LOCUS       NM_024694               5318 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens androglobin (ADGB), mRNA.
ACCESSION   NM_024694 XM_001716966 XM_929679 XM_941958
VERSION     NM_024694.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5318)
  AUTHORS   Qu,R., Zhang,Z., Wu,L., Li,Q., Mu,J., Zhao,L., Yan,Z., Wang,W.,
            Zeng,Y., Liu,R., Dong,J., Li,Q., Sun,X., Wang,L., Sang,Q., Chen,B.
            and Kuang,Y.
  TITLE     ADGB variants cause asthenozoospermia and male infertility
  JOURNAL   Hum Genet 142 (6), 735-748 (2023)
   PUBMED   36995441
  REMARK    GeneRIF: ADGB variants cause asthenozoospermia and male
            infertility.
REFERENCE   2  (bases 1 to 5318)
  AUTHORS   Koay,T.W., Osterhof,C., Orlando,I.M.C., Keppner,A., Andre,D.,
            Yousefian,S., Suarez Alonso,M., Correia,M., Markworth,R.,
            Schodel,J., Hankeln,T. and Hoogewijs,D.
  TITLE     Androglobin gene expression patterns and FOXJ1-dependent regulation
            indicate its functional association with ciliogenesis
  JOURNAL   J Biol Chem 296, 100291 (2021)
   PUBMED   33453283
  REMARK    GeneRIF: Androglobin gene expression patterns and FOXJ1-dependent
            regulation indicate its functional association with ciliogenesis.
REFERENCE   3  (bases 1 to 5318)
  AUTHORS   Huang,B., Lu,Y.S., Li,X., Zhu,Z.C., Li,K., Liu,J.W., Zheng,J. and
            Hu,Z.L.
  TITLE     Androglobin knockdown inhibits growth of glioma cell lines
  JOURNAL   Int J Clin Exp Pathol 7 (5), 2179-2184 (2014)
   PUBMED   24966926
  REMARK    GeneRIF: Suggest ADGB is involved in the progression of glioma in
            vitro.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5318)
  AUTHORS   Hoogewijs,D., Ebner,B., Germani,F., Hoffmann,F.G., Fabrizius,A.,
            Moens,L., Burmester,T., Dewilde,S., Storz,J.F., Vinogradov,S.N. and
            Hankeln,T.
  TITLE     Androglobin: a chimeric globin in metazoans that is preferentially
            expressed in Mammalian testes
  JOURNAL   Mol Biol Evol 29 (4), 1105-1114 (2012)
   PUBMED   22115833
  REMARK    GeneRIF: Molecular evolutionary analyses indicate that this
            chimeric globin family is phylogenetically ancient and originated
            in the common ancestor to animals and choanoflagellates. In humans
            and mice, the gene is predominantly expressed in testis tissue.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL359547.26, AK097570.1, AL832192.1, DN831198.1, AK026774.1 and
            BG199812.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024694.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1968968, SAMEA2148874
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000397944.8/ ENSP00000381036.3
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AL359547.26        27274-27301
            29-997              AK097570.1         1-969
            998-1776            AL832192.1         740-1518
            1777-2306           AK097570.1         1749-2278
            2307-2859           DN831198.1         103-655             c
            2860-4376           AL832192.1         4323-5839
            4377-4931           AK026774.1         1182-1736
            4932-5318           BG199812.1         34-420
FEATURES             Location/Qualifiers
     source          1..5318
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q24.3"
     gene            1..5318
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /note="androglobin"
                     /db_xref="GeneID:79747"
                     /db_xref="HGNC:HGNC:21212"
                     /db_xref="MIM:614630"
     exon            1..143
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..5073
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /note="calpain-7-like protein"
                     /codon_start=1
                     /product="androglobin"
                     /protein_id="NP_078970.3"
                     /db_xref="GeneID:79747"
                     /db_xref="HGNC:HGNC:21212"
                     /db_xref="MIM:614630"
                     /translation="MASKQTKKKEVHRINSAHGSDKSKDFYPFGSNVQSGSTEQKKGK
                     FPLWPEWSEADINSEKWDAGKGAKEKDKTGKSPVFHFFEDPEGKIELPPSLKIYSWKR
                     PQDILFSQTPVVVKNEITFDLFSANEHLLCSELMRWIISEIYAVWKIFNGGILSNYFK
                     GTSGEPPLLPWKPWEHIYSLCKAVKGHMPLFNSYGKYVVKLYWMGCWRKITIDDFLPF
