LOCUS       NM_198827               5390 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens adhesion G protein-coupled receptor D1 (ADGRD1),
            transcript variant 1, mRNA.
ACCESSION   NM_198827 XM_290578
VERSION     NM_198827.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5390)
  AUTHORS   Sun,J.X., Yao,Y., Li,W.X., Su,X., Yang,H., Lu,Z., Liu,C., Xu,X.H.
            and Jin,L.
  TITLE     Upregulation of GPR133 expression impaired the phagocytosis of
            macrophages in recurrent spontaneous miscarriage
  JOURNAL   Epigenetics 19 (1), 2337087 (2024)
   PUBMED   38564758
  REMARK    GeneRIF: Upregulation of GPR133 expression impaired the
            phagocytosis of macrophages in recurrent spontaneous miscarriage.
REFERENCE   2  (bases 1 to 5390)
  AUTHORS   Stephan,G., Haddock,S., Wang,S., Erdjument-Bromage,H., Liu,W.,
            Ravn-Boess,N., Frenster,J.D., Bready,D., Cai,J., Ronnen,R.,
            Sabio-Ortiz,J., Fenyo,D., Neubert,T.A. and Placantonakis,D.G.
  TITLE     Modulation of GPR133 (ADGRD1) signaling by its intracellular
            interaction partner extended synaptotagmin 1
  JOURNAL   Cell Rep 43 (5), 114229 (2024)
   PUBMED   38758649
  REMARK    GeneRIF: Modulation of GPR133 (ADGRD1) signaling by its
            intracellular interaction partner extended synaptotagmin 1.
REFERENCE   3  (bases 1 to 5390)
  AUTHORS   Zackova,S., Pavova,M., Trylcova,J., Chalupova,J., Priss,A.,
            Luksan,O. and Weber,J.
  TITLE     Upregulation of mRNA Expression of ADGRD1/GPR133 and ADGRG7/GPR128
            in SARS-CoV-2-Infected Lung Adenocarcinoma Calu-3 Cells
  JOURNAL   Cells 13 (10), 791 (2024)
   PUBMED   38786015
  REMARK    GeneRIF: Upregulation of mRNA Expression of ADGRD1/GPR133 and
            ADGRG7/GPR128 in SARS-CoV-2-Infected Lung Adenocarcinoma Calu-3
            Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5390)
  AUTHORS   Lv,M., Li,X., Tian,W., Yang,H. and Zhou,B.
  TITLE     ADGRD1 as a Potential Prognostic and Immunological Biomarker in
            Non-Small-Cell Lung Cancer
  JOURNAL   Biomed Res Int 2022, 5699892 (2022)
   PUBMED   36457341
  REMARK    GeneRIF: ADGRD1 as a Potential Prognostic and Immunological
            Biomarker in Non-Small-Cell Lung Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5390)
  AUTHORS   Wu,G., Zhai,D., Xie,J., Zhu,S., Liang,Z., Liu,X. and Zhao,Z.
  TITLE     N6 -methyladenosine (m6 A) RNA modification of G protein-coupled
            receptor 133 increases proliferation of lung adenocarcinoma
  JOURNAL   FEBS Open Bio 12 (3), 571-581 (2022)
   PUBMED   34185971
  REMARK    GeneRIF: N(6) -methyladenosine (m(6) A) RNA modification of G
            protein-coupled receptor 133 increases proliferation of lung
            adenocarcinoma.
REFERENCE   6  (bases 1 to 5390)
  AUTHORS   Yashin,A.I., Wu,D., Arbeev,K.G. and Ukraintseva,S.V.
  TITLE     Joint influence of small-effect genetic variants on human longevity
  JOURNAL   Aging (Albany NY) 2 (9), 612-620 (2010)
   PUBMED   20834067
REFERENCE   7  (bases 1 to 5390)
  AUTHORS   Tonjes,A., Koriath,M., Schleinitz,D., Dietrich,K., Bottcher,Y.,
            Rayner,N.W., Almgren,P., Enigk,B., Richter,O., Rohm,S.,
            Fischer-Rosinsky,A., Pfeiffer,A., Hoffmann,K., Krohn,K., Aust,G.,
            Spranger,J., Groop,L., Bluher,M., Kovacs,P. and Stumvoll,M.
