LOCUS       NM_001704               6090 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens adhesion G protein-coupled receptor B3 (ADGRB3), mRNA.
ACCESSION   NM_001704
VERSION     NM_001704.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6090)
  AUTHORS   Gonda,X., Eszlari,N., Torok,D., Gal,Z., Bokor,J., Millinghoffer,A.,
            Baksa,D., Petschner,P., Antal,P., Breen,G., Juhasz,G. and Bagdy,G.
  TITLE     Genetic underpinnings of affective temperaments: a pilot GWAS
            investigation identifies a new genome-wide significant SNP for
            anxious temperament in ADGRB3 gene
  JOURNAL   Transl Psychiatry 11 (1), 337 (2021)
   PUBMED   34075027
  REMARK    GeneRIF: Genetic underpinnings of affective temperaments: a pilot
            GWAS investigation identifies a new genome-wide significant SNP for
            anxious temperament in ADGRB3 gene.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6090)
  AUTHORS   Beliu,G., Altrichter,S., Guixa-Gonzalez,R., Hemberger,M.,
            Brauer,I., Dahse,A.K., Scholz,N., Wieduwild,R., Kuhlemann,A.,
            Batebi,H., Seufert,F., Perez-Hernandez,G., Hildebrand,P.W.,
            Sauer,M. and Langenhan,T.
  TITLE     Tethered agonist exposure in intact adhesion/class B2 GPCRs through
            intrinsic structural flexibility of the GAIN domain
  JOURNAL   Mol Cell 81 (5), 905-921 (2021)
   PUBMED   33497605
  REMARK    GeneRIF: Tethered agonist exposure in intact adhesion/class B2
            GPCRs through intrinsic structural flexibility of the GAIN domain.
REFERENCE   3  (bases 1 to 6090)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 6090)
  AUTHORS   Scuderi,C., Saccuzzo,L., Vinci,M., Castiglia,L., Galesi,O.,
            Salemi,M., Mattina,T., Borgione,E., Citta,S., Romano,C. and
            Fichera,M.
  TITLE     Biallelic intragenic duplication in ADGRB3 (BAI3) gene associated
            with intellectual disability, cerebellar atrophy, and behavioral
            disorder
  JOURNAL   Eur J Hum Genet 27 (4), 594-602 (2019)
   PUBMED   30659260
  REMARK    GeneRIF: These findings further support this association and also
            suggest that biallelic variants affecting the function of the
            ADGRB3 gene may also cause cognitive impairments and ataxia.
REFERENCE   5  (bases 1 to 6090)
  AUTHORS   Gupta,R., Nguyen,D.C., Schaid,M.D., Lei,X., Balamurugan,A.N.,
            Wong,G.W., Kim,J.A., Koltes,J.E., Kimple,M.E. and Bhatnagar,S.
  TITLE     Complement 1q-like-3 protein inhibits insulin secretion from
            pancreatic beta-cells via the cell adhesion G protein-coupled
            receptor BAI3
  JOURNAL   J Biol Chem 293 (47), 18086-18098 (2018)
   PUBMED   30228187
  REMARK    GeneRIF: BAI3 mediates the inhibitory effects of C1ql3 on insulin
            secretion from pancreatic beta-cells.
REFERENCE   6  (bases 1 to 6090)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 6090)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 6090)
  AUTHORS   DeRosse,P., Lencz,T., Burdick,K.E., Siris,S.G., Kane,J.M. and
            Malhotra,A.K.
  TITLE     The genetics of symptom-based phenotypes: toward a molecular
            classification of schizophrenia
  JOURNAL   Schizophr Bull 34 (6), 1047-1053 (2008)
   PUBMED   18628273
  REMARK    GeneRIF: Level of disorganized symptoms was significantly (P < 6.00
            x 10(-5)) associated 2 SNPs within the brain-specific angiogenesis
            inhibitor 3 (BAI3) gene, which is highly expressed in brain during
            development.
