LOCUS       NM_153840               5432 bp    mRNA    linear   PRI 18-JUL-2022
DEFINITION  Homo sapiens adhesion G protein-coupled receptor F1 (ADGRF1),
            transcript variant 1, mRNA.
ACCESSION   NM_153840
VERSION     NM_153840.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5432)
  AUTHORS   Hidaka S, Mouri Y, Akiyama M, Miyasaka N and Nakahama KI.
  TITLE     GPR110, a receptor for synaptamide, expressed in osteoclasts
            negatively regulates osteoclastogenesis
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 182, 102457 (2022)
   PUBMED   35690003
  REMARK    GeneRIF: GPR110, a receptor for synaptamide, expressed in
            osteoclasts negatively regulates osteoclastogenesis.
REFERENCE   2  (bases 1 to 5432)
  AUTHORS   Abdulkareem NM, Bhat R, Qin L, Vasaikar S, Gopinathan A, Mitchell
            T, Shea MJ, Nanda S, Thangavel H, Zhang B, De Angelis C, Schiff R
            and Trivedi MV.
  TITLE     A novel role of ADGRF1 (GPR110) in promoting cellular quiescence
            and chemoresistance in human epidermal growth factor receptor
            2-positive breast cancer
  JOURNAL   FASEB J 35 (7), e21719 (2021)
   PUBMED   34110646
  REMARK    GeneRIF: A novel role of ADGRF1 (GPR110) in promoting cellular
            quiescence and chemoresistance in human epidermal growth factor
            receptor 2-positive breast cancer.
REFERENCE   3  (bases 1 to 5432)
  AUTHORS   Zhu X, Huang G and Jin P.
  TITLE     Clinicopathological and prognostic significance of aberrant G
            protein-couple receptor 110 (GPR110) expression in gastric cancer
  JOURNAL   Pathol Res Pract 215 (3), 539-545 (2019)
   PUBMED   30638950
  REMARK    GeneRIF: Our study revealed that high expression of GPR110 predicts
            the poor prognosis of gastric cancer patients, and GPTR110 may
            function as a potential biomarker for the diagnosis of gastric
            cancer.
REFERENCE   4  (bases 1 to 5432)
  AUTHORS   Kim HY and Spector AA.
  TITLE     N-Docosahexaenoylethanolamine: A neurotrophic and neuroprotective
            metabolite of docosahexaenoic acid
  JOURNAL   Mol Aspects Med 64, 34-44 (2018)
   PUBMED   29572109
  REMARK    GeneRIF: This signaling pathway leads to the expression of
            neurogenic and synaptogenic genes and suppresses the expression of
            proinflammatory genes. The GPR110-dependent cellular effects of
            synaptamide are recapitulated in animal models, suggesting that
            synaptamide-derived mechanisms may have translational implications.
            Review article
REFERENCE   5  (bases 1 to 5432)
  AUTHORS   Bhat RR, Yadav P, Sahay D, Bhargava DK, Creighton CJ, Yazdanfard S,
            Al-Rawi A, Yadav V, Qin L, Nanda S, Sethunath V, Fu X, De Angelis
            C, Narkar VA, Osborne CK, Schiff R and Trivedi MV.
  TITLE     GPCRs profiling and identification of GPR110 as a potential new
            target in HER2+ breast cancer
  JOURNAL   Breast Cancer Res Treat 170 (2), 279-292 (2018)
   PUBMED   29574636
  REMARK    GeneRIF: we found that GPR110 knockdown significantly reduced
            anchorage-dependent/independent cell growth as well as
            migration/invasion of parental and LTR cells and mammosphere
            formation in LTR derivatives and not in parental cells.
REFERENCE   6  (bases 1 to 5432)
  AUTHORS   Fredriksson R, Hoglund PJ, Gloriam DE, Lagerstrom MC and Schioth
            HB.
