LOCUS       NM_001083909            4264 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens adhesion G protein-coupled receptor A1 (ADGRA1),
            transcript variant 1, mRNA.
ACCESSION   NM_001083909
VERSION     NM_001083909.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4264)
  AUTHORS   Krasnova,O.A., Kulakova,K.A., Sopova,J.V., Smirnov,E.Y.,
            Silonov,S.A., Lomert,E.V., Bystrova,O.A., Martynova,M.G. and
            Neganova,I.E.
  TITLE     Essential Role of Adhesion GPCR, GPR123, for Human Pluripotent Stem
            Cells and Reprogramming towards Pluripotency
  JOURNAL   Cells 12 (2), 304 (2023)
   PUBMED   36672239
  REMARK    GeneRIF: Essential Role of Adhesion GPCR, GPR123, for Human
            Pluripotent Stem Cells and Reprogramming towards Pluripotency.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4264)
  AUTHORS   Liu,Y., Wang,G., Cui,T. and Lv,L.
  TITLE     Adhesion GPR123 is an indicator for recurrence and prognosis in
            bladder cancer
  JOURNAL   Genes Genomics 43 (11), 1317-1325 (2021)
   PUBMED   33945147
  REMARK    GeneRIF: Adhesion GPR123 is an indicator for recurrence and
            prognosis in bladder cancer.
REFERENCE   3  (bases 1 to 4264)
  AUTHORS   Hamann,J., Aust,G., Arac,D., Engel,F.B., Formstone,C.,
            Fredriksson,R., Hall,R.A., Harty,B.L., Kirchhoff,C., Knapp,B.,
            Krishnan,A., Liebscher,I., Lin,H.H., Martinelli,D.C., Monk,K.R.,
            Peeters,M.C., Piao,X., Promel,S., Schoneberg,T., Schwartz,T.W.,
            Singer,K., Stacey,M., Ushkaryov,Y.A., Vallon,M., Wolfrum,U.,
            Wright,M.W., Xu,L., Langenhan,T. and Schioth,H.B.
  TITLE     International Union of Basic and Clinical Pharmacology. XCIV.
            Adhesion G protein-coupled receptors
  JOURNAL   Pharmacol Rev 67 (2), 338-367 (2015)
   PUBMED   25713288
  REMARK    Review article
REFERENCE   4  (bases 1 to 4264)
  AUTHORS   Mills,J.D., Kavanagh,T., Kim,W.S., Chen,B.J., Kawahara,Y.,
            Halliday,G.M. and Janitz,M.
  TITLE     Unique transcriptome patterns of the white and grey matter
            corroborate structural and functional heterogeneity in the human
            frontal lobe
  JOURNAL   PLoS One 8 (10), e78480 (2013)
   PUBMED   24194939
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4264)
  AUTHORS   Lagerstrom,M.C., Rabe,N., Haitina,T., Kalnina,I., Hellstrom,A.R.,
            Klovins,J., Kullander,K. and Schioth,H.B.
  TITLE     The evolutionary history and tissue mapping of GPR123: specific CNS
            expression pattern predominantly in thalamic nuclei and regions
            containing large pyramidal cells
  JOURNAL   J Neurochem 100 (4), 1129-1142 (2007)
   PUBMED   17212699
  REMARK    GeneRIF: Studies indicate that the orthologs of GP123 in mouse and
            rat play a role in the regulation of neuronal signaling pathways.
REFERENCE   6  (bases 1 to 4264)
  AUTHORS   Bjarnadottir,T.K., Geirardsdottir,K., Ingemansson,M., Mirza,M.A.,
            Fredriksson,R. and Schioth,H.B.
  TITLE     Identification of novel splice variants of Adhesion G
            protein-coupled receptors
  JOURNAL   Gene 387 (1-2), 38-48 (2007)
   PUBMED   17056209
REFERENCE   7  (bases 1 to 4264)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
REFERENCE   8  (bases 1 to 4264)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   9  (bases 1 to 4264)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
REFERENCE   10 (bases 1 to 4264)
  AUTHORS   Fredriksson,R., Gloriam,D.E., Hoglund,P.J., Lagerstrom,M.C. and
            Schioth,H.B.
