LOCUS       NM_001702               6020 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens adhesion G protein-coupled receptor B1 (ADGRB1),
            transcript variant 1, mRNA.
ACCESSION   NM_001702 XM_011517199 XM_940726 XM_944761
VERSION     NM_001702.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6020)
  AUTHORS   Zeng,Z., Xu,X., Wang,Q., Zhang,Z., Meng,P. and Huo,X.
  TITLE     Maternal exposure to atmospheric PM2.5 and fetal brain development:
            Associations with BAI1 methylation and thyroid hormones
  JOURNAL   Environ Pollut 308, 119665 (2022)
   PUBMED   35738517
  REMARK    GeneRIF: Maternal exposure to atmospheric PM2.5 and fetal brain
            development: Associations with BAI1 methylation and thyroid
            hormones.
REFERENCE   2  (bases 1 to 6020)
  AUTHORS   Pesta,M., Travnicek,I., Kulda,V., Windrichova,J., Rezackova,H.,
            Houfkova,K., Macanova,T., Bendova,B., Nestorova,A., Hes,O.,
            Hora,M., Topolcan,O. and Polivka,J.
  TITLE     BAI1 as a Prognostic Marker of Clear Cell Renal Cell Carcinoma
            (ccRCC)
  JOURNAL   Anticancer Res 41 (9), 4463-4470 (2021)
   PUBMED   34475070
  REMARK    GeneRIF: BAI1 as a Prognostic Marker of Clear Cell Renal Cell
            Carcinoma (ccRCC).
REFERENCE   3  (bases 1 to 6020)
  AUTHORS   An,H.J., Kim,S.H., Yang,J.W., Kim,M.H., Baek,H.J., Ryu,K.H.,
            Jeon,K.N., Lee,C.S., Choi,J.Y. and Song,D.H.
  TITLE     BAI1 nuclear expression reflects the survival of nonsmoking
            non-small cell lung cancer patients
  JOURNAL   Thorac Cancer 12 (11), 1673-1680 (2021)
   PUBMED   33934543
  REMARK    GeneRIF: BAI1 nuclear expression reflects the survival of
            nonsmoking non-small cell lung cancer patients.
REFERENCE   4  (bases 1 to 6020)
  AUTHORS   Liu,L., Chai,L., Ran,J., Yang,Y. and Zhang,L.
  TITLE     BAI1 acts as a tumor suppressor in lung cancer A549 cells by
            inducing metabolic reprogramming via the SCD1/HMGCR module
  JOURNAL   Carcinogenesis 41 (12), 1724-1734 (2020)
   PUBMED   32255478
  REMARK    GeneRIF: BAI1 acts as a tumor suppressor in lung cancer A549 cells
            by inducing metabolic reprogramming via the SCD1/HMGCR module.
REFERENCE   5  (bases 1 to 6020)
  AUTHORS   Gerhart,J., Bowers,J., Gugerty,L., Gerhart,C., Martin,M.,
            Abdalla,F., Bravo-Nuevo,A., Sullivan,J.T., Rimkunas,R.,
            Albertus,A., Casta,L., Getts,L., Getts,R. and George-Weinstein,M.
  TITLE     Brain-specific angiogenesis inhibitor 1 is expressed in the Myo/Nog
            cell lineage
  JOURNAL   PLoS One 15 (7), e0234792 (2020)
   PUBMED   32614850
  REMARK    GeneRIF: Brain-specific angiogenesis inhibitor 1 is expressed in
            the Myo/Nog cell lineage.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6020)
  AUTHORS   Fukushima,Y., Oshika,Y., Tsuchida,T., Tokunaga,T., Hatanaka,H.,
            Kijima,H., Yamazaki,H., Ueyama,Y., Tamaoki,N. and Nakamura,M.
  TITLE     Brain-specific angiogenesis inhibitor 1 expression is inversely
            correlated with vascularity and distant metastasis of colorectal
            cancer
  JOURNAL   Int J Oncol 13 (5), 967-970 (1998)
   PUBMED   9772287
REFERENCE   7  (bases 1 to 6020)
  AUTHORS   Shiratsuchi,T., Futamura,M., Oda,K., Nishimori,H., Nakamura,Y. and
            Tokino,T.
