacagggaag actttcgctt ctgcagccag cggaaccaga
      301 cacacaggag cagcctccac tacaaaccca caccagacct gcgcatctcc atcgagaact
      361 ccgaagaggc cctcacagtc catgcccctt tccctgcagc ccaccctgct tcccgatcct
      421 tccctgaccc caggggcctc taccacttct gcctctactg gaaccgacat gctgggagat
      481 tacatcttct ctatggcaag cgtgacttct tgctgagtga caaagcctct agcctcctct
      541 gcttccagca ccaggaggag agcctggctc agggcccccc gctgttagcc acttctgtca
      601 cctcctggtg gagccctcag aacatcagcc tgcccagtgc cgccagcttc accttctcct
      661 tccacagtcc tccccacacg gccgctcaca atgcctcggt ggacatgtgc gagctcaaaa
      721 gggacctcca gctgctcagc cagttcctga agcatcccca gaaggcctca aggaggccct
      781 cggctgcccc cgccagccag cagttgcaga gcctggagtc gaaactgacc tctgtgagat
      841 tcatggggga catggtgtcc ttcgaggagg accggatcaa cgccacggtg tggaagctcc
      901 agcccacagc cggcctccag gacctgcaca tccactcccg gcaggaggag gagcagagcg
      961 agatcatgga gtactcggtg ctgctgcctc gaacactctt ccagaggacg aaaggccgga
     1021 gcggggaggc tgagaagaga ctcctcctgg tggacttcag cagccaagcc ctgttccagg
     1081 acaagaattc cagccaagtc ctgggtgaga aggtcttggg gattgtggta cagaacacca
     1141 aagtagccaa cctcacggag cccgtggtgc tcactttcca gcaccagcta cagccgaaga
     1201 atgtgactct gcaatgtgtg ttctgggttg aagaccccac attgagcagc ccggggcatt
     1261 ggagcagtgc tgggtgtgag accgtcagga gagaaaccca aacatcctgc ttctgcaacc
     1321 acttgaccta ctttgcagtg ctgatggtct cctcggtgga ggtggacgcc gtgcacaagc
     1381 actacctgag cctcctctcc tacgtgggct gtgtcgtctc tgccctggcc tgccttgtca
     1441 ccattgccgc ctacctctgc tccaggagga aacctcggga ctacaccatc aaggtgcaca
     1501 tgaacctgct gctggccgtc ttcctgctgg acacgagctt cctgctcagc gagccggtgg
     1561 ccctgacagg ctctgaggct ggctgccgag ccagtgccat cttcctgcac ttctccctgc
     1621 tcacctgcct ttcctggatg ggcctcgagg ggtacaacct ctaccgactc gtggtggagg
     1681 tctttggcac ctatgtccct ggctacctac tcaagctgag cgccatgggc tggggcttcc
     1741 ccatctttct ggtgacgctg gtggccctgg tggatgtgga caactatggc cccatcatct
     1801 tggctgtgca taggactcca gagggcgtca tctacccttc catgtgctgg atccgggact
     1861 ccctggtcag ctacatcacc aacctgggcc tcttcagcct ggtgtttctg ttcaacatgg
     1921 ccatgctagc caccatggtg gtgcagatcc tgcggctgcg cccccacacc caaaagtggt
     1981 cacatgtgct gacactgctg ggcctcagcc tggtccttgg cctgccctgg gccttgatct
     2041 tcttctcctt tgcttctggc accttccagc ttgtcgtcct ctaccttttc agcatcatca
     2101 cctccttcca aggcttcctc atcttcatct ggtactggtc catgcggctg caggcccggg
     2161 gtggcccctc ccctctgaag agcaactcag acagcgccag gctccccatc agctcgggca
     2221 gcacctcgtc cagccgcatc taggcctcca gcccacctgc ccatgtgatg aagcagagat
     2281 tcggcctcgt cgcacactgc ctgtggcccc cgagcccggc ccagccccag gccagtcagc
     2341 cgcagacttt ggaaagccca acgaccatgg agagatgggc cgttgccatg gtggacggac
     2401 tcccgggctg ggcttttgaa ttggccttgg ggactactcg gctctcactc agctcccacg
     2461 ggactcagaa gtgcgccgcc atgctgccta gggtactgtc cccacatctg tcccaaccca
     2521 gctggaggcc tggtctctcc ttacaacccc tgggcccagc cctcattgct gggggccagg
     2581 ccttggatct tgagggtctg gcacatcctt aatcctgtgc ccctgcctgg gacagaaatg
     2641 tggctccagt tgctctgtct ctcgtggtca ccctgagggc actctgcatc ctctgtcatt
     2701 ttaacctcag gtggcaccca gggcgaatgg ggcccagggc agaccttcag ggccagagcc
     2761 ctggcggagg agaggccctt tgccaggagc acagcagcag ctcgcctacc tctgagccca
     2821 ggccccctcc ctccctcagc cccccagtcc tccctccatc ttccctgggg ttctcctcct
     2881 ctcccagggc ctccttgctc cttcgttcac agctgggggt ccccgattcc aatgctgttt
     2941 tttggggagt ggtttccagg agctgcctgg tgtctgctgt aaatgtttgt ctactgcaca
     3001 agcctcggcc tgcccctgag ccaggctcgg taccgatgcg tgggctgggc taggtccctc
     3061 tgtccatctg ggcctttgta tgagctgcat tgcccttgct caccctgacc aagcacacgc
     3121 ctcagagggg ccctcagcct ctcctgaagc cctcttgtgg caagaactgt ggaccatgcc
     3181 agtcccgtct ggtttccatc ccaccactcc aaggactgag actgacctcc tctggtgaca
     3241 ctggcctagg gcctgacact ctcctaagag gttctctcca agcccccaaa tagctccagg
     3301 cgccctcggc cgcccatcat ggttaattct gtccaacaaa cacacacggg tagattgctg
     3361 gcctgttgta ggtggtaggg acacagatga ccgacctggt cactcctcct gccaacattc
     3421 agtctggtat gtgaggcgtg cgtgaagcaa gaactcctgg agctacaggg acagggagcc
     3481 atcattcctg cctgggaatc ctggaagact tcctgcagga gtcagcgttc aatcttgacc
     3541 ttgaagatgg gaaggatgtt ctttttacgt accaattctt ttgtcttttg atattaaaaa
     3601 gaagtacatg ttcattgtag agaatttgga aactgtagaa gagaatcaag aagaaaaata
     3661 aaaatcagct gttgtaatca cctagcaaac tggcgtaagc attttgggtc atttccttct
     3721 gagctttttc ctgtgcttct attgaaagag tcactgatac taatacaaat accttggggc
     3781 caatcaggaa acatgaaaga gagaagaggg ctgtgtgtga agaaaaaaaa aaaatcgact
     3841 gctggaaacc tcatcaacca gggcacaggg gaagataaat ggcaacttgg tgtctgtgct
     3901 ggggaggcaa tggggagtgg tggggcctgt ggcgaactgg agactcccaa ccccatgctg
     3961 agagcgtggc tgctcatcag ctccagctgg tcactacctt gcagggatga gggcccatgt
     4021 agccagacca cctgcctttt atgagaaatg ggaaatccag actgtggttt gacatcccct
     4081 gattttaaaa ttttggcgaa tccaaaacat tttctggcca aagagattac agtcaaaagc
     4141 tgcctggtcc tgggatttat gcaaccagtt tactgatcac tctgcagcag gtgggctgca
     4201 agaattaaat cactggactt ctctccca
//