  TITLE     There exist at least 30 human G-protein-coupled receptors with long
            Ser/Thr-rich N-termini
  JOURNAL   Biochem Biophys Res Commun 301 (3), 725-734 (2003)
   PUBMED   12565841
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL445199.37, DA208698.1,
            EF536972.1 and BC044247.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 30, 2019 this sequence version replaced NM_001083909.2.
            
            Summary: This gene encodes a protein that belongs to the adhesion
            family of G-protein-coupled receptors. Members of this family
            function in several sensory systems and regulate blood pressure,
            immune responses, food intake and development. A similar protein in
            rodents is thought to play a role in in the regulation of neuronal
            signaling pathways. Several alternatively spliced transcript
            variants of this gene have been described, but the full-length
            nature of some of these variants has not been determined. [provided
            by RefSeq, Mar 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.3627836.1,
                                           SRR14372080.3602197.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392607.8/ ENSP00000376384.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AL445199.37        57007-57086
            81-291              DA208698.1         1-211
            292-2142            EF536972.1         1-1851
            2143-3931           AL445199.37        98637-100425
            3932-4264           BC044247.1         1638-1970
FEATURES             Location/Qualifiers
     source          1..4264
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.3"
     gene            1..4264
                     /gene="ADGRA1"
                     /gene_synonym="GPR123"
                     /note="adhesion G protein-coupled receptor A1"
                     /db_xref="GeneID:84435"
                     /db_xref="HGNC:HGNC:13838"
                     /db_xref="MIM:612302"
     exon            1..215
                     /gene="ADGRA1"
                     /gene_synonym="GPR123"
                     /inference="alignment:Splign:2.1.0"
     exon            216..420
                     /gene="ADGRA1"
                     /gene_synonym="GPR123"
                     /inference="alignment:Splign:2.1.0"
     CDS             418..2100
                     /gene="ADGRA1"
                     /gene_synonym="GPR123"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable G-protein coupled receptor 123"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor A1 isoform
                     1"
                     /protein_id="NP_001077378.1"
                     /db_xref="CCDS:CCDS41580.1"
                     /db_xref="GeneID:84435"
                     /db_xref="HGNC:HGNC:13838"
                     /db_xref="MIM:612302"
                     /translation="MDLKTVLSLPRYPGEFLHPVVYACTAVMLLCLLASFVTYIVHQS
                     AIRISRKGRHTLLNFCFHAALTFTVFAGGINRTKYPILCQAVGIVLHYSTLSTMLWIG
                     VTARNIYKQVTKKAPLCLDTDQPPYPRQPLLRFYLVSGGVPFIICGVTAATNIRNYGT
                     EDEDTAYCWMAWEPSLGAFYGPAAIITLVTCVYFLGTYVQLRRHPGRRYELRTQPEEQ
                     RRLATPEGGRGIRPGTPPAHDAPGASVLQNEHSFQAQLRAAAFTLFLFTATWAFGALA
                     VSQGHFLDMVFSCLYGAFCVTLGLFVLIHHCAKREDVWQCWWACCPPRKDAHPALDAN
                     GAALGRAACLHSPGLGQPRGFAHPPGPCKMTNLQAAQGHASCLSPATPCCAKMHCEPL
                     TADEAHVHLQEEGAFGHDPHLHGCLQGRTKPPYFSRHPAEEPEYAYHIPSSLDGSPRS
