LOCUS       NM_001098518            5761 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens adhesion G protein-coupled receptor F5 (ADGRF5),
            transcript variant 2, mRNA.
ACCESSION   NM_001098518
VERSION     NM_001098518.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5761)
  AUTHORS   Xiang,Q., Li,N., Zhang,Y., Wang,T., Wang,Y. and Bian,J.
  TITLE     GPR116 alleviates acetaminophen-induced liver injury in mice by
            inhibiting endoplasmic reticulum stress
  JOURNAL   Cell Mol Life Sci 81 (1), 299 (2024)
   PUBMED   39001944
  REMARK    GeneRIF: GPR116 alleviates acetaminophen-induced liver injury in
            mice by inhibiting endoplasmic reticulum stress.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5761)
  AUTHORS   Wu,Y., Liu,H., Sun,Z., Liu,J., Li,K., Fan,R., Dai,F., Tang,H.,
            Hou,Q., Li,J. and Tang,X.
  TITLE     The adhesion-GPCR ADGRF5 fuels breast cancer progression by
            suppressing the MMP8-mediated antitumorigenic effects
  JOURNAL   Cell Death Dis 15 (6), 455 (2024)
   PUBMED   38937435
  REMARK    GeneRIF: The adhesion-GPCR ADGRF5 fuels breast cancer progression
            by suppressing the MMP8-mediated antitumorigenic effects.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5761)
  AUTHORS   Jacenik,D., Hikisz,P., Beswick,E.J. and Fichna,J.
  TITLE     The clinical relevance of the adhesion G protein-coupled receptor
            F5 for human diseases and cancers
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (5), 166683 (2023)
   PUBMED   36878303
  REMARK    GeneRIF: The clinical relevance of the adhesion G protein-coupled
            receptor F5 for human diseases and cancers.
            Review article
REFERENCE   4  (bases 1 to 5761)
  AUTHORS   Kang,H., Fichna,J., Matlawska-Wasowska,K. and Jacenik,D.
  TITLE     The Expression Pattern of Adhesion G Protein-Coupled Receptor F5 Is
            Related to Cell Adhesion and Metastatic Pathways in Colorectal
            Cancer-Comprehensive Study Based on In Silico Analysis
  JOURNAL   Cells 11 (23), 3876 (2022)
   PUBMED   36497132
  REMARK    GeneRIF: The Expression Pattern of Adhesion G Protein-Coupled
            Receptor F5 Is Related to Cell Adhesion and Metastatic Pathways in
            Colorectal Cancer-Comprehensive Study Based on In Silico Analysis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5761)
  AUTHORS   Georgiadi,A., Lopez-Salazar,V., Merahbi,R.E., Karikari,R.A., Ma,X.,
            Mourao,A., Klepac,K., Buhler,L., Alfaro,A.J., Kaczmarek,I.,
            Linford,A., Bosma,M., Shilkova,O., Ritvos,O., Nakamura,N.,
            Hirose,S., Lassi,M., Teperino,R., Machado,J., Scheideler,M.,
            Dietrich,A., Geerlof,A., Feuchtinger,A., Blutke,A., Fischer,K.,
            Muller,T.D., Kessler,K., Schoneberg,T., Thor,D., Hornemann,S.,
            Kruse,M., Nawroth,P., Pivovarova-Ramich,O., Pfeiffer,A.F.H.,
            Sattler,M., Bluher,M. and Herzig,S.
  TITLE     Orphan GPR116 mediates the insulin sensitizing effects of the
            hepatokine FNDC4 in adipose tissue
  JOURNAL   Nat Commun 12 (1), 2999 (2021)
   PUBMED   34016966
  REMARK    GeneRIF: Orphan GPR116 mediates the insulin sensitizing effects of
            the hepatokine FNDC4 in adipose tissue.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5761)
  AUTHORS   Sandberg,A., Johansson,D.G., Macao,B. and Hard,T.
  TITLE     SEA domain autoproteolysis accelerated by conformational strain:
            energetic aspects
  JOURNAL   J Mol Biol 377 (4), 1117-1129 (2008)
   PUBMED   18308334
  REMARK    GeneRIF: SEA domain autoproteolysis accelerated by conformational
            strain.
            Erratum:[J Mol Biol. 2008 Jun 27;380(1):264]
REFERENCE   7  (bases 1 to 5761)
  AUTHORS   Liu,T., Qian,W.J., Gritsenko,M.A., Camp,D.G. 2nd, Monroe,M.E.,
            Moore,R.J. and Smith,R.D.