  TITLE     Cloning and characterization of BAI-associated protein 1: a PDZ
            domain-containing protein that interacts with BAI1
  JOURNAL   Biochem Biophys Res Commun 247 (3), 597-604 (1998)
   PUBMED   9647739
REFERENCE   8  (bases 1 to 6020)
  AUTHORS   Nishimori,H., Shiratsuchi,T., Urano,T., Kimura,Y., Kiyono,K.,
            Tatsumi,K., Yoshida,S., Ono,M., Kuwano,M., Nakamura,Y. and
            Tokino,T.
  TITLE     A novel brain-specific p53-target gene, BAI1, containing
            thrombospondin type 1 repeats inhibits experimental angiogenesis
  JOURNAL   Oncogene 15 (18), 2145-2150 (1997)
   PUBMED   9393972
REFERENCE   9  (bases 1 to 6020)
  AUTHORS   Shiratsuchi,T., Nishimori,H., Ichise,H., Nakamura,Y. and Tokino,T.
  TITLE     Cloning and characterization of BAI2 and BAI3, novel genes
            homologous to brain-specific angiogenesis inhibitor 1 (BAI1)
  JOURNAL   Cytogenet Cell Genet 79 (1-2), 103-108 (1997)
   PUBMED   9533023
REFERENCE   10 (bases 1 to 6020)
  AUTHORS   Van Meir,E.G., Polverini,P.J., Chazin,V.R., Su Huang,H.J., de
            Tribolet,N. and Cavenee,W.K.
  TITLE     Release of an inhibitor of angiogenesis upon induction of wild type
            p53 expression in glioblastoma cells
  JOURNAL   Nat Genet 8 (2), 171-176 (1994)
   PUBMED   7531056
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC139676.3.
            
            On or before May 7, 2019 this sequence version replaced
            XM_011517199.2, NM_001702.2.
            
            Summary: Angiogenesis is controlled by a local balance between
            stimulators and inhibitors of new vessel growth and is suppressed
            under normal physiologic conditions. Angiogenesis has been shown to
            be essential for growth and metastasis of solid tumors. In order to
            obtain blood supply for their growth, tumor cells are potently
            angiogenic and attract new vessels as results of increased
            secretion of inducers and decreased production of endogenous
            negative regulators.  BAI1 contains at least one 'functional'
            p53-binding site within an intron, and its expression has been
            shown to be induced by wildtype p53. There are two other
            brain-specific angiogenesis inhibitor genes, designated BAI2 and
            BAI3 which along with BAI1 have similar tissue specificities and
            structures, however only BAI1 is transcriptionally regulated by
            p53. BAI1 is postulated to be a member of the secretin receptor
            family, an inhibitor of angiogenesis and a growth suppressor of
            glioblastomas [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AB005297.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2154665, SAMN02400308 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000517894.6/ ENSP00000430945.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-456               AC139676.3         3372-3827
            457-1459            AC139676.3         17703-18705
            1460-1621           AC139676.3         29197-29358
            1622-1732           AC139676.3         30308-30418
            1733-1897           AC139676.3         30837-31001
            1898-2062           AC139676.3         31108-31272
            2063-2236           AC139676.3         31910-32083
            2237-2401           AC139676.3         33046-33210
            2402-2503           AC139676.3         33416-33517
            2504-2610           AC139676.3         34977-35083
            2611-2805           AC139676.3         35240-35434
