LOCUS       NM_145290               4577 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens adhesion G protein-coupled receptor A3 (ADGRA3), mRNA.
ACCESSION   NM_145290 XM_291111
VERSION     NM_145290.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4577)
  AUTHORS   Spiess,K., Bagger,S.O., Torz,L.J., Jensen,K.H.R., Walser,A.L.,
            Kvam,J.M., Mogelmose,A.K., Daugvilaite,V., Junnila,R.K.,
            Hjorto,G.M. and Rosenkilde,M.M.
  TITLE     Arrestin-independent constitutive endocytosis of GPR125/ADGRA3
  JOURNAL   Ann N Y Acad Sci 1456 (1), 186-199 (2019)
   PUBMED   31659746
  REMARK    GeneRIF: data support that the constitutive internalization of
            GPR125 contributes to its biological functions by controlling
            receptor surface expression and accessibility for ligands
REFERENCE   2  (bases 1 to 4577)
  AUTHORS   Wu,Y., Chen,W., Gong,L., Ke,C., Wang,H. and Cai,Y.
  TITLE     Elevated G-Protein Receptor 125 (GPR125) Expression Predicts Good
            Outcomes in Colorectal Cancer and Inhibits Wnt/beta-Catenin
            Signaling Pathway
  JOURNAL   Med Sci Monit 24, 6608-6616 (2018)
   PUBMED   30231258
  REMARK    GeneRIF: GPR125 overexpression inhibited the beta-catenin
            transcriptional activity, and down-regulated the expression levels
            of the Wnt downstream proteins-Axin2, c-Myc, cylinD1, and lef-1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4577)
  AUTHORS   Hamann,J., Aust,G., Arac,D., Engel,F.B., Formstone,C.,
            Fredriksson,R., Hall,R.A., Harty,B.L., Kirchhoff,C., Knapp,B.,
            Krishnan,A., Liebscher,I., Lin,H.H., Martinelli,D.C., Monk,K.R.,
            Peeters,M.C., Piao,X., Promel,S., Schoneberg,T., Schwartz,T.W.,
            Singer,K., Stacey,M., Ushkaryov,Y.A., Vallon,M., Wolfrum,U.,
            Wright,M.W., Xu,L., Langenhan,T. and Schioth,H.B.
  TITLE     International Union of Basic and Clinical Pharmacology. XCIV.
            Adhesion G protein-coupled receptors
  JOURNAL   Pharmacol Rev 67 (2), 338-367 (2015)
   PUBMED   25713288
  REMARK    Review article
REFERENCE   4  (bases 1 to 4577)
  AUTHORS   Sachs,C., Robinson,B.D., Andres Martin,L., Webster,T., Gilbert,M.,
            Lo,H.Y., Rafii,S., Ng,C.K. and Seandel,M.
  TITLE     Evaluation of candidate spermatogonial markers ID4 and GPR125 in
            testes of adult human cadaveric organ donors
  JOURNAL   Andrology 2 (4), 607-614 (2014)
   PUBMED   24902969
  REMARK    GeneRIF: ID4 and GPR125 are expressed on partially overlapping
            spermatogonial populations and are more broadly expressed in normal
            adult human testis.  ID4 and GPR125 could be used for identifying
            previously unrecognized human spermatogonial subpopulations
REFERENCE   5  (bases 1 to 4577)
  AUTHORS   Christoforou,A., Le Hellard,S., Thomson,P.A., Morris,S.W.,
            Tenesa,A., Pickard,B.S., Wray,N.R., Muir,W.J., Blackwood,D.H.,
            Porteous,D.J. and Evans,K.L.
  TITLE     Association analysis of the chromosome 4p15-p16 candidate region
            for bipolar disorder and schizophrenia
  JOURNAL   Mol Psychiatry 12 (11), 1011-1025 (2007)
   PUBMED   17457313
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   6  (bases 1 to 4577)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
REFERENCE   7  (bases 1 to 4577)
  AUTHORS   Yamamoto,Y., Irie,K., Asada,M., Mino,A., Mandai,K. and Takai,Y.
