LOCUS       NM_001974               3112 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens adhesion G protein-coupled receptor E1 (ADGRE1),
            transcript variant 1, mRNA.
ACCESSION   NM_001974
VERSION     NM_001974.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3112)
  AUTHORS   Akter,R., Park,R., Lee,S.K., Han,E.J., Park,K.S., Park,J. and
            Cho,M.Y.
  TITLE     Upregulation of EMR1 (ADGRE1) by Tumor-Associated Macrophages
            Promotes Colon Cancer Progression by Activating the JAK2/STAT1,3
            Signaling Pathway in Tumor Cells
  JOURNAL   Int J Mol Sci 25 (8), 4388 (2024)
   PUBMED   38673975
  REMARK    GeneRIF: Upregulation of EMR1 (ADGRE1) by Tumor-Associated
            Macrophages Promotes Colon Cancer Progression by Activating the
            JAK2/STAT1,3 Signaling Pathway in Tumor Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3112)
  AUTHORS   Ali,H., Olsson,L., Lindmark,G., Hammarstrom,M.L., Hammarstrom,S.
            and Sitohy,B.
  TITLE     The myeloid cell biomarker EMR1 is ectopically expressed in colon
            cancer
  JOURNAL   Tumour Biol 43 (1), 209-223 (2021)
   PUBMED   34486997
  REMARK    GeneRIF: The myeloid cell biomarker EMR1 is ectopically expressed
            in colon cancer.
REFERENCE   3  (bases 1 to 3112)
  AUTHORS   Wang,Y. and Tatakis,D.N.
  TITLE     Human gingiva transcriptome during wound healing
  JOURNAL   J Clin Periodontol 44 (4), 394-402 (2017)
   PUBMED   28005267
  REMARK    GeneRIF: EMR1 expression is significantly upregulated in human
            masticatory mucosa during wound healing
REFERENCE   4  (bases 1 to 3112)
  AUTHORS   Hamann,J., Aust,G., Arac,D., Engel,F.B., Formstone,C.,
            Fredriksson,R., Hall,R.A., Harty,B.L., Kirchhoff,C., Knapp,B.,
            Krishnan,A., Liebscher,I., Lin,H.H., Martinelli,D.C., Monk,K.R.,
            Peeters,M.C., Piao,X., Promel,S., Schoneberg,T., Schwartz,T.W.,
            Singer,K., Stacey,M., Ushkaryov,Y.A., Vallon,M., Wolfrum,U.,
            Wright,M.W., Xu,L., Langenhan,T. and Schioth,H.B.
  TITLE     International Union of Basic and Clinical Pharmacology. XCIV.
            Adhesion G protein-coupled receptors
  JOURNAL   Pharmacol Rev 67 (2), 338-367 (2015)
   PUBMED   25713288
  REMARK    Review article
REFERENCE   5  (bases 1 to 3112)
  AUTHORS   Divaris,K., Monda,K.L., North,K.E., Olshan,A.F., Reynolds,L.M.,
            Hsueh,W.C., Lange,E.M., Moss,K., Barros,S.P., Weyant,R.J., Liu,Y.,
            Newman,A.B., Beck,J.D. and Offenbacher,S.
  TITLE     Exploring the genetic basis of chronic periodontitis: a genome-wide
            association study
  JOURNAL   Hum Mol Genet 22 (11), 2312-2324 (2013)
   PUBMED   23459936
REFERENCE   6  (bases 1 to 3112)
  AUTHORS   Lin,H.H., Stacey,M., Hamann,J., Gordon,S. and McKnight,A.J.
  TITLE     Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is
            closely related to CD97
  JOURNAL   Genomics 67 (2), 188-200 (2000)
   PUBMED   10903844
REFERENCE   7  (bases 1 to 3112)
  AUTHORS   Carver,E.A., Hamann,J., Olsen,A.S. and Stubbs,L.
  TITLE     Physical mapping of EMR1 and CD97 in human Chromosome 19 and
            assignment of Cd97 to mouse Chromosome 8 suggest an ancient genomic
            duplication
  JOURNAL   Mamm Genome 10 (10), 1039-1040 (1999)
   PUBMED   10501980
REFERENCE   8  (bases 1 to 3112)
  AUTHORS   McKnight,A.J. and Gordon,S.