  TITLE     Genetic variation in GPR133 is associated with height: genome wide
            association study in the self-contained population of Sorbs
  JOURNAL   Hum Mol Genet 18 (23), 4662-4668 (2009)
   PUBMED   19729412
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 5390)
  AUTHORS   Marroni,F., Pfeufer,A., Aulchenko,Y.S., Franklin,C.S., Isaacs,A.,
            Pichler,I., Wild,S.H., Oostra,B.A., Wright,A.F., Campbell,H.,
            Witteman,J.C., Kaab,S., Hicks,A.A., Gyllensten,U., Rudan,I.,
            Meitinger,T., Pattaro,C., van Duijn,C.M., Wilson,J.F. and
            Pramstaller,P.P.
  CONSRTM   EUROSPAN Consortium
  TITLE     A genome-wide association scan of RR and QT interval duration in 3
            European genetically isolated populations: the EUROSPAN project
  JOURNAL   Circ Cardiovasc Genet 2 (4), 322-328 (2009)
   PUBMED   20031603
  REMARK    GeneRIF: A role for GPR133 protein in affecting the length of the
            electrocardiographic RR interval and heart rate.
            GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   9  (bases 1 to 5390)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
REFERENCE   10 (bases 1 to 5390)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA520615.1, BC112307.1,
            AC078925.18, AY532280.1, BC112309.1, EU523118.1, AK131538.1,
            AL162032.1 and BQ028954.1.
            
            On Nov 22, 2018 this sequence version replaced NM_198827.4.
            
            Summary: The adhesion G-protein-coupled receptors (GPCRs),
            including GPR133, are membrane-bound proteins with long N termini
            containing multiple domains. GPCRs, or GPRs, contain 7
            transmembrane domains and transduce extracellular signals through
            heterotrimeric G proteins (summary by Bjarnadottir et al., 2004
            [PubMed 15203201]).[supplied by OMIM, Nov 2010].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.175070.1, AY532280.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261654.10/ ENSP00000261654.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-529               DA520615.1         1-529
            530-1002            BC112307.1         1-473
            1003-1004           AC078925.18        150796-150797       c
            1005-2832           AY532280.1         619-2446
            2833-3048           BC112309.1         2304-2519
            3049-3200           EU523118.1         2564-2715
            3201-4092           AK131538.1         1955-2846
            4093-4309           AL162032.1         1595-1811
            4310-5381           AK131538.1         3064-4135
            5382-5390           BQ028954.1         16-24               c
FEATURES             Location/Qualifiers
     source          1..5390
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     gene            1..5390
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /note="adhesion G protein-coupled receptor D1"
                     /db_xref="GeneID:283383"
                     /db_xref="HGNC:HGNC:19893"
                     /db_xref="MIM:613639"
     exon            1..625
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /inference="alignment:Splign:2.1.0"
     CDS             560..3184
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; probable G-protein coupled receptor 133;
                     G-protein coupled receptor PGR25"
                     /codon_start=1
