LOCUS       NM_001364857            5708 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens adhesion G protein-coupled receptor B2 (ADGRB2),
            transcript variant 3, mRNA.
ACCESSION   NM_001364857 NM_001703
VERSION     NM_001364857.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5708)
  AUTHORS   Purcell,R.H., Toro,C., Gahl,W.A. and Hall,R.A.
  TITLE     A disease-associated mutation in the adhesion GPCR BAI2 (ADGRB2)
            increases receptor signaling activity
  JOURNAL   Hum Mutat 38 (12), 1751-1760 (2017)
   PUBMED   28891236
  REMARK    GeneRIF: These studies provide new insights into the signaling
            capabilities of the adhesion GPCR BAI2/ADGRB2 and shed light on how
            an apparent gain-of-function mutation to the receptor's C-terminus
            may lead to human disease.
REFERENCE   2  (bases 1 to 5708)
  AUTHORS   Hamann,J., Aust,G., Arac,D., Engel,F.B., Formstone,C.,
            Fredriksson,R., Hall,R.A., Harty,B.L., Kirchhoff,C., Knapp,B.,
            Krishnan,A., Liebscher,I., Lin,H.H., Martinelli,D.C., Monk,K.R.,
            Peeters,M.C., Piao,X., Promel,S., Schoneberg,T., Schwartz,T.W.,
            Singer,K., Stacey,M., Ushkaryov,Y.A., Vallon,M., Wolfrum,U.,
            Wright,M.W., Xu,L., Langenhan,T. and Schioth,H.B.
  TITLE     International Union of Basic and Clinical Pharmacology. XCIV.
            Adhesion G protein-coupled receptors
  JOURNAL   Pharmacol Rev 67 (2), 338-367 (2015)
   PUBMED   25713288
  REMARK    Review article
REFERENCE   3  (bases 1 to 5708)
  AUTHORS   Zencir,S., Ovee,M., Dobson,M.J., Banerjee,M., Topcu,Z. and
            Mohanty,S.
  TITLE     Identification of brain-specific angiogenesis inhibitor 2 as an
            interaction partner of glutaminase interacting protein
  JOURNAL   Biochem Biophys Res Commun 411 (4), 792-797 (2011)
   PUBMED   21787750
  REMARK    GeneRIF: This is the first study reporting BAI2 as an interaction
            partner of GIP.
REFERENCE   4  (bases 1 to 5708)
  AUTHORS   Okajima,D., Kudo,G. and Yokota,H.
  TITLE     Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by
            proteolytic processing
  JOURNAL   J Recept Signal Transduct Res 30 (3), 143-153 (2010)
   PUBMED   20367554
  REMARK    GeneRIF: BAI2 is a functional GPCR regulated by proteolytic
            processing and activates the NFAT pathway
REFERENCE   5  (bases 1 to 5708)
  AUTHORS   Jeong,B.C., Kim,M.Y., Lee,J.H., Kee,H.J., Kho,D.H., Han,K.E.,
            Qian,Y.R., Kim,J.K. and Kim,K.K.
  TITLE     Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP
            that acts as a transcriptional repressor
  JOURNAL   FEBS Lett 580 (2), 669-676 (2006)
   PUBMED   16412436
REFERENCE   6  (bases 1 to 5708)
  AUTHORS   Kee,H.J., Ahn,K.Y., Choi,K.C., Won Song,J., Heo,T., Jung,S.,
            Kim,J.K., Bae,C.S. and Kim,K.K.
  TITLE     Expression of brain-specific angiogenesis inhibitor 3 (BAI3) in
            normal brain and implications for BAI3 in ischemia-induced brain
            angiogenesis and malignant glioma
  JOURNAL   FEBS Lett 569 (1-3), 307-316 (2004)
   PUBMED   15225653
REFERENCE   7  (bases 1 to 5708)
  AUTHORS   Kee,H.J., Koh,J.T., Kim,M.Y., Ahn,K.Y., Kim,J.K., Bae,C.S.,
            Park,S.S. and Kim,K.K.