  TITLE     Human plasma N-glycoproteome analysis by immunoaffinity
            subtraction, hydrazide chemistry, and mass spectrometry
  JOURNAL   J Proteome Res 4 (6), 2070-2080 (2005)
   PUBMED   16335952
REFERENCE   8  (bases 1 to 5761)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
REFERENCE   9  (bases 1 to 5761)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
REFERENCE   10 (bases 1 to 5761)
  AUTHORS   Fredriksson,R., Lagerstrom,M.C., Hoglund,P.J. and Schioth,H.B.
  TITLE     Novel human G protein-coupled receptors with long N-terminals
            containing GPS domains and Ser/Thr-rich regions
  JOURNAL   FEBS Lett 531 (3), 407-414 (2002)
   PUBMED   12435584
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB230925.1, AB018301.2, AL096772.5, AY498875.1 and AY140958.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001098518.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.261933.1,
                                           SRR1660807.130135.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000283296.12/ ENSP00000283296.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                DB230925.1         40-62
            24-549              AB018301.2         1-526
            550-551             AL096772.5         71972-71973
            552-2060            AY498875.1         390-1898
            2061-4066           AY140958.1         1808-3813
            4067-4323           AY498875.1         3905-4161
            4324-5761           AL096772.5         106376-107813
FEATURES             Location/Qualifiers
     source          1..5761
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.3"
     gene            1..5761
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
                     /note="adhesion G protein-coupled receptor F5"
                     /db_xref="GeneID:221395"
                     /db_xref="HGNC:HGNC:19030"
                     /db_xref="MIM:620874"
     exon            1..226
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
                     /inference="alignment:Splign:2.1.0"
     exon            227..352
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..4291
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
                     /note="probable G-protein coupled receptor 116; Ig-Hepta
                     homolog"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor F5
                     precursor"
                     /protein_id="NP_001091988.1"
                     /db_xref="CCDS:CCDS4919.1"
                     /db_xref="GeneID:221395"
                     /db_xref="HGNC:HGNC:19030"
                     /db_xref="MIM:620874"
                     /translation="MKSPRRTTLCLMFIVIYSSKAALNWNYESTIHPLSLHEHEPAGE
                     EALRQKRAVATKSPTAEEYTVNIEISFENASFLDPIKAYLNSLSFPIHGNNTDQITDI
                     LSINVTTVCRPAGNEIWCSCETGYGWPRERCLHNLICQERDVFLPGHHCSCLKELPPN
                     GPFCLLQEDVTLNMRVRLNVGFQEDLMNTSSALYRSYKTDLETAFRKGYGILPGFKGV
                     TVTGFKSGSVVVTYEVKTTPPSLELIHKANEQVVQSLNQTYKMDYNSFQAVTINESNF
                     FVTPEIIFEGDTVSLVCEKEVLSSNVSWRYEEQQLEIQNSSRFSIYTALFNNMTSVSK
                     LTIHNITPGDAGEYVCKLILDIFEYECKKKIDVMPIQILANEEMKVMCDNNPVSLNCC
                     SQGNVNWSKVEWKQEGKINIPGTPETDIDSSCSRYTLKADGTQCPSGSSGTTVIYTCE
                     FISAYGARGSANIKVTFISVANLTITPDPISVSEGQNFSIKCISDVSNYDEVYWNTSA
                     GIKIYQRFYTTRRYLDGAESVLTVKTSTREWNGTYHCIFRYKNSYSIATKDVIVHPLP
                     LKLNIMVDPLEATVSCSGSHHIKCCIEEDGDYKVTFHTGSSSLPAAKEVNKKQVCYKH