            2806-2874           AC139676.3         37700-37768
            2875-2983           AC139676.3         38379-38487
            2984-3127           AC139676.3         42087-42230
            3128-3203           AC139676.3         42758-42833
            3204-3306           AC139676.3         43059-43161
            3307-3350           AC139676.3         44495-44538
            3351-3492           AC139676.3         64655-64796
            3493-3596           AC139676.3         71861-71964
            3597-3699           AC139676.3         74546-74648
            3700-3850           AC139676.3         75688-75838
            3851-3920           AC139676.3         76364-76433
            3921-3987           AC139676.3         77961-78027
            3988-4073           AC139676.3         80265-80350
            4074-4245           AC139676.3         87018-87189
            4246-4341           AC139676.3         90710-90805
            4342-4381           AC139676.3         93097-93136
            4382-5088           AC139676.3         95664-96370
            5089-5124           AC139676.3         97126-97161
            5125-5232           AC139676.3         97324-97431
            5233-6020           AC139676.3         97943-98730
FEATURES             Location/Qualifiers
     source          1..6020
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..6020
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /note="adhesion G protein-coupled receptor B1"
                     /db_xref="GeneID:575"
                     /db_xref="HGNC:HGNC:943"
                     /db_xref="MIM:602682"
     exon            1..456
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            457..1459
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     CDS             676..5430
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; brain-specific angiogenesis inhibitor 1"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor B1 isoform 1
                     precursor"
                     /protein_id="NP_001693.2"
                     /db_xref="CCDS:CCDS64985.1"
                     /db_xref="GeneID:575"
                     /db_xref="HGNC:HGNC:943"
                     /db_xref="MIM:602682"
                     /translation="MRGQAAAPGPVWILAPLLLLLLLLGRRARAAAGADAGPGPEPCA
                     TLVQGKFFGYFSAAAVFPANASRCSWTLRNPDPRRYTLYMKVAKAPVPCSGPGRVRTY
                     QFDSFLESTRTYLGVESFDEVLRLCDPSAPLAFLQASKQFLQMRRQQPPQHDGLRPRA
                     GPPGPTDDFSVEYLVVGNRNPSRAACQMLCRWLDACLAGSRSSHPCGIMQTPCACLGG
                     EAGGPAAGPLAPRGDVCLRDAVAGGPENCLTSLTQDRGGHGATGGWKLWSLWGECTRD
                     CGGGLQTRTRTCLPAPGVEGGGCEGVLEEGRQCNREACGPAGRTSSRSQSLRSTDARR
                     REELGDELQQFGFPAPQTGDPAAEEWSPWSVCSSTCGEGWQTRTRFCVSSSYSTQCSG
                     PLREQRLCNNSAVCPVHGAWDEWSPWSLCSSTCGRGFRDRTRTCRPPQFGGNPCEGPE
                     KQTKFCNIALCPGRAVDGNWNEWSSWSACSASCSQGRQQRTRECNGPSYGGAECQGHW
                     VETRDCFLQQCPVDGKWQAWASWGSCSVTCGAGSQRRERVCSGPFFGGAACQGPQDEY
                     RQCGTQRCPEPHEICDEDNFGAVIWKETPAGEVAAVRCPRNATGLILRRCELDEEGIA
                     YWEPPTYIRCVSIDYRNIQMMTREHLAKAQRGLPGEGVSEVIQTLVEISQDGTSYSGD
                     LLSTIDVLRNMTEIFRRAYYSPTPGDVQNFVQILSNLLAEENRDKWEEAQLAGPNAKE
                     LFRLVEDFVDVIGFRMKDLRDAYQVTDNLVLSIHKLPASGATDISFPMKGWRATGDWA
                     KVPEDRVTVSKSVFSTGLTEADEASVFVVGTVLYRNLGSFLALQRNTTVLNSKVISVT
                     VKPPPRSLRTPLEIEFAHMYNGTTNQTCILWDETDVPSSSAPPQLGPWSWRGCRTVPL
                     DALRTRCLCDRLSTFAILAQLSADANMEKATLPSVTLIVGCGVSSLTLLMLVIIYVSV