REFERENCE   9  (bases 1 to 6090)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
REFERENCE   10 (bases 1 to 6090)
  AUTHORS   Shiratsuchi,T., Nishimori,H., Ichise,H., Nakamura,Y. and Tokino,T.
  TITLE     Cloning and characterization of BAI2 and BAI3, novel genes
            homologous to brain-specific angiogenesis inhibitor 1 (BAI1)
  JOURNAL   Cytogenet Cell Genet 79 (1-2), 103-108 (1997)
   PUBMED   9533023
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL391807.13, AL356117.16,
            AL359714.18, KF458189.1, AL158051.10, AL133378.16 and AL160401.12.
            
            On Nov 22, 2018 this sequence version replaced NM_001704.2.
            
            Summary: This p53-target gene encodes a brain-specific angiogenesis
            inhibitor, a seven-span transmembrane protein, and is thought to be
            a member of the secretin receptor family. Brain-specific
            angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in
            structure, have similar tissue specificities, and may also play a
            role in angiogenesis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.15274.1,
                                           SRR1803611.78414.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370598.6/ ENSP00000359630.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-719               AL391807.13        36335-37053
            720-891             AL391807.13        38444-38615
            892-1663            AL391807.13        39714-40485
            1664-1774           AL356117.16        42200-42310
            1775-1936           AL356117.16        48160-48321
            1937-2101           AL356117.16        55471-55635
            2102-2266           AL356117.16        67665-67829
            2267-2431           AL356117.16        68286-68450
            2432-2533           AL356117.16        86404-86505
            2534-2640           AL356117.16        86875-86981
            2641-2835           AL356117.16        105409-105603
            2836-2904           AL356117.16        125679-125747
            2905-2945           AL359714.18        3053-3093
            2946-3013           KF458189.1         301-368             c
            3014-3163           AL359714.18        32847-32996
            3164-3239           AL359714.18        33933-34008
            3240-3342           AL359714.18        47596-47698
            3343-3386           AL359714.18        60657-60700
            3387-3513           AL158051.10        61923-62049
            3514-3617           AL158051.10        63665-63768
            3618-3720           AL158051.10        67757-67859
            3721-3871           AL133378.16        84083-84233
            3872-3941           AL133378.16        87031-87100
            3942-4008           AL133378.16        89717-89783
            4009-4094           AL133378.16        92134-92219
            4095-4193           AL133378.16        98127-98225
            4194-4365           AL133378.16        98544-98715
            4366-4461           AL133378.16        113444-113539
            4462-4501           AL160401.12        1306-1345
            4502-5145           AL160401.12        6354-6997
            5146-5181           AL160401.12        17891-17926
            5182-5286           AL160401.12        28316-28420