                     NFNASSVSWCSKTVDVCCHFTNAANNSVWSPSMKLNLVPGENITCQDPVIGVGEPGKV
                     IQKLCRFSNVPSSPESPIGGTITYKCVGSQWEEKRNDCISAPINSLLQMAKALIKSPS
                     QDEMLPTYLKDLSISIDKAEHEISSSPGSLGAIINILDLLSTVPTQVNSEMMTHVLST
                     VNVILGKPVLNTWKVLQQQWTNQSSQLLHSVERFSQALQSGDSPPLSFSQTNVQMSSM
                     VIKSSHPETYQQRFVFPYFDLWGNVVIDKSYLENLQSDSSIVTMAFPTLQAILAQDIQ
                     ENNFAESLVMTTTVSHNTTMPFRISMTFKNNSPSGGETKCVFWNFRLANNTGGWDSSG
                     CYVEEGDGDNVTCICDHLTSFSILMSPDSPDPSSLLGILLDIISYVGVGFSILSLAAC
                     LVVEAVVWKSVTKNRTSYMRHTCIVNIAASLLVANTWFIVVAAIQDNRYILCKTACVA
                     ATFFIHFFYLSVFFWMLTLGLMLFYRLVFILHETSRSTQKAIAFCLGYGCPLAISVIT
                     LGATQPREVYTRKNVCWLNWEDTKALLAFAIPALIIVVVNITITIVVITKILRPSIGD
                     KPCKQEKSSLFQISKSIGVLTPLLGLTWGFGLTTVFPGTNLVFHIIFAILNVFQGLFI
                     LLFGCLWDLKVQEALLNKFSLSRWSSQHSKSTSLGSSTPVFSMSSPISRRFNNLFGKT
                     GTYNVSTPEATSSSLENSSSASSLLN"
     exon            353..407
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
                     /inference="alignment:Splign:2.1.0"
     exon            408..578
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
                     /inference="alignment:Splign:2.1.0"
     exon            579..755
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
                     /inference="alignment:Splign:2.1.0"
     exon            756..862
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
                     /inference="alignment:Splign:2.1.0"
     exon            863..921
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1064
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1286
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1490
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1661
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1871
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2084
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2240
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2449
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2629
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..4024
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
                     /inference="alignment:Splign:2.1.0"
     exon            4025..4066
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
                     /inference="alignment:Splign:2.1.0"
     exon            4067..4126
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
                     /inference="alignment:Splign:2.1.0"
     exon            4127..4211
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
                     /inference="alignment:Splign:2.1.0"
     exon            4212..5761
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5668..5673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
                     /note="hexamer: TATAAA"
     polyA_site      5685
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
                     /note="major polyA site"
     regulatory      5741..5746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
                     /note="hexamer: AATAAA"
     polyA_site      5761
                     /gene="ADGRF5"
                     /gene_synonym="GPR116; KPG_001"
ORIGIN      
        1 gactctgtga gactgggagg atcatagctg ggggaggctg agcgtgggag cggtgctgcc
       61 agtcctgcct gaaaacgcga aatgagtctt gcttggttct ccctccactg ggcgtgagag
      121 cccctgccca ggaggcccag gacaaatggc cccatagtgg aaactgggaa gcttttaggc