  TITLE     Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in
            normal and ischemic brain: involvement of BAI2 in the
            ischemia-induced brain angiogenesis
  JOURNAL   J Cereb Blood Flow Metab 22 (9), 1054-1067 (2002)
   PUBMED   12218411
  REMARK    GeneRIF: involvement of BAI2 in the ischemia-induced brain
            angiogenesis
REFERENCE   8  (bases 1 to 5708)
  AUTHORS   Shiratsuchi,T., Nishimori,H., Ichise,H., Nakamura,Y. and Tokino,T.
  TITLE     Cloning and characterization of BAI2 and BAI3, novel genes
            homologous to brain-specific angiogenesis inhibitor 1 (BAI1)
  JOURNAL   Cytogenet Cell Genet 79 (1-2), 103-108 (1997)
   PUBMED   9533023
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354919.16 and AC114488.3.
            
            On Nov 30, 2019 this sequence version replaced NM_001364857.1.
            
            Summary: This gene encodes a a seven-span transmembrane protein
            that is thought to be a member of the secretin receptor family. The
            encoded protein is a brain-specific inhibitor of angiogenesis. The
            mature peptide may be further cleaved into additional products
            (PMID:20367554). Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jun 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000373658.8/ ENSP00000362762.3
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-457               AL354919.16        16315-16771         c
            458-587             AL354919.16        9813-9942           c
            588-668             AL354919.16        9632-9712           c
            669-1485            AL354919.16        8430-9246           c
            1486-1569           AC114488.3         179933-180016       c
            1570-1734           AC114488.3         179478-179642       c
            1735-1899           AC114488.3         178123-178287       c
            1900-2064           AC114488.3         177338-177502       c
            2065-2232           AC114488.3         177085-177252       c
            2233-2334           AC114488.3         176909-177010       c
            2335-2441           AC114488.3         176658-176764       c
            2442-2636           AC114488.3         175632-175826       c
            2637-2705           AC114488.3         175395-175463       c
            2706-2814           AC114488.3         175211-175319       c
            2815-3142           AC114488.3         174593-174920       c
            3143-3248           AC114488.3         174117-174222       c
            3249-3292           AC114488.3         173872-173915       c
            3293-3419           AC114488.3         173485-173611       c
            3420-3523           AC114488.3         172937-173040       c
            3524-3626           AC114488.3         172714-172816       c
            3627-3777           AC114488.3         171858-172008       c
            3778-3847           AC114488.3         171606-171675       c
            3848-3914           AC114488.3         171112-171178       c
            3915-4000           AC114488.3         170865-170950       c
            4001-4099           AC114488.3         170468-170566       c
            4100-4271           AC114488.3         168257-168428       c
            4272-4367           AC114488.3         167802-167897       c