                     /product="adhesion G-protein coupled receptor D1 isoform 1
                     precursor"
                     /protein_id="NP_942122.2"
                     /db_xref="CCDS:CCDS9272.1"
                     /db_xref="GeneID:283383"
                     /db_xref="HGNC:HGNC:19893"
                     /db_xref="MIM:613639"
                     /translation="MEKLLRLCCWYSWLLLFYYNFQVRGVYSRSQDHPGFQVLASASH
                     YWPLENVDGIHELQDTTGDIVEGKVNKGIYLKEEKGVTLLYYGRYNSSCISKPEQCGP
                     EGVTFSFFWKTQGEQSRPIPSAYGGQVISNGFKVCSSGGRGSVELYTRDNSMTWEASF
                     SPPGPYWTHVLFTWKSKEGLKVYVNGTLSTSDPSGKVSRDYGESNVNLVIGSEQDQAK
                     CYENGAFDEFIIWERALTPDEIAMYFTAAIGKHALLSSTLPSLFMTSTASPVMPTDAY
                     HPIITNLTEERKTFQSPGVILSYLQNVSLSLPSKSLSEQTALNLTKTFLKAVGEILLL
                     PGWIALSEDSAVVLSLIDTIDTVMGHVSSNLHGSTPQVTVEGSSAMAEFSVAKILPKT
                     VNSSHYRFPAHGQSFIQIPHEAFHRHAWSTVVGLLYHSMHYYLNNIWPAHTKIAEAMH
                     HQDCLLFATSHLISLEVSPPPTLSQNLSGSPLITVHLKHRLTRKQHSEATNSSNRVFV
                     YCAFLDFSSGEGVWSNHGCALTRGNLTYSVCRCTHLTNFAILMQVVPLELARGHQVAL
                     SSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQVLLLISFR
                     LEPGTTPCQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGF
                     PLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFVAPALFVIVVNIGILIAVTRVISQ
                     ISADNYKIHGDPSAFKLTAKAVAVLLPILGTSWVFGVLAVNGCAVVFQYMFATLNSLQ
                     GLFIFLFHCLLNSEVRAAFKHKTKVWSLTSSSARTSNAKPFHSDLMNGTRPGMASTKL
                     SPWDKSSHSAHRVDLSAV"
     exon            626..662
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /inference="alignment:Splign:2.1.0"
     exon            663..746
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /inference="alignment:Splign:2.1.0"
     exon            747..869
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1049
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1304
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1369
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1525
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1585
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1703
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1814
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1890
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2032
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2106
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2230
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2334
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2446
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2600
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2667
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2734
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..2826
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /inference="alignment:Splign:2.1.0"
     exon            2827..2953
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /inference="alignment:Splign:2.1.0"
     exon            2954..2995
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..3088
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /inference="alignment:Splign:2.1.0"
     exon            3089..5390
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5366..5371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /note="hexamer: AATAAA"
     polyA_site      5390
                     /gene="ADGRD1"
