LOCUS       NM_032571               2349 bp    mRNA    linear   PRI 17-APR-2022
DEFINITION  Homo sapiens adhesion G protein-coupled receptor E3 (ADGRE3),
            transcript variant 1, mRNA.
ACCESSION   NM_032571
VERSION     NM_032571.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2349)
  AUTHORS   Zhou X, Lei S, Li L, Xu T, Gu W, Ma F and Yang R.
  TITLE     [Peripheral blood EMR3 gene methylation level is correlated with
            breast cancer in Chinese women]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 41 (10), 1456-1463 (2021)
   PUBMED   34755660
  REMARK    GeneRIF: [Peripheral blood EMR3 gene methylation level is
            correlated with breast cancer in Chinese women].
REFERENCE   2  (bases 1 to 2349)
  AUTHORS   Hamann J, Aust G, Arac D, Engel FB, Formstone C, Fredriksson R,
            Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I,
            Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Promel S,
            Schoneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon
            M, Wolfrum U, Wright MW, Xu L, Langenhan T and Schioth HB.
  TITLE     International Union of Basic and Clinical Pharmacology. XCIV.
            Adhesion G protein-coupled receptors
  JOURNAL   Pharmacol Rev 67 (2), 338-367 (2015)
   PUBMED   25713288
  REMARK    Review article
REFERENCE   3  (bases 1 to 2349)
  AUTHORS   Kane AJ, Sughrue ME, Rutkowski MJ, Phillips JJ and Parsa AT.
  TITLE     EMR-3: a potential mediator of invasive phenotypic variation in
            glioblastoma and novel therapeutic target
  JOURNAL   Neuroreport 21 (16), 1018-1022 (2010)
   PUBMED   20827226
  REMARK    GeneRIF: Given the poor survival associated with high levels of
            EMR-3 expression in glioma patients, impetus is provided to explore
            EMR-3 as a potential therapeutic target.
REFERENCE   4  (bases 1 to 2349)
  AUTHORS   Plager DA, Kahl JC, Asmann YW, Nilson AE, Pallanch JF, Friedman O
            and Kita H.
  TITLE     Gene transcription changes in asthmatic chronic rhinosinusitis with
            nasal polyps and comparison to those in atopic dermatitis
  JOURNAL   PLoS One 5 (7), e11450 (2010)
   PUBMED   20625511
  REMARK    GeneRIF: Additional transcription changes likely associated with
            Th2-like eosinophilic inflammation were prominent and included
            increased EMR1&3.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2349)
  AUTHORS   Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H,
            Hibberd ML and Seielstad M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 2349)
  AUTHORS   Matmati M, Pouwels W, van Bruggen R, Jansen M, Hoek RM, Verhoeven
            AJ and Hamann J.
  TITLE     The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes
  JOURNAL   J Leukoc Biol 81 (2), 440-448 (2007)
   PUBMED   17108056
  REMARK    GeneRIF: The expression of EGF-TM7 receptors on myeloid cells is
            differentially regulated. EMR3 is the first family member found
            mainly on granulocytes.
REFERENCE   7  (bases 1 to 2349)
  AUTHORS   Bjarnadottir TK, Fredriksson R, Hoglund PJ, Gloriam DE, Lagerstrom
            MC and Schioth HB.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
REFERENCE   8  (bases 1 to 2349)
  AUTHORS   Stacey M, Lin HH, Hilyard KL, Gordon S and McKnight AJ.
  TITLE     Human epidermal growth factor (EGF) module-containing mucin-like
            hormone receptor 3 is a new member of the EGF-TM7 family that
            recognizes a ligand on human macrophages and activated neutrophils
  JOURNAL   J Biol Chem 276 (22), 18863-18870 (2001)
   PUBMED   11279179
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL832663.1, BC121130.2,
            AF239764.1, BC128053.1 and AK298653.1.
            
            On May 17, 2019 this sequence version replaced NM_032571.4.