            5287-6090           AL160401.12        34188-34991
FEATURES             Location/Qualifiers
     source          1..6090
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q12-q13"
     gene            1..6090
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /note="adhesion G protein-coupled receptor B3"
                     /db_xref="GeneID:577"
                     /db_xref="HGNC:HGNC:945"
                     /db_xref="MIM:602684"
     exon            1..719
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            720..891
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1663
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     CDS             907..5475
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /note="dJ91B17.1 (brain-specific angiogenesis inhibitor
                     3)"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor B3"
                     /protein_id="NP_001695.2"
                     /db_xref="CCDS:CCDS4968.1"
                     /db_xref="GeneID:577"
                     /db_xref="HGNC:HGNC:945"
                     /db_xref="MIM:602684"
                     /translation="MKAVRNLLIYIFSTYLLVMFGFNAAQDFWCSTLVKGVIYGSYSV
                     SEMFPKNFTNCTWTLENPDPTKYSIYLKFSKKDLSCSNFSLLAYQFDHFSHEKIKDLL
                     RKNHSIMQLCNSKNAFVFLQYDKNFIQIRRVFPTNFPGLQKKGEEDQKSFFEFLVLNK
                     VSPSQFGCHVLCTWLESCLKSENGRTESCGIMYTKCTCPQHLGEWGIDDQSLILLNNV
                     VLPLNEQTEGCLTQELQTTQVCNLTREAKRPPKEEFGMMGDHTIKSQRPRSVHEKRVP
                     QEQADAAKFMAQTGESGVEEWSQWSTCSVTCGQGSQVRTRTCVSPYGTHCSGPLRESR
                     VCNNTALCPVHGVWEEWSPWSLCSFTCGRGQRTRTRSCTPPQYGGRPCEGPETHHKPC
                     NIALCPVDGQWQEWSSWSQCSVTCSNGTQQRSRQCTAAAHGGSECRGPWAESRECYNP
                     ECTANGQWNQWGHWSGCSKSCDGGWERRIRTCQGAVITGQQCEGTGEEVRRCNEQRCP
                     APYEICPEDYLMSMVWKRTPAGDLAFNQCPLNATGTTSRRCSLSLHGVAFWEQPSFAR
                     CISNEYRHLQHSIKEHLAKGQRMLAGDGMSQVTKTLLDLTQRKNFYAGDLLMSVEILR
                     NVTDTFKRASYIPASDGVQNFFQIVSNLLDEENKEKWEDAQQIYPGSIELMQVIEDFI
                     HIVGMGMMDFQNSYLMTGNVVASIQKLPAASVLTDINFPMKGRKGMVDWARNSEDRVV
                     IPKSIFTPVSSKELDESSVFVLGAVLYKNLDLILPTLRNYTVINSKIIVVTIRPEPKT
                     TDSFLEIELAHLANGTLNPYCVLWDDSKTNESLGTWSTQGCKTVLTDASHTKCLCDRL
                     STFAILAQQPREIIMESSGTPSVTLIVGSGLSCLALITLAVVYAALWRYIRSERSIIL
                     INFCLSIISSNILILVGQTQTHNKSICTTTTAFLHFFFLASFCWVLTEAWQSYMAVTG
                     KIRTRLIRKRFLCLGWGLPALVVATSVGFTRTKGYGTDHYCWLSLEGGLLYAFVGPAA
                     AVVLVNMVIGILVFNKLVSRDGILDKKLKHRAGQMSEPHSGLTLKCAKCGVVSTTALS
                     ATTASNAMASLWSSCVVLPLLALTWMSAVLAMTDKRSILFQILFAVFDSLQGFVIVMV
                     HCILRREVQDAFRCRLRNCQDPINADSSSSFPNGHAQIMTDFEKDVDIACRSVLHKDI
                     GPCRAATITGTLSRISLNDDEEEKGTNPEGLSYSTLPGNVISKVIIQQPTGLHMPMSM
                     NELSNPCLKKENSELRRTVYLCTDDNLRGADMDIVHPQERMMESDYIVMPRSSVNNQP
                     SMKEESKMNIGMETLPHERLLHYKVNPEFNMNPPVMDQFNMNLEQHLAPQEHMQNLPF
                     EPRTAVKNFMASELDDNAGLSRSETGSTISMSSLERRKSRYSDLDFEKVMHTRKRHME
                     LFQELNQKFQTLDRFRDIPNTSSMENPAPNKNPWDTFKNPSEYPHYTTINVLDTEAKD
                     ALELRPAEWEKCLNLPLDVQEGDFQTEV"
     exon            1664..1774