      181 atctgatcag agcgggagcc agccggggga ccacagtgct ggacaggcca accaactcaa
      241 acttgaagac atgaaatccc caaggagaac cactttgtgc ctcatgttta ttgtgattta
      301 ttcttccaaa gctgcactga actggaatta cgagtctact attcatcctt tgagtcttca
      361 tgaacatgaa ccagctggtg aagaggcact gaggcaaaaa cgagccgttg ccacaaaaag
      421 tcctacggct gaagaataca ctgttaatat tgagatcagt tttgaaaatg catccttcct
      481 ggatcctatc aaagcctact tgaacagcct cagttttcca attcatggga ataacactga
      541 ccaaattacc gacattttga gcataaatgt gacaacagtc tgcagacctg ctggaaatga
      601 aatctggtgc tcctgcgaga caggttatgg gtggcctcgg gaaaggtgtc ttcacaatct
      661 catttgtcaa gagcgtgacg tcttcctccc agggcaccat tgcagttgcc ttaaagaact
      721 gcctcccaat ggaccttttt gcctgcttca ggaagatgtt accctgaaca tgagagtcag
      781 actaaatgta ggctttcaag aagacctcat gaacacttcc tccgccctct ataggtccta
      841 caagaccgac ttggaaacag cgttccggaa gggttacgga attttaccag gcttcaaggg
      901 cgtgactgtg acagggttca agtctggaag tgtggttgtg acatatgaag tcaagactac
      961 accaccatca cttgagttaa tacataaagc caatgaacaa gttgtacaga gcctcaatca
     1021 gacctacaaa atggactaca actcctttca agcagttact atcaatgaaa gcaatttctt
     1081 tgtcacacca gaaatcatct ttgaagggga cacagtcagt ctggtgtgtg aaaaggaagt
     1141 tttgtcctcc aatgtgtctt ggcgctatga agaacagcag ttggaaatcc agaacagcag
     1201 cagattctcg atttacaccg cacttttcaa caacatgact tcggtgtcca agctcaccat
     1261 ccacaacatc actccaggtg atgcaggtga atatgtttgc aaactgatat tagacatttt
     1321 tgaatatgag tgcaagaaga aaatagatgt tatgcccatc caaattttgg caaatgaaga
     1381 aatgaaggtg atgtgcgaca acaatcctgt atctttgaac tgctgcagtc agggtaatgt
     1441 taattggagc aaagtagaat ggaagcagga aggaaaaata aatattccag gaacccctga
     1501 gacagacata gattctagct gcagcagata caccctcaag gctgatggaa cccagtgccc
     1561 aagcgggtcg tctggaacaa cagtcatcta cacttgtgag ttcatcagtg cctatggagc
     1621 cagaggcagt gcaaacataa aagtgacatt catctctgtg gccaatctaa caataacccc
     1681 ggacccaatt tctgtttctg agggacaaaa cttttctata aaatgcatca gtgatgtgag
     1741 taactatgat gaggtttatt ggaacacttc tgctggaatt aaaatatacc aaagatttta
     1801 taccacgagg aggtatcttg atggagcaga atcagtactg acagtcaaga cctcgaccag
     1861 ggagtggaat ggaacctatc actgcatatt tagatataag aattcataca gtattgcaac
     1921 caaagacgtc attgttcacc cgctgcctct aaagctgaac atcatggttg atcctttgga
     1981 agctactgtt tcatgcagtg gttcccatca catcaagtgc tgcatagagg aggatggaga
     2041 ctacaaagtt actttccata cgggttcctc atcccttcct gctgcaaaag aagttaacaa
     2101 aaaacaagtg tgctacaaac acaatttcaa tgcaagctca gtttcctggt gttcaaaaac
     2161 tgttgatgtg tgttgtcact ttaccaatgc tgctaataat tcagtctgga gcccatctat
     2221 gaagctgaat ctggttcctg gggaaaacat cacatgccag gatcccgtaa taggtgtcgg
     2281 agagccgggg aaagtcatcc agaagctatg ccggttctca aacgttccca gcagccctga
     2341 gagtcccatt ggcgggacca tcacttacaa atgtgtaggc tcccagtggg aggagaagag
     2401 aaatgactgc atctctgccc caataaacag tctgctccag atggctaagg ctttgatcaa
     2461 gagcccctct caggatgaga tgctccctac atacctgaag gatctttcta ttagcataga
     2521 caaagcggaa catgaaatca gctcttctcc tgggagtctg ggagccatta ttaacatcct
     2581 tgatctgctc tcaacagttc caacccaagt aaattcagaa atgatgacgc acgtgctctc
     2641 tacggttaat gtcatccttg gcaagcccgt cttgaacacc tggaaggttt tacaacagca
     2701 atggaccaat cagagttcac agctactaca ttcagtggaa agattttccc aagcattaca
     2761 gtcgggagat agccctcctt tgtccttctc ccaaactaat gtgcagatga gcagcatggt
     2821 aatcaagtcc agccacccag aaacctatca acagaggttt gttttcccat actttgacct
     2881 ctggggcaat gtggtcattg acaagagcta tctagaaaac ttgcagtcgg attcgtctat
     2941 tgtcaccatg gctttcccaa ctctccaagc catccttgcc caggatatcc aggaaaataa