  TITLE     Seven evolutionarily conserved human rhodopsin G protein-coupled
            receptors lacking close relatives
  JOURNAL   FEBS Lett 554 (3), 381-388 (2003)
   PUBMED   14623098
REFERENCE   7  (bases 1 to 5432)
  AUTHORS   Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L,
            Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel
            G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD,
            Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker
            DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP,
            Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC,
            Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY,
            Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman
            LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M,
            Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD,
            Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ,
            Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S,
            Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL,
            Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL,
            Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson
            CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK,
            Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR,
            Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M,
            Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A,
            Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K,
            Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore
            B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM,
            Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith
            M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G,
            Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A,
            Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL,
            Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt
            JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard
            T, Sulston JE, Dunham I, Rogers J and Beck S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   8  (bases 1 to 5432)
  AUTHORS   Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT,
            Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE and
            Gaitanaris GA.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
REFERENCE   9  (bases 1 to 5432)
  AUTHORS   Fredriksson R, Lagerstrom MC, Hoglund PJ and Schioth HB.
  TITLE     Novel human G protein-coupled receptors with long N-terminals
            containing GPS domains and Ser/Thr-rich regions
  JOURNAL   FEBS Lett 531 (3), 407-414 (2002)
   PUBMED   12435584
REFERENCE   10 (bases 1 to 5432)
  AUTHORS   Takeda S, Kadowaki S, Haga T, Takaesu H and Mitaku S.
  TITLE     Identification of G protein-coupled receptor genes from the human
            genome sequence
  JOURNAL   FEBS Lett 520 (1-3), 97-101 (2002)
   PUBMED   12044878
  REMARK    Erratum:[FEBS Lett 2002 Jul 17;523(1-3):257]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK095348.1, AB045123.1, AY140952.1 and AL355518.20.
            
            On Nov 22, 2018 this sequence version replaced NM_153840.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB045123.1, DRR138512.579731.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371253.7/ ENSP00000360299.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AK095348.1         19-136