                     DEDNNLLLPATTYEFELWPMLLSKAIIKLANIDIHVADRRELGEFTVIHALTGWLPEV
                     ISLHPGYMDKVWELLKEILPEFKLSDEASSESKIAVLDSKLKEPGKEGKEGKEIKDGK
                     EVKDVKEFKPESSLTTLKAPEKSDKVPKEKADARDIGKKRSKDGEKEKFKFSLHGSRP
                     SSEVQYSVQSLSDCSSAIQTSHMVVYATFTPLYLFENKIFSLEKMADSAEKLREYGLS
                     HICSHPVLVTRSRSCPLVAPPKPPPLPPWKLIRQKKETVITDEAQELIVKKPERFLEI
                     SSPFLNYRMTPFTIPTEMHFVRSLIKKGIPPGSDLPSVSETDETATHSQTDLSQITKA
                     TSQGNTASQVILGKGTDEQTDFGLGDAHQSDGLNLEREIVSQTTATQEKSQEELPTTN
                     NSVSKEIWLDFEDFCVCFQNIYIFHKPSSYCLNFQKSEFKFSEERVSYYLFVDSLKPI
                     ELLVCFSALVRWGEYGALTKDSPPIEPGLLTAETFSWKSLKPGSLVLKIHTYATKATV
                     VRLPVGRHMLLFNAYSPVGHSIHICSMVSFVIGDEHVVLPNFEPESCRFTEQSLLIMK
                     AIGNVIANFKDKGKLSAALKDLQTAHYPVPFHDKELTAQHFRVFHLSLWRLMKKVQIT
                     KPPPNFKFAFRAMVLDLELLNSSLEEVSLVEWLDVKYCMPTSDKEYSAEEVAAAIKIQ
                     AMWRGTYVRLLMKARIPDTKENISVADTLQKVWAVLEMNLEQYAVSLLRLMFKSKCKS
                     LESYPCYQDEETKIAFADYTVTYQEQPPNSWFIVFRETFLVHQDMILVPKVYTTLPIC
                     ILHIVNNDTMEQVPKVFQKVVPYLYTKNKKGYTFVAEAFTGDTYVAASRWKLRLIGSS
                     APLPCLSRDSPCNSFAIKEIRDYYIPNDKKILFRYSVKVLTPQPATIQVRTSKPDAFI
                     KLQVLENEETMVSSTGKGQAIIPAFHFLKSEKGLSSQSSKHILSFHSASKKEQEVYVK
                     KKAAQGIQKSPKGRAVSAIQDIGLPLVEEETTSTPTREDSSSTPLQNYKYIIQCSVLY
                     NSWPLTESQLTFVQALKDLKKSNTKAYGERHEELINLGSPDSHTISEGQKSSVTSKTT
                     RKGKEKSSEKEKTAKEKQAPRFEPQISTVHPQQEDPNKPYWILRLVTEHNESELFEVK
                     KDTERADEIRAMKQAWETTEPGRAIKASQARLHYLSGFIKKTSDAESPPISESQTKPK
                     EEVETAARGVKEPNSKNSAGSESKEMTQTGSGSAVWKKWQLTKGLRDVAKSTSSESGG
                     VSSPGKEEREQSTRKENIQTGPRTRSPTILETSPRLIRKALEFMDLSQYVRKTDTDPL
                     LQTDELNQQQAMQKAEEIHQFRQHRTRVLSIRNIDQEERLKLKDEVLDMYKEMQDSLD
                     EARQKIFDIREEYRNKLLEAEHLKLETLAAQEAAMKLETEKMTPAPDTQKKKKGKKK"
     exon            144..306
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            307..399
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            400..471
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            472..681
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            682..821
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            822..908
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1156
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1285
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1380
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1555
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1646
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1776
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1810
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1997
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2061
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2164
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2306
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2421
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2589
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2725
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2863
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            2864..2957
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            2958..3092
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            3093..3246
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            3247..3434
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            3435..3619
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            3620..3819
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            3820..3931
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            3932..4104
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            4105..4281
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            4282..4384
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            4385..4606
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            4607..4703
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            4704..4887
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     exon            4888..5318