  TITLE     Direct binding of the human homologue of the Drosophila disc large
            tumor suppressor gene to seven-pass transmembrane proteins, tumor
            endothelial marker 5 (TEM5), and a novel TEM5-like protein
  JOURNAL   Oncogene 23 (22), 3889-3897 (2004)
   PUBMED   15021905
REFERENCE   8  (bases 1 to 4577)
  AUTHORS   Fredriksson,R., Gloriam,D.E., Hoglund,P.J., Lagerstrom,M.C. and
            Schioth,H.B.
  TITLE     There exist at least 30 human G-protein-coupled receptors with long
            Ser/Thr-rich N-termini
  JOURNAL   Biochem Biophys Res Commun 301 (3), 725-734 (2003)
   PUBMED   12565841
REFERENCE   9  (bases 1 to 4577)
  AUTHORS   Fahim,A.T., Daiger,S.P. and Weleber,R.G.
  TITLE     Nonsyndromic Retinitis Pigmentosa Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301590
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093814.3, BC035645.1 and
            AL832257.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_145290.3.
            
            Summary: This gene encodes a member of the G protein-coupled
            receptor superfamily. This membrane protein may play a role in
            tumor angiogenesis through its interaction with the human homolog
            of the Drosophila disc large tumor suppressor gene. This gene is
            mapped to a candidate region of chromosome 4 which may be
            associated with bipolar disorder and schizophrenia. [provided by
            RefSeq, Oct 2012].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.284389.1, BC035645.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334304.10/ ENSP00000334952.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC093814.3         124468-124479       c
            13-1331             BC035645.1         12-1330
            1332-1332           AC093814.3         46704-46704         c
            1333-4063           BC035645.1         1332-4062
            4064-4577           AL832257.1         2521-3034
FEATURES             Location/Qualifiers
     source          1..4577
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.2"
     gene            1..4577
                     /gene="ADGRA3"
                     /gene_synonym="GPR125; PGR21; TEM5L"
                     /note="adhesion G protein-coupled receptor A3"
                     /db_xref="GeneID:166647"
                     /db_xref="HGNC:HGNC:13839"
                     /db_xref="MIM:612303"
     exon            1..539
                     /gene="ADGRA3"
                     /gene_synonym="GPR125; PGR21; TEM5L"
                     /inference="alignment:Splign:2.1.0"
     CDS             283..4248
                     /gene="ADGRA3"
                     /gene_synonym="GPR125; PGR21; TEM5L"
                     /note="probable G-protein coupled receptor 125"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor A3
                     precursor"
                     /protein_id="NP_660333.2"
                     /db_xref="CCDS:CCDS33964.1"
                     /db_xref="GeneID:166647"
                     /db_xref="HGNC:HGNC:13839"
                     /db_xref="MIM:612303"
                     /translation="MEPPGRRRGRAQPPLLLPLSLLALLALLGGGGGGGAAALPAGCK
                     HDGRPRGAGRAAGAAEGKVVCSSLELAQVLPPDTLPNRTVTLILSNNKISELKNGSFS
                     GLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLNADIFRGLTNLVRLNL
                     SGNLFSSLSQGTFDYLASLRSLEFQTEYLLCDCNILWMHRWVKEKNITVRDTRCVYPK
                     SLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSLPFQCMASYIDQDMQVL
                     WYQDGRIVETDESQGIFVEKNMIHNCSLIASALTISNIQAGSTGNWGCHVQTKRGNNT
                     RTVDIVVLESSAQYCPPERVVNNKGDFRWPRTLAGITAYLQCTRNTHGSGIYPGNPQD
                     ERKAWRRCDRGGFWADDDYSRCQYANDVTRVLYMFNQMPLNLTNAVATARQLLAYTVE
                     AANFSDKMDVIFVAEMIEKFGRFTKEEKSKELGDVMVDIASNIMLADERVLWLAQREA
                     KACSRIVQCLQRIATYRLAGGAHVYSTYSPNIALEAYVIKSTGFTGMTCTVFQKVAAS
                     DRTGLSDYGRRDPEGNLDKQLSFKCNVSNTFSSLALKNTIVEASIQLPPSLFSPKQKR
                     ELRPTDDSLYKLQLIAFRNGKLFPATGNSTNLADDGKRRTVVTPVILTKIDGVNVDTH
                     HIPVNVTLRRIAHGADAVAARWDFDLLNGQGGWKSDGCHILYSDENITTIQCYSLSNY
                     AVLMDLTGSELYTQAASLLHPVVYTTAIILLLCLLAVIVSYIYHHSLIRISLKSWHML
                     VNLCFHIFLTCVVFVGGITQTRNASICQAVGIILHYSTLATVLWVGVTARNIYKQVTK
                     KAKRCQDPDEPPPPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGSRPNAPYCWMAWE
                     PSLGAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGEINH
                     QDSMSLSLISTSALENEHTFHSQLLGASLTLLLYVALWMFGALAVSLYYPLDLVFSFV
                     FGATSLSFSAFFVVHHCVNREDVRLAWIMTCCPGRSSYSVQVNVQPPNSNGTNGEAPK
                     CPNSSAESSCTNKSASSFKNSSQGCKLTNLQAAAAQCHANSLPLNSTPQLDNSLTEHS
                     MDNDIKMHVAPLEVQFRTNVHSSRHHKNRSKGHRASRLTVLREYAYDVPTSVEGSVQN
                     GLPKSRLGNNEGHSRSRRAYLAYRERQYNPPQQDSSDACSTLPKSSRNFEKPVSTTSK
                     KDALRKPAVVELENQQKSYGLNLAIQNGPIKSNGQEGPLLGTDSTGNVRTGLWKHETT
                     V"
     exon            540..611
                     /gene="ADGRA3"
                     /gene_synonym="GPR125; PGR21; TEM5L"
                     /inference="alignment:Splign:2.1.0"
     exon            612..683
                     /gene="ADGRA3"
                     /gene_synonym="GPR125; PGR21; TEM5L"
                     /inference="alignment:Splign:2.1.0"
     exon            684..755
                     /gene="ADGRA3"
                     /gene_synonym="GPR125; PGR21; TEM5L"
                     /inference="alignment:Splign:2.1.0"
     exon            756..827
                     /gene="ADGRA3"
                     /gene_synonym="GPR125; PGR21; TEM5L"
                     /inference="alignment:Splign:2.1.0"
     exon            828..988
                     /gene="ADGRA3"
                     /gene_synonym="GPR125; PGR21; TEM5L"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1202
                     /gene="ADGRA3"
                     /gene_synonym="GPR125; PGR21; TEM5L"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1367
                     /gene="ADGRA3"
                     /gene_synonym="GPR125; PGR21; TEM5L"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1569
                     /gene="ADGRA3"
                     /gene_synonym="GPR125; PGR21; TEM5L"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1725
                     /gene="ADGRA3"
                     /gene_synonym="GPR125; PGR21; TEM5L"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1887
                     /gene="ADGRA3"
                     /gene_synonym="GPR125; PGR21; TEM5L"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2091
                     /gene="ADGRA3"
                     /gene_synonym="GPR125; PGR21; TEM5L"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2305
                     /gene="ADGRA3"
                     /gene_synonym="GPR125; PGR21; TEM5L"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2514
                     /gene="ADGRA3"
