LOCUS       NM_001271052            6024 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens adhesion G protein-coupled receptor E2 (ADGRE2),
            transcript variant 8, mRNA.
ACCESSION   NM_001271052
VERSION     NM_001271052.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6024)
  AUTHORS   Huang,D., Yu,Z., Lu,H., Jiang,P., Qian,X., Han,Y. and Qian,P.
  TITLE     Adhesion GPCR ADGRE2 Maintains Proteostasis to Promote Progression
            in Acute Myeloid Leukemia
  JOURNAL   Cancer Res 84 (13), 2090-2108 (2024)
   PUBMED   39082681
  REMARK    GeneRIF: Adhesion GPCR ADGRE2 Maintains Proteostasis to Promote
            Progression in Acute Myeloid Leukemia.
REFERENCE   2  (bases 1 to 6024)
  AUTHORS   Zheng,L., Rang,M., Fuchs,C., Kess,A., Wunsch,M., Hentschel,J.,
            Hsiao,C.C., Kleber,C., Osterhoff,G. and Aust,G.
  TITLE     The Posttraumatic Increase of the Adhesion GPCR EMR2/ADGRE2 on
            Circulating Neutrophils Is Not Related to Injury Severity
  JOURNAL   Cells 12 (22), 2657 (2023)
   PUBMED   37998392
  REMARK    GeneRIF: The Posttraumatic Increase in the Adhesion of GPCR
            EMR2/ADGRE2 to Circulating Neutrophils Is Not Related to Injury
            Severity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6024)
  AUTHORS   Beliu,G., Altrichter,S., Guixa-Gonzalez,R., Hemberger,M.,
            Brauer,I., Dahse,A.K., Scholz,N., Wieduwild,R., Kuhlemann,A.,
            Batebi,H., Seufert,F., Perez-Hernandez,G., Hildebrand,P.W.,
            Sauer,M. and Langenhan,T.
  TITLE     Tethered agonist exposure in intact adhesion/class B2 GPCRs through
            intrinsic structural flexibility of the GAIN domain
  JOURNAL   Mol Cell 81 (5), 905-921 (2021)
   PUBMED   33497605
  REMARK    GeneRIF: Tethered agonist exposure in intact adhesion/class B2
            GPCRs through intrinsic structural flexibility of the GAIN domain.
REFERENCE   4  (bases 1 to 6024)
  AUTHORS   Chiu,P.L., Ng,B.H., Chang,G.W., Gordon,S. and Lin,H.H.
  TITLE     Putative alternative trans-splicing of leukocyte adhesion-GPCR
            pre-mRNAs generates functional chimeric receptors
  JOURNAL   FEBS Lett 582 (5), 792-798 (2008)
   PUBMED   18267122
  REMARK    GeneRIF: EGF-TM7 pre-mRNAs also undergo the rare trans-splicing,
            leading to the generation of functional chimeric receptors.
REFERENCE   5  (bases 1 to 6024)
  AUTHORS   Bjarnadottir,T.K., Geirardsdottir,K., Ingemansson,M., Mirza,M.A.,
            Fredriksson,R. and Schioth,H.B.
  TITLE     Identification of novel splice variants of Adhesion G
            protein-coupled receptors
  JOURNAL   Gene 387 (1-2), 38-48 (2007)
   PUBMED   17056209
REFERENCE   6  (bases 1 to 6024)
  AUTHORS   Aust,G., Hamann,J., Schilling,N. and Wobus,M.
  TITLE     Detection of alternatively spliced EMR2 mRNAs in colorectal tumor
            cell lines but rare expression of the molecule in colorectal
            adenocarcinomas
  JOURNAL   Virchows Arch 443 (1), 32-37 (2003)
   PUBMED   12761622
REFERENCE   7  (bases 1 to 6024)
  AUTHORS   Aust,G., Steinert,M., Schutz,A., Boltze,C., Wahlbuhl,M., Hamann,J.
            and Wobus,M.
  TITLE     CD97, but not its closely related EGF-TM7 family member EMR2, is
            expressed on gastric, pancreatic, and esophageal carcinomas
  JOURNAL   Am J Clin Pathol 118 (5), 699-707 (2002)
   PUBMED   12428789
REFERENCE   8  (bases 1 to 6024)
  AUTHORS   Kwakkenbos,M.J., Chang,G.W., Lin,H.H., Pouwels,W., de Jong,E.C.,
            van Lier,R.A., Gordon,S. and Hamann,J.