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1936
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2101
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2266
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2431
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2533
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2640
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2835
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            2836..2904
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..3013
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3163
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            3164..3239
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            3240..3342
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            3343..3386
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            3387..3513
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            3514..3617
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            3618..3720
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            3721..3871
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            3872..3941
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            3942..4008
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            4009..4094
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            4095..4193
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            4194..4365
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            4366..4461
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            4462..4501
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            4502..5145
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            5146..5181
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            5182..5286
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     exon            5287..6090
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6073..6078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /note="hexamer: AATAAA"
     polyA_site      6090
                     /gene="ADGRB3"
                     /gene_synonym="BAI3"
                     /note="major polyA site"
ORIGIN      
        1 actgcgcgcc ggcgcgcaca cccgagacag agctttacta tctcgctccc tctcgcgcct
       61 ccctcctcgc tgggcattca aacagctttc cgacatcacc agccaaggat ttttttcccc
      121 gctctcctta gtcgccgtcc gtccatcagt acctgcaggg gggaggagga ggagggagga
      181 aagcggaaag aggaaaaagc ataagcttga gccttccgat ccgaccacga atactcctgt
      241 aataaaccca ccgccccaac aaatctgcca tagcagccgc cgccgccgcc ggtcacttct
      301 cgtctcagcg ctttctttgc ttcttggttt gttgggggta gcttttatga aacaaatctt
      361 tgctattaag ccacttacat tttggggggt tccttagagt ctcccttggg ggggcttctc
      421 cctcccttta gcccccctcg gtttggaggt tggattcagt tggatacggc gcaaggttct
      481 gggctcctgc tggctttttt ttcctctctc tcatcgaccc ccctttggtt cccacccccc
      541 accttttgct tttcgtatgt atgcattttt aaaaataaat cctgattttg gaagctgagc
      601 cggggaaaat gggcaacggt gattgggacc gaaggggagt ctctccgtca ctgttgctgg
      661 gacgcgtgcc tgtgctggtg tcttagagca agagcctccc tgagctttcg gagtggaaga
      721 acagtggaag agactgcagc ctaaagactt ttaaaattaa cttggcatca cttttatcag
      781 ctcaaaggct aaacaaacaa acaaaagcag tgtcatttat tctaagaaat aacttcttaa