                     /gene_synonym="GPR125; PGR21; TEM5L"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2639
                     /gene="ADGRA3"
                     /gene_synonym="GPR125; PGR21; TEM5L"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2763
                     /gene="ADGRA3"
                     /gene_synonym="GPR125; PGR21; TEM5L"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2909
                     /gene="ADGRA3"
                     /gene_synonym="GPR125; PGR21; TEM5L"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..3005
                     /gene="ADGRA3"
                     /gene_synonym="GPR125; PGR21; TEM5L"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..4577
                     /gene="ADGRA3"
                     /gene_synonym="GPR125; PGR21; TEM5L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4552..4557
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRA3"
                     /gene_synonym="GPR125; PGR21; TEM5L"
                     /note="hexamer: AATAAA"
     polyA_site      4577
                     /gene="ADGRA3"
                     /gene_synonym="GPR125; PGR21; TEM5L"
                     /note="major polyA site"
ORIGIN      
        1 agtggcggcg gcggcggcgg cagaggagga ggaggaggcg gtgctcgcgc cgggcggtag
       61 agcggcgctg ggacccatgc ggccgtgacc cccggctccc tagaggccca gcgcagccgc
      121 agcggacaaa ggagcatgtc cgcgccgggg aaggcccgtc ctccggccgc cataaggctc
      181 cggtcgccgc tgggcccgcg ccgcgctcct gcccgcccgg gctccggggc ggcccgctag
      241 gccagtgcgc cgccgctcgc cccgcaggcc ccggcccgca gcatggagcc acccggacgc
      301 cggcggggcc gcgcgcagcc gccgctgttg ctgccgctct cgctgttagc gctgctcgcg
      361 ctgctgggag gcggcggcgg cggcggcgcc gcggcgctgc ccgccggctg caagcacgat
      421 gggcggcccc gaggggctgg cagggcggcg ggcgccgccg agggcaaggt ggtgtgcagc
      481 agcctggaac tcgcgcaggt cctgccccca gatactctgc ccaaccgcac ggtcaccctg
      541 attctgagta acaataagat atccgagctg aagaatggct cattttctgg gttaagtctc
      601 cttgaaagat tggacctccg aaacaatctt attagtagta tagatccagg tgccttctgg
      661 ggactgtcat ctctaaaaag attggatctg acaaacaatc gaataggatg tctgaatgca
      721 gacatatttc gaggactcac caatctggtt cggctaaacc tttcggggaa tttgttttct
      781 tcattatctc aaggaacttt tgattatctt gcgtcattac ggtctttgga attccagact
      841 gagtatcttt tgtgtgactg taacatactg tggatgcatc gctgggtaaa ggagaagaac
      901 atcacggtac gggataccag gtgtgtttat cctaagtcac tgcaggccca accagtcaca
      961 ggcgtgaagc aggagctgtt gacatgcgac cctccgcttg aattgccgtc tttctacatg
     1021 actccatctc atcgccaagt tgtgtttgaa ggagacagcc ttcctttcca gtgcatggct
     1081 tcatatattg atcaggacat gcaagtgttg tggtatcagg atgggagaat agttgaaacc
     1141 gatgaatcgc aaggtatttt tgttgaaaag aacatgattc acaactgctc cttgattgca
     1201 agtgccctaa ccatttctaa tattcaggct ggatctactg gaaattgggg ctgtcatgtc
     1261 cagaccaaac gtgggaataa tacgaggact gtggatattg tggtattaga gagttctgca
     1321 cagtactgtc ctccagagag ggtggtaaac aacaaaggtg acttcagatg gcccagaaca
     1381 ttggcaggca ttactgcata tctgcagtgt acgcggaaca cccatggcag tgggatatat
     1441 cccggaaacc cacaggatga gagaaaagct tggcgcagat gtgatagagg tggcttttgg
     1501 gcagatgatg attattctcg ctgtcagtat gcaaatgatg tcactagagt tctttatatg
     1561 tttaatcaga tgcccctcaa tcttaccaat gccgtggcaa cagctcgaca gttactggct
     1621 tacactgtgg aagcagccaa cttttctgac aaaatggatg ttatatttgt ggcagaaatg
     1681 attgaaaaat ttggaagatt taccaaggag gaaaaatcaa aagagctagg tgacgtgatg
     1741 gttgacattg caagtaacat catgttggct gatgaacgtg tcctgtggct ggcgcagagg