  TITLE     The human EGF-TM7 family member EMR2 is a heterodimeric receptor
            expressed on myeloid cells
  JOURNAL   J Leukoc Biol 71 (5), 854-862 (2002)
   PUBMED   11994511
REFERENCE   9  (bases 1 to 6024)
  AUTHORS   Lin,H.H., Stacey,M., Saxby,C., Knott,V., Chaudhry,Y., Evans,D.,
            Gordon,S., McKnight,A.J., Handford,P. and Lea,S.
  TITLE     Molecular analysis of the epidermal growth factor-like short
            consensus repeat domain-mediated protein-protein interactions:
            dissection of the CD97-CD55 complex
  JOURNAL   J Biol Chem 276 (26), 24160-24169 (2001)
   PUBMED   11297558
REFERENCE   10 (bases 1 to 6024)
  AUTHORS   Lin,H.H., Stacey,M., Hamann,J., Gordon,S. and McKnight,A.J.
  TITLE     Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is
            closely related to CD97
  JOURNAL   Genomics 67 (2), 188-200 (2000)
   PUBMED   10903844
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC127004.1, AK298700.1,
            AC005327.1, AC090427.2 and CN480316.1.
            
            Summary: This gene encodes a member of the class B seven-span
            transmembrane (TM7) subfamily of G-protein coupled receptors. These
            proteins are characterized by an extended extracellular region with
            a variable number of N-terminal epidermal growth factor-like
            domains coupled to a TM7 domain via a mucin-like spacer domain. The
            encoded protein is expressed mainly in myeloid cells where it
            promotes cell-cell adhesion through interaction with chondroitin
            sulfate chains. This gene is situated in a cluster of related genes
            on chromosome 19. Alternatively spliced transcript variants
            encoding multiple isoforms have been observed for this gene.
            [provided by RefSeq, Aug 2012].
            
            Transcript Variant: This variant (8) differs in the 5' UTR and
            lacks an alternate in-frame exon in the coding region, compared to
            variant 1. The encoded isoform (h) is shorter than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.149154.1, AK298700.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                BC127004.1         282-367
            87-302              AK298700.1         3-218
            303-303             AC005327.1         21844-21844         c
            304-1838            AK298700.1         220-1754
            1839-2598           BC127004.1         2294-3053
            2599-5516           AC090427.2         83157-86074         c
            5517-6024           CN480316.1         1-508               c
FEATURES             Location/Qualifiers
     source          1..6024
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..6024
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /note="adhesion G protein-coupled receptor E2"
                     /db_xref="GeneID:30817"
                     /db_xref="HGNC:HGNC:3337"
                     /db_xref="MIM:606100"
     exon            1..202
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..2469
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /note="isoform h precursor is encoded by transcript
                     variant 8; EGF-like module-containing mucin-like hormone
                     receptor-like 2; egf-like module containing, mucin-like,
                     hormone receptor-like 2; CD97 antigen; Leukocyte antigen
                     CD97"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor E2 isoform h
