LOCUS       NM_153838               3128 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens adhesion G protein-coupled receptor F4 (ADGRF4),
            transcript variant 1, mRNA.
ACCESSION   NM_153838
VERSION     NM_153838.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3128)
  AUTHORS   Nishiwada,S., Shimura,T., Yamamura,K., Nakagawa,K., Nagai,M.,
            Nakamura,K., Terai,T., Yamada,S., Fujii,T., Kodera,Y., Sho,M. and
            Goel,A.
  TITLE     Clinical significance and functional role of adhesion
            G-protein-coupled receptors in human pancreatic ductal
            adenocarcinoma
  JOURNAL   Br J Cancer 128 (2), 321-330 (2023)
   PUBMED   36396823
  REMARK    GeneRIF: Clinical significance and functional role of adhesion
            G-protein-coupled receptors in human pancreatic ductal
            adenocarcinoma.
REFERENCE   2  (bases 1 to 3128)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3128)
  AUTHORS   Hamann,J., Aust,G., Arac,D., Engel,F.B., Formstone,C.,
            Fredriksson,R., Hall,R.A., Harty,B.L., Kirchhoff,C., Knapp,B.,
            Krishnan,A., Liebscher,I., Lin,H.H., Martinelli,D.C., Monk,K.R.,
            Peeters,M.C., Piao,X., Promel,S., Schoneberg,T., Schwartz,T.W.,
            Singer,K., Stacey,M., Ushkaryov,Y.A., Vallon,M., Wolfrum,U.,
            Wright,M.W., Xu,L., Langenhan,T. and Schioth,H.B.
  TITLE     International Union of Basic and Clinical Pharmacology. XCIV.
            Adhesion G protein-coupled receptors
  JOURNAL   Pharmacol Rev 67 (2), 338-367 (2015)
   PUBMED   25713288
  REMARK    Review article
REFERENCE   4  (bases 1 to 3128)
  AUTHORS   Xu,B., Roos,J.L., Dexheimer,P., Boone,B., Plummer,B., Levy,S.,
            Gogos,J.A. and Karayiorgou,M.
  TITLE     Exome sequencing supports a de novo mutational paradigm for
            schizophrenia
  JOURNAL   Nat Genet 43 (9), 864-868 (2011)
   PUBMED   21822266
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3128)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
REFERENCE   6  (bases 1 to 3128)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
REFERENCE   7  (bases 1 to 3128)
  AUTHORS   Fredriksson,R., Lagerstrom,M.C., Hoglund,P.J. and Schioth,H.B.
  TITLE     Novel human G protein-coupled receptors with long N-terminals
            containing GPS domains and Ser/Thr-rich regions
  JOURNAL   FEBS Lett 531 (3), 407-414 (2002)
   PUBMED   12435584
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DQ315370.1, AY255556.1,
            DB313938.1 and BU683873.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 5, 2019 this sequence version replaced NM_153838.4.
            
            Summary: Sequence analysis of this gene suggests that it is encodes
            a member of the superfamily of G protein-couple receptors. G
            protein-coupled receptors typically contain seven hydrophobic
            transmembrane domains, interact with guanine nucleotide binding
            regulatory proteins, and detect molecules outside the cell and act
            to transduce these signals into intracellular responses.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Dec 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ315370.1, SRR14038194.4133919.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000283303.3/ ENSP00000283303.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1853              DQ315370.1         15-1867
            1854-1854           AY255556.1         1251-1251
            1855-2560           DQ315370.1         1869-2574
            2561-2981           DB313938.1         1-421               c
            2982-3128           BU683873.1         26-172              c
FEATURES             Location/Qualifiers
     source          1..3128
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.3"
     gene            1..3128
                     /gene="ADGRF4"