                     WRYIRSERSVILINFCLSIISSNALILIGQTQTRNKVVCTLVAAFLHFFFLSSFCWVL
                     TEAWQSYMAVTGHLRNRLIRKRFLCLGWGLPALVVAISVGFTKAKGYSTMNYCWLSLE
                     GGLLYAFVGPAAAVVLVNMVIGILVFNKLVSKDGITDKKLKERAGASLWSSCVVLPLL
                     ALTWMSAVLAVTDRRSALFQILFAVFDSLEGFVIVMVHCILRREVQDAVKCRVVDRQE
                     EGNGDSGGSFQNGHAQLMTDFEKDVDLACRSVLNKDIAACRTATITGTLKRPSLPEEE
                     KLKLAHAKGPPTNFNSLPANVSKLHLHGSPRYPGGPLPDFPNHSLTLKRDKAPKSSFV
                     GDGDIFKKLDSELSRAQEKALDTSYVILPTATATLRPKPKEEPKYSIHIDQMPQTRLI
                     HLSTAPEASLPARSPPSRQPPSGGPPEAPPAQPPPPPPPPPPPPQQPLPPPPNLEPAP
                     PSLGDPGEPAAHPGPSTGPSTKNENVATLSVSSLERRKSRYAELDFEKIMHTRKRHQD
                     MFQDLNRKLQHAAEKDKEVLGPDSKPEKQQTPNKRPWESLRKAHGTPTWVKKELEPLQ
                     PSPLELRSVEWERSGATIPLVGQDIIDLQTEV"
     exon            1460..1621
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1732
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1897
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2062
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2236
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2401
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2503
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2610
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2805
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2874
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..2983
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3127
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            3128..3203
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            3204..3306
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            3307..3350
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            3351..3492
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..3596
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            3597..3699
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            3700..3850
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            3851..3920
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            3921..3987
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            3988..4073
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            4074..4245
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            4246..4341
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            4342..4381
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            4382..5088
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            5089..5124
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            5125..5232
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     exon            5233..6020
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5999..6004
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /note="hexamer: AATAAA"
     polyA_site      6020
                     /gene="ADGRB1"
                     /gene_synonym="BAI1; GDAIF"
                     /note="major polyA site"
ORIGIN      
        1 gagaagagcc gggcaggcga gaggagcgga gcggcggcgg cggccggaga gggagcggcg
       61 ggcgcaggcg gcggcggcgg gcgcggcgtt ggcggcggcc ccggcggagc gagcgcggag
      121 ccggagagcc gggagcacag gcggccgcgc cgcgtcctgg cccggcccgg gcccgcgcgc
      181 cagcatcgtc cgcagcgcgg gcatccggac cctccgggcg cccggggggc tccagcaggc
      241 gcgggggaac gggagggggc ctgcgtgcgc cggcgggtgc tctccagggg gcgtcccggc
      301 gaggcccaga gcgggccggg ggcggcggcg gctggaggag ccccccccac ctccggtcgg