  TITLE     The EGF-TM7 family: unusual structures at the leukocyte surface
  JOURNAL   J Leukoc Biol 63 (3), 271-280 (1998)
   PUBMED   9500513
  REMARK    Review article
REFERENCE   9  (bases 1 to 3112)
  AUTHORS   McKnight,A.J., Macfarlane,A.J., Seldin,M.F. and Gordon,S.
  TITLE     Chromosome mapping of the Emr1 gene
  JOURNAL   Mamm Genome 8 (12), 946 (1997)
   PUBMED   9383301
REFERENCE   10 (bases 1 to 3112)
  AUTHORS   Baud,V., Chissoe,S.L., Viegas-Pequignot,E., Diriong,S.,
            N'Guyen,V.C., Roe,B.A. and Lipinski,M.
  TITLE     EMR1, an unusual member in the family of hormone receptors with
            seven transmembrane segments
  JOURNAL   Genomics 26 (2), 334-344 (1995)
   PUBMED   7601460
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA465986.1, BC059395.1,
            X81479.1 and AK297003.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001974.4.
            
            Summary: This gene encodes a protein that has a domain resembling
            seven transmembrane G protein-coupled hormone receptors (7TM
            receptors) at its C-terminus. The N-terminus of the encoded protein
            has six EGF-like modules, separated from the transmembrane segments
            by a serine/threonine-rich domain, a feature reminiscent of
            mucin-like, single-span, integral membrane glycoproteins with
            adhesive properties. Multiple alternatively spliced transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X81479.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312053.9/ ENSP00000311545.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-198               DA465986.1         31-228
            199-1794            BC059395.1         212-1807
            1795-2017           X81479.1           1803-2025
            2018-2839           AK297003.1         1603-2424
            2840-3112           BC059395.1         2658-2930
FEATURES             Location/Qualifiers
     source          1..3112
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3-p13.2"
     gene            1..3112
                     /gene="ADGRE1"
                     /gene_synonym="EMR1; TM7LN3"
                     /note="adhesion G protein-coupled receptor E1"
                     /db_xref="GeneID:2015"
                     /db_xref="HGNC:HGNC:3336"
                     /db_xref="MIM:600493"
     exon            1..61
                     /gene="ADGRE1"
                     /gene_synonym="EMR1; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..2691
                     /gene="ADGRE1"
                     /gene_synonym="EMR1; TM7LN3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; egf-like module containing, mucin-like, hormone
                     receptor-like sequence 1; EGF-like module-containing
                     mucin-like hormone receptor-like 1; EMR1 hormone receptor;
                     EGF-like module receptor 1; egf-like module containing,
                     mucin-like, hormone receptor-like 1"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor E1 isoform 1
                     precursor"
                     /protein_id="NP_001965.3"
                     /db_xref="CCDS:CCDS12175.1"
                     /db_xref="GeneID:2015"
                     /db_xref="HGNC:HGNC:3336"
                     /db_xref="MIM:600493"
                     /translation="MRGFNLLLFWGCCVMHSWEGHIRPTRKPNTKGNNCRDSTLCPAY
                     ATCTNTVDSYYCACKQGFLSSNGQNHFKDPGVRCKDIDECSQSPQPCGPNSSCKNLSG
                     RYKCSCLDGFSSPTGNDWVPGKPGNFSCTDINECLTSSVCPEHSDCVNSMGSYSCSCQ
                     VGFISRNSTCEDVDECADPRACPEHATCNNTVGNYSCFCNPGFESSSGHLSFQGLKAS
                     CEDIDECTEMCPINSTCTNTPGSYFCTCHPGFAPSNGQLNFTDQGVECRDIDECRQDP
                     STCGPNSICTNALGSYSCGCIAGFHPNPEGSQKDGNFSCQRVLFKCKEDVIPDNKQIQ
                     QCQEGTAVKPAYVSFCAQINNIFSVLDKVCENKTTVVSLKNTTESFVPVLKQISTWTK