     3001 ctttgcagag agcttagtga tgacaaccac tgtcagccac aatacaacta tgccattcag
     3061 gatttcaatg acttttaaga acaatagccc ttcaggcggc gaaacgaagt gtgtcttctg
     3121 gaacttcagg cttgccaaca acacaggggg gtgggacagc agtgggtgct atgtagaaga
     3181 aggtgatggg gacaatgtca cctgtatctg tgaccaccta acatcattct ccatcctcat
     3241 gtcccctgac tccccagatc ctagttctct cctgggaata ctcctggata ttatttctta
     3301 tgttggggtg ggcttttcca tcttgagctt ggcagcctgt ctagttgtgg aagctgtggt
     3361 gtggaaatcg gtgaccaaga accggacttc ttatatgcgc cacacctgca tagtgaatat
     3421 cgctgcctcc cttctggtcg ccaacacctg gttcattgtg gtcgctgcca tccaggacaa
     3481 tcgctacata ctctgcaaga cagcctgtgt ggctgccacc ttcttcatcc acttcttcta
     3541 cctcagcgtc ttcttctgga tgctgacact gggcctcatg ctgttctatc gcctggtttt
     3601 cattctgcat gaaacaagca ggtccactca gaaagccatt gccttctgtc ttggctatgg
     3661 ctgcccactt gccatctcgg tcatcacgct gggagccacc cagccccggg aagtctatac
     3721 gaggaagaat gtctgttggc tcaactggga ggacaccaag gccctgctgg ctttcgccat
     3781 cccagcactg atcattgtgg tggtgaacat aaccatcact attgtggtca tcaccaagat
     3841 cctgaggcct tccattggag acaagccatg caagcaggag aagagcagcc tgtttcagat
     3901 cagcaagagc attggggtcc tcacaccact cttgggcctc acttggggtt ttggtctcac
     3961 cactgtgttc ccagggacca accttgtgtt ccatatcata tttgccatcc tcaatgtctt
     4021 ccagggatta ttcattttac tctttggatg cctctgggat ctgaaggtac aggaagcttt
     4081 gctgaataag ttttcattgt cgagatggtc ttcacagcac tcaaagtcaa catccctggg
     4141 ttcatccaca cctgtgtttt ctatgagttc tccaatatca aggagattta acaatttgtt
     4201 tggtaaaaca ggaacgtata atgtttccac cccagaagca accagctcat ccctggaaaa
     4261 ctcatccagt gcttcttcgt tgctcaacta agaacaggat aatccaacct acgtgacctc
     4321 ccggggacag tggctgtgct tttaaaaaga gatgcttgca aagcaatggg gaacgtgttc
     4381 tcggggcagg tttccgggag cagatgccaa aaagactttt tcatagagaa gaggctttct
     4441 tttgtaaaga cagaataaaa ataattgtta tgtttctgtt tgttccctcc ccctccccct
     4501 tgtgtgatac cacatgtgta tagtatttaa gtgaaactca agccctcaag gcccaacttc
     4561 tctgtctata ttgtaatata gaatttcgaa gagacatttt cactttttac acattgggca
     4621 caaagataag ctttgattaa agtagtaagt aaaaggctac ctaggaaata cttcagtgaa
     4681 ttctaagaag gaaggaagga agaaaggaag gaaagaaggg agggaaacag ggagaaaggg
     4741 aaaaagaaga aaaagagaaa gatgaaaata ggaacaaata aagacaaaca acattaaggg
     4801 ccatattgta agatttccat gttaatgatc taatataatc actcagtgca acattgagaa
     4861 ttttttttta atggctcaaa aatggaaact gaaagcaagt catggggaat gaatactttg
     4921 ggcagtatct tcctgatgtc ttcttagcta agaggaggaa aaaaaggctg aaaaaatagg
     4981 gaggaaattc cttcatcaga acgacttcaa gtggataaca atatttataa gaaatgaatg
     5041 gaaggaaata tgatcctcct gagactaact ttgtatgtta aggtttgaac taagtgaatg
     5101 tatctgcaga ggaagtatta caaagatatg tcattagatc caagtgctga ttaaattttt
     5161 atagtttatc agaaaagcct tatattttag tttgttccac attttgaaag caaaaaatat
     5221 atatttgata tacccttcaa ttgccaaatt tgatatgttg cactgaagac agaccctgtc
     5281 atatatttaa tggcttcaag caggtacttc tctgtgcatt atagaataga ttttaataat
     5341 cttatagcat tgtatattat tattgctgtt gtcactgtta ttattattgt ggatactggc
     5401 ccttggtgtg ttgcatagct ccctatgtat tctctgtttc catctttaag ttcccagacc
     5461 aatatacatt aagagttttg catggtctaa attgtgttta ttccaaccac gtggaaagct
     5521 cctggaaaga aattttacat tcggttgttc tgtgctccta atgacacttg accttgttga
     5581 acaaatggca gagcctttcc caaggatttg attgtttgtg aattatctgc atgtgtgctt
     5641 ttttttggtg tgtatttcat taaaaaatat aaatatttat gaaaattgca cgcatattag
     5701 agttaaccat gtactattga tacagcaacg ctacattgca aataaaagtc cgatcccaaa
     5761 a
//