            4368-4407           AC114488.3         167400-167439       c
            4408-5027           AC114488.3         166085-166704       c
            5028-5063           AC114488.3         163883-163918       c
            5064-5162           AC114488.3         163467-163565       c
            5163-5219           AC114488.3         163310-163366       c
            5220-5708           AC114488.3         162402-162890       c
FEATURES             Location/Qualifiers
     source          1..5708
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.2"
     gene            1..5708
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /note="adhesion G protein-coupled receptor B2"
                     /db_xref="GeneID:576"
                     /db_xref="HGNC:HGNC:944"
                     /db_xref="MIM:602683"
     exon            1..457
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            458..587
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            588..668
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     CDS             648..5405
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /note="isoform 3 preproprotein is encoded by transcript
                     variant 3; brain-specific angiogenesis inhibitor 2"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor B2 isoform 3
                     preproprotein"
                     /protein_id="NP_001351786.1"
                     /db_xref="CCDS:CCDS346.2"
                     /db_xref="GeneID:576"
                     /db_xref="HGNC:HGNC:944"
                     /db_xref="MIM:602683"
                     /translation="MENTGWMGKGHRMTPACPLLLSVILSLRLATAFDPAPSACSALA
                     SGVLYGAFSLQDLFPTIASGCSWTLENPDPTKYSLYLRFNRQEQVCAHFAPRLLPLDH
                     YLVNFTCLRPSPEEAVAQAESEVGRPEEEEAEAAAGLELCSGSGPFTFLHFDKNFVQL
                     CLSAEPSEAPRLLAPAALAFRFVEVLLINNNNSSQFTCGVLCRWSEECGRAAGRACGF
                     AQPGCSCPGEAGAGSTTTTSPGPPAAHTLSNALVPGGPAPPAEADLHSGSSNDLFTTE
                     MRYGEEPEEEPKVKTQWPRSADEPGLYMAQTGDPAAEEWSPWSVCSLTCGQGLQVRTR
                     SCVSSPYGTLCSGPLRETRPCNNSATCPVHGVWEEWGSWSLCSRSCGRGSRSRMRTCV
                     PPQHGGKACEGPELQTKLCSMAACPVEGQWLEWGPWGPCSTSCANGTQQRSRKCSVAG
                     PAWATCTGALTDTRECSNLECPATDSKWGPWNAWSLCSKTCDTGWQRRFRMCQATGTQ
                     GYPCEGTGEEVKPCSEKRCPAFHEMCRDEYVMLMTWKKAAAGEIIYNKCPPNASGSAS
                     RRCLLSAQGVAYWGLPSFARCISHEYRYLYLSLREHLAKGQRMLAGEGMSQVVRSLQE
                     LLARRTYYSGDLLFSVDILRNVTDTFKRATYVPSADDVQRFFQVVSFMVDAENKEKWD
                     DAQQVSPGSVHLLRVVEDFIHLVGDALKAFQSSLIVTDNLVISIQREPVSAVSSDITF
                     PMRGRRGMKDWVRHSEDRLFLPKEVLSLSSPGKPATSGAAGSPGRGRGPGTVPPGPGH
                     SHQRLLPADPDESSYFVIGAVLYRTLGLILPPPRPPLAVTSRVMTVTVRPPTQPPAEP
                     LITVELSYIINGTTDPHCASWDYSRADASSGDWDTENCQTLETQAAHTRCQCQHLSTF
                     AVLAQPPKDLTLELAGSPSVPLVIGCAVSCMALLTLLAIYAAFWRFIKSERSIILLNF
                     CLSILASNILILVGQSRVLSKGVCTMTAAFLHFFFLSSFCWVLTEAWQSYLAVIGRMR
                     TRLVRKRFLCLGWGLPALVVAVSVGFTRTKGYGTSSYCWLSLEGGLLYAFVGPAAVIV
                     LVNMLIGIIVFNKLMARDGISDKSKKQRAGSERCPWASLLLPCSACGAVPSPLLSSAS
                     ARNAMASLWSSCVVLPLLALTWMSAVLAMTDRRSVLFQALFAVFNSAQGFVITAVHCF
                     LRREVQDVVKCQMGVCRADESEDSPDSCKNGQLQILSDFEKDVDLACQTVLFKEVNTC
