LOCUS       NM_152917               6122 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens adhesion G protein-coupled receptor E2 (ADGRE2),
            transcript variant 3, mRNA.
ACCESSION   NM_152917 XM_047438726
VERSION     NM_152917.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6122)
  AUTHORS   Huang,D., Yu,Z., Lu,H., Jiang,P., Qian,X., Han,Y. and Qian,P.
  TITLE     Adhesion GPCR ADGRE2 Maintains Proteostasis to Promote Progression
            in Acute Myeloid Leukemia
  JOURNAL   Cancer Res 84 (13), 2090-2108 (2024)
   PUBMED   39082681
  REMARK    GeneRIF: Adhesion GPCR ADGRE2 Maintains Proteostasis to Promote
            Progression in Acute Myeloid Leukemia.
REFERENCE   2  (bases 1 to 6122)
  AUTHORS   Zheng,L., Rang,M., Fuchs,C., Kess,A., Wunsch,M., Hentschel,J.,
            Hsiao,C.C., Kleber,C., Osterhoff,G. and Aust,G.
  TITLE     The Posttraumatic Increase of the Adhesion GPCR EMR2/ADGRE2 on
            Circulating Neutrophils Is Not Related to Injury Severity
  JOURNAL   Cells 12 (22), 2657 (2023)
   PUBMED   37998392
  REMARK    GeneRIF: The Posttraumatic Increase in the Adhesion of GPCR
            EMR2/ADGRE2 to Circulating Neutrophils Is Not Related to Injury
            Severity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6122)
  AUTHORS   Beliu,G., Altrichter,S., Guixa-Gonzalez,R., Hemberger,M.,
            Brauer,I., Dahse,A.K., Scholz,N., Wieduwild,R., Kuhlemann,A.,
            Batebi,H., Seufert,F., Perez-Hernandez,G., Hildebrand,P.W.,
            Sauer,M. and Langenhan,T.
  TITLE     Tethered agonist exposure in intact adhesion/class B2 GPCRs through
            intrinsic structural flexibility of the GAIN domain
  JOURNAL   Mol Cell 81 (5), 905-921 (2021)
   PUBMED   33497605
  REMARK    GeneRIF: Tethered agonist exposure in intact adhesion/class B2
            GPCRs through intrinsic structural flexibility of the GAIN domain.
REFERENCE   4  (bases 1 to 6122)
  AUTHORS   Chiu,P.L., Ng,B.H., Chang,G.W., Gordon,S. and Lin,H.H.
  TITLE     Putative alternative trans-splicing of leukocyte adhesion-GPCR
            pre-mRNAs generates functional chimeric receptors
  JOURNAL   FEBS Lett 582 (5), 792-798 (2008)
   PUBMED   18267122
  REMARK    GeneRIF: EGF-TM7 pre-mRNAs also undergo the rare trans-splicing,
            leading to the generation of functional chimeric receptors.
REFERENCE   5  (bases 1 to 6122)
  AUTHORS   Bjarnadottir,T.K., Geirardsdottir,K., Ingemansson,M., Mirza,M.A.,
            Fredriksson,R. and Schioth,H.B.
  TITLE     Identification of novel splice variants of Adhesion G
            protein-coupled receptors
  JOURNAL   Gene 387 (1-2), 38-48 (2007)
   PUBMED   17056209
REFERENCE   6  (bases 1 to 6122)
  AUTHORS   Aust,G., Hamann,J., Schilling,N. and Wobus,M.
  TITLE     Detection of alternatively spliced EMR2 mRNAs in colorectal tumor
            cell lines but rare expression of the molecule in colorectal
            adenocarcinomas
  JOURNAL   Virchows Arch 443 (1), 32-37 (2003)
   PUBMED   12761622
REFERENCE   7  (bases 1 to 6122)
  AUTHORS   Aust,G., Steinert,M., Schutz,A., Boltze,C., Wahlbuhl,M., Hamann,J.
            and Wobus,M.
  TITLE     CD97, but not its closely related EGF-TM7 family member EMR2, is
            expressed on gastric, pancreatic, and esophageal carcinomas
  JOURNAL   Am J Clin Pathol 118 (5), 699-707 (2002)
   PUBMED   12428789
REFERENCE   8  (bases 1 to 6122)
  AUTHORS   Kwakkenbos,M.J., Chang,G.W., Lin,H.H., Pouwels,W., de Jong,E.C.,
            van Lier,R.A., Gordon,S. and Hamann,J.