                     precursor"
                     /protein_id="NP_001257981.1"
                     /db_xref="CCDS:CCDS59361.1"
                     /db_xref="GeneID:30817"
                     /db_xref="HGNC:HGNC:3337"
                     /db_xref="MIM:606100"
                     /translation="MGGRVFLVFLAFCVWLTLPGAETQDSRGCARWCPQDSSCVNATA
                     CRCNPGFSSFSEIITTPMETCDDINECATLSKVSCGKFSDCWNTEGSYDCVCSPGYEP
                     VSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKLKPEDPKL
                     CTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSS
                     GQHQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQ
                     TLSRFFDKVQDLGRDYKPGLANNTIQSILQALDELLEAPGDLETLPRLQQHCVASHLL
                     DGLEDVLRGLSKNLSNGLLNFSYPAGTELSLEVQKQVDRSVTLRQNQAVMQLDWNQAQ
                     KSGDPGPSVVGLVSIPGMGKLLAEAPLVLEPEKQMLLHETHQGLLQDGSPILLSDVIS
                     AFLSNNDTQNLSSPVTFTFSHREEDPVLTVITYMGLSVSLLCLLLAALTFLLCKAIQN
                     TSTSLHLQLSLCLFLAHLLFLVAIDQTGHKVLCSIIAGTLHYLYLATLTWMLLEALYL
                     FLTARNLTVVNYSSINRFMKKLMFPVGYGVPAVTVAISAASRPHLYGTPSRCWLQPEK
                     GFIWGFLGPVCAIFSVNLVLFLVTLWILKNRLSSLNSEVSTLRNTRMLAFKATAQLFI
                     LGCTWCLGILQVGPAARVMAYLFTIINSLQGVFIFLVYCLLSQQVREQYGKWSKGIRK
                     LKTESEMHTLSSSAKADTSKPSTVN"
     exon            203..253
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            254..370
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            371..526
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            527..658
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            659..805
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            806..952
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            953..999
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1077
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1255
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1363
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1587
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1785
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..2021
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2088
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2180
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2349
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2460
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..6008
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5889..5894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /note="hexamer: AATAAA"
     polyA_site      5911
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
     regulatory      5980..5985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /note="hexamer: AATAAA"
     polyA_site      6001
                     /gene="ADGRE2"
                     /gene_synonym="CD312; CD97; EMR2; VBU"
                     /note="major polyA site"
ORIGIN      
        1 ctgcaccgcc agttccgggg agggccctgg gccagcggct gtccgccccc cctcctttat
       61 aaagtcctgg cctcgggaca gcccgcacag ctgcccagcc tgcggagacg ggacagccct
      121 gtcccactca ctctttcccc tgctgctcct gccggcagct cagctggaac catgggaggc
      181 cgcgtctttc tcgtctttct cgcattctgt gtctggctga ctctgccggg agctgaaacc
      241 caggactcca ggggctgtgc ccggtggtgc cctcaggact cctcgtgtgt caatgccacc
      301 gcctgtcgct gcaatccagg gttcagctct ttttctgaga tcatcaccac ccccatggag
      361 acttgtgacg acatcaacga gtgtgcaaca ctgtcgaaag tgtcatgcgg aaaattctcg