     1801 gaagctaaag cctgcagtag gattgtgcag tgtcttcagc gcattgctac ctaccggcta
     1861 gccggtggag ctcacgttta ttcaacatat tcacccaata ttgctctgga agcttatgtc
     1921 atcaagtcta ctggcttcac ggggatgacc tgtaccgtgt tccagaaagt ggcagcctct
     1981 gatcgtacag gactttcgga ttatgggagg cgggatccag agggaaacct ggataagcag
     2041 ctgagcttta agtgcaatgt ttcaaataca ttttcgagtc tggcactaaa gaatactatt
     2101 gtggaggctt ctattcagct tcctccttcc cttttctcac caaagcaaaa aagagaactc
     2161 agaccaactg atgactctct ttacaagctt caactcattg cattccgcaa tggaaagctt
     2221 tttccagcca ctggaaattc aacaaatttg gctgatgatg gaaaacgacg tactgtggtt
     2281 acccctgtga ttctcaccaa aatagatggt gtgaatgtag atacccacca catccctgtt
     2341 aatgtgacac tgcgtcgaat tgcacatgga gcagatgctg ttgcagcccg gtgggatttc
     2401 gatttgctga acggacaagg aggctggaag tcagatgggt gccatatact ctattcagat
     2461 gaaaatatca ctacgattca gtgctactcc cttagtaact atgcagtttt aatggatttg
     2521 acgggatctg aactatacac ccaggcggcc agcctcctgc atcctgtggt ttatactacc
     2581 gctatcattc tcctcttatg tctcttagcc gtcattgtca gttacatata ccatcacagt
     2641 ttgattagaa tcagcctcaa gagctggcac atgcttgtga acttgtgctt tcatattttc
     2701 ctaacctgtg tggtctttgt gggaggaata acccagacta ggaatgccag catctgccaa
     2761 gcagttggga taattcttca ctattccacc cttgccacag tactatgggt aggagtgaca
     2821 gctcgaaata tctacaaaca agtcactaaa aaagctaaaa gatgccagga tcctgatgaa
     2881 ccaccacctc caccaagacc aatgctcaga ttttacctga ttggtggtgg tatccccatc
     2941 attgtttgcg gcataactgc agcagcgaac attaagaatt acggcagtcg gccaaacgca
     3001 ccctattgct ggatggcatg ggaaccctcc ttgggagcct tctatgggcc agccagcttc
     3061 atcacttttg taaactgcat gtactttctg agcatattta ttcagttgaa aagacaccct
     3121 gagcgcaaat atgagcttaa ggagcccacg gaggagcaac agagattggc agccaatgaa
     3181 aatggcgaaa taaatcatca ggattcaatg tctttgtctc tgatttctac atcagccttg
     3241 gaaaatgagc acacttttca ttctcagctc ttgggggcca gccttacttt gctcttatat
     3301 gttgcactgt ggatgtttgg ggctttggct gtttctttgt attacccttt ggacttggtt
     3361 tttagcttcg tttttggagc cacaagttta agcttcagtg cgttcttcgt ggtccaccat
     3421 tgtgttaata gggaggatgt tagacttgcg tggatcatga cttgctgccc aggacggagc
     3481 tcgtattcag tgcaagtcaa cgtccagccc cccaactcta atgggacgaa tggagaggca
     3541 cccaaatgcc ccaatagcag tgcggagtct tcatgcacaa acaaaagtgc ttcaagcttc
     3601 aaaaattcct cccagggctg caaattaaca aacttgcagg cggctgcagc tcagtgccat
     3661 gccaattctt tacctttgaa ctccacccct cagcttgata atagtctgac agaacattca
     3721 atggacaatg atattaaaat gcacgtggcg cctttagaag ttcagtttcg aacaaatgtg
     3781 cactcaagcc gccaccataa aaacagaagt aaaggacacc gggcaagccg actcacagtc
     3841 ctgagagaat atgcctacga tgtcccaacg agcgtggaag gaagcgtgca gaacggctta
     3901 cctaaaagcc ggctgggcaa taacgaagga cactcgagga gccgaagagc ttatttagcc
     3961 tacagagaga gacagtacaa cccaccccag caagacagca gcgatgcttg tagcacactt
     4021 cccaaaagta gcagaaattt tgaaaagcca gtttcaacca ctagtaaaaa agatgcgtta
     4081 aggaagccag ctgtggttga acttgaaaat cagcaaaaat cttatggcct caacttggcc
     4141 attcagaatg gaccaattaa aagcaatggg caggagggac ccttgctcgg taccgatagc
     4201 actggcaatg ttaggactgg attatggaaa cacgaaacta ctgtgtaaca ttgctgggct
     4261 tcctaggcag aaattcatat aaactgtgat actcacattc cttgaagcta tgagcattta
     4321 aaaactgttt acagccacca tagggattca aaagaatttg gaataaactt tgaagttttg
     4381 gattttactt atttttatcc ccaaattgtt gctatttttt aggatctgaa acaaaatctt
     4441 tctaaaacat tgttttagtt gtcaaagcac caacaggaca ttttgggatg tgaaatgtaa
     4501 tttcttggaa tctgtaattt gtacttaata tttcaggctt gtatttaata taataaatag
     4561 gtgtttgtta ttgtgtc
//