  TITLE     The human EGF-TM7 family member EMR2 is a heterodimeric receptor
            expressed on myeloid cells
  JOURNAL   J Leukoc Biol 71 (5), 854-862 (2002)
   PUBMED   11994511
REFERENCE   9  (bases 1 to 6122)
  AUTHORS   Lin,H.H., Stacey,M., Saxby,C., Knott,V., Chaudhry,Y., Evans,D.,
            Gordon,S., McKnight,A.J., Handford,P. and Lea,S.
  TITLE     Molecular analysis of the epidermal growth factor-like short
            consensus repeat domain-mediated protein-protein interactions:
            dissection of the CD97-CD55 complex
  JOURNAL   J Biol Chem 276 (26), 24160-24169 (2001)
   PUBMED   11297558
REFERENCE   10 (bases 1 to 6122)
  AUTHORS   Lin,H.H., Stacey,M., Hamann,J., Gordon,S. and McKnight,A.J.
  TITLE     Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is
            closely related to CD97
  JOURNAL   Genomics 67 (2), 188-200 (2000)
   PUBMED   10903844
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005327.1 and AC090427.2.
            
            On or before Jul 29, 2022 this sequence version replaced
            XM_047438726.1, NM_152917.1.
            
            Summary: This gene encodes a member of the class B seven-span
            transmembrane (TM7) subfamily of G-protein coupled receptors. These
            proteins are characterized by an extended extracellular region with
            a variable number of N-terminal epidermal growth factor-like
            domains coupled to a TM7 domain via a mucin-like spacer domain. The
            encoded protein is expressed mainly in myeloid cells where it
            promotes cell-cell adhesion through interaction with chondroitin
            sulfate chains. This gene is situated in a cluster of related genes
            on chromosome 19. Alternatively spliced transcript variants
            encoding multiple isoforms have been observed for this gene.
            [provided by RefSeq, Aug 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.2674539.1,
                                           SRR11853567.15259.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AC005327.1         24565-24680         c
            117-167             AC005327.1         22095-22145         c
            168-284             AC005327.1         21777-21893         c
            285-440             AC005327.1         20181-20336         c
            441-587             AC005327.1         13497-13643         c
            588-634             AC005327.1         13363-13409         c
            635-712             AC005327.1         13159-13236         c
            713-890             AC005327.1         12272-12449         c
            891-998             AC090427.2         106206-106313       c
            999-1222            AC090427.2         105622-105845       c
            1223-1396           AC090427.2         104922-105095       c
            1397-1594           AC090427.2         102297-102494       c
            1595-1830           AC090427.2         101404-101639       c
            1831-1897           AC090427.2         96864-96930         c
            1898-1989           AC090427.2         96200-96291         c
            1990-2158           AC090427.2         93584-93752         c
            2159-2269           AC090427.2         93388-93498         c
            2270-6122           AC090427.2         82360-86212         c
FEATURES             Location/Qualifiers
     source          1..6122
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..6122
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /note="adhesion G protein-coupled receptor E2"
                     /db_xref="GeneID:30817"
                     /db_xref="HGNC:HGNC:3337"
                     /db_xref="MIM:606100"
     exon            1..116
