LOCUS       NM_032777               6944 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens adhesion G protein-coupled receptor A2 (ADGRA2), mRNA.
ACCESSION   NM_032777
VERSION     NM_032777.10
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6944)
  AUTHORS   Shen,Y., Cui,Q., Xiao,L., Wang,L., Li,Q., Zhang,R., Chen,Z. and
            Niu,J.
  TITLE     Down-regulated Wnt7a and GPR124 in early-onset preeclampsia
            placentas reduce invasion and migration of trophoblast cells
  JOURNAL   J Perinat Med 52 (1), 41-49 (2023)
   PUBMED   37694534
  REMARK    GeneRIF: Down-regulated Wnt7a and GPR124 in early-onset
            preeclampsia placentas reduce invasion and migration of trophoblast
            cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6944)
  AUTHORS   America,M., Bostaille,N., Eubelen,M., Martin,M., Stainier,D.Y.R.
            and Vanhollebeke,B.
  TITLE     An integrated model for Gpr124 function in Wnt7a/b signaling among
            vertebrates
  JOURNAL   Cell Rep 39 (9), 110902 (2022)
   PUBMED   35649360
  REMARK    GeneRIF: An integrated model for Gpr124 function in Wnt7a/b
            signaling among vertebrates.
REFERENCE   3  (bases 1 to 6944)
  AUTHORS   Ta,S., Rong,X., Guo,Z.N., Jin,H., Zhang,P., Li,F., Li,Z., Lin,L.,
            Zheng,C., Gu,Q., Zhang,Y., Liu,W., Yang,Y. and Chang,J.
  TITLE     Variants of WNT7A and GPR124 are associated with hemorrhagic
            transformation following intravenous thrombolysis in ischemic
            stroke
  JOURNAL   CNS Neurosci Ther 27 (1), 71-81 (2021)
   PUBMED   32991049
  REMARK    GeneRIF: Variants of WNT7A and GPR124 are associated with
            hemorrhagic transformation following intravenous thrombolysis in
            ischemic stroke.
REFERENCE   4  (bases 1 to 6944)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 6944)
  AUTHORS   Pietrzyk,L. and Wdowiak,P.
  TITLE     Serum TEM5 and TEM7 concentrations correlate with clinicopathologic
            features and poor prognosis of colorectal cancer patients
  JOURNAL   Adv Med Sci 64 (2), 402-408 (2019)
   PUBMED   31352222
  REMARK    GeneRIF: Serum TEM5 and TEM7 concentrations correlate with
            clinicopathologic features and poor prognosis of colorectal cancer
            patients
REFERENCE   6  (bases 1 to 6944)
  AUTHORS   Vallon,M. and Essler,M.
  TITLE     Proteolytically processed soluble tumor endothelial marker (TEM) 5
            mediates endothelial cell survival during angiogenesis by linking
            integrin alpha(v)beta3 to glycosaminoglycans
  JOURNAL   J Biol Chem 281 (45), 34179-34188 (2006)
   PUBMED   16982628
  REMARK    GeneRIF: Proteolytically processed soluble tumor endothelial marker
            TEM5 mediates endothelial cell survival during angiogenesis by
            linking integrin alpha(v)beta3 to glycosaminoglycans
REFERENCE   7  (bases 1 to 6944)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
REFERENCE   8  (bases 1 to 6944)
  AUTHORS   Yamamoto,Y., Irie,K., Asada,M., Mino,A., Mandai,K. and Takai,Y.
  TITLE     Direct binding of the human homologue of the Drosophila disc large
            tumor suppressor gene to seven-pass transmembrane proteins, tumor
            endothelial marker 5 (TEM5), and a novel TEM5-like protein
  JOURNAL   Oncogene 23 (22), 3889-3897 (2004)
   PUBMED   15021905
REFERENCE   9  (bases 1 to 6944)
  AUTHORS   Fredriksson,R., Gloriam,D.E., Hoglund,P.J., Lagerstrom,M.C. and
            Schioth,H.B.