                     /gene_synonym="GPR115; PGR18"
                     /note="adhesion G protein-coupled receptor F4"
                     /db_xref="GeneID:221393"
                     /db_xref="HGNC:HGNC:19011"
                     /db_xref="MIM:614268"
     exon            1..215
                     /gene="ADGRF4"
                     /gene_synonym="GPR115; PGR18"
                     /inference="alignment:Splign:2.1.0"
     exon            216..324
                     /gene="ADGRF4"
                     /gene_synonym="GPR115; PGR18"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..2319
                     /gene="ADGRF4"
                     /gene_synonym="GPR115; PGR18"
                     /note="probable G-protein coupled receptor 115; seven
                     transmembrane helix receptor; G-protein coupled receptor
                     PGR18"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor F4
                     precursor"
                     /protein_id="NP_722580.3"
                     /db_xref="CCDS:CCDS4922.2"
                     /db_xref="GeneID:221393"
                     /db_xref="HGNC:HGNC:19011"
                     /db_xref="MIM:614268"
                     /translation="MKMKSQATMICCLVFFLSTECSHYRSKIHLKAGDKLQSPEGKPK
                     TGRIQEKCEGPCISSSNCSQPCAKDFHGEIGFTCNQKKWQKSAETCTSLSVEKLFKDS
                     TGASRLSVAAPSIPLHILDFRAPETIESVAQGIRKNCPFDYACITDMVKSSETTSGNI
                     AFIVELLKNISTDLSDNVTREKMKSYSEVANHILDTAAISNWAFIPNKNASSDLLQSV
                     NLFARQLHIHNNSENIVNELFIQTKGFHINHNTSEKSLNFSMSMNNTTEDILGMVQIP
                     RQELRKLWPNASQAISIAFPTLGAILREAHLQNVSLPRQVNGLVLSVVLPERLQEIIL
                     TFEKINKTRNARAQCVGWHSKKRRWDEKACQMMLDIRNEVKCRCNYTSVVMSFSILMS
                     SKSMTDKVLDYITCIGLSVSILSLVLCLIIEATVWSRVVVTEISYMRHVCIVNIAVSL
                     LTANVWFIIGSHFNIKAQDYNMCVAVTFFSHFFYLSLFFWMLFKALLIIYGILVIFRR
                     MMKSRMMVIGFAIGYGCPLIIAVTTVAITEPEKGYMRPEACWLNWDNTKALLAFAIPA
                     FVIVAVNLIVVLVVAVNTQRPSIGSSKSQDVVIIMRISKNVAILTPLLGLTWGFGIAT
                     LIEGTSLTFHIIFALLNAFQGFFILLFGTIMDHKIRDALRMRMSSLKGKSRAAENASL
                     GPTNGSKLMNRQG"
     exon            325..379
                     /gene="ADGRF4"
                     /gene_synonym="GPR115; PGR18"
                     /inference="alignment:Splign:2.1.0"
     exon            380..531
                     /gene="ADGRF4"
                     /gene_synonym="GPR115; PGR18"
                     /inference="alignment:Splign:2.1.0"
     exon            532..783
                     /gene="ADGRF4"
                     /gene_synonym="GPR115; PGR18"
                     /inference="alignment:Splign:2.1.0"
     exon            784..2163
                     /gene="ADGRF4"
                     /gene_synonym="GPR115; PGR18"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2205
                     /gene="ADGRF4"
                     /gene_synonym="GPR115; PGR18"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2265
                     /gene="ADGRF4"
                     /gene_synonym="GPR115; PGR18"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2322
                     /gene="ADGRF4"
                     /gene_synonym="GPR115; PGR18"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..3128
                     /gene="ADGRF4"
                     /gene_synonym="GPR115; PGR18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3104..3109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRF4"
                     /gene_synonym="GPR115; PGR18"
                     /note="hexamer: CATAAA"
     polyA_site      3128
                     /gene="ADGRF4"
                     /gene_synonym="GPR115; PGR18"
                     /note="major polyA site"
ORIGIN      
        1 acagttctca gatcggcttc tcgcaacagg cagtcagttc tcactgggcc ccttggactc