                     /gene_synonym="GPR133; PGR25"
                     /note="major polyA site"
ORIGIN      
        1 actcactccc cctccaccca gagagcagga cggaggtgtg aacttgagcc agaccagaag
       61 gagctcgaga gcggccgcag gacaagcccg aggagcaggc gggcgctcca ggggaaaacc
      121 acgcacaaaa ccttcttcag agaaaaggga agctccaaac ctgactgaga caaacggagg
      181 ctcttgaaat aaaaagaaaa taccgcagga caaacagcct cccgtccccg ggcgcaggtc
      241 gcggtcacag tggtgacctg ggattgcttt cccaggactg cgagtcgggt ttgggtttct
      301 cctccctgca ttccacagct gctctggtca tcgcaacgtg tttattgatc actgaagaat
      361 ctcaagtttt gagacgagga agaaacaccc attaggtctc caagacagct gtgtttcaca
      421 aactttaagg agacagaaat tttctcccct ggaacctgtg aaaatgtccc ttttccaagg
      481 aagtgaaggt taagaggtcc cgttctcaca gaccctcagg aatttcactt ggctccgagc
      541 tttgacctcc gagagagcca tggaaaagct gctgcggctg tgctgctggt actcctggct
      601 gctgctattt tattacaact ttcaggtgcg tggcgtctac tccagatcgc aggaccatcc
      661 aggatttcag gtgttggcgt ctgcttccca ttactggcca ctggagaatg tggatgggat
      721 ccatgaactt caggatacaa ctggagatat tgtggaaggg aaggtcaaca aaggcattta
      781 cctgaaagag gaaaagggag tcacgcttct ctattacggc aggtacaaca gctcctgcat
      841 cagcaagcca gagcagtgtg gccctgaagg ggtcacgttt tcttttttct ggaagacaca
      901 aggagaacag tctagaccaa tcccttctgc gtatggggga caggtcatct ccaatgggtt
      961 caaagtctgc tccagcggtg gcagaggctc tgtggagctg tatacgcggg acaattccat
     1021 gacatgggag gcctccttca gccccccagg cccctattgg actcatgtcc tatttacatg
     1081 gaaatccaag gagggcctga aagtctacgt caacgggacc ctgagcacct ctgatccgag
     1141 tggaaaagtg tctcgtgact atggagagtc caacgtcaac ctcgtgatag ggtctgagca
     1201 ggaccaggcc aagtgttatg agaacggtgc tttcgatgag ttcatcatct gggagcgggc
     1261 tctgactccg gatgagatcg ccatgtactt cactgctgcc attggaaagc atgctttatt
     1321 gtcttcaacg ctgccaagcc tcttcatgac atccacagca agccccgtga tgcccacaga
     1381 tgcctaccat cccatcataa ccaacctgac agaagagaga aaaaccttcc aaagtcccgg
     1441 agtgatactg agttacctcc aaaatgtatc cctcagctta cccagtaagt ccctctcgga
     1501 gcagacagcc ttgaatctca ccaagacctt cttaaaagcc gtgggagaga tccttctact
     1561 gcctggttgg attgctctgt cagaggacag cgccgtggta ctgagtctca tcgacactat
     1621 tgacaccgtc atgggccatg tatcctccaa cctgcacggc agcacgcccc aggtcaccgt
     1681 ggagggctcc tctgccatgg cagagttttc cgtggccaaa atcctgccca agaccgtgaa
     1741 ttcctcccat taccgcttcc cggcccacgg gcagagcttc atccagatcc cccacgaggc
     1801 cttccacagg cacgcctgga gcaccgtcgt gggtctgctg taccacagca tgcactacta
     1861 cctgaacaac atctggcccg cccacaccaa gatcgcggag gccatgcatc accaggactg
     1921 cctgctgttc gccaccagcc acctgatttc cctggaggtg tccccaccac ccaccctgtc
     1981 tcagaacctg tcgggctctc cactcattac ggtccacctc aagcacagat tgacacgtaa
     2041 gcagcacagt gaggccacca acagcagcaa ccgagtcttc gtgtactgcg ccttcctgga
     2101 cttcagctcc ggagaagggg tctggtcgaa ccacggctgt gcgctcacga gaggaaacct
     2161 cacctactcc gtctgccgct gcactcacct caccaacttt gccatcctca tgcaggtggt
     2221 cccgctggag cttgcacgcg gacaccaggt ggcgctgtcg tctatcagct atgtgggctg
     2281 ctccctctcc gtgctctgcc tggtggccac gctggtcacc ttcgccgtgc tgtcctccgt
     2341 gagcaccatc cggaaccagc gctaccacat ccacgccaac ctgtccttcg ccgtgctggt
     2401 ggcccaggtc ctgctgctca ttagtttccg cctcgagccg ggcacgaccc cctgccaagt
     2461 gatggccgtg ctcctacact acttcttcct gagtgccttc gcatggatgc tggtggaggg
     2521 gctgcacctc tacagcatgg tgatcaaggt ctttgggtcg gaggacagca agcaccgtta
     2581 ctactatggg atgggatggg gttttcctct tctgatctgc atcatttcac tgtcatttgc