            
            Summary: This gene encodes a member of the class B seven-span
            transmembrane (TM7) receptor family expressed predominantly by
            cells of the immune system. Family members are characterized by an
            extended extracellular region with a variable number of N-terminal
            epidermal growth factor (EGF)-like domains coupled to a TM7 domain
            via a mucin-like spacer domain. This gene is closely linked to the
            gene encoding egf-like molecule containing mucin-like hormone
            receptor 2 on chromosome 19. This protein may play a role in
            myeloid-myeloid interactions during immune and inflammatory
            responses. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Jan
            2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF239764.1, AK290909.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253673.6/ ENSP00000253673.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AL832663.1         76-128
            54-452              BC121130.2         50-448
            453-1227            AF239764.1         464-1238
            1228-1301           BC128053.1         1224-1297
            1302-2227           AF239764.1         1313-2238
            2228-2349           AK298653.1         1850-1971
FEATURES             Location/Qualifiers
     source          1..2349
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..2349
                     /gene="ADGRE3"
                     /gene_synonym="EMR3"
                     /note="adhesion G protein-coupled receptor E3"
                     /db_xref="GeneID:84658"
                     /db_xref="HGNC:HGNC:23647"
                     /db_xref="MIM:606101"
     exon            1..99
                     /gene="ADGRE3"
                     /gene_synonym="EMR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..2033
                     /gene="ADGRE3"
                     /gene_synonym="EMR3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; egf-like module-containing mucin-like receptor
                     3; EGF-like module-containing mucin-like hormone
                     receptor-like 3; EGF-like module receptor 3; egf-like
                     module containing, mucin-like, hormone receptor-like 3"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor E3 isoform 1
                     precursor"
                     /protein_id="NP_115960.2"
                     /db_xref="CCDS:CCDS12315.1"
                     /db_xref="GeneID:84658"
                     /db_xref="HGNC:HGNC:23647"
                     /db_xref="MIM:606101"
                     /translation="MQGPLLLPGLCFLLSLFGAVTQKTKTSCAKCPPNASCVNNTHCT
                     CNHGYTSGSGQKLFTFPLETCNDINECTPPYSVYCGFNAVCYNVEGSFYCQCVPGYRL
                     HSGNEQFSNSNENTCQDTTSSKTTEGRKELQKIVDKFESLLTNQTLWRTEGRQEISST
                     ATTILRDVESKVLETALKDPEQKVLKIQNDSVAIETQAITDNCSEERKTFNLNVQMNS
                     MDIRCSDIIQGDTQGPSAIAFISYSSLGNIINATFFEEMDKKDQVYLNSQVVSAAIGP
                     KRNVSLSKSVTLTFQHVKMTPSTKKVFCVYWKSTGQGSQWSRDGCFLIHVNKSHTMCN
                     CSHLSSFAVLMALTSQEEDPVLTVITYVGLSVSLLCLLLAALTFLLCKAIRNTSTSLH
                     LQLSLCLFLAHLLFLVGIDRTEPKVLCSIIAGALHYLYLAAFTWMLLEGVHLFLTARN
                     LTVVNYSSINRLMKWIMFPVGYGVPAVTVAISAASWPHLYGTADRCWLHLDQGFMWSF
                     LGPVCAIFSANLVLFILVFWILKRKLSSLNSEVSTIQNTRMLAFKATAQLFILGCTWC
                     LGLLQVGPAAQVMAYLFTIINSLQGFFIFLVYCLLSQQVQKQYQKWFREIVKSKSESE
                     TYTLSSKMGPDSKPSEGDVFPGQVKRKY"
     exon            100..150
                     /gene="ADGRE3"
                     /gene_synonym="EMR3"
                     /inference="alignment:Splign:2.1.0"
     exon            151..273
                     /gene="ADGRE3"
                     /gene_synonym="EMR3"
                     /inference="alignment:Splign:2.1.0"
     exon            274..429
                     /gene="ADGRE3"
                     /gene_synonym="EMR3"
                     /inference="alignment:Splign:2.1.0"
     exon            430..467
                     /gene="ADGRE3"
                     /gene_synonym="EMR3"
                     /inference="alignment:Splign:2.1.0"
     exon            468..651
                     /gene="ADGRE3"
                     /gene_synonym="EMR3"
                     /inference="alignment:Splign:2.1.0"