      841 aggttaaagc tgaaaaatat tcaagttatt tttggataac aacttacaga ggccaaatga
      901 cataggatga aggctgttcg taacctgctg atttatatat tttccaccta tctcctggtt
      961 atgtttggat ttaatgctgc ccaagacttc tggtgttcaa ctttggtgaa gggagtcatt
     1021 tatggatcgt attctgtaag tgaaatgttt cctaaaaact ttacaaactg cacttggacg
     1081 ctggaaaatc cagatccaac caaatatagc atttacctga aattttccaa aaaggacctt
     1141 agctgctcta acttttcact cctggcttat cagtttgatc atttttccca tgaaaaaata
     1201 aaggatcttt taagaaagaa tcattctata atgcaactct gcaattccaa gaatgctttc
     1261 gtttttctac agtatgataa aaattttatt caaatacgtc gagtatttcc aactaatttc
     1321 ccaggattac agaaaaaagg ggaagaagat cagaaatctt tttttgagtt tttggtattg
     1381 aacaaggtca gcccaagcca gtttggttgc catgtattat gtacttggtt ggagagctgc
     1441 ttaaaatcag aaaatgggag aacagaatca tgtgggatca tgtatacaaa atgcacctgc
     1501 cctcagcatt tgggagagtg ggggatcgac gaccagtcgc tgattttgtt aaataacgtg
     1561 gtgttacccc tgaatgagca gacagagggc tgcctgaccc aggagctgca aaccacccaa
     1621 gtctgcaatc ttaccaggga ggccaagcga ccacccaaag aagaatttgg aatgatggga
     1681 gatcatacaa ttaaaagtca gcgacctcga tctgttcatg aaaaaagggt ccctcaggaa
     1741 caagctgatg ctgctaaatt tatggcacaa actggtgaat ctggtgtgga agagtggtcc
     1801 cagtggagca catgttcggt tacttgtggt caagggtcgc aggtgcgaac cagaacttgt
     1861 gtatcacctt acgggacaca ctgcagcggc ccattaagag aatcaagggt ttgcaataac
     1921 actgccctct gtccagtaca cggagtatgg gaggaatggt caccatggag tttatgttca
     1981 tttacatgtg gtcgaggcca aagaacaaga acaaggtcat gcacacctcc tcagtatgga
     2041 ggaaggccgt gtgaaggacc tgaaacacat cataagcctt gtaatattgc tctttgccca
     2101 gttgatggac agtggcaaga gtggagttcg tggagccagt gctcagtaac gtgctcgaat
     2161 gggactcagc agagaagccg gcagtgcact gcagctgccc atggaggctc cgaatgcaga
     2221 gggccatggg cagaaagcag agagtgctat aaccctgaat gtacagccaa tggtcaatgg
     2281 aatcagtggg gtcattggag tggttgttcc aagtcctgtg atggcggctg ggaaaggcga
     2341 ataaggacct gtcagggtgc agtgataaca gggcagcaat gtgaaggaac gggcgaagaa
     2401 gtgagaagat gcaatgagca gcgatgccct gcaccttatg aaatatgccc tgaggattat
     2461 ctgatgtcga tggtgtggaa aagaactcca gcaggcgact tggcattcaa tcaatgtccc
     2521 ctgaatgcca caggcaccac tagcagacgc tgctctctca gtcttcatgg agtggccttc
     2581 tgggaacagc cgagctttgc aagatgcata tcaaatgagt acagacactt gcagcattca
     2641 attaaagagc accttgctaa ggggcagcga atgctggcag gtgatggaat gtcccaggtg
     2701 accaagacac tgttggattt aactcagaga aaaaatttct atgcaggcga tcttctgatg
     2761 tctgtggaga tcctgagaaa tgtgacagac acatttaaaa gggcaagtta catccctgca
     2821 tctgatggtg tccagaactt ctttcaaata gttagcaacc ttctagatga agaaaacaag
     2881 gaaaaatggg aagatgcaca acagatttat ccagggtcaa tagagttaat gcaggtgatt
     2941 gaagatttta tacacattgt tggaatgggg atgatggact ttcagaattc atacttaatg
     3001 actggaaatg tagtggctag tattcagaag cttcctgcag cctctgttct aacagacatc
     3061 aactttccaa tgaaaggacg gaagggaatg gttgactggg caagaaactc agaagatagg
     3121 gtagtaattc caaaaagcat tttcactccg gtgtcatcaa aagaattaga tgaatcatct
     3181 gtatttgttc ttggcgcagt cctatacaaa aacttagatc taattttgcc cactttgaga
     3241 aattatactg tcattaattc caaaatcatc gtggtcacaa taaggcctga acccaaaaca
     3301 accgattcgt ttctggagat agaactagct catttggcta atggtacttt gaatccctat
     3361 tgtgtattgt gggatgactc caaaacgaac gagtctttgg gaacgtggtc cacccaggga
     3421 tgtaaaactg tgcttaccga tgcatcccat acgaaatgct tatgtgatcg tctctctacc