  TITLE     There exist at least 30 human G-protein-coupled receptors with long
            Ser/Thr-rich N-termini
  JOURNAL   Biochem Biophys Res Commun 301 (3), 725-734 (2003)
   PUBMED   12565841
REFERENCE   10 (bases 1 to 6944)
  AUTHORS   Carson-Walter,E.B., Watkins,D.N., Nanda,A., Vogelstein,B.,
            Kinzler,K.W. and St Croix,B.
  TITLE     Cell surface tumor endothelial markers are conserved in mice and
            humans
  JOURNAL   Cancer Res 61 (18), 6649-6655 (2001)
   PUBMED   11559528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA569569.1, AY090637.1, AF378755.1, AL110244.1, AI346793.1,
            AC138356.3 and AC130304.12.
            
            On May 17, 2019 this sequence version replaced NM_032777.9.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF378755.1, AK074099.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000412232.3/ ENSP00000406367.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               DA569569.1         1-338
            339-373             AY090637.1         301-335
            374-3724            AF378755.1         1-3351
            3725-6022           AL110244.1         346-2643
            6023-6034           AI346793.1         17-28               c
            6035-6125           AC138356.3         1-91                c
            6126-6944           AC130304.12        95406-96224         c
FEATURES             Location/Qualifiers
     source          1..6944
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.23"
     gene            1..6944
                     /gene="ADGRA2"
                     /gene_synonym="GPR124; TEM5"
                     /note="adhesion G protein-coupled receptor A2"
                     /db_xref="GeneID:25960"
                     /db_xref="HGNC:HGNC:17849"
                     /db_xref="MIM:606823"
     exon            1..652
                     /gene="ADGRA2"
                     /gene_synonym="GPR124; TEM5"
                     /inference="alignment:Splign:2.1.0"
     CDS             387..4403
                     /gene="ADGRA2"
                     /gene_synonym="GPR124; TEM5"
                     /note="tumor endothelial marker 5; G-protein coupled
                     receptor 124"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor A2
                     precursor"
                     /protein_id="NP_116166.9"
                     /db_xref="CCDS:CCDS6097.2"
                     /db_xref="GeneID:25960"
                     /db_xref="HGNC:HGNC:17849"
                     /db_xref="MIM:606823"
                     /translation="MGAGGRRMRGAPARLLLPLLPWLLLLLAPEARGAPGCPLSIRSC
                     KCSGERPKGLSGGVPGPARRRVVCSGGDLPEPPEPGLLPNGTVTLLLSNNKITGLRNG
                     SFLGLSLLEKLDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLR
                     LNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLC
                     AYPSALHAQALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQCSASYLGND
                     TRIRWYHNRAPVEGDEQAGILLAESLIHDCTFITSELTLSHIGVWASGEWECTVSMAQ
                     GNASKKVEIVVLETSASYCPAERVANNRGDFRWPRTLAGITAYQSCLQYPFTSVPLGG
                     GAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVY
                     TAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQRE
                     DKACSRIVGALERIGGAALSPHAQHISVNARNVALEAYLIKPHSYVGLTCTAFQRREG
                     GVPGTRPGSPGQNPPPEPEPPADQQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPS
                     LFSSLPAALAPPVPPDCTLQLLVFRNGRLFHSHSNTSRPGAAGPGKRRGVATPVIFAG
                     TSGCGVGNLTEPVAVSLRHWAEGAEPVAAWWSQEGPGEAGGWTSEGCQLRSSQPNVSA
                     LHCQHLGNVAVLMELSAFPREVGGAGAGLHPVVYPCTALLLLCLFATIITYILNHSSI
                     RVSRKGWHMLLNLCFHIAMTSAVFAGGITLTNYQMVCQAVGITLHYSSLSTLLWMGVK
                     ARVLHKELTWRAPPPQEGDPALPTPSPMLRFYLIAGGIPLIICGITAAVNIHNYRDHS
                     PYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRGPLAQNPKAGNSRASLEAGEE
                     LRGSTRLRGSGPLLSDSGSLLATGSARVGTPGPPEDGDSLYSPGVQLGALVTTHFLYL
                     AMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACCPPAS
                     PAAPHAPPRALPAAAEDGSPVFGEGPPSLKSSPSGSSGHPLALGPCKLTNLQLAQSQV
                     CEAGAAAGGEGEPEPAGTRGNLAHRHPNNVHHGRRAHKSRAKGHRAGEACGKNRLKAL
                     RGGAAGALELLSSESGSLHNSPTDSYLGSSRNSPGAGLQLEGEPMLTPSEGSDTSAAP
                     LSEAGRAGQRRSASRDSLKGGGALEKESHRRSYPLNAASLNGAPKGGKYDDVTLMGAE
                     VASGGCMKTGLWKSETTV"
     exon            653..724
                     /gene="ADGRA2"
                     /gene_synonym="GPR124; TEM5"
                     /inference="alignment:Splign:2.1.0"
     exon            725..796
                     /gene="ADGRA2"
                     /gene_synonym="GPR124; TEM5"
                     /inference="alignment:Splign:2.1.0"
     exon            797..868
                     /gene="ADGRA2"
                     /gene_synonym="GPR124; TEM5"
                     /inference="alignment:Splign:2.1.0"
     exon            869..940
                     /gene="ADGRA2"
                     /gene_synonym="GPR124; TEM5"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1104
                     /gene="ADGRA2"
                     /gene_synonym="GPR124; TEM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1318
                     /gene="ADGRA2"
                     /gene_synonym="GPR124; TEM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1483
                     /gene="ADGRA2"
                     /gene_synonym="GPR124; TEM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1682
                     /gene="ADGRA2"
                     /gene_synonym="GPR124; TEM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1832
                     /gene="ADGRA2"
                     /gene_synonym="GPR124; TEM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1994
                     /gene="ADGRA2"
                     /gene_synonym="GPR124; TEM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2219
                     /gene="ADGRA2"
                     /gene_synonym="GPR124; TEM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2436
                     /gene="ADGRA2"
                     /gene_synonym="GPR124; TEM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2645
                     /gene="ADGRA2"
                     /gene_synonym="GPR124; TEM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2773
                     /gene="ADGRA2"