                     NPSTITGTLSRLSLDEDEEPKSCLVGPEGSLSFSPLPGNILVPMAASPGLGEPPPPQE
                     ANPVYMCGEGGLRQLDLTWLRPTEPGSEGDYMVLPRRTLSLQPGGGGGGGEDAPRARP
                     EGTPRRAAKTVAHTEGYPSFLSVDHSGLGLGPAYGSLQNPYGMTFQPPPPTPSARQVP
                     EPGERSRTMPRTVPGSTMKMGSLERKKLRYSDLDFEKVMHTRKRHSELYHELNQKFHT
                     FDRYRSQSTAKREKRWSVSSGGAAERSVCTDKPSPGERPSLSQHRRHQSWSTFKSMTL
                     GSLPPKPRERLTLHRAAAWEPTEPPDGDFQTEV"
     exon            669..1485
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1569
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1734
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1899
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2064
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2232
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2334
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2441
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2636
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            2637..2705
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2814
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            2815..3142
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            3143..3248
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            3249..3292
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            3293..3419
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            3420..3523
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            3524..3626
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            3627..3777
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            3778..3847
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            3848..3914
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            3915..4000
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            4001..4099
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            4100..4271
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            4272..4367
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            4368..4407
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            4408..5027
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            5028..5063
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            5064..5162
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            5163..5219
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            5220..5708
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5689..5694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /note="hexamer: AATAAA"
     polyA_site      5708
                     /gene="ADGRB2"
                     /gene_synonym="BAI2"
                     /note="major polyA site"
ORIGIN      
        1 actcggcccg gcgcgcgctg cgggcagcgg ccggagcggc cggaggaacc gggttcggcg
       61 gcagcggcgg cggcgctcag agaccgaaga ggatgcggca ccggctctca gagcccgggg
      121 ctgcggccgc cgcccgcaaa taggaggcgg cgcgcggcgc gggcggtgct cggggcgggg
      181 gagcggggga gcggggggcg gcgcggcaag gaggcggcgg cggcggcggc ggcaggagcc
      241 cgcgcccggc ccggcgccgc ccgcccgccc gccccgcgct gctccgcggc gccttttctg
      301 cacccgccgc ccgggagagc gggagcctcg gccctccgcg cggctgcagc tacctaccct
      361 gcgcccggcc cggtccccga cttagggatg gcaaacttgc gccccgtggc cgcccccgcc