      361 gcgcccggct cagccgccgg cgacgcgagg cgctcgcggg gatttgcaac tcgccggatc
      421 gagtcctcgc cggcggggcc gctgctgctg gggaagctgc tgctggtggc cacaggctgg
      481 caccagggcc ctggacttta gaagccgttg ctgccctctc tgtcacctga agcggggccc
      541 tctcccatcc cacccttgcc ccgcctccct gcccccaccg ggccggccct gcccgccgcc
      601 ggaccctggc atgtcaagac ctggtccgcg cctgcctgcc cagcccgcgg aaccccggcg
      661 gccccgcgag ctaggatgag gggccaggcc gccgccccgg gccccgtctg gatcctcgcc
      721 ccgctgctac tgctgctgct gctgctggga cgccgcgcgc gggcggccgc cggagcagac
      781 gcggggcccg ggcccgagcc gtgcgccacg ctggtgcagg gaaagttctt cggctacttc
      841 tccgcggccg ccgtgttccc ggccaacgcc tcgcgctgct cctggacgct acgcaacccg
      901 gacccgcggc gctacactct ctacatgaag gtggccaagg cgcccgtgcc ctgcagcggc
      961 cccggccgcg tgcgcaccta ccagttcgac tccttcctcg agtccacgcg cacctacctg
     1021 ggcgtggaga gcttcgacga ggtgctgcgg ctctgcgacc cctccgcacc cctggccttc
     1081 ctgcaggcca gcaagcagtt cctgcagatg cggcgccagc agccgcccca gcacgacggg
     1141 ctccggcccc gggccgggcc gccgggcccc accgacgact tctccgtgga gtacctggtg
     1201 gtggggaacc gcaaccccag ccgtgccgcc tgccagatgc tgtgccgctg gctggacgcg
     1261 tgtctggccg gtagtcgcag ctcgcacccc tgcgggatca tgcagacccc ctgcgcctgc
     1321 ctgggcggcg aggcgggcgg ccctgccgcg ggacccctgg ccccccgcgg ggatgtctgc
     1381 ttgagagatg cggtggctgg tggccctgaa aactgcctca ccagcctgac ccaggaccgg
     1441 ggcgggcacg gcgccacagg cggctggaag ctgtggtccc tgtggggcga atgcacgcgg
     1501 gactgcgggg gaggcctcca gacgcggacg cgcacctgcc tgcccgcgcc gggcgtggag
     1561 ggcggcggct gcgagggggt gctggaggag ggtcgccagt gcaaccgcga ggcctgcggc
     1621 cccgctgggc gcaccagctc ccggagccag tccctgcggt ccacagatgc ccggcggcgc
     1681 gaggagctgg gggacgagct gcagcagttt gggttcccag ccccccagac cggtgaccca
     1741 gcagccgagg agtggtcccc gtggagcgtg tgctccagca cctgcggcga gggctggcag
     1801 acccgcacgc gcttctgcgt gtcctcctcc tacagcacgc agtgcagcgg acccctgcgc
     1861 gagcagcggc tgtgcaacaa ctctgccgtg tgcccagtgc atggtgcctg ggatgagtgg
     1921 tcgccctgga gcctctgctc cagcacctgt ggccgtggct ttcgggatcg cacgcgcacc
     1981 tgcaggcccc cccagtttgg gggcaacccc tgtgagggcc ctgagaagca aaccaagttc
     2041 tgcaacattg ccctgtgccc tggccgggca gtggatggaa actggaatga gtggtcgagc
     2101 tggagcgcct gctccgccag ctgctcccag ggccgacagc agcgcacgcg tgaatgcaac
     2161 gggccttcct acgggggtgc ggagtgccag ggccactggg tggagacccg agactgcttc
     2221 ctgcagcagt gcccagtgga tggcaagtgg caggcctggg cgtcatgggg cagttgcagc
     2281 gtcacgtgtg gggctggcag ccagcgacgg gagcgtgtct gctctgggcc cttcttcggg
     2341 ggagcagcct gccagggccc ccaggatgag taccggcagt gcggcaccca gcggtgtccc
     2401 gagccccatg agatctgtga tgaggacaac tttggtgctg tgatctggaa ggagacccca
     2461 gcgggagagg tggctgctgt ccggtgtccc cgcaacgcca caggactcat cctgcgacgg
     2521 tgtgagctgg acgaggaagg catcgcctac tgggagcccc ccacctacat ccgctgtgtt
     2581 tccattgact acagaaacat ccagatgatg acccgggagc acctggccaa ggctcagcga
     2641 gggctgcctg gggagggggt ctcggaggtc atccagacac tggtggagat ctctcaggac
     2701 gggaccagct acagtgggga cctgctgtcc accatcgatg tcctgaggaa catgacagag
     2761 attttccgga gagcgtacta cagccccacc cctggggacg tacagaactt tgtccagatc
     2821 cttagcaacc tgttggcaga ggagaatcgg gacaagtggg aggaggccca gctggcgggc
     2881 cccaacgcca aggagctgtt ccggctggtg gaggactttg tggacgtcat cggcttccgc
     2941 atgaaggacc tgagggatgc ataccaggtg acagacaacc tggttctcag catccataag
     3001 ctcccagcca gcggagccac tgacatcagc ttccccatga agggctggcg ggccacgggt
     3061 gactgggcca aggtgccaga ggacagggtc actgtgtcca agagtgtctt ctccacgggg
     3121 ctgacagagg ccgatgaagc atccgtgttt gtggtgggca ccgtgctcta caggaacctg