            119-2516            AB045123.1         104-2501
            2517-2517           AY140952.1         1741-1741
            2518-2918           AB045123.1         2503-2903
            2919-5432           AL355518.20        37474-39987         c
FEATURES             Location/Qualifiers
     source          1..5432
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.3"
     gene            1..5432
                     /gene="ADGRF1"
                     /gene_synonym="GPR110; hGPCR36; KPG_012; PGR19"
                     /note="adhesion G protein-coupled receptor F1"
                     /db_xref="GeneID:266977"
                     /db_xref="HGNC:HGNC:18990"
                     /db_xref="MIM:617430"
     exon            1..142
                     /gene="ADGRF1"
                     /gene_synonym="GPR110; hGPCR36; KPG_012; PGR19"
                     /inference="alignment:Splign:2.1.0"
     exon            143..254
                     /gene="ADGRF1"
                     /gene_synonym="GPR110; hGPCR36; KPG_012; PGR19"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..2918
                     /gene="ADGRF1"
                     /gene_synonym="GPR110; hGPCR36; KPG_012; PGR19"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; probable G-protein coupled receptor 110; G
                     protein-coupled receptor PGR19; seven transmembrane helix
                     receptor; G-protein coupled receptor KPG_012; G
                     protein-coupled receptor 110"
                     /codon_start=1
                     /product="adhesion G-protein coupled receptor F1 isoform 1
                     precursor"
                     /protein_id="NP_722582.2"
                     /db_xref="CCDS:CCDS34471.1"
                     /db_xref="GeneID:266977"
                     /db_xref="HGNC:HGNC:18990"
                     /db_xref="MIM:617430"
                     /translation="MKVGVLWLISFFTFTDGHGGFLGKNDGIKTKKELIVNKKKHLGP
                     VEEYQLLLQVTYRDSKEKRDLRNFLKLLKPPLLWSHGLIRIIRAKATTDCNSLNGVLQ
                     CTCEDSYTWFPPSCLDPQNCYLHTAGALPSCECHLNNLSQSVNFCERTKIWGTFKINE
                     RFTNDLLNSSSAIYSKYANGIEIQLKKAYERIQGFESVQVTQFRNGSIVAGYEVVGSS
                     SASELLSAIEHVAEKAKTALHKLFPLEDGSFRVFGKAQCNDIVFGFGSKDDEYTLPCS
                     SGYRGNITAKCESSGWQVIRETCVLSLLEELNKNFSMIVGNATEAAVSSFVQNLSVII
                     RQNPSTTVGNLASVVSILSNISSLSLASHFRVSNSTMEDVISIADNILNSASVTNWTV
                     LLREEKYASSRLLETLENISTLVPPTALPLNFSRKFIDWKGIPVNKSQLKRGYSYQIK
                     MCPQNTSIPIRGRVLIGSDQFQRSLPETIISMASLTLGNILPVSKNGNAQVNGPVIST
                     VIQNYSINEVFLFFSKIESNLSQPHCVFWDFSHLQWNDAGCHLVNETQDIVTCQCTHL
                     TSFSILMSPFVPSTIFPVVKWITYVGLGISIGSLILCLIIEALFWKQIKKSQTSHTRR
                     ICMVNIALSLLIADVWFIVGATVDTTVNPSGVCTAAVFFTHFFYLSLFFWMLMLGILL
                     AYRIILVFHHMAQHLMMAVGFCLGYGCPLIISVITIAVTQPSNTYKRKDVCWLNWSNG
                     SKPLLAFVVPALAIVAVNFVVVLLVLTKLWRPTVGERLSRDDKATIIRVGKSLLILTP
                     LLGLTWGFGIGTIVDSQNLAWHVIFALLNAFQGFFILCFGILLDSKLRQLLFNKLSAL
                     SSWKQTEKQNSSDLSAKPKFSKPFNPLQNKGHYAFSHTGDSSDNIMLTQFVSNE"
     exon            255..312
                     /gene="ADGRF1"
                     /gene_synonym="GPR110; hGPCR36; KPG_012; PGR19"
                     /inference="alignment:Splign:2.1.0"
     exon            313..462