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..2278
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /note="isoform c precursor is encoded by transcript
                     variant 3; EGF-like module-containing mucin-like hormone
                     receptor-like 2; egf-like module containing, mucin-like,
                     hormone receptor-like 2; CD97 antigen; Leukocyte antigen
                     CD97"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor E2 isoform c
                     precursor"
                     /protein_id="NP_690881.1"
                     /db_xref="CCDS:CCDS32933.1"
                     /db_xref="GeneID:30817"
                     /db_xref="HGNC:HGNC:3337"
                     /db_xref="MIM:606100"
                     /translation="MGGRVFLVFLAFCVWLTLPGAETQDSRGCARWCPQDSSCVNATA
                     CRCNPGFSSFSEIITTPMETCDDINECATLSKVSCGKFSDCWNTEGSYDCVCSPGYEP
                     VSGAKTFKNESENTCQDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNN
                     QKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDYKPGLANNTIQSILQALDEL
                     LEAPGDLETLPRLQQHCVASHLLDGLEDVLRGLSKNLSNGLLNFSYPAGTELSLEVQK
                     QVDRSVTLRQNQAVMQLDWNQAQKSGDPGPSVVGLVSIPGMGKLLAEAPLVLEPEKQM
                     LLHETHQGLLQDGSPILLSDVISAFLSNNDTQNLSSPVTFTFSHRSVIPRQKVLCVFW
                     EHGQNGCGHWATTGCSTIGTRDTSTICRCTHLSSFAVLMAHYDVQEEDPVLTVITYMG
                     LSVSLLCLLLAALTFLLCKAIQNTSTSLHLQLSLCLFLAHLLFLVAIDQTGHKVLCSI
                     IAGTLHYLYLATLTWMLLEALYLFLTARNLTVVNYSSINRFMKKLMFPVGYGVPAVTV
                     AISAASRPHLYGTPSRCWLQPEKGFIWGFLGPVCAIFSVNLVLFLVTLWILKNRLSSL
                     NSEVSTLRNTRMLAFKATAQLFILGCTWCLGILQVGPAARVMAYLFTIINSLQGVFIF
                     LVYCLLSQQVREQYGKWSKGIRKLKTESEMHTLSSSAKADTSKPSTVN"
     exon            117..167
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            168..284
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            285..440
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            441..587
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            588..634
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            635..712
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            713..890
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            891..998
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1222
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1396
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1594
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1830
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1897
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..1989
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2158
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2269
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..6122
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5698..5703
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /note="hexamer: AATAAA"
     polyA_site      5720
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
     regulatory      5789..5794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /note="hexamer: AATAAA"
     polyA_site      5810
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /note="major polyA site"
     regulatory      6100..6105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /note="hexamer: AATAAA"
     polyA_site      6122
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
ORIGIN      
        1 acagctgccc agcctgcgga gacgggacag ccctgtccca ctcactcttt cccctgctgc
       61 tcctgccggc agctcagctg gaaccatggg aggccgcgtc tttctcgtct ttctcgcatt
      121 ctgtgtctgg ctgactctgc cgggagctga aacccaggac tccaggggct gtgcccggtg
