LOCUS       NM_001321971            4481 bp    mRNA    linear   PRI 28-JUN-2024
DEFINITION  Homo sapiens adhesion G protein-coupled receptor F3 (ADGRF3),
            transcript variant 4, mRNA.
ACCESSION   NM_001321971
VERSION     NM_001321971.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4481)
  AUTHORS   Hamann,J., Aust,G., Arac,D., Engel,F.B., Formstone,C.,
            Fredriksson,R., Hall,R.A., Harty,B.L., Kirchhoff,C., Knapp,B.,
            Krishnan,A., Liebscher,I., Lin,H.H., Martinelli,D.C., Monk,K.R.,
            Peeters,M.C., Piao,X., Promel,S., Schoneberg,T., Schwartz,T.W.,
            Singer,K., Stacey,M., Ushkaryov,Y.A., Vallon,M., Wolfrum,U.,
            Wright,M.W., Xu,L., Langenhan,T. and Schioth,H.B.
  TITLE     International Union of Basic and Clinical Pharmacology. XCIV.
            Adhesion G protein-coupled receptors
  JOURNAL   Pharmacol Rev 67 (2), 338-367 (2015)
   PUBMED   25713288
  REMARK    Review article
REFERENCE   2  (bases 1 to 4481)
  AUTHORS   Carr,J.C., Sherman,S.K., Wang,D., Dahdaleh,F.S., Bellizzi,A.M.,
            O'Dorisio,M.S., O'Dorisio,T.M. and Howe,J.R.
  TITLE     Overexpression of membrane proteins in primary and metastatic
            gastrointestinal neuroendocrine tumors
  JOURNAL   Ann Surg Oncol 20 Suppl 3 (0 3), S739-S746 (2013)
   PUBMED   24114056
  REMARK    GeneRIF: Overexpression of GPR113 is associated with Small bowel
            primary and metastatic neuroendocrine tumors.
REFERENCE   3  (bases 1 to 4481)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
REFERENCE   4  (bases 1 to 4481)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   5  (bases 1 to 4481)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
REFERENCE   6  (bases 1 to 4481)
  AUTHORS   Fredriksson,R., Lagerstrom,M.C., Hoglund,P.J. and Schioth,H.B.
  TITLE     Novel human G protein-coupled receptors with long N-terminals
            containing GPS domains and Ser/Thr-rich regions
  JOURNAL   FEBS Lett 531 (3), 407-414 (2002)
   PUBMED   12435584
REFERENCE   7  (bases 1 to 4481)
  AUTHORS   Takeda,S., Kadowaki,S., Haga,T., Takaesu,H. and Mitaku,S.
  TITLE     Identification of G protein-coupled receptor genes from the human
            genome sequence
  JOURNAL   FEBS Lett 520 (1-3), 97-101 (2002)
   PUBMED   12044878
  REMARK    Erratum:[FEBS Lett 2002 Jul 17;523(1-3):257]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY358172.1, AK293887.1, AC010896.15 and BC043211.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001321971.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.3688509.1,
                                           SRR1803615.913.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000651242.2/ ENSP00000498434.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-880               AY358172.1         29-908
            881-1054            AK293887.1         349-522
            1055-1769           AK293887.1         550-1264
            1770-1770           AC010896.15        83770-83770         c
            1771-2643           AK293887.1         1266-2138
            2644-2644           AC010896.15        81774-81774         c
            2645-3492           AK293887.1         2140-2987
            3493-4481           BC043211.1         3027-4015
FEATURES             Location/Qualifiers
     source          1..4481
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..4481
                     /gene="ADGRF3"
                     /gene_synonym="GPR113; PGR23"
                     /note="adhesion G protein-coupled receptor F3"