                     /gene="ADGRF1"
                     /gene_synonym="GPR110; hGPCR36; KPG_012; PGR19"
                     /inference="alignment:Splign:2.1.0"
     exon            463..636
                     /gene="ADGRF1"
                     /gene_synonym="GPR110; hGPCR36; KPG_012; PGR19"
                     /inference="alignment:Splign:2.1.0"
     exon            637..737
                     /gene="ADGRF1"
                     /gene_synonym="GPR110; hGPCR36; KPG_012; PGR19"
                     /inference="alignment:Splign:2.1.0"
     exon            738..796
                     /gene="ADGRF1"
                     /gene_synonym="GPR110; hGPCR36; KPG_012; PGR19"
                     /inference="alignment:Splign:2.1.0"
     exon            797..948
                     /gene="ADGRF1"
                     /gene_synonym="GPR110; hGPCR36; KPG_012; PGR19"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1112
                     /gene="ADGRF1"
                     /gene_synonym="GPR110; hGPCR36; KPG_012; PGR19"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1301
                     /gene="ADGRF1"
                     /gene_synonym="GPR110; hGPCR36; KPG_012; PGR19"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..2675
                     /gene="ADGRF1"
                     /gene_synonym="GPR110; hGPCR36; KPG_012; PGR19"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2717
                     /gene="ADGRF1"
                     /gene_synonym="GPR110; hGPCR36; KPG_012; PGR19"
                     /inference="alignment:Splign:2.1.0"
     exon            2718..2777
                     /gene="ADGRF1"
                     /gene_synonym="GPR110; hGPCR36; KPG_012; PGR19"
                     /inference="alignment:Splign:2.1.0"
     exon            2778..2844
                     /gene="ADGRF1"
                     /gene_synonym="GPR110; hGPCR36; KPG_012; PGR19"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..5432
                     /gene="ADGRF1"
                     /gene_synonym="GPR110; hGPCR36; KPG_012; PGR19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3036..3041
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRF1"
                     /gene_synonym="GPR110; hGPCR36; KPG_012; PGR19"
                     /note="hexamer: AATAAA"
     polyA_site      3064
                     /gene="ADGRF1"
                     /gene_synonym="GPR110; hGPCR36; KPG_012; PGR19"
                     /note="major polyA site"
     regulatory      3087..3092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRF1"
                     /gene_synonym="GPR110; hGPCR36; KPG_012; PGR19"
                     /note="hexamer: ATTAAA"
     polyA_site      3107
                     /gene="ADGRF1"
                     /gene_synonym="GPR110; hGPCR36; KPG_012; PGR19"
     regulatory      3742..3747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRF1"
                     /gene_synonym="GPR110; hGPCR36; KPG_012; PGR19"
                     /note="hexamer: AATAAA"
     polyA_site      3761
                     /gene="ADGRF1"
                     /gene_synonym="GPR110; hGPCR36; KPG_012; PGR19"
     regulatory      5416..5421
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRF1"
                     /gene_synonym="GPR110; hGPCR36; KPG_012; PGR19"
                     /note="hexamer: AATAAT"
     polyA_site      5432
                     /gene="ADGRF1"
                     /gene_synonym="GPR110; hGPCR36; KPG_012; PGR19"