     3481 ttcgccattt tggctcagca acctagagaa ataatcatgg aatcctctgg cacaccttca
     3541 gttaccctaa tagtaggcag tggtctttct tgcttggcct tgattaccct agcagttgtc
     3601 tatgcagcat tatggaggta catacgctct gagagatcca taatactaat taacttctgc
     3661 ctgtctatca tctcatccaa tatcctcata ctggttggac agactcagac acataataag
     3721 agtatctgca caaccaccac tgcatttttg cactttttct tcctggcttc attctgttgg
     3781 gttttgactg aggcgtggca atcatatatg gctgtaactg gaaaaattag gacacggctt
     3841 ataagaaaac gctttttgtg ccttggatgg ggtttaccag cattagtagt ggccacatca
     3901 gtaggcttca ccagaacaaa aggatatggc actgatcact actgctggct ctctcttgaa
     3961 ggaggactac tctatgcttt tgtgggacct gcagccgctg ttgtcctggt caacatggtg
     4021 attggcattt tggtatttaa taaacttgtt tccagagatg gaatcctaga taaaaagctc
     4081 aaacacagag ccggtcagat gagtgagcct catagcggtt tgacgctcaa atgtgccaag
     4141 tgtggagtag tttcaacaac agctttgtca gccaccaccg ccagtaacgc catggcgtct
     4201 ctttggagct cctgtgtggt gttgcccctt ctggctttga cgtggatgtc tgcggttctg
     4261 gccatgacag ataaacgctc catattgttt caaatacttt ttgctgtgtt tgattcattg
     4321 caaggctttg ttatagtcat ggtccactgc attcttcgga gagaggttca ggatgcattt
     4381 agatgccgat tgagaaactg tcaggatccc atcaatgcag attcttcgag ttcgtttcct
     4441 aatgggcatg ctcaaatcat gacagacttt gaaaaggatg tagacattgc ctgtcgatca
     4501 gttcttcata aggatattgg tccttgccga gcagccacaa taacaggaac actttctagg
     4561 atttctctaa atgatgatga agaagaaaag ggaacaaacc ctgaagggct aagctattca
     4621 acattgcctg gaaatgtcat ttccaaagtc atcatccagc aacccacagg tttgcacatg
     4681 cccatgagta tgaatgagct tagcaatcca tgtttgaaaa aagaaaatag tgaattgcgg
     4741 agaactgtgt acttatgtac ggatgataat ttgagagggg ctgacatgga catagtccat
     4801 cctcaagaaa gaatgatgga aagtgactat attgtgatgc ccagaagttc tgtaaataac
     4861 cagccttcaa tgaaagaaga aagcaaaatg aatattggca tggaaacctt gccgcatgaa
     4921 aggctattgc actacaaagt aaaccctgaa ttcaatatga atccccctgt aatggaccag
     4981 ttcaatatga acttagagca acatctcgca ccccaggaac atatgcagaa tttgcccttt
     5041 gaacctcgca cagctgtgaa gaatttcatg gcctctgagt tggatgataa tgcaggacta
     5101 tcaagaagtg aaactggatc aacgatatca atgagttctt tagagagaag aaaatcacga
     5161 tattcagacc ttgactttga gaaggtcatg catacaagga agaggcatat ggaactattt
     5221 caagaactaa atcagaaatt tcaaactttg gacagatttc gggatatacc aaatacaagc
     5281 agtatggaaa accccgcacc aaacaagaat ccatgggaca ctttcaaaaa ccccagtgaa
     5341 tacccgcatt acaccacaat caatgtctta gacacagagg caaaggatgc tttggaactg
     5401 aggccagcag agtgggagaa gtgtctgaat ttgcctctgg atgtgcaaga gggtgacttt
     5461 caaacagaag tttaaaaaaa tcaaaatgga ctaaggtaga gacaaaactt tattgcactg
     5521 acacttaaga cttgggaagc ctgacatttc tatctggaca gtgtgactat cttatgtcag
     5581 gaccttcatg tgccaaacgt cagtggtgtt ttcatatggt aacttctcac tagtcaggct
     5641 agtggagaga tgaccaggtg tacagttctg accatcctgt gttgtaagta cccgtggaat
     5701 ggatttgtaa ggtaatcttt atagataaac ctcaagcaac gattcatgtt gtaaccgctt
     5761 catatggttt agttttcaaa aaacttcacc atgaagcaca atgtatatat ttatgcagtt
     5821 tttaaagttt ataacagtct gtttggccat tactacactt tttactttat aatataaaag
     5881 caaagttttt gtcattaaat gaatgtttgt tgagctacat tcttcattgc tttaaatgca
     5941 ataaagtaat aatctcactt ttatatgaat aatatatttc acatctttat tattgcagtt
     6001 ttctctagaa agctctgaga agctttctct gctgcagctg tgtataaaat atttaaaatg
     6061 ttgtatggtg taaataaact tttgtctaca
//