      421 agcgccggcc cccgctcctg ctgctgacgg cgcccaggaa atccacagca gtgatacatg
      481 tgacgtccac actgacagtg ccctcctgtg ggcatggctc aggttgtgcg cagttcctgg
      541 cacactggct gtaactccgc ccctttctct ccctctcagt aaagcaagat tacgcggtga
      601 catgcctcac agctgatcac gacacacggg gatggagagc aagagttatg gagaatacag
      661 gttggatggg caagggacat aggatgaccc cagcctgtcc cctcttactg tctgtgattc
      721 tgtccctgcg cctggccacc gccttcgacc ccgcccccag tgcctgctct gccctggcct
      781 cgggtgtgct ctacggggcc ttctcgctgc aggacctctt tcctaccatc gcctcgggct
      841 gctcctggac cctggagaac cctgacccca ccaagtactc cctctacctg cgcttcaacc
      901 gccaggagca ggtgtgcgca cactttgccc cccgcctgct gcccctggac cactacctgg
      961 tcaactttac ctgcctgcgg cctagccccg aggaggcggt ggcccaggcg gagtcagagg
     1021 tggggcggcc agaagaggag gaggcagagg cggcagcggg gttggagctg tgcagcggct
     1081 caggcccctt taccttcctg cacttcgaca agaacttcgt gcagctgtgc ctgtcggctg
     1141 agccctccga ggccccgcgc ctgctggcgc ccgctgccct agccttccgc tttgtcgagg
     1201 tcttgctcat caacaacaac aactctagcc aattcacctg tggtgtgctc tgccgctgga
     1261 gtgaggagtg tggccgcgct gccggcaggg cctgcggctt tgctcagcca ggctgcagct
     1321 gccctggaga ggcgggggcc ggctccacca ccaccacatc tccaggccct cctgctgccc
     1381 acaccctgtc caatgccctg gtgcccgggg gcccagcccc acctgctgag gccgatttgc
     1441 actcggggag cagcaatgat ctgttcacaa ccgagatgag atatggtgag gagccggaag
     1501 aggaaccgaa agtgaaaacc cagtggccga ggtctgcaga tgagcctggg ctatacatgg
     1561 cgcagacagg cgacccggcg gctgaggagt ggtccccgtg gagcgtgtgt tccctgacgt
     1621 gtgggcaggg tctgcaggtg cggacccgct cctgtgtgtc ctccccctat gggaccctgt
     1681 gcagcgggcc cctgcgggag accaggccct gcaacaattc agccacctgc ccagtgcacg
     1741 gcgtgtggga ggagtggggg tcctggagcc tgtgctcccg cagctgcggg cgggggtccc
     1801 ggagccggat gcggacctgc gtgccccccc agcacggcgg caaggcctgc gagggtcctg
     1861 agctgcagac taagctctgc agtatggctg cctgcccggt ggaaggccag tggttagaat
     1921 ggggtccctg gggcccatgc tccacgtcct gtgccaatgg gacccaacag cgcagccgga
     1981 agtgcagcgt ggcgggccca gcctgggcca catgcacggg tgccctcact gacacccggg
     2041 agtgcagcaa cctcgagtgc ccggccactg atagcaagtg ggggccatgg aatgcgtgga
     2101 gcctgtgctc taagacgtgt gacacaggct ggcagcgccg cttccgcatg tgccaggcca
     2161 cgggcacgca gggctacccc tgcgagggca ccggagagga ggtgaagcct tgtagtgaga
     2221 agaggtgtcc agccttccat gagatgtgca gggatgagta cgtgatgctg atgacgtgga
     2281 agaaggcagc tgctggcgag atcatctaca acaagtgccc cccgaatgcc tcagggtctg
     2341 ccagccgccg ctgtctcctc agtgcccaag gcgtggcgta ctgggggctg cccagctttg
     2401 ctcgctgcat ctcccatgag taccgctacc tgtatctgtc acttagggag cacctggcca
     2461 aggggcagcg catgctggca ggcgagggca tgtcgcaggt ggtgcgcagc ctgcaggagc
     2521 tactggcccg gcgcacctac tatagtgggg acctgctctt ctctgtggac attctgagga
     2581 atgtcactga cacctttaag agggccacct acgtgccctc ggctgatgat gtgcagcgct
     2641 tcttccaggt ggtgagcttc atggtggatg cggaaaacaa ggagaagtgg gacgatgctc
     2701 agcaggtgtc ccctggctct gtgcacctgc tccgtgtcgt ggaggacttc attcacctgg
     2761 tgggcgatgc tctcaaggcc ttccagagct ctctgattgt cacagataat ctagtgatca
     2821 gcattcagcg agagcccgtc tcagctgtgt ccagtgacat cacgttcccc atgcggggcc
     2881 gccggggcat gaaggactgg gtgcggcact cagaggaccg cctcttcctg cccaaggagg
     2941 tgctcagcct ctcctcccca gggaagccag ccacatctgg ggcagcaggc agccctggca
     3001 gggggagggg cccaggaacg gtgcctcctg gcccaggcca ctcccaccag cgcctcctcc