ORIGIN      
        1 agtgagcctg tgttcatgcc agtgagctgc tgtggctcag atactgatac tttctttcca
       61 aacagcataa gaagtgattg agccacaagt atactgaagg aagggctccc tcgagttctg
      121 gtgtgaagag ataaatcacc agtcacagac tatgcacccg actgctgctg ttcagtccag
      181 ggaaaatgaa agttggagtg ctgtggctca tttctttctt caccttcact gacggccacg
      241 gtggcttcct ggggaaaaat gatggcatca aaacaaaaaa agaactcatt gtgaataaga
      301 aaaaacatct aggcccagtc gaagaatatc agctgctgct tcaggtgacc tatagagatt
      361 ccaaggagaa aagagatttg agaaattttc tgaagctctt gaagcctcca ttattatggt
      421 cacatgggct aattagaatt atcagagcaa aggctaccac agactgcaac agcctgaatg
      481 gagtcctgca gtgtacctgt gaagacagct acacctggtt tcctccctca tgccttgatc
      541 cccagaactg ctaccttcac acggctggag cactcccaag ctgtgaatgt catctcaaca
      601 acctcagcca gagtgtcaat ttctgtgaga gaacaaagat ttggggcact ttcaaaatta
      661 atgaaaggtt tacaaatgac cttttgaatt catcttctgc tatatactcc aaatatgcaa
      721 atggaattga aattcaactt aaaaaagcat atgaaagaat tcaaggtttt gagtcggttc
      781 aggtcaccca atttcgaaat ggaagcatcg ttgctgggta tgaagttgtt ggctccagca
      841 gtgcatctga actgctgtca gccattgaac atgttgccga gaaggctaag acagcccttc
      901 acaagctgtt tccattagaa gacggctctt tcagagtgtt cggaaaagcc cagtgtaatg
      961 acattgtctt tggatttggg tccaaggatg atgaatatac cctgccctgc agcagtggct
     1021 acaggggaaa catcacagcc aagtgtgagt cctctgggtg gcaggtcatc agggagactt
     1081 gtgtgctctc tctgcttgaa gaactgaaca agaatttcag tatgattgta ggcaatgcca
     1141 ctgaggcagc tgtgtcatcc ttcgtgcaaa atctttctgt catcattcgg caaaacccat
     1201 caaccacagt ggggaatctg gcttcggtgg tgtcgattct gagcaatatt tcatctctgt
     1261 cactggccag ccatttcagg gtgtccaatt caacaatgga ggatgtcatc agtatagctg
     1321 acaatatcct taattcagcc tcagtaacca actggacagt cttactgcgg gaagaaaagt
     1381 atgccagctc acggttacta gagacattag aaaacatcag cactctggtg cctccgacag
     1441 ctcttcctct gaatttttct cggaaattca ttgactggaa agggattcca gtgaacaaaa
     1501 gccaactcaa aaggggttac agctatcaga ttaaaatgtg tccccaaaat acatctattc
     1561 ccatcagagg ccgtgtgtta attgggtcag accaattcca gagatccctt ccagaaacta
     1621 ttatcagcat ggcctcgttg actctgggga acattctacc cgtttccaaa aatggaaatg
     1681 ctcaggtcaa tggacctgtg atatccacgg ttattcaaaa ctattccata aatgaagttt
     1741 tcctattttt ttccaagata gagtcaaacc tgagccagcc tcattgtgtg ttttgggatt
     1801 tcagtcattt gcagtggaac gatgcaggct gccacctagt gaatgaaact caagacatcg
     1861 tgacgtgcca atgtactcac ttgacctcct tctccatatt gatgtcacct tttgtcccct
     1921 ctacaatctt ccccgttgta aaatggatca cctatgtggg actgggtatc tccattggaa
     1981 gtctcatttt atgcctgatc atcgaggctt tgttttggaa gcagattaaa aaaagccaaa
     2041 cctctcacac acgtcgtatt tgcatggtga acatagccct gtccctcttg attgctgatg
     2101 tctggtttat tgttggtgcc acagtggaca ccacggtgaa cccttctgga gtctgcacag
     2161 ctgctgtgtt ctttacacac ttcttctacc tctctttgtt cttctggatg ctcatgcttg
     2221 gcatcctgct ggcttaccgg atcatcctcg tgttccatca catggcccag catttgatga
     2281 tggctgttgg attttgcctg ggttatgggt gccctctcat tatatctgtc attaccattg
     2341 ctgtcacgca acctagcaat acctacaaaa ggaaagatgt gtgttggctt aactggtcca
     2401 atggaagcaa accactcctg gcttttgttg tccctgcact ggctattgtg gctgtgaact
     2461 tcgttgtggt gctgctagtt ctcacaaagc tctggaggcc gactgttggg gaaagactga
     2521 gtcgggatga caaggccacc atcatccgcg tggggaagag cctcctcatt ctgacccctc
     2581 tgctagggct cacctggggc tttggaatag gaacaatagt ggacagccag aatctggctt
     2641 ggcatgttat ttttgcttta ctcaatgcat tccagggatt ttttatctta tgctttggaa