     3181 ggcagcttcc tggccctgca gaggaacacg accgtcctga attctaaggt gatctccgtg
     3241 actgtgaaac ccccgcctcg ctccctgcgc acacccttgg agatcgagtt tgcccacatg
     3301 tataatggca ccaccaacca gacctgtatc ctgtgggatg agacggatgt accctcctcc
     3361 tccgcccccc cgcagctcgg gccctggtcg tggcgcggct gccgcacggt gcccctcgac
     3421 gccctccgga cgcgctgcct ctgtgaccgg ctctccacct tcgccatctt agcccagctc
     3481 agcgccgacg cgaacatgga gaaggcgact ctgccgtcgg tgacgctcat cgtgggctgt
     3541 ggcgtgtcct ctctcaccct gctcatgctg gtcatcatct acgtgtccgt gtggaggtac
     3601 attcgctcag agcgttctgt catcctcatc aacttctgcc tgtccatcat ctcctccaat
     3661 gccctcatcc tcatcgggca gacccagacc cgcaacaagg tggtgtgcac gctggtggcc
     3721 gccttcctgc acttcttctt cctgtcctcc ttctgctggg tgctcaccga ggcctggcag
     3781 tcctacatgg cggtgacggg ccacctccgg aaccgcctca tccgcaagcg cttcctctgc
     3841 ctgggctggg ggctccctgc actggttgtg gccatttctg tgggattcac caaggccaaa
     3901 gggtacagca ccatgaacta ctgctggctc tccctggagg ggggactgct ctatgccttc
     3961 gtgggacctg ccgctgccgt tgtgctggtg aacatggtca ttgggatcct ggtgttcaac
     4021 aagctcgtgt ccaaagacgg catcacggac aagaagctga aggagcgggc aggggcctcc
     4081 ctgtggagct cctgcgtggt gctgccgctg ctggcgctga cctggatgtc ggctgtgctc
     4141 gccgtcaccg accgccgctc cgccctcttc cagatcctct tcgctgtctt cgactcgctg
     4201 gagggcttcg tcatcgtcat ggtgcactgt atcctccgta gagaggtcca ggacgctgtg
     4261 aaatgccgtg tggttgaccg gcaggaggag ggcaacgggg actcaggggg ctccttccag
     4321 aacggccacg cccagctcat gaccgacttc gagaaggacg tggatctggc ctgtagatca
     4381 gtgctgaaca aggacatcgc ggcctgccgc actgccacca tcacgggcac actgaagcgg
     4441 ccgtctctgc ccgaggagga gaagctgaag ctggcccatg ccaaggggcc gcccaccaat
     4501 ttcaacagcc tgccggccaa cgtgtccaag ctgcacctgc acggctcacc ccgctatccc
     4561 ggcgggcccc tgcccgactt ccccaaccac tcactgaccc tcaagaggga caaggcgccc
     4621 aagtcctcct tcgtcggtga cggggacatc ttcaagaagc tggactcgga gctgagccgg
     4681 gcccaggaga aggctctgga cacgagctac gtgatcctgc ccacggccac ggccacgctg
     4741 cggcccaagc ccaaggagga gcccaagtac agcatccaca ttgaccagat gccgcagacc
     4801 cgcctcatcc acctcagcac ggcccccgag gccagcctcc ccgcccgcag cccgccctcc
     4861 cgccagcccc ccagcggcgg gccccccgag gcaccccctg cccagccccc accgcctccg
     4921 cccccaccgc caccacctcc ccagcagccc ctgcccccac cgcccaatct ggagccggca
     4981 ccccccagcc tgggggatcc cggggagcct gccgcccatc cgggacccag cacggggccc
     5041 agcaccaaga acgagaatgt cgccaccttg tctgtgagct ccctggagcg gcggaagtcg
     5101 cggtatgcag aactggactt tgagaagatc atgcacaccc ggaagcggca ccaagacatg
     5161 ttccaggacc tgaaccggaa gctgcagcac gcagcggaga aggacaagga ggtgctgggg
     5221 ccggacagca agccggaaaa gcagcagacg cccaacaaga ggccctggga gagcctccgg
     5281 aaagcccacg ggacgcccac gtgggtgaag aaggagctgg agccgctgca gccgtcgccg
     5341 ctggagcttc gcagcgtgga gtgggagagg tcgggcgcca cgatcccgct ggtgggccag
     5401 gacatcatcg acctccagac cgaggtctga gcgggtgggc ggcggccacg cactgggcca
     5461 cggaggaggg atgctgctcc gcccgctcct gccgcagacg ggcacagaca cgctcgcggg
     5521 cagcgggcca ggcccgcacc ccggcctcag ggcgctcaga cggcggccag gcacagggcc
     5581 cgcagtgctg ggaccagagc cagatgcagg acaggaggcg gcccggccag cgggcacagg
     5641 gcaccagagg ccgaaggtgc ctcagactcc gccctcctcg ggccgaggcc cagcgggcag
     5701 atgggcggac ggctgtggac cgtggacagg cccagcgcgg ccagcgtccc agggtacccg
     5761 cctgagctcc tgctgcggag gagctgcctg cttggcccgg ccggcctggc accgtttttt
     5821 aaacaccccc atccctcggg aagcagccag ctccccacac cttccagggc cctaggcccc
     5881 tcctagaccc aggtggaggg cacagccctc cgaccctcat ggcccccagg ggcaggactg
     5941 agtcccctcc aggaagaagc aggggggaat ctattttttc tctccttttc ttttcttcaa
     6001 taaaaagaat taaaaaccca
//