                     SRTDSPPSSLDGPAGTHTLACCTQGDPFPMVTQPEGSDGSPALYSCPTQPGREAALGP
                     GHLEMLRRTQSLPFGGPSQNGLPKGKLLEGLPFGTDGTGNIRTGPWKNETTV"
     exon            421..548
                     /gene="ADGRA1"
                     /gene_synonym="GPR123"
                     /inference="alignment:Splign:2.1.0"
     exon            549..672
                     /gene="ADGRA1"
                     /gene_synonym="GPR123"
                     /inference="alignment:Splign:2.1.0"
     exon            673..818
                     /gene="ADGRA1"
                     /gene_synonym="GPR123"
                     /inference="alignment:Splign:2.1.0"
     exon            819..917
                     /gene="ADGRA1"
                     /gene_synonym="GPR123"
                     /inference="alignment:Splign:2.1.0"
     exon            918..4264
                     /gene="ADGRA1"
                     /gene_synonym="GPR123"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3998..4003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRA1"
                     /gene_synonym="GPR123"
                     /note="hexamer: AATACA"
     polyA_site      4017
                     /gene="ADGRA1"
                     /gene_synonym="GPR123"
                     /note="major polyA site"
     regulatory      4237..4242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGRA1"
                     /gene_synonym="GPR123"
                     /note="hexamer: ATTAAA"
     polyA_site      4264
                     /gene="ADGRA1"
                     /gene_synonym="GPR123"
ORIGIN      
        1 gcagaggcgg cggcgctgct ggccgggctg ggccgctcgt gcgcggggct gtgactcacc
       61 ggccggcgcc gcagccccgc aatctgttga taactcggtc ccagctcggc cgctgccctc
      121 gcgaatggag agcgggtccc cggcgggggg agcgcagcgc gtctgtctcc gggagcgcgg
      181 cccggccgcc ccggcagccg cttcggccac agcagatggg agcagctccc ggactgcgcc
      241 cgccccgccg cggtcaccct gaggccaggg gcccgggagc gcgacctcct ggccgccgtc
      301 tgggactttg accttccaga ggccatggag gctggcgggg agcagggcgc cacctgatcg
      361 cctccccctg gacgcctcct ccagcggcgc tcacgcttcc gcaactttgc agcgctcatg
      421 gatctgaaga cagtgctctc cctgccccgc tacccagggg agttcctgca ccccgtggtg
      481 tacgcgtgca cggccgtcat gctgctctgc ctcctggcct ccttcgtcac ctacatcgtg
      541 caccagagcg ccatccgcat cagccgcaag ggccggcaca cgctcctgaa tttctgcttc
      601 cacgcggccc tgaccttcac tgtgttcgcc ggcggcatca atcgcaccaa gtaccccatc
      661 ctgtgccagg cggtgggcat cgtgctgcac tattctacac tgtccaccat gctgtggata
      721 ggagtgaccg ccaggaacat ctacaagcag gtgaccaaga aggcccctct gtgcctggac
      781 acagaccagc caccgtaccc caggcagccc ctgctcaggt tttacctcgt cagcggaggg
      841 gtccccttta tcatctgtgg ggtcacggct gccacgaaca tcaggaatta cgggacagag
      901 gacgaggaca cggcgtactg ctggatggcc tgggagccca gcctgggcgc cttctacggc
      961 ccagccgcca tcatcaccct ggtcacctgt gtgtacttcc tgggcaccta cgtgcagctg
     1021 cggcgccacc cagggcgcag gtacgagctg cgcacacagc ccgaggagca gcggcggctg
     1081 gcgacacccg agggcggccg tgggatccgg ccaggcaccc cacccgcaca cgatgccccc
     1141 ggcgcctccg tgctgcagaa cgagcactca ttccaggcac agctgcgcgc cgccgccttc
     1201 acgctgttcc tgttcacggc cacgtgggcc ttcggggcgc tggcggtgtc acagggccac
     1261 ttcctggaca tggtcttcag ctgcctgtac ggcgccttct gcgtgaccct gggactcttc
     1321 gtgctcatcc accactgcgc caagcgtgag gacgtgtggc agtgctggtg ggcatgctgc
     1381 ccgccccgca aggacgccca ccccgcactt gacgccaacg gggccgcgct gggccgcgcc
     1441 gcctgcctgc actcgccggg actgggccag ccacggggct tcgcgcaccc accgggcccc