                     /gene_synonym="GPR124; TEM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2897
                     /gene="ADGRA2"
                     /gene_synonym="GPR124; TEM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..3043
                     /gene="ADGRA2"
                     /gene_synonym="GPR124; TEM5"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3133
                     /gene="ADGRA2"
                     /gene_synonym="GPR124; TEM5"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..6944
                     /gene="ADGRA2"
                     /gene_synonym="GPR124; TEM5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5993..5998
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRA2"
                     /gene_synonym="GPR124; TEM5"
                     /note="hexamer: ATTAAA"
     polyA_site      6022
                     /gene="ADGRA2"
                     /gene_synonym="GPR124; TEM5"
                     /note="major polyA site"
ORIGIN      
        1 atccatggca cggagcggcg gcggcggcgg cagcaggagc ccggcgcgat ccgctaggtc
       61 ccagcccagc gcccagcgag caggcgacgc ggaggggccg ggcctccagt gtcccgaggg
      121 ccgggcgctg agactccggc cgcgcagctg ggagctgccc gcgctgcgct gacagccgcg
      181 ccgacgtcct ccccgccggg gcgctcgcag gacatgcccc cggggcgcgg cggcggggac
      241 cccggggctc gcctccgccc agggcccccc tccacgccct cgggagcccc gggcccccgc
      301 tgagcactcc tcccgcacgc ctgggtccct ccggccggcg cgcagcccgg ccccagcgct
      361 gtgggtcccc gcggggcgat gggttgatgg gcgccggggg acgcaggatg cggggggcgc
      421 ccgcgcgcct gctgctgccg ctgctgccgt ggctcctgct gctcctggcg cccgaggctc
      481 ggggcgcgcc cggctgcccg ctatccatcc gcagctgcaa gtgctcgggg gagcggccca
      541 aggggctgag cggcggcgtc cctggcccgg ctcggcggag ggtggtgtgc agcggcgggg
      601 acctcccgga gcctcccgag cccggccttc tgcctaacgg caccgttacc ctgctcttga
      661 gcaataacaa gatcacgggg ctccgcaatg gctccttcct gggactgtca ctgctggaga
      721 agctggacct gaggaacaac atcatcagca cagtgcagcc gggcgccttc ctgggcctgg
      781 gggagctgaa gcgtttagat ctctccaaca accggattgg ctgtctcacc tccgagacct
      841 tccagggcct ccccaggctt ctccgactaa acatatctgg aaacatcttc tccagtctgc
      901 aacctggggt ctttgatgag ctgccagccc ttaaggttgt ggacttgggc accgagttcc
      961 tgacctgtga ctgccacctg cgctggctgc tgccctgggc ccagaatcgc tccctgcagc
     1021 tgtcggaaca cacgctctgt gcttacccca gtgccctgca tgctcaggcc ctgggcagcc
     1081 tccaggaggc ccagctctgc tgcgaggggg ccctggagct gcacacacac cacctcatcc
     1141 cgtccctacg ccaagtggtg ttccaggggg atcggctgcc cttccagtgc tctgccagct
     1201 acctgggcaa cgacacccgc atccgctggt accacaaccg agcccctgtg gagggtgatg
     1261 agcaggcggg catcctcctg gccgagagcc tcatccacga ctgcaccttc atcaccagtg
     1321 agctgacgct gtctcacatc ggcgtgtggg cctcaggcga gtgggagtgc accgtgtcca
     1381 tggcccaagg caacgccagc aagaaggtgg agatcgtggt gctggagacc tctgcctcct
     1441 actgccccgc cgagcgtgtt gccaacaacc gcggggactt caggtggccc cgaactctgg
     1501 ctggcatcac agcctaccag tcctgcctgc agtatccctt cacctcagtg cccctgggcg
     1561 ggggtgcccc gggcacccga gcctcccgcc ggtgtgaccg tgccggccgc tgggagccag
     1621 gggactactc ccactgtctc tacaccaacg acatcaccag ggtgctgtac accttcgtgc
     1681 tgatgcccat caatgcctcc aatgcgctga ccctggctca ccagctgcgc gtgtacacag
     1741 ccgaggccgc tagcttttca gacatgatgg atgtagtcta tgtggctcag atgatccaga