                     FTKEETSSLATVFLESVESMTLASFWKPSANITPAVRTEYLDIESKVINKECSEENVT
                     LDLVAKGDKMKIGCSTIEESESTETTGVAFVSFVGMESVLNERFFKDHQAPLTTSEIK
                     LKMNSRVVGGIMTGEKKDGFSDPIIYTLENIQPKQKFERPICVSWSTDVKGGRWTSFG
                     CVILEASETYTICSCNQMANLAVIMASGELTMDFSLYIISHVGIIISLVCLVLAIATF
                     LLCRSIRNHNTYLHLHLCVCLLLAKTLFLAGIHKTDNKMGCAIIAGFLHYLFLACFFW
                     MLVEAVILFLMVRNLKVVNYFSSRNIKMLHICAFGYGLPMLVVVISASVQPQGYGMHN
                     RCWLNTETGFIWSFLGPVCTVIVINSLLLTWTLWILRQRLSSVNAEVSTLKDTRLLTF
                     KAFAQLFILGCSWVLGIFQIGPVAGVMAYLFTIINSLQGAFIFLIHCLLNGQVREEYK
                     RWITGKTKPSSQSQTSRILLSSMPSASKTG"
     exon            62..124
                     /gene="ADGRE1"
                     /gene_synonym="EMR1; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            125..268
                     /gene="ADGRE1"
                     /gene_synonym="EMR1; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            269..424
                     /gene="ADGRE1"
                     /gene_synonym="EMR1; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            425..544
                     /gene="ADGRE1"
                     /gene_synonym="EMR1; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            545..691
                     /gene="ADGRE1"
                     /gene_synonym="EMR1; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            692..832
                     /gene="ADGRE1"
                     /gene_synonym="EMR1; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            833..979
                     /gene="ADGRE1"
                     /gene_synonym="EMR1; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1068
                     /gene="ADGRE1"
                     /gene_synonym="EMR1; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1152
                     /gene="ADGRE1"
                     /gene_synonym="EMR1; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1330
                     /gene="ADGRE1"
                     /gene_synonym="EMR1; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1450
                     /gene="ADGRE1"
                     /gene_synonym="EMR1; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1650
                     /gene="ADGRE1"
                     /gene_synonym="EMR1; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1821
                     /gene="ADGRE1"
                     /gene_synonym="EMR1; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..2016
                     /gene="ADGRE1"
                     /gene_synonym="EMR1; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2252
                     /gene="ADGRE1"
                     /gene_synonym="EMR1; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2319
                     /gene="ADGRE1"
                     /gene_synonym="EMR1; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2411
                     /gene="ADGRE1"
                     /gene_synonym="EMR1; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2580
                     /gene="ADGRE1"
                     /gene_synonym="EMR1; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2581..2685
                     /gene="ADGRE1"
                     /gene_synonym="EMR1; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..3112
                     /gene="ADGRE1"
                     /gene_synonym="EMR1; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3075..3080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRE1"
                     /gene_synonym="EMR1; TM7LN3"
                     /note="hexamer: AATAAA"
     polyA_site      3112
                     /gene="ADGRE1"
                     /gene_synonym="EMR1; TM7LN3"
                     /note="major polyA site"
ORIGIN      
        1 cttttctttg aatgacagaa ctacagcata atgcgtggct tcaacctgct cctcttctgg