     exon            652..771
                     /gene="ADGRE3"
                     /gene_synonym="EMR3"
                     /inference="alignment:Splign:2.1.0"
     exon            772..956
                     /gene="ADGRE3"
                     /gene_synonym="EMR3"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1124
                     /gene="ADGRE3"
                     /gene_synonym="EMR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1322
                     /gene="ADGRE3"
                     /gene_synonym="EMR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1558
                     /gene="ADGRE3"
                     /gene_synonym="EMR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1625
                     /gene="ADGRE3"
                     /gene_synonym="EMR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1717
                     /gene="ADGRE3"
                     /gene_synonym="EMR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1886
                     /gene="ADGRE3"
                     /gene_synonym="EMR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..1994
                     /gene="ADGRE3"
                     /gene_synonym="EMR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2349
                     /gene="ADGRE3"
                     /gene_synonym="EMR3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggaaaggtg gttggcttac ggcacagtag agagcttcca gggctggctg gcgtgggata
       61 cccgtaccac agaaatgcag ggaccattgc ttcttccagg cctctgcttt ctgctgagcc
      121 tctttggagc tgtgactcag aaaaccaaaa cttcctgtgc taagtgcccc ccaaatgctt
      181 cctgtgtcaa taacactcac tgcacctgca accatggata tacttctgga tctgggcaga
      241 aactattcac attccccttg gagacatgta acgacattaa tgaatgtaca ccaccctata
      301 gtgtatattg tggatttaac gctgtgtgtt acaatgtcga aggaagtttc tactgtcaat
      361 gtgtcccagg atatagactg cattctggga atgaacaatt cagtaattcc aatgagaaca
      421 cctgtcagga caccacctcc tcaaagacaa ccgagggcag gaaagagctg caaaagattg
      481 tggacaaatt tgagtcactt ctcaccaatc agactttatg gagaacagaa gggagacaag
      541 aaatctcatc cacagctacc actattctcc gggatgtgga atcgaaagtt ctagaaactg
      601 ccttgaaaga tccagaacaa aaagtcctga aaatccaaaa cgatagtgta gctattgaaa
      661 ctcaagcgat tacagacaat tgctctgaag aaagaaagac attcaacttg aacgtccaaa
      721 tgaactcaat ggacatccgt tgcagtgaca tcatccaggg agacacacaa ggtcccagtg
      781 ccattgcctt tatctcatat tcttctcttg gaaacatcat aaatgcaact ttttttgaag
      841 agatggataa gaaagatcaa gtgtatctga actctcaggt tgtgagtgct gctattggac
      901 ccaaaaggaa cgtgtctctc tccaagtctg tgacgctgac tttccagcac gtgaagatga
      961 cccccagtac caaaaaggtc ttctgtgtct actggaagag cacagggcag ggcagccagt
     1021 ggtccaggga tggctgcttc ctgatacacg tgaacaagag tcacaccatg tgtaattgca
     1081 gtcacctgtc cagcttcgct gtcctgatgg ccctgaccag ccaggaggag gatcccgtgc
     1141 tgactgtcat cacctacgtg gggctgagcg tctctctgct gtgcctcctc ctggcggccc
     1201 tcacttttct cctgtgtaaa gccatccgga acaccagcac ctcactgcat ctgcagctct
     1261 cgctctgcct cttcctggcc cacctcctct tcctcgtggg gattgatcga actgaaccca
     1321 aggtgctgtg ctccatcatc gccggtgctt tgcactatct ctacctggcc gccttcacct
     1381 ggatgctgct ggagggtgtg cacctcttcc tcactgcacg gaacctgaca gtggtcaact
     1441 actcaagcat caatagactc atgaagtgga tcatgttccc agtcggctat ggcgttcccg
     1501 ctgtgactgt ggccatttct gcagcctcct ggcctcacct ttatggaact gctgatcgat
     1561 gctggctcca cctggaccag ggattcatgt ggagtttcct tggcccagtc tgtgccattt
     1621 tctctgcgaa tttagtattg tttatcttgg tcttttggat tttgaaaaga aaactttcct
     1681 ccctcaatag tgaagtgtca accatccaga acacaaggat gctggctttc aaagcaacag
     1741 ctcagctctt catcctgggc tgcacatggt gtctgggctt gctacaggtg ggtccagctg
     1801 cccaggtcat ggcctacctc ttcaccatca tcaacagcct ccaaggcttc ttcatcttct
     1861 tggtctactg cctcctcagc cagcaggtcc agaaacaata tcaaaagtgg tttagagaga
     1921 tcgtaaaatc aaaatctgag tctgagacat acacactttc cagcaagatg ggtcctgact
     1981 caaaacccag tgagggggat gtttttccag gacaagtgaa gagaaaatat taaaactaga
     2041 atattcaact ccatatggaa aatcatatcc atggatctct ttggcattat gaagaatgaa
     2101 gctaaggaaa agggaattca ttaaacatat catccttgga gaggaagtaa tcaaccttta
     2161 cttcccaagc tgtttgttct ccacaatagg ctctcaacaa atgtgtggta aattgcattt
     2221 ctcttcacta tggtgtattc agtcaatgct tgtccctgga aacccaaagc atgaccactg
     2281 caaatatttc cttgactttt tgtaaatgaa gaggtccttt tcctcaagtt cttagtccca
     2341 ctcatccta
//