     1801 aatttttggg ttatgtcgac cagatcaaag agctggtaga ggtgatggtg gacatggcca
     1861 gcaacctgat gctggtggac gagcacctgc tgtggctggc ccagcgcgag gacaaggcct
     1921 gcagccgcat cgtgggtgcc ctggagcgca ttgggggggc cgccctcagc ccccatgccc
     1981 agcacatctc agtgaatgcg aggaacgtgg cattggaggc ctacctcatc aagccgcaca
     2041 gctacgtggg cctgacctgc acagccttcc agaggaggga gggaggggtg ccgggcacac
     2101 ggccaggaag ccctggccag aaccccccac ctgagcccga gcccccagct gaccagcagc
     2161 tccgcttccg ctgcaccacc gggaggccca atgtttctct gtcgtccttc cacatcaaga
     2221 acagcgtggc cctggcctcc atccagctgc ccccgagtct attctcatcc cttccggctg
     2281 ccctggctcc cccggtgccc ccagactgca ccctgcaact gctcgtcttc cgaaatggcc
     2341 gcctcttcca cagccacagc aacacctccc gccctggagc tgctgggcct ggcaagaggc
     2401 gtggcgtggc cacccccgtc atcttcgcag gaaccagtgg ctgtggcgtg ggaaacctga
     2461 cagagccagt ggccgtttcg ctgcggcact gggctgaggg agccgaacct gtggccgctt
     2521 ggtggagcca ggaggggccc ggggaggctg ggggctggac ctcggagggc tgccagctcc
     2581 gctccagcca gcccaatgtc agcgccctgc actgccagca cttgggcaat gtggccgtgc
     2641 tcatggagct gagcgccttt cccagggagg tggggggcgc cggggcaggg ctgcaccccg
     2701 tggtataccc ctgcacggcc ttgctgctgc tctgcctctt cgccaccatc atcacctaca
     2761 tcctcaacca cagctccatc cgtgtgtccc ggaaaggctg gcacatgctg ctgaacttgt
     2821 gcttccacat agccatgacc tctgctgtct ttgcgggggg catcacactc accaactacc
     2881 agatggtctg ccaggcggtg ggcatcaccc tgcactactc ctccctatcc acgctgctct
     2941 ggatgggcgt gaaggcgcga gtgctccata aggagctcac ctggagggca ccccctccgc
     3001 aagaagggga ccccgctctg cctactccca gtcctatgct ccggttctat ttgatcgctg
     3061 gagggattcc actcattatc tgtggcatca cagctgcagt caacatccac aactaccggg
     3121 accacagccc ctactgctgg ctggtgtggc gtccaagcct tggcgccttc tacatccctg
     3181 tggctttgat tctgctcatc acctggatct atttcctgtg cgccgggcta cgcttacggg
     3241 gtcctctggc acagaacccc aaggcgggca acagcagggc ctccctggag gcaggggagg
     3301 agctgagggg ttccaccagg ctcaggggca gcggccccct cctgagtgac tcaggttccc
     3361 ttcttgctac tgggagcgcg cgagtgggga cgcccgggcc cccggaggat ggtgacagcc
     3421 tctattctcc gggagtccag ctaggggcgc tggtgaccac gcacttcctg tacttggcca
     3481 tgtgggcctg cggggctctg gcagtgtccc agcgctggct gccccgggtg gtgtgcagct
     3541 gcttgtacgg ggtggcagcc tccgccctgg gcctcttcgt cttcactcac cactgtgcca
     3601 ggcggaggga cgtgagagcc tcgtggcgcg cctgctgccc ccctgcctct cccgcggccc
     3661 cccatgcccc gccccgggcc ctgcccgccg ccgcagagga cggttccccg gtgttcgggg
     3721 agggcccccc ctccctcaag tcctccccaa gcggcagcag cggccatccg ctggctctgg
     3781 gcccctgcaa gctcaccaac ctgcagctgg cccagagtca ggtgtgcgag gcgggggcgg
     3841 cggccggcgg ggaaggagag ccggagccgg cgggcacccg gggaaacctc gcccaccgcc
     3901 accccaacaa cgtgcaccac gggcgtcggg cgcacaagag ccgggccaag ggacaccgcg
     3961 cgggggaggc ctgcggcaag aaccggctca aggccctgcg cgggggcgcg gcgggggcgc
     4021 tggagctgct gtccagcgag agcggcagtc tgcacaacag ccccaccgac agctacctgg
     4081 gcagcagccg caacagcccg ggcgccggcc tgcagctgga aggcgagccc atgctcacgc
     4141 cgtccgaggg cagcgacacc agcgccgcgc cgctttctga ggcgggccgg gcaggccagc
     4201 gccgcagcgc cagccgcgac agtctcaagg gcggcggcgc gctggagaag gagagccatc
     4261 gccgctcgta cccgctcaac gccgccagcc taaacggcgc ccccaagggg ggcaagtacg
     4321 acgacgtcac cctgatgggc gcggaggtag ccagcggcgg ctgcatgaag accggactct