                     /db_xref="GeneID:165082"
                     /db_xref="HGNC:HGNC:18989"
                     /db_xref="MIM:620873"
     exon            1..669
                     /gene="ADGRF3"
                     /gene_synonym="GPR113; PGR23"
                     /inference="alignment:Splign:2.1.0"
     CDS             556..3570
                     /gene="ADGRF3"
                     /gene_synonym="GPR113; PGR23"
                     /note="isoform 4 is encoded by transcript variant 4;
                     probable G-protein coupled receptor 113; G protein-coupled
                     receptor PGR23; seven transmembrane helix receptor; G
                     protein-coupled receptor 113"
                     /codon_start=1
                     /product="adhesion G-protein coupled receptor F3 isoform
                     4"
                     /protein_id="NP_001308900.1"
                     /db_xref="CCDS:CCDS92721.1"
                     /db_xref="GeneID:165082"
                     /db_xref="HGNC:HGNC:18989"
                     /db_xref="MIM:620873"
                     /translation="MTTRKLSAHSAATPGYKAVTHKHHTGWARMAKTGLPEKGQSQAG
                     GESGSGQLLDQENGAGESALVSVYVHLDFPDKTWPPELSRTLTLPAASASSSPRPLLT
                     GLRLTTECNVNHKGNFYCACLSGYQWNTSICLHYPPCQSLHNHQPCGCLVFSHPEPGY
                     CQLLPPVPGILNLNSQLQMPGDTLSLTLHLSQEATNLSWFLRHPGSPSPILLQPGTQV
                     SVTSSHGQAALSVSNMSHHWAGEYMSCFEAQGFKWNLYEVVRVPLKATDVARLPYQLS
                     ISCATSPGFQLSCCIPSTNLAYTAAWSPGEGSKASSFNESGSQCFVLAVQRCPMADTT
                     YACDLQSLGLAPLRVPISITIIQDGDITCPEDASVLTWNVTKAGHVAQAPCPESKRGI
                     VRRLCGADGVWGPVHSSCTDARLLALFTRTKLLQAGQGSPAEEVPQILAQLPGQAAEA
                     SSPSDLLTLLSTMKYVAKVVAEARIQLDRRALKNLLIATDKVLDMDTRSLWTLAQARK
                     PWAGSTLLLAVETLACSLCPQDHPFAFSLPNVLLQSQLFGPTFPADYSISFPTRPPLQ
                     AQIPRHSLAPLVRNGTEISITSLVLRKLDHLLPSNYGQGLGDSLYATPGLVLVISIMA
                     GDRAFSQGEVIMDFGNTDGSPHCVFWDHSLFQGRGGWSKEGCQAQVASASPTAQCLCQ
                     HLTAFSVLMSPHTVPEEPALALLTQVGLGASILALLVCLGVYWLVWRVVVRNKISYFR
                     HAALLNMVFCLLAADTCFLGAPFLSPGPRSPLCLAAAFLCHFLYLATFFWMLAQALVL
                     AHQLLFVFHQLAKHRVLPLMVLLGYLCPLGLAGVTLGLYLPQGQYLREGECWLDGKGG
                     ALYTFVGPVLAIIGVNGLVLAMAMLKLLRPSLSEGPPAEKRQALLGVIKALLILTPIF
                     GLTWGLGLATLLEEVSTVPHYIFTILNTLQGVFILLFGCLMDRKIQEALRKRFCRAQA
                     PSSTISLATNEGCILEHSKGGSDTARKTDASE"
     exon            670..736
                     /gene="ADGRF3"
                     /gene_synonym="GPR113; PGR23"
                     /inference="alignment:Splign:2.1.0"
     exon            737..880
                     /gene="ADGRF3"
                     /gene_synonym="GPR113; PGR23"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1054
                     /gene="ADGRF3"
                     /gene_synonym="GPR113; PGR23"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1273
                     /gene="ADGRF3"
                     /gene_synonym="GPR113; PGR23"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1483
                     /gene="ADGRF3"
                     /gene_synonym="GPR113; PGR23"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1627
                     /gene="ADGRF3"
                     /gene_synonym="GPR113; PGR23"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1824
                     /gene="ADGRF3"