     3061 cagcagaccc tgatgagtcc tcctactttg tgatcggtgc tgtactctac cgcacccttg
     3121 gcctcatcct gccgcctccc aggcccccgc tggccgtcac atcccgggtg atgacagtga
     3181 ctgtgcgccc ccctacccag cctccagctg agcccctcat cactgtggag ctctcctaca
     3241 tcatcaatgg gaccacggat ccccattgcg ccagctggga ctactccaga gcagatgcca
     3301 gctcaggaga ctgggacact gaaaattgcc agaccctgga gacccaggca gctcacaccc
     3361 gctgccagtg ccagcacctg tccacctttg ctgtactagc ccagccgccc aaggacctga
     3421 ccctggagct ggcgggctcc ccctcggtcc ccctggtgat cggctgtgca gtgtcgtgca
     3481 tggcgctgct caccctgctc gccatctatg ccgccttttg gaggttcata aaatctgaac
     3541 gctccatcat cttgctgaac ttctgcctgt ccatcttggc atccaacatc ctgatcctcg
     3601 tgggccagtc ccgggtgctg agcaagggcg tgtgcaccat gacggctgcc ttcctgcact
     3661 tcttctttct ctcctccttt tgctgggtgc ttaccgaggc ctggcagtcc tacctggctg
     3721 tcattgggcg gatgcgcacc cgcctcgttc gcaagcgctt cctctgcctg ggctggggtc
     3781 tgcctgccct ggtggtggcc gtgtctgttg gctttacccg aacgaaagga tacggtacat
     3841 ccagctactg ctggctctcc ctggagggcg gcctgctcta cgcctttgtg ggccctgcag
     3901 ccgtcattgt cctggtgaac atgctcatcg gaatcatcgt cttcaacaag ctcatggcac
     3961 gtgatggcat ctccgacaaa tccaagaagc agagggccgg gtcggagcgg tgcccctggg
     4021 ccagcctgct cctcccctgc tcagcgtgtg gagcggtccc cagccccctg ctcagctcag
     4081 cctcggccag gaacgccatg gcctcactct ggagctcctg cgtggtgctg cccctgctgg
     4141 cgctcacctg gatgtctgcc gtcctggcta tgacagaccg ccgttccgtc ctcttccagg
     4201 ccctctttgc tgtcttcaac tccgcgcagg gctttgtcat cactgctgtg cactgcttcc
     4261 tgcgccgaga ggtccaggat gtggtgaagt gccagatggg ggtgtgccgg gctgatgaga
     4321 gcgaagactc ccctgactcg tgtaagaacg ggcagctgca gatcctgtca gactttgaaa
     4381 aggatgtgga tctggcttgt caaacagtgc tgttcaagga ggtcaacact tgcaacccgt
     4441 ccaccatcac gggcacacta tcccgcctgt ccctggatga ggatgaggag cccaagtcct
     4501 gcctcgtggg ccctgagggc agcctcagct tctcaccact gcctgggaat atcctggtgc
     4561 ccatggcagc ctcaccaggg ctgggggagc ctccgccccc acaggaggcc aaccctgttt
     4621 acatgtgtgg ggagggtggc ctgcggcagc tggacctcac atggctgcgg cccactgagc
     4681 caggctctga gggagactac atggtgctgc cccggcggac tttgagcctg cagcctggcg
     4741 gtgggggtgg aggtggtgag gatgccccca gggcccggcc ggaggggacc ccccggcgag
     4801 ctgccaagac agtggcccac actgaaggct accccagctt cctgtccgtg gaccactcgg
     4861 gcctggggct gggccctgcc tatggatctc tccagaatcc ctatggaatg accttccaac
     4921 cgccaccgcc gacacccagc gcccgccaag tgcccgagcc aggggagcgc agccggacca
     4981 tgcctcgcac cgtgcccggc tctaccatga agatgggctc cctggagcga aagaaattac
     5041 ggtattcaga cctggacttt gagaaggtga tgcacacccg gaaacggcat tcagaactct
     5101 accacgagct caaccagaag ttccacactt tcgaccgcta ccgcagccag tccacggcca
     5161 agagggagaa gcggtggagt gtgtcctcgg gtggggcagc cgagcggagc gtgtgcaccg
     5221 ataagcccag ccctggggag cgccccagct tgtcccaaca tcggcgccat cagagctgga
     5281 gcaccttcaa atctatgaca ctgggctcgc tgccccccaa gccccgagaa cggctgactc
     5341 tgcaccgggc agcagcctgg gagcccacag aaccaccgga tggtgacttc cagacagagg
     5401 tgtgagtgcc acgctggact gcccactgca tataaatata tatatctctc tattttcaca
     5461 ctccactttg gaactaccca ggagccagcg ccctctcccc tctcccgagg gctgggcagg
     5521 gaggcgccgt ggactcagcc aggctggggg agccggacat ggcttggcct ggggtcccag
     5581 ggcccttcct tgtttctcag aggcccctca gccactggaa ccccatcttc agcccagcct
     5641 gtccgtccct gtcccgggct ggggaggggg gaggggaact ttgttgggaa taaacttcac
     5701 tctgtgga
//