      421 gactgctgga acacagaggg gagctacgac tgcgtgtgca gcccaggata tgagcctgtt
      481 tctggggcaa aaacattcaa gaatgagagc gagaacacgt gtcaagatgt ggacgaatgt
      541 cagcagaacc caaggctctg taaaagctac ggcacctgcg tcaacaccct cggcagctac
      601 acgtgccagt gcctgcctgg cttcaagctc aaacctgagg acccgaagct ctgcacagat
      661 gtgaatgaat gcacctccgg acaaaaccca tgccacagct ccacccactg cctcaacaac
      721 gtgggcagct atcagtgccg ctgccgcccg ggctggcaac cgattccggg gtcccccaat
      781 ggcccaaaca ataccgtctg tgaagatgtg gacgagtgca gctccgggca gcatcagtgt
      841 gacagctcca ccgtctgctt caacaccgtg ggttcataca gctgccgctg ccgcccaggc
      901 tggaagccca gacacggaat cccgaataac caaaaggaca ctgtctgtga agatatgact
      961 ttctccacct ggaccccgcc ccctggagtc cacagccaga cgctttcccg attcttcgac
     1021 aaagtccagg acctgggcag agactacaag ccaggcttgg ccaataacac catccagagc
     1081 atcttacagg cgctggatga gctgctggag gcccctgggg acctggagac cctgccccgc
     1141 ttacagcagc actgtgtggc cagtcacctg ctggatggcc tagaggatgt cctcagaggc
     1201 ctgagcaaga acctttccaa tgggctgttg aacttcagtt atcctgcagg cacagaattg
     1261 tccctggagg tgcagaagca agtagacagg agtgtcacct tgagacagaa tcaggcagtg
     1321 atgcagctcg actggaatca ggcacagaaa tctggtgacc caggcccttc tgtggtgggc
     1381 cttgtctcca ttccagggat gggcaagttg ctggctgagg cccctctggt cctggaacct
     1441 gagaagcaga tgcttctgca tgagacacac cagggcttgc tgcaggacgg ctcccccatc
     1501 ctgctctcag atgtgatctc tgcctttctg agcaacaacg acacccaaaa cctcagctcc
     1561 ccagttacct tcaccttctc ccaccgtgag gaggatcccg tgctgactgt catcacctac
     1621 atggggctga gcgtctctct gctgtgcctc ctcctggcgg ccctcacttt tctcctgtgt
     1681 aaagccatcc agaacaccag cacctcactg catctgcagc tctcgctctg cctcttcctg
     1741 gcccacctcc tcttcctcgt ggcaattgat caaaccggac acaaggtgct gtgctccatc
     1801 atcgccggta ccttgcacta tctctacctg gccaccttga cctggatgct gctggaggcc
     1861 ctgtacctct tcctcactgc acggaacctg acggtggtca actactcaag catcaacaga
     1921 ttcatgaaga agctcatgtt ccctgtgggc tacggagtcc cagctgtgac agtggccatt
     1981 tctgcagcct ccaggcctca cctttatgga acaccttccc gctgctggct ccaaccagaa
     2041 aagggattta tatggggctt ccttggacct gtctgcgcca tcttctctgt gaatttagtt
     2101 ctctttctgg tgactctctg gattttgaaa aacagactct cctccctcaa tagtgaagtg
     2161 tccaccctcc ggaacacaag gatgctggca tttaaagcga cagctcagct gttcatcctg
     2221 ggctgcacgt ggtgtctggg catcttgcag gtgggtccgg ctgcccgggt catggcctac
     2281 ctcttcacca tcatcaacag cctgcagggt gtcttcatct tcctggtgta ctgcctcctc
     2341 agccagcagg tccgggagca atatgggaaa tggtccaaag ggatcaggaa attgaaaact
     2401 gagtctgaga tgcacacact ctccagcagt gctaaggctg acacctccaa acccagcacg
     2461 gttaactaga aaaatcttct gaataagatc ttccctcttt gcccgtggaa aatctgaaca
     2521 atctttgagc catctagagg ggaaagaaaa gactttgttc tgtgtgtttc aagaaattca
     2581 ccatgtcagc aatatgaagg atgttatgga aggcgtgcta ggcattcaat tcctgcagaa
     2641 accggaaatc ttccatgccc tgcaatgtgc tcatcaaact ctcagcatat ggacggccag
     2701 ctgtggccca tatcttggtc actctgaagc acaatattta tgaagctata gaacgttaag
     2761 acctctttca cagcctctcc ttcctacaaa gactcctcca aatcttaaaa tgaagcagga
     2821 aaacgagcct aagaggactt tcataccgac aacatctgaa aggactagaa tgttcacacc
     2881 acgatctgga tttcttaatt ttttgttttt gtttttgttg ttctctagtt ctacgggttt
     2941 gattatttag tcatgtgaaa aatattgatt actcacacat agatcaagag agacacggct
     3001 cctgccttca tggagctttt aggggaaaat gaagtggctc ttgcagctag agttgactca
     3061 gaagccgaaa ttcctagaaa tcaggtttct actgctaggc aattgaagta taaactattt
     3121 tataaacact gtcttctttc gtcttcacac caacatgcag aaaagtttct aatctcagat
     3181 cggggatgtg caacaaattc catttcaaag gaatgacctg caaaactcct aaatattcca