                     /gene_synonym="GPR113; PGR23"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..2004
                     /gene="ADGRF3"
                     /gene_synonym="GPR113; PGR23"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..3387
                     /gene="ADGRF3"
                     /gene_synonym="GPR113; PGR23"
                     /inference="alignment:Splign:2.1.0"
     exon            3388..3429
                     /gene="ADGRF3"
                     /gene_synonym="GPR113; PGR23"
                     /inference="alignment:Splign:2.1.0"
     exon            3430..3492
                     /gene="ADGRF3"
                     /gene_synonym="GPR113; PGR23"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..3548
                     /gene="ADGRF3"
                     /gene_synonym="GPR113; PGR23"
                     /inference="alignment:Splign:2.1.0"
     exon            3549..4481
                     /gene="ADGRF3"
                     /gene_synonym="GPR113; PGR23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4460..4465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRF3"
                     /gene_synonym="GPR113; PGR23"
                     /note="hexamer: AATAAA"
     polyA_site      4481
                     /gene="ADGRF3"
                     /gene_synonym="GPR113; PGR23"
                     /note="major polyA site"
ORIGIN      
        1 acaagctgcc gcttaggaag tccctgccgg gagcagaagt ggagacatca gcaggatggc
       61 atcggcaagt cgctcccctc ccgggcctca tctgccaaac gatcatctcc tcctccgaag
      121 ttgtatgcat gacaggcgag tggaaacttc actaaaatga aggcgattga cacaacagaa
      181 ggaactccat cctttcgggg gcttacgaaa ataataagtt taaaaaaaat aggaagggaa
      241 ttccctcgct ccatgatcac tgagcgctct cctaaggaaa aggaaatctc ccggggggtg
      301 ccgactacgg gcggcgggct taggatgctc ccacgctccc cgacccccaa tccccaggac
      361 ccgcaggacc tccggaggaa cgcccgccag cccgcccgga gccacgcggc acaaggtgac
      421 acggaccgcg ccgcgcgggc ccctcagccg cctgggcgag gccgggagca gggagagggg
      481 catccgccgg cccgcggtac cttgtactta tcaaagccag ccagctgctc cgggctcacg
      541 tattcgtagc cagccatgac gacccgaaaa ctgagcgccc actcggcagc gactcccggc
      601 tacaaggctg tgacacacaa gcaccacacc ggctgggcaa ggatggcaaa gactgggctg
      661 cccgagaagg gacagagtca ggctggaggg gaatctggat ctgggcagct cctggaccaa
      721 gagaatggag caggggaatc agcgctggtc tccgtctatg tacatctgga ctttccagat
      781 aagacctggc cccctgaact ctccaggaca ctgactctcc ctgctgcctc agcttcctct
      841 tccccaaggc ctcttctcac tggcctcaga ctcacaacag agtgtaatgt caaccacaag
      901 gggaatttct attgtgcttg cctctctggc taccagtgga acaccagcat ctgcctccat
      961 taccctcctt gtcaaagcct ccacaaccac cagccttgtg gctgccttgt cttcagccat
     1021 cccgaacccg ggtactgcca gttgctgcca cctgtccccg ggatcctcaa cctgaactcc
     1081 cagctgcaga tgcctggtga cacgctgagc ctgactctcc atctgagcca ggaggccacc
     1141 aacctgagct ggttcctgag gcacccaggg agccccagtc ccatcctcct gcagccaggg
     1201 acacaggtgt ctgtgacttc cagccacggc caggctgccc tcagcgtctc caacatgtcc
     1261 catcactggg caggtgagta catgagctgc ttcgaggccc agggcttcaa gtggaacctg
     1321 tatgaggtgg tgagggtgcc cttgaaggcg acagatgtgg ctcgacttcc ataccagctg
     1381 tccatctcct gtgccacctc ccctggcttc cagctgagct gctgcatccc cagcacaaac
     1441 ctggcctaca ccgcggcctg gagccctgga gagggcagca aagcttcctc cttcaacgag
     1501 tcaggctctc agtgctttgt gctggctgtt cagcgctgcc cgatggctga caccacgtac
     1561 gcttgtgacc tgcagagcct gggcctggct ccactcaggg tccccatctc catcaccatc
     1621 atccaggatg gagacatcac ctgccctgag gacgcctcgg tgctcacctg gaatgtcacc