       61 ggatgttgtg ttatgcacag ctgggaaggg cacataagac ccacacggaa accaaacaca
      121 aagggtaata actgtagaga cagtaccttg tgcccagctt atgccacctg caccaataca
      181 gtggacagtt actattgcgc ttgcaaacaa ggcttcctgt ccagcaatgg gcaaaatcac
      241 ttcaaggatc caggagtgcg atgcaaagat attgatgaat gttctcaaag cccccagccc
      301 tgtggtccta actcatcctg caaaaacctg tcagggaggt acaagtgcag ctgtttagat
      361 ggtttctctt ctcccactgg aaatgactgg gtcccaggaa agccgggcaa tttctcctgt
      421 actgatatca atgagtgcct caccagcagc gtctgccctg agcattctga ctgtgtcaac
      481 tccatgggaa gctacagttg cagctgtcaa gttggattca tctctagaaa ctccacctgt
      541 gaagacgtgg atgaatgtgc agatccaaga gcttgcccag agcatgcaac ttgtaataac
      601 actgttggaa actactcttg tttctgcaac ccaggatttg aatccagcag tggccacttg
      661 agtttccagg gtctcaaagc atcgtgtgaa gatattgatg aatgcactga aatgtgcccc
      721 atcaattcaa catgcaccaa cactcctggg agctactttt gcacctgcca ccctggcttt
      781 gcaccaagca atggacagtt gaatttcaca gaccaaggag tggaatgtag agatattgat
      841 gagtgccgcc aagatccatc aacctgtggt cctaattcta tctgcaccaa tgccctgggc
      901 tcctacagct gtggctgcat tgcaggcttt catcccaatc cagaaggctc ccagaaagat
      961 ggcaacttca gctgccaaag ggttctcttc aaatgtaagg aagatgtgat acccgataat
     1021 aagcagatcc agcaatgcca agagggaacc gcagtgaaac ctgcatatgt ctccttttgt
     1081 gcacaaataa ataacatctt cagcgttctg gacaaagtgt gtgaaaataa aacgaccgta
     1141 gtttctctga agaatacaac tgagagcttt gtccctgtgc ttaaacaaat atccacgtgg
     1201 actaaattca ccaaggaaga gacgtcctcc ctggccacag tcttcctgga gagtgtggaa
     1261 agcatgacac tggcatcttt ttggaaaccc tcagcaaata tcactccggc tgttcggacg
     1321 gaatacttag acattgagag caaagttatc aacaaagaat gcagtgaaga gaatgtgacg
     1381 ttggacttgg tagccaaggg ggataagatg aagatcgggt gttccacaat tgaggaatct
     1441 gaatccacag agaccactgg tgtggctttt gtctcctttg tgggcatgga atcggtttta
     1501 aatgagcgct tcttcaaaga ccaccaggct cccttgacca cctctgagat caagctgaag
     1561 atgaattctc gagtcgttgg gggcataatg actggagaga agaaagacgg cttctcagat
     1621 ccaatcatct acactctgga gaacattcag ccaaagcaga agtttgagag gcccatctgt
     1681 gtttcctgga gcactgatgt gaagggtgga agatggacat cctttggctg tgtgatcctg
     1741 gaagcttctg agacatatac catctgcagc tgtaatcaga tggcaaatct tgccgttatc
     1801 atggcgtctg gggagctcac gatggacttt tccttgtaca tcattagcca tgtaggcatt
     1861 atcatctcct tggtgtgcct cgtcttggcc atcgccacct ttctgctgtg tcgctccatc
     1921 cgaaatcaca acacctacct ccacctgcac ctctgcgtgt gtctcctctt ggcgaagact
     1981 ctcttcctcg ccggtataca caagactgac aacaagatgg gctgcgccat catcgcgggc
     2041 ttcctgcact accttttcct tgcctgcttc ttctggatgc tggtggaggc tgtgatactg
     2101 ttcttgatgg tcagaaacct gaaggtggtg aattacttca gctctcgcaa catcaagatg
     2161 ctgcacatct gtgcctttgg ttatgggctg ccgatgctgg tggtggtgat ctctgccagt
     2221 gtgcagccac agggctatgg aatgcataat cgctgctggc tgaatacaga gacagggttc
     2281 atctggagtt tcttggggcc agtttgcaca gttatagtga tcaactccct tctcctgacc
     2341 tggaccttgt ggatcctgag gcagaggctt tccagtgtta atgccgaagt ctcaacgcta
     2401 aaagacacca ggttactgac cttcaaggcc tttgcccagc tcttcatcct gggctgctcc
     2461 tgggtgctgg gcatttttca gattggacct gtggcaggtg tcatggctta cctgttcacc
     2521 atcatcaaca gcctgcaggg ggccttcatc ttcctcatcc actgtctgct caacggccag
     2581 gtacgagaag aatacaagag gtggatcact gggaagacga agcccagctc ccagtcccag
     2641 acctcaagga tcttgctgtc ctccatgcca tccgcttcca agacgggtta aagtcctttc
     2701 ttgctttcaa atatgctatg gagccacagt tgaggacagt agtttcctgc aggagcctac
     2761 cctgaaatct cttctcagct taacatggaa atgaggatcc caccagcccc agaaccctct
     2821 ggggaagaat gttgggggcg gtcttcctgt ggttgtatgc actgatgaga aatcaggcgt
     2881 ttctgctcca aacgaccatt ttatcttcgt gctctgcaac ttcttcaatt ccagagtttc
     2941 tgagaacaga cccaaattca atggcatgac caagaacacc tggctaccat tttgttttct
     3001 cctgcccttg ttggtgcatg gttctaagca tgcccctcca gagcctatca tacgcctgat
     3061 acagagaacc tctcaataaa tgatttgtcg cctgtctgac tgatttaccc ta
//