     3241 agcaaatgcc cttaaccctg tctgttatct gctttccttg aacagaaatt ctacatgacc
     3301 ataaaacctc gaagatgggt atggcacagt tcatgccctg taatcctagc actttgggag
     3361 ggtgaggcag gaggatggct caagcccagg agtttgagac cagtgtgggc aacagagtga
     3421 gaaccatctc tacccaaaaa aaaaattaaa aattagccaa gcatggtgat gatataggag
     3481 ttaaggagaa atcatttagg caaatagcaa gggtaggaag tcctcagtaa ggttttccat
     3541 ttaatgaaaa gcagccccca aaatcatttt cttttctaac aaagaacagc ctgtaaaatc
     3601 gagctgcaga catagacaag caagctggaa gcttccacgg gtgaatgccg gcagctgtgc
     3661 caataggaaa aagctaccta gactaggcat gtccaaaatg gcggctccaa gttcccttct
     3721 ctttgccagc catgtgtaca gtaaaaagca ggcaacatag tgtcagccaa agctcatttg
     3781 cataataaga ttagggtggg gtggccagct cacatagggg taggccctag gtaaatcaga
     3841 caccgccttc tcaagcctgt ctataaaatc tggtacacta tgacgagggt cagatttccc
     3901 attcagacgc ccctctccca tgcaagagaa agagctgttc tcctttctct ttcttttgcc
     3961 tattaaacct ctgctcctgg ccaggcacag tggctcacgc ctataatccc agcactttgg
     4021 gaggctgagg tggtcagatc acctaaggtc aggagttcaa gaccagcctg gtcaacatgg
     4081 tgaaatcttg tctctagtaa aaatacaaaa atatatgaaa tctcacatag atgataatat
     4141 taagttccaa aagcaactca acctggtaga ttctaatttt ttttgaggca gggtcttgct
     4201 ttgtcaccca tgctggagta caatggcaca aacactgctc actgcagcct cgacctccca
     4261 aggcctaagc aatcctcctg cctcagtccc cctccaggta tttgaaacta caggtgtgta
     4321 ccaccacacc gggctaattt ttgtattttt tgtagagacg tgggtctcac tatgctgccc
     4381 aggctcaggt cttaatctcc tgagctcagg caatccgcag gcctcagcct ccctaagtgc
     4441 ggggattaca ggcttgagcc actgcaccta gcctctattt gttttacaaa agagaaattg
     4501 agatcctgaa tgttaagtga cttgcctgag gccatcccac taacaggagc cagggttagg
     4561 attcaaaccc catccaactg gtcccagagc tggagcttct tgcactgccc tacactacct
     4621 accatctcca tcctctgggc acctttttat aagaaccaaa acattacaga gcattgcttt
     4681 gtcaactcag ctgggaacat ttcccagtgc aactcacatt tttcactgct ctgtgcctgt
     4741 ccgtataagc tcaatgagta ttgatttagg ggctttggag aactttgaat gctacccccc
     4801 aagtaaccat tgttggcaac ctggtacctc tacttttagc catttctcct tctctataaa
     4861 tagtgcagaa gtaacccact tggtaacagg catccttgcc aagcctccac cactaggtca
     4921 gtgtaagaat taaagaaaga ggaaagaaac acaaaaagtg gcttgatggt taagacaggt
     4981 ttattttaga gaaaacacac ctgagagggg ctgctggctg aattaggtta gagtcttttc
     5041 tacagactaa gagtgtttaa ggatttaggg tgggagagtt tcttagaggc ttggactgct
     5101 tctgtgtttt ttttgttgtg cttatatggg agggagagtg gtgtgtttgc ttttatacat
     5161 ttttctgcag ctgtaggcat accccccaag tctgctttta gcttccctat tttagtgcac
     5221 ctggagggaa aggaatgtgc ttattaaggc ccactgtttt actggggccc attgtatgag
     5281 ggtgaagttt ggcagttacc caagagactt ttcctccacc ttcctctgtg cccgagctgt
     5341 tttatctgca ttttactgtc tgcttttttt ggctgcttat agtttttaaa aaagtaattt
     5401 ccttaaatcc agaaggctaa aaatgaagct gaaacttaaa gtggcggtgt ttgtccaaaa
     5461 taacggggct cctgctctgc cagtcagtac cctcaagtca ctcctgatcc tcaacctcca
     5521 tgcctaaggc tggttcaaga gaccacataa tatctgcctt ttattacata catgatgggt
     5581 gcatgggatt ctgcgtgccc tttgcttgat atagactgct aaggtgagat ggggaatatc
     5641 agagtcagct gctgcttgag gaagcagaac acacagctgg aggcttggaa catgtgggtc
     5701 cctatgagtg tagagcccat atccccatag agtctaccta gagcaggggt cgccaaatgt
     5761 tttcttaaag agcctgatag tgtatatgtt aggctttgtg agccaggtat ttacagcaac
     5821 tcaattctac cactgtggta tgaaaacagc tatagacaat cataaatgaa tgatcatggc
     5881 tatgttttaa taaaacttta cagacactga acttgaactt ccattgtgat atgaaaacag
     5941 ctatagacaa tcataaatga atgatcatgg ctatgtttta ataaaacttt atggacactg
     6001 agcttgaaaa aaaaaaaaaa aaaa
//