     1501 tgcaagatga ccaacctgca ggccgcgcag ggccacgcca gttgcctgtc accggccacc
     1561 ccgtgctgcg ccaagatgca ctgcgagcca ctgacggcgg acgaggcgca cgtgcacctg
     1621 caggaggagg gcgccttcgg gcacgacccc cacctgcacg ggtgccttca gggcagaact
     1681 aagccgccct actttagccg gcacccagca gaggagcccg agtacgccta ccacatccca
     1741 tccagcctgg atggcagccc ccgcagctcg cgcacagaca gcccccccag ctctctggat
     1801 ggcccggcgg ggacacacac gctggcctgc tgcacccagg gcgacccctt ccccatggtc
     1861 acccagcccg agggcagtga tgggagccct gccctctaca gctgccccac gcagccgggc
     1921 agggaggcag cgctcgggcc cggccacttg gagatgctgc ggaggacaca gtccctgccc
     1981 tttggtggcc ccagccagaa cgggctgccc aagggtaaat tgctagaagg cctgccgttt
     2041 ggcaccgacg ggaccggcaa catccgaacg ggaccctgga aaaacgaaac tactgtgtag
     2101 atgggggcag aggacacggt gttcctggag gagcttcaga gcagagtggg gggcccatct
     2161 gccacatgag gtcactgggg gtaccgaagt gaccccgcct ttcagaagcc gttcacaccc
     2221 ctgccccttc cttgtgatca cacccctgcc ccttccttgt gatcacaccc ctgccccttc
     2281 cttgtgatca cacccctgcc ccttccttgt gaaagacctc agcggggaaa cgctccgggc
     2341 cacgcccact ccccttatcc caattccgcg tgctggtccc gcacacggtc atccggtttc
     2401 tgtcctgtgg tctccagtcc tggggcaccc tagaggcaga gcaggggatt ccatcaaagg
     2461 acccactgag accccagcat ggccctgccc gagatgccct gctgcccacg gagtcctggc
     2521 ttcccctggt gtggccgggc agggccgaga tcgcaggagg gggctgccct gacctttccc
     2581 agtgttcaat gtgtgtgtct tgcgttctac tccgggggtg gcggcggcag gtctgtcccc
     2641 agcattctcg ctctgggcag aaccctcggg accctccgct gtcgtgtgtc tgagccaccc
     2701 ctgcagcttc acagggcccc tgcacacctc tgcccactca gtgtgccctg tcagccctgt
     2761 ccttgtcgta gccccagccc tgcagggctg agagcaccac agatgctggg ggctgctctg
     2821 gactttgggg atggctgtca gcctcagagg gccaatgggg ggctttcacg ggcccaaggc
     2881 ttgggaaaat gcccagacat cctttagtga agactcgact tccaaaacca gccaccgctg
     2941 ggactggatt ccactccagt ataggcactt agcaacacga aggtttattc caaaaagaaa
     3001 aggggctgac agacgggaga ttctcatgga caaaatccct ttcccttttt ctcgtctcca
     3061 tgaacatctg ggtaccaagc cctgactcaa aggacagatg tggatgacag caagacttct
     3121 gtgaaagcaa gtggcccgtc cctaggtggg agggagtcca gagggtcatg ggtgtgaaac
     3181 tgtgcacagc tttccctccc tccctcttcc tccttgtctg tgacacatgt gcacccacac
     3241 acacacacac aaacacatgt gcatatcaca cacatgcaca cacacaaaca catgtgcata
     3301 tcacacacgc gcacacaccc aaacacgtgc atatcacaca catgcacaca cacaaacacg
     3361 tgcatatcac acacatgcac acaaacgtgc atatcacaca cacgcacaca cacccaaaca
     3421 cgtgcatatc acacacacgc acacacacaa acacgtgcat atcacacaca aacacacgtg
     3481 cacacatact taacacacac ttgcacctgc tgtgcacatg tgcacacaca cgtagtagtg
     3541 tgttttccag ccacccacac actgggtttg cattggagat tgtttcaccc tgcaaacgtc
     3601 aacgtcagca gactcgtcgg tgcgctgtgc tatccggttg ggaggtctca ccaggagcag
     3661 agcctcccta acgtgcacct ccgagaagag gggtgtcggg gagtgttccc agcacctgct
     3721 cggtggaagg gctctccgga gactggcact cagtatctga gtatgaggag cctcacttcc
     3781 cggggtgtcg gtaaacttga ccgtgactca gtaacccaca gcgtgctcct cccagcaaac
     3841 cccgtgtgtc cttacaggtc gaccagacgg gccgtcggag gaccaccagg tggctctgcc
     3901 tctgcctcac cttctcacct gcttccatag ctgatgtgaa cccgaatccc cacgctgtgc
     3961 tgtgtacgca ctgtaggtgc agaaccgtcc acacaaaaat acagtcttgg cattgtttgt
     4021 tctttgtgag gctggttaat agcatccccg tgtgtttttc tcaccctcga tggggtagag
     4081 gggcacctga atgtgtggcc cccgtctgtg tcctggatcc tggggcaggg ctgctctccc
     4141 tggcccctgc agcccctcat gaactttcca ccctcagtgc ccccggctga gcagagaggc
     4201 gtcccaccat tcaaccaaag aaagtcaaca ttgaacatta aacctctgtg tgtttctata
     4261 ctga
//