      181 gtgccctcag gactcctcgt gtgtcaatgc caccgcctgt cgctgcaatc cagggttcag
      241 ctctttttct gagatcatca ccacccccat ggagacttgt gacgacatca acgagtgtgc
      301 aacactgtcg aaagtgtcat gcggaaaatt ctcggactgc tggaacacag aggggagcta
      361 cgactgcgtg tgcagcccag gatatgagcc tgtttctggg gcaaaaacat tcaagaatga
      421 gagcgagaac acgtgtcaag atgtggacga gtgcagctcc gggcagcatc agtgtgacag
      481 ctccaccgtc tgcttcaaca ccgtgggttc atacagctgc cgctgccgcc caggctggaa
      541 gcccagacac ggaatcccga ataaccaaaa ggacactgtc tgtgaagata tgactttctc
      601 cacctggacc ccgccccctg gagtccacag ccagacgctt tcccgattct tcgacaaagt
      661 ccaggacctg ggcagagact acaagccagg cttggccaat aacaccatcc agagcatctt
      721 acaggcgctg gatgagctgc tggaggcccc tggggacctg gagaccctgc cccgcttaca
      781 gcagcactgt gtggccagtc acctgctgga tggcctagag gatgtcctca gaggcctgag
      841 caagaacctt tccaatgggc tgttgaactt cagttatcct gcaggcacag aattgtccct
      901 ggaggtgcag aagcaagtag acaggagtgt caccttgaga cagaatcagg cagtgatgca
      961 gctcgactgg aatcaggcac agaaatctgg tgacccaggc ccttctgtgg tgggccttgt
     1021 ctccattcca gggatgggca agttgctggc tgaggcccct ctggtcctgg aacctgagaa
     1081 gcagatgctt ctgcatgaga cacaccaggg cttgctgcag gacggctccc ccatcctgct
     1141 ctcagatgtg atctctgcct ttctgagcaa caacgacacc caaaacctca gctccccagt
     1201 taccttcacc ttctcccacc gttcagtgat cccgagacag aaggtgctct gtgtcttctg
     1261 ggagcatggc cagaatggat gtggtcactg ggccaccaca ggctgcagca caataggcac
     1321 cagagacacc agcaccatct gccgttgcac ccacctgagc agctttgccg tcctcatggc
     1381 ccactacgat gtgcaggagg aggatcccgt gctgactgtc atcacctaca tggggctgag
     1441 cgtctctctg ctgtgcctcc tcctggcggc cctcactttt ctcctgtgta aagccatcca
     1501 gaacaccagc acctcactgc atctgcagct ctcgctctgc ctcttcctgg cccacctcct
     1561 cttcctcgtg gcaattgatc aaaccggaca caaggtgctg tgctccatca tcgccggtac
     1621 cttgcactat ctctacctgg ccaccttgac ctggatgctg ctggaggccc tgtacctctt
     1681 cctcactgca cggaacctga cggtggtcaa ctactcaagc atcaacagat tcatgaagaa
     1741 gctcatgttc cctgtgggct acggagtccc agctgtgaca gtggccattt ctgcagcctc
     1801 caggcctcac ctttatggaa caccttcccg ctgctggctc caaccagaaa agggatttat
     1861 atggggcttc cttggacctg tctgcgccat cttctctgtg aatttagttc tctttctggt
     1921 gactctctgg attttgaaaa acagactctc ctccctcaat agtgaagtgt ccaccctccg
     1981 gaacacaagg atgctggcat ttaaagcgac agctcagctg ttcatcctgg gctgcacgtg
     2041 gtgtctgggc atcttgcagg tgggtccggc tgcccgggtc atggcctacc tcttcaccat
     2101 catcaacagc ctgcagggtg tcttcatctt cctggtgtac tgcctcctca gccagcaggt
     2161 ccgggagcaa tatgggaaat ggtccaaagg gatcaggaaa ttgaaaactg agtctgagat
     2221 gcacacactc tccagcagtg ctaaggctga cacctccaaa cccagcacgg ttaactagaa
     2281 aaatcttctg aataagatct tccctctttg cccgtggaaa atctgaacaa tctttgagcc
     2341 atctagaggg gaaagaaaag actttgttct gtgtgtttca agaaattcac catgtcagca
     2401 atatgaagga tgttatggaa ggcgtgctag gcattcaatt cctgcagaaa ccggaaatct
     2461 tccatgccct gcaatgtgct catcaaactc tcagcatatg gacggccagc tgtggcccat
     2521 atcttggtca ctctgaagca caatatttat gaagctatag aacgttaaga cctctttcac
     2581 agcctctcct tcctacaaag actcctccaa atcttaaaat gaagcaggaa aacgagccta
     2641 agaggacttt cataccgaca acatctgaaa ggactagaat gttcacacca cgatctggat
     2701 ttcttaattt tttgtttttg tttttgttgt tctctagttc tacgggtttg attatttagt
     2761 catgtgaaaa atattgatta ctcacacata gatcaagaga gacacggctc ctgccttcat
     2821 ggagctttta ggggaaaatg aagtggctct tgcagctaga gttgactcag aagccgaaat
     2881 tcctagaaat caggtttcta ctgctaggca attgaagtat aaactatttt ataaacactg
     2941 tcttctttcg tcttcacacc aacatgcaga aaagtttcta atctcagatc ggggatgtgc
     3001 aacaaattcc atttcaaagg aatgacctgc aaaactccta aatattccaa gcaaatgccc
     3061 ttaaccctgt ctgttatctg ctttccttga acagaaattc tacatgacca taaaacctcg
     3121 aagatgggta tggcacagtt catgccctgt aatcctagca ctttgggagg gtgaggcagg