     2701 tactcttgga cagtaagctg cgacaacttc tgttcaacaa gttgtctgcc ttaagttctt
     2761 ggaagcaaac agaaaagcaa aactcatcag atttatctgc caaacccaaa ttctcaaagc
     2821 ctttcaaccc actgcaaaac aaaggccatt atgcattttc tcatactgga gattcctccg
     2881 acaacatcat gctaactcag tttgtctcaa atgaataagg caaggaatca taaaatcaag
     2941 aaaaaatttc cagaacaact tgacatttag agacaaatgt caatgaagaa attatgctca
     3001 gtattcgatc gggttttctg atttaggggt ctgggaataa aacaagaatg tctcagtggc
     3061 ttcattactg ctcccttttg tcttcaatta aatgaaaaga agatttattt ccatgtgatt
     3121 tgattcaaag aaagtgctcc ataaatgcag aagagtaggt tttgttggaa atcgtgtcag
     3181 ttgtaccctg accataaaat atggtttcta ttttcataaa acagcattat tcacatggca
     3241 tttccaataa tctggattga aggaagaaaa ttttatgaaa tagctttaga taaattaata
     3301 ggccacgttc attttcttgt caaaaagtta ctggtggggg gatggtggga aaaagttatt
     3361 agtgcaaatt tcctagagaa aaaaccattt ctctttcaaa ttttccagtt gaattttatg
     3421 ttcgcttttg cttcttaggt tctatcactt aatattgaaa gttaatcaga aataaaatgt
     3481 aaacttctat ttcagatagc tttgtaacca tttatcagaa agtataataa tgtgatatga
     3541 tatataatgt ggtatttttc agtttacaag gcacttccat ctggtcctaa accctgcaaa
     3601 caaaagtgtc aaggcagacc tagtgcagag atgagggcat gggggctcag agaggtaaag
     3661 tgacttgcca aagattgtga agccagttaa gggaaattgg ggatttttag gacatttgtc
     3721 tcccagacca tttctacagc caataaaagc cttgaaaatt acctacatct ctagtaaatc
     3781 tttctgaggt cagttacaca gttcaccatt cccagaattc tatgtaagag agaaattaag
     3841 ggagaatttg gttgtcagct tccagggagg taccttaaaa catccttatt ttctttcata
     3901 atacaccata ggcactttgt ggaagttatt ttcttgtaca gccagtgcca cttttggatg
     3961 acatacaaag cagcaggagt tgacgctatg tgaagcaaca cttctcttcc atacttccat
     4021 cacatttggc tcacctacct gagtttcagc cgtgaccata gtgcccagag gaacccgagc
     4081 ctttgattca tccttgctgt tttgagaggc ctagggagtg tctcttagcc tcctgacatg
     4141 gaaagccttc atgctatgca aataaagaca gctgggggaa cttctagtta gtggtggtag
     4201 attaaataag catacctgag agaaattcaa agttagactt ccacaaggca ccaaggtgca
     4261 gcacacatga aatatgaaag tgagaggttc aaaggaaatg actgaggatc agttagatgg
     4321 ttctataccc cacaaatatg tatgagagtc aacagaattt tatgagaaag acttctttgc
     4381 agaaaactgc tctatgagcc ttctcactct acctacccac aaaagtgaga gaaggaggaa
     4441 tgtctgctcc ttgacctcaa atttagtgag agaagatttc tcagatagct cagatagctc
     4501 agatttctca gaaccacaac aattaggatg catggctgat ggaagtctga ttcttgccta
     4561 gaattgtggc cacagctccg gtagtagagc cctgaatgag ttctgtgttg agaatagcct
     4621 gtatgtctag tgtttgtcag ggcaatggat gtgtgtgttt cccatgaacc atagtgagac
     4681 atgcaagagt gaaggtcagc atggggctct tttaggtcct ctctgatagg gttgtccaaa
     4741 gaggtggagg gaacccagca tcaagaagtg ggaggtgaag ccagattgtg ggatgaggaa
     4801 ggagtcacaa atgaccacct ggaatacaaa aaaatctaca caagctaaag atgagaagtc
     4861 agggctatga gaatttctat gggagttctt gaatgctccc tctcttatta cacacaatta
     4921 ctatccagag aaccctgaca ccatgtgaag gcagccctat ctcataagac agatttcttt
     4981 ttttggggac cttggggaaa gggaggccag aaacctccgt gtccaaggtg gggtggaagg
     5041 agagggagaa atcttagcaa aaatgtcaac cagcaaggga agatgtgcta gcgcaagtag
     5101 gcaactcaac acaagactca gttggagagg gaagaaaaat ttagtactaa attattgtag
     5161 tttcttctta ttgtaggcga ctgggagtca taattaccaa actatttaaa atgaccaaaa
     5221 tgttgctctt acctgagtat gttggcatac aactggaatg tatctgatgg aagaaaaagc
     5281 ttctcccact gaataaattt tatgaggatg atgagagaca aaaaaatgtt tgatcagata
     5341 tcatgtatgt gcatgcttgt ctaattcact gattatgcat acattcacct caaaatgcta
     5401 ctaaaacaac aataaaataa tgaaaaagtg aa
//