     2641 catggacagt tacggaacaa gcaacaattg ctggctgtcg ttggcgagtg gcgccatctg
     2701 ggcctttgta gcccctgccc tgtttgtcat cgtggtcaac attggcatcc tcatcgctgt
     2761 gaccagagtc atctcacaga tcagcgccga caactacaag atccatggag accccagtgc
     2821 cttcaagttg acagccaagg cagtggccgt gctgctgccc atcctgggta cctcgtgggt
     2881 ctttggcgtg cttgctgtca acggttgtgc tgtggttttc cagtacatgt ttgccacgct
     2941 caactccctg cagggactgt tcatattcct ctttcattgt ctcctgaatt cagaggtgag
     3001 agccgccttc aagcacaaaa ccaaggtctg gtcgctcacg agcagctctg cccgcacctc
     3061 caacgcgaag cccttccact cggacctcat gaatgggacc cggccaggca tggcctccac
     3121 caagctcagc ccttgggaca agagcagcca ctctgcccac cgcgtcgacc tgtcagccgt
     3181 gtgagccggg aggctgccaa ccaggccagg ctgcgctcag aacacacccc cccaaacaga
     3241 atgaaatgcc ccacctttgc ccatggaccc tctccttgct gctgtctgga catgggtgtt
     3301 gtggccccga gacagctgtc ctcccctgtg actctggctg tcggagcaca ctgctcagcc
     3361 cagcagcctg atgcccaggc cagcgtgggc cctcctgcct tgcatccacc cgtgggctga
     3421 gtgacttcct cgggggattc ccaggacaca gtggcctgac tgtgatggtg cccttgagcc
     3481 tcccttcatc actcagcatc agacccagcg aggccaggac actcggggcc ggtcccgcag
     3541 caccaggagg ggatgttcag cctctgtgcc ttggtggggc ttggggactc agggccaaag
     3601 aggtggttca ggtccccacg caccctcagt caggcgcagg cagctggggg tgtgtgggga
     3661 agagcatgcg gagtccccag tgtctgaatc cactgagtgg tgagttcccc acagccggcg
     3721 ctagccgtgg tgtgtgtctc tgtaggtggt gccggcgtgg gccaacctgt gctgtgtcat
     3781 cagttggggg cccctgccca agccgagctc gagccgtggg cgggagtcgt tgactctcca
     3841 ggtgagggcg acccctctgc cctgtccttg ggggggtccc ctctgctcac gtgaagagcc
     3901 gctctgggcc ttgaggctgc ctgatggtgc ctgtgcttgg gggagcttct cggccatccg
     3961 ctgtgagttt tgcctctttg gaccccaatt cggccttaag atgccctcct ccctcgtgtg
     4021 ccagcctcct tggttgttct tgggccacag gagctggccg tgtccccgca gtgcctggtg
     4081 tccaggtgga aagtggaggg cattttccag ggcactgctt tccccagagg cttcctcatg
     4141 gctcacaggc actctacgaa gtttctaatg ggcagaccac gcggcaggta gcacagtgcg
     4201 ctccgtctgg tcaccatgag accgacctgc gctgagtccc cactgacctg gagagggagg
     4261 gctggtgaca gccgtgtctt ctgtgttgag ggaaatttat ggactcagat tcagccccag
     4321 aggagatggg ataattgtta tggacccatg tgtgggcatg atcctgtgga acacaggttt
     4381 gggatcatag atgtgaatta agacaccacc gagatacggg ctgtgaggtt catactgtgc
     4441 tgatagcact cgtggtgtct gtgaaatgtg ggtaagacat tcaaacctgg ttttgatact
     4501 ggaaactctt cctttaaaac tgtgaccatg atttcattca gcccctccac acccctatgt
     4561 ctgccttgtt tcagagtgag ttttctatgg agcctgtggc ccttttgcag cccacctggt
     4621 ggcttcttaa tgtaactctt cccctggtcg cctggagtgg accactcatc tgcaggcctc
     4681 tcctgcatgg ggagggtagg cagggagcag catgtctgca ggggtgaacc tttgctcttc
     4741 tgtcaggcga ggcccaggct gcaccagcca cctgccacat ggtgacagtg ccacgggccc
     4801 tgcgtatggc ccctgcaacc gtgctctggc gggcacacct ggctgctgca ggccaaggcc
     4861 gctgttcagt gaagagtccc atgtttagta tggactaaag tcccatgttt agccactgcc
     4921 ccaggctccc gtgaccccag aaaccaggtc acatggacca cagtgccaga tcctcatcac
     4981 gccggtgagc acctagaagt gagaacactg tattcctaca atgtacactt ggatatttct
     5041 ccttatttag tttctagtga aacaaatcaa gtaaggaact atctttagtt tagatggaat
     5101 tatttgtttt taattgttgc cgtattcatc tatatagcta atatttcaag ataagtaatg
     5161 aacaaaacct gtctaaacct tttgtttcca atgaatgaaa gtcatgcact ttatttatag
     5221 gctctatgtt ttggcttctg cagtactttt attatctata cataatttgg ccaaaaataa
     5281 gaaattggaa agaatgaaat gtttagttta tagtagaaga aagatgatga cactaagttg
     5341 tgaaaatatg ttgtgatttt tatgaaataa actcatgtcc tgaaaagaaa
//