     3181 aggatggctc aagcccagga gtttgagacc agtgtgggca acagagtgag aaccatctct
     3241 acccaaaaaa aaaattaaaa attagccaag catggtgatg atataggagt taaggagaaa
     3301 tcatttaggc aaatagcaag ggtaggaagt cctcagtaag gttttccatt taatgaaaag
     3361 cagcccccaa aatcattttc ttttctaaca aagaacagcc tgtaaaatcg agctgcagac
     3421 atagacaagc aagctggaag cttccacggg tgaatgccgg cagctgtgcc aataggaaaa
     3481 agctacctag actaggcatg tccaaaatgg cggctccaag ttcccttctc tttgccagcc
     3541 atgtgtacag taaaaagcag gcaacatagt gtcagccaaa gctcatttgc ataataagat
     3601 tagggtgggg tggccagctc acataggggt aggccctagg taaatcagac accgccttct
     3661 caagcctgtc tataaaatct ggtacactat gacgagggtc agatttccca ttcagacgcc
     3721 cctctcccat gcaagagaaa gagctgttct cctttctctt tcttttgcct attaaacctc
     3781 tgctcctggc caggcacagt ggctcacgcc tataatccca gcactttggg aggctgaggt
     3841 ggtcagatca cctaaggtca ggagttcaag accagcctgg tcaacatggt gaaatcttgt
     3901 ctctagtaaa aatacaaaaa tatatgaaat ctcacataga tgataatatt aagttccaaa
     3961 agcaactcaa cctggtagat tctaattttt tttgaggcag ggtcttgctt tgtcacccat
     4021 gctggagtac aatggcacaa acactgctca ctgcagcctc gacctcccaa ggcctaagca
     4081 atcctcctgc ctcagtcccc ctccaggtat ttgaaactac aggtgtgtac caccacaccg
     4141 ggctaatttt tgtatttttt gtagagacgt gggtctcact atgctgccca ggctcaggtc
     4201 ttaatctcct gagctcaggc aatccgcagg cctcagcctc cctaagtgcg gggattacag
     4261 gcttgagcca ctgcacctag cctctatttg ttttacaaaa gagaaattga gatcctgaat
     4321 gttaagtgac ttgcctgagg ccatcccact aacaggagcc agggttagga ttcaaacccc
     4381 atccaactgg tcccagagct ggagcttctt gcactgccct acactaccta ccatctccat
     4441 cctctgggca cctttttata agaaccaaaa cattacagag cattgctttg tcaactcagc
     4501 tgggaacatt tcccagtgca actcacattt ttcactgctc tgtgcctgtc cgtataagct
     4561 caatgagtat tgatttaggg gctttggaga actttgaatg ctacccccca agtaaccatt
     4621 gttggcaacc tggtacctct acttttagcc atttctcctt ctctataaat agtgcagaag
     4681 taacccactt ggtaacaggc atccttgcca agcctccacc actaggtcag tgtaagaatt
     4741 aaagaaagag gaaagaaaca caaaaagtgg cttgatggtt aagacaggtt tattttagag
     4801 aaaacacacc tgagaggggc tgctggctga attaggttag agtcttttct acagactaag
     4861 agtgtttaag gatttagggt gggagagttt cttagaggct tggactgctt ctgtgttttt
     4921 tttgttgtgc ttatatggga gggagagtgg tgtgtttgct tttatacatt tttctgcagc
     4981 tgtaggcata ccccccaagt ctgcttttag cttccctatt ttagtgcacc tggagggaaa
     5041 ggaatgtgct tattaaggcc cactgtttta ctggggccca ttgtatgagg gtgaagtttg
     5101 gcagttaccc aagagacttt tcctccacct tcctctgtgc ccgagctgtt ttatctgcat
     5161 tttactgtct gctttttttg gctgcttata gtttttaaaa aagtaatttc cttaaatcca
     5221 gaaggctaaa aatgaagctg aaacttaaag tggcggtgtt tgtccaaaat aacggggctc
     5281 ctgctctgcc agtcagtacc ctcaagtcac tcctgatcct caacctccat gcctaaggct
     5341 ggttcaagag accacataat atctgccttt tattacatac atgatgggtg catgggattc
     5401 tgcgtgccct ttgcttgata tagactgcta aggtgagatg gggaatatca gagtcagctg
     5461 ctgcttgagg aagcagaaca cacagctgga ggcttggaac atgtgggtcc ctatgagtgt
     5521 agagcccata tccccataga gtctacctag agcaggggtc gccaaatgtt ttcttaaaga
     5581 gcctgatagt gtatatgtta ggctttgtga gccaggtatt tacagcaact caattctacc
     5641 actgtggtat gaaaacagct atagacaatc ataaatgaat gatcatggct atgttttaat
     5701 aaaactttac agacactgaa cttgaacttc cattgtgata tgaaaacagc tatagacaat
     5761 cataaatgaa tgatcatggc tatgttttaa taaaacttta tggacactga gcttgaactt
     5821 catatatcag tcatgtgaca caaaatatca ttcttctttt tatttgtttt cacccatttg
     5881 aaaaatgtaa aaactattct tagctgtaca gaaacagatg gtgggtcaga tttgactcac
     5941 tgcccatagt ttccagacca tgatgttcag gttcatggaa gcacttcact ctacactaat
     6001 ttattcatcc attcatcaca tatgtgatga gcacatacag acacacctca gagatattgc
     6061 aggctccact ccagatcacc acaataatgt gaatattgca ataaagcaag tcatacacat
     6121 tt
//