       61 ccatttcaaa aatggagaag acagatcaca gccactgacc agggaccgtg ggaggtgcca
      121 cgtgatggtg aggcatcatg ctagggagct gagctctgac cttcctgctg ggtgattctc
      181 cacctctggg ctgctagatc tacttcctgg atgccgtgaa gatcctcatg tatgaaaatg
      241 aagtcccagg caaccatgat ttgctgctta gtgttctttc tgtccacaga atgttcccac
      301 tatagatcca agattcacct aaaagctgga gataaacttc aaagccctga agggaaaccc
      361 aagactggaa ggatccaaga gaaatgcgaa ggaccttgta tttcttcttc caactgcagc
      421 cagccctgtg ctaaggactt tcatggagaa ataggattta catgtaatca aaaaaagtgg
      481 caaaaatcag ctgaaacatg tacaagcctt tctgtggaaa aactctttaa ggactcaact
      541 ggtgcatctc gcctttctgt agcagcacca tctatacctc tgcatattct agactttcga
      601 gctccagaga ccattgagag tgtagctcaa ggaatccgta agaactgccc ctttgattat
      661 gcctgcatca ctgacatggt gaaatcatca gaaacaacat ctggaaatat tgcatttata
      721 gtggagttat taaaaaatat ttctacagac ttgtctgata atgttactcg agagaaaatg
      781 aagagctata gtgaagtggc caaccacatc ctcgacacag cagccatttc aaactgggct
      841 ttcattccca acaaaaatgc cagctcggat ttgttgcagt cagtgaattt gtttgccaga
      901 caactccaca tccacaataa ttctgagaac attgtgaatg aactcttcat tcagacaaaa
      961 gggtttcaca tcaaccataa tacctcagag aaaagcctca atttctccat gagcatgaac
     1021 aataccacag aagatatctt aggaatggta cagattccca ggcaagagct aaggaagctg
     1081 tggccaaatg catcccaagc cattagcata gctttcccaa ccttgggggc tatcctgaga
     1141 gaagcccact tgcaaaatgt gagtcttccc agacaggtaa atggtctggt gctatcagtg
     1201 gttttaccag aaaggttgca agaaatcata ctcaccttcg aaaagatcaa taaaacccgc
     1261 aatgccagag cccagtgtgt tggctggcac tccaagaaaa ggagatggga tgagaaagcg
     1321 tgccaaatga tgttggatat caggaacgaa gtgaaatgcc gctgtaacta caccagtgtg
     1381 gtgatgtctt tttccattct catgtcctcc aaatcgatga ccgacaaagt tctggactac
     1441 atcacctgca ttgggctcag cgtctcaatc ctaagcttgg ttctttgcct gatcattgaa
     1501 gccacagtgt ggtcccgggt ggttgtgacg gagatatcat acatgcgtca cgtgtgcatc
     1561 gtgaatatag cagtgtccct tctgactgcc aatgtgtggt ttatcatagg ctctcacttt
     1621 aacattaagg cccaggacta caacatgtgt gttgcagtga catttttcag ccactttttc
     1681 tacctctctc tgtttttctg gatgctcttc aaagcattgc tcatcattta tggaatattg
     1741 gtcattttcc gtaggatgat gaagtcccga atgatggtca ttggctttgc cattggctat
     1801 gggtgcccat tgatcattgc tgtcactaca gttgctatca cagagccaga gaaaggctac
     1861 atgagacctg aggcctgttg gcttaactgg gacaatacca aagccctttt agcatttgcc
     1921 atcccggcgt tcgtcattgt ggctgtaaat ctgattgtgg ttttggttgt tgctgtcaac
     1981 actcagaggc cctctattgg cagttccaag tctcaggatg tggtcataat tatgaggatc
     2041 agcaaaaatg ttgccatcct cactccactg ctgggactga cctggggttt tggaatagcc
     2101 actctcatag aaggcacttc cttgacgttc catataattt ttgccttgct caatgctttc
     2161 cagggttttt tcatcctgct gtttggaacc attatggatc acaagataag agatgctttg
     2221 aggatgagga tgtcttcact gaaggggaaa tcgagggcag ctgagaatgc atcactaggc
     2281 ccaaccaatg gatctaaatt aatgaatcgt caaggatgaa atgctgcccc atttctcatg
     2341 gatgtcctga gaccaagagg ggagatccag gagaaagagg ccatggaaag caggctggag
     2401 tgaggaggaa tggtcatgct tccttggaag actttctctt cttgtcagga gtgactccca
     2461 agctcttggt cggccgaaga aaaactgagg ataacatttg ctgactgggc tttaaggagc
     2521 atgatttatg gaccccttaa cctacccgtg ccctgcaaga ggctggcttc ttggtcaatc
     2581 ttgactagat taagagtcaa tctgcaagcc attttatggt ctccctggcc agctgggggc
     2641 tgtagggccc tgctgggctt ggtcgtcttt cactcctgag gcctgctctg tggctccata
     2701 gctcagtcct ccatcactct gcgtggatcc tgggtacttt ggacagtgag ggttcgatcc
     2761 aattttaggg gtagggttgg gggtgggagt gggagtgtgg gttggcagga ggaagaatga
     2821 gtctactttg gagacaatta agtcatggta cgtttcctaa agatagggaa cggaagaaaa
     2881 gcaagagaac tgtttaatat gctgattatt ttagtctatt ttagaccttg agtaaactaa
     2941 tttagcttct aggatccaag tttccttatt tgtgaaacag gaaaaaaaaa ttcttgtagg
     3001 tattactgtt tgtgtgtttg agtttactgc acatgtttgt gtttgtgtat atgtgtcttt
     3061 taaaaatact atatataaag aagattctgg ttgttatttt agacataaac gaatatatgt
     3121 acctttca
//