     4381 ggaagagcga aactaccgtc taaggtgggg cgggcgacgc ggtagacggg ctggccacgc
     4441 ggctcgttcc cccgctcctc ggggccctcc aaggtgtctc cgtagtcagc aggttggagg
     4501 cagaggagcc gatggctgga ggaagcccac aggcggatgt tccccacttg cctagagggc
     4561 atccctctgg ggtagcgaca gacaatccca gaaacacgca taatacattt ccgtccagcc
     4621 cggggcagtc tgactgtcgg tgccctccca ggaacgggga aggcctccgt ctgtgtgaaa
     4681 gggcacagca catcccaggt gcaccctccc caagtactcc caccccgcct actgtccatg
     4741 cggcctcact gggggccatc agcctcacca gcaaagcaga gatgagagcg tgggaactgt
     4801 gttctttcct ccctgccctc tactgatttc agcccagccc ctgcctagat cctaggtccc
     4861 ttttcctccc gagtttggct ggcacgagag ctagcccagc acatgaagca ggtgatgtta
     4921 agtcacaagg tgctgctttt cagatccact atgcaagagg ggagggtggg gccacgtgaa
     4981 aggcagctct agacatcaac cagtcctggg ggaggggagt gggaaccggg cacaactagg
     5041 aacaatgcca ccattcccac aggagtggta cttaaaccag acagcagggt tcagaggtgg
     5101 cacaccggga caaagctgag gccctgcacc tcaacagctg actgccaggt gcctgtgggt
     5161 gaactgaggg gagtagaggg agagggcagg tggaactggg gcagaatcta gtcatgccct
     5221 aaagctagtc ctgtaaacaa tggtgcccca gaaagctgca ggtggtgttt ggagaagcag
     5281 ttacttttca gttacaagac ccatctccct agtctcagcc ttacaacacc acgggactaa
     5341 ggaagagcac ttccttgcct ccgtaaggcc agaggaagaa ccatcccaat catttgatct
     5401 ccagctccac agtagagaga aacctacaaa atgtcaaacc agcttcccga ctcccaggag
     5461 ctcaagccaa gcccagaggc agtggctggg gtccctgcag gtcatgaggg gcctatgcct
     5521 ttactccttt taaacaccag cacccgtctt ttccccaacc taaaaccaac caccagcatt
     5581 tcactacagg accaaatgga aaccgaggga accctgggtc ttgggaagaa caacaggaaa
     5641 ccaaggtctg acctagggtt ccctcccagt cttcacatca ctctggcctc atcaccaagg
     5701 tgacagagga cacaggggag ggggaaaacc cacacacact ccttggaatg ggtcctgtta
     5761 tttatgcttg ctgcacagac atattagaag aaaaaaaaaa gctttgtatt attcttccac
     5821 atatgctggc tgctgtttac acaccctgcc aatgccttag cactggagag ctttttgcaa
     5881 tatgctgggg aaaggggagg gagggaatga aagtgccaaa gaaaacatgt ttttaagaac
     5941 tcgggtttta tacaatagaa tgttttctag cagatgcctc ttgttttaat atattaaaat
     6001 tttgcaaagc cctttgagct actgccttag tctacccact gtccttttgt tatgaggtag
     6061 aggatctcat gacaccatac acacaaaccc atcattgcct gtgaatgcac gtagggccag
     6121 aattccccag ttcccgctcc tctgagggtt gatactgctg ggaatgccaa ccactccaca
     6181 agcagaggga agccccctca ggcctgcagg aggagccgca gcagtgtgtc caattcaaac
     6241 cagcagcaaa gagcctgaca ttttcccatc catctatgag gaaagccatc tcacagaaca
     6301 tggacatagg caacttgctc tcccacacca agggatggga atctctccta cctatagtca
     6361 tccctgcact cctgacttta ctccaggacc cagggtccaa ctaatggcag agcccctctt
     6421 ggttccttca aacaagaaaa gcaataccta cggactggtg tacacttcca tccttggtta
     6481 taacaggaat gttatcaagc tgtcagaaca ggatgaagtg ctcccagtgg atatccatca
     6541 gggagggtta gggacactcg tggcagcctg tctagcagcc tgggctctct gaaagtccct
     6601 aacttcctga ggggtacgca aatactgttc tatttcacta tcagaaatgt tctcatctcc
     6661 agtgacagtg gagacagggg gtacagggca gatccgcttc ggggacttca acatgcaggg
     6721 tggcaagaga agggcaggac tggccggccg cttcccctgg ggtaaaccta aggaattatt
     6781 tcccacctcc ccttctcctt gcccctgtcc ccaccccggt ggctccttct ctcgggtctc
     6841 cacttctgct gtcccatccc gaaaggcaga gcggaccagt gactggcggt gctggagaag
     6901 gtcaccgatg tgcttcacca cagaccgttt gtcaagtctc agaa
//