     1681 aaggctggcc acgtggcaca ggccccatgt cctgagagca agaggggcat agtgaggagg
     1741 ctctgtgggg ctgacggagt ctgggggccg gtccacagca gctgcacaga tgcgaggctc
     1801 ctggccttgt tcactagaac caagctgctg caggcaggcc agggcagtcc tgctgaggag
     1861 gtgccacaga tcctggcaca gctgccaggg caggcggcag aggcaagttc accctccgac
     1921 ttactgaccc tgctgagcac catgaaatac gtggccaagg tggtggcaga ggccagaata
     1981 cagcttgacc gcagagccct gaagaatctc ctgattgcca cagacaaggt cctagatatg
     2041 gacaccaggt ctctgtggac cctggcccaa gcccggaagc cctgggcagg ctcgactctc
     2101 ctgctggctg tggagaccct ggcatgcagc ctgtgcccac aggaccaccc cttcgccttc
     2161 agcttaccca atgtgctgct gcagagccag ctgtttggac ccacgtttcc tgctgactac
     2221 agcatctcct tccctactcg gcccccactg caggctcaga ttcccaggca ctcactggcc
     2281 ccattggtcc gtaatggaac tgaaataagt attactagcc tggtgctgcg aaaactggac
     2341 caccttctgc cctcaaacta tggacaaggg ctgggggatt ccctctatgc cactcctggc
     2401 ctggtccttg tcatttccat catggcaggt gaccgggcct tcagccaggg agaggtcatc
     2461 atggactttg ggaacacaga tggttcccct cactgtgtct tctgggatca cagtctcttc
     2521 cagggcaggg ggggttggtc caaagaaggg tgccaggcac aggtggccag tgccagcccc
     2581 actgctcagt gcctctgcca gcacctcact gccttctccg tcctcatgtc cccacacact
     2641 gttccggaag aacccgctct ggcgctgctg actcaagtgg gcttgggagc ttccatactg
     2701 gcgctgcttg tgtgcctggg tgtgtactgg ctggtgtgga gagtcgtggt gcggaacaag
     2761 atctcctatt tccgccacgc cgccctgctc aacatggtgt tctgcttgct ggccgcagac
     2821 acttgcttcc tgggcgcccc attcctctct ccagggcccc gaagcccgct ctgccttgct
     2881 gccgccttcc tctgtcattt cctctacctg gccacctttt tctggatgct ggcgcaggcc
     2941 ctggtgttgg cccaccagct gctctttgtc tttcaccagc tggcaaagca ccgagttctc
     3001 cccctcatgg tgctcctggg ctacctgtgc ccactggggt tggcaggtgt caccctgggg
     3061 ctctacctac ctcaagggca atacctgagg gagggggaat gctggttgga tgggaaggga
     3121 ggggcgttat acaccttcgt ggggccagtg ctggccatca taggcgtgaa tgggctggta
     3181 ctagccatgg ccatgctgaa gttgctgaga ccttcgctgt cagagggacc cccagcagag
     3241 aagcgccaag ctctgctggg ggtgatcaaa gccctgctca ttcttacacc catctttggc
     3301 ctcacctggg ggctgggcct ggccactctg ttagaggaag tctccacggt ccctcattac
     3361 atcttcacca ttctcaacac cctccagggc gtcttcatcc tattgtttgg ttgcctcatg
     3421 gacaggaaga tacaagaagc tttgcgcaaa cgcttctgcc gcgcccaagc ccccagctcc
     3481 accatctccc tggccacaaa tgaaggctgc atcttggaac acagcaaagg aggaagcgac
     3541 actgccagga agacagatgc ttcagagtga accacacacg gacccatgtt cctgcaaggg
     3601 agttgaggct gtgtgcttga acccaccaga tgagccctgg cccaatgctc tgaactcttc
     3661 ccgcctcccg gagctcagcc cttgagaaag gcaggcttat atttccctta gtgacactca
     3721 tttatcttac agctcacccc ttctcatttc taaagtatcc agcaagaata gcaggaaaaa
     3781 ttagctaaag gcacctaatg aataagcctg cctttgctcc agaaataatc gacagatatc
     3841 aaagtgcgga ataattacaa gtaaactttc tcaaccagtt tttaactaca acaatacatg
     3901 ttgtgaatga atatatttga taaaaatggt tttaattgac ctattcagcg atttctgatt
     3961 atttcttttt caatagttat gaagaaagga tgacttactt gacaggaacc tctgatcttt
     4021 caaacattgg agatgaaggg cagaatttgg tttgtctttt caagtttagg aaaaggtgaa
     4081 gttaattggt ccctctttct ttaaccttta aaaaatcaat ataaaatgta agtttcttaa
     4141 ccatatccat gtatagaggc attgattgat atgagcacgt tgtaagaata ggttataaaa
     4201 atttaaagtt taatataaat ttatatcaat taataaagtt taatttatat ttaaaaatga
     4261 atactagaag aaaatctttt tgaagacacc aagatatcta tctggctgaa ttaacttatg
     4321 gaattcacaa gaggaagatg acaggattct gagaaatttt taaactagat acgtgaaaaa
     4381 agtctgatga atcggtcttt gttaattatg caattcatgg atatttttta taaaatggga
     4441 cgggggcatt ttctgttaaa ataaaaatgg ttatgctatc a
//