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5294..5299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /note="hexamer: AATAAA"
     polyA_site      5318
                     /gene="ADGB"
                     /gene_synonym="C6orf103; CAPN16"
                     /note="major polyA site"
ORIGIN      
        1 agacgcggag ccgagcgcgc ccgcaggctc tttgctcaga gctcagccct acatagatcg
       61 gcttctgcca tggcctccaa acaaaccaaa aagaaagagg tgcatcgtat caactcggcg
      121 cacggatcgg ataaatcgaa agatttctat ccttttggca gtaatgtaca atctggttct
      181 actgaacaaa agaaggggaa attcccactc tggccagagt ggagtgaagc tgacataaat
      241 tcagaaaagt gggatgcagg caaaggtgca aaagaaaagg acaaaacagg aaaaagccct
      301 gtatttcatt tttttgagga ccctgaagga aagattgagt taccaccatc cttgaaaatt
      361 tattcctgga aacgtccaca agatatttta tttagtcaga ctccagtagt tgtgaaaaat
      421 gaaatcacgt ttgacttatt ttcagcaaat gaacatttac tctgcagcga gctgatgaga
      481 tggattatca gtgaaatcta tgcagtgtgg aagatcttca atggaggaat tttgagcaat
      541 tattttaagg ggacttcagg ggaacctcct cttctcccct ggaagccctg ggaacacata
      601 tactctctgt gcaaggctgt gaagggtcat atgcctttgt tcaatagcta tggaaagtat
      661 gttgtgaaac tttactggat gggttgctgg agaaagataa caattgatga ctttttgcct
      721 tttgatgaag ataacaatct attgcttcca gctacaactt atgaatttga actgtggcca
      781 atgcttttgt ctaaagctat tatcaagctg gcaaatattg acatccatgt agcagacagg
      841 agagagctgg gggagttcac ggttattcat gcgctcacag gatggttacc agaagtcatt
      901 tctcttcacc cgggatatat ggacaaagtt tgggagctcc tgaaagaaat attgcctgag
      961 tttaagctgt cagatgaggc cagctctgaa agcaaaatag cagtgttaga ttctaaatta
     1021 aaagaaccag ggaaagaagg gaaggaggga aaagaaataa aggatggaaa ggaagtaaaa
     1081 gacgtgaagg aattcaaacc tgaaagttct ttgacaacac taaaggctcc tgagaaaagc
     1141 gacaaagttc caaaggagaa agcagatgca agagacattg gaaagaagag aagcaaagat
     1201 ggagaaaaag aaaaattcaa attctcactt catggttcaa gaccctcatc agaagtgcag
     1261 tactctgtgc agtccctatc agattgttct tctgcaatac agacctctca tatggtcgta
     1321 tatgcgacat ttacacctct ttatttgttt gaaaacaaga tcttttcatt agagaagatg
     1381 gcagattctg ctgagaaact tagagaatat gggctttccc acatctgtag ccatcctgtg
     1441 ctggtgacta gaagtaggtc ttgtcctctg gtagcaccac caaaaccacc tcctctacct
     1501 ccctggaaac tcattcgtca aaaaaaggaa actgttataa cagatgaagc tcaagagtta
     1561 atagtaaaga agcctgaacg gttccttgag atttcaagtc catttttgaa ttatagaatg
     1621 actccattta caattccaac agaaatgcat tttgtgcgct ccttaattaa gaaaggaata
     1681 cctccaggat ctgatttacc ttccgtcagt gaaactgatg aaactgcaac acatagccag
     1741 acagacttga gtcaaataac aaaagctaca tctcagggaa atactgcttc acaagttata
     1801 cttggaaaag gcacagatga acaaacagac tttggattgg gtgatgctca tcagagtgat
     1861 ggattaaact tggaaagaga gatagtcagc cagaccacag caacacagga aaagtcacag
     1921 gaagaacttc caacaacaaa taatagtgtt tctaaagaaa tatggttaga ttttgaagat
     1981 ttctgtgtat gctttcaaaa tatatatatt ttccacaagc caagttcata ttgccttaac
     2041 tttcaaaaat cagaatttaa gttctcagaa gaacgagtgt cctactatct atttgtagat
     2101 agtctaaaac ctattgaact actggtttgc ttttctgcat tggtacgctg gggggagtat
     2161 ggagccttaa caaaagacag tcctcccata gagcctggac ttctcacagc tgaaacgttt
     2221 tcttggaaat ccctgaaacc aggcagtctt gttctgaaga ttcacacata tgctaccaag
     2281 gctacagtgg ttcgtctgcc tgttgggaga cacatgctac tcttcaacgc atactcccca
     2341 gtaggacact ccatacacat ctgcagcatg gtgtcatttg tcattgggga tgaacacgtt
     2401 gtactgccca actttgaacc agagagctgc cgatttacgg aacagtctct gttgattatg
     2461 aaagctattg gaaatgtgat tgctaatttc aaagataagg gtaaactctc tgcagctttg
     2521 aaggatctgc aaacagctca ctaccctgtc cccttccatg ataaagaact aactgcacag
     2581 cacttcaggg tttttcatct ttccttatgg cgtttaatga aaaaagttca aataacaaaa
     2641 cctcctccaa acttcaaatt tgcattccgg gctatggttt tggacttgga gttactcaat
     2701 tcctccttgg aagaggtttc tttagtggaa tggctggacg ttaaatattg tatgcccaca
     2761 agtgataaag agtattctgc tgaggaagta gcagcagcaa ttaaaattca agccatgtgg
     2821 agaggaactt acgttagatt gcttatgaaa gccagaatac cagacacaaa agaaaatatc
     2881 agtgttgcag atactcttca aaaagtttgg gctgtattgg aaatgaattt agaacagtat
     2941 gcagtttctc tcttaagact aatgtttaaa agcaagtgca agtctttgga atcttatcca
     3001 tgctatcaag atgaagaaac taagattgct tttgcagatt atactgtgac ttatcaagaa
     3061 cagccaccaa attcttggtt tatagtattc agagaaacat ttttggttca tcaagacatg
     3121 attttggttc ccaaagtata tactacactt ccaatctgta tcctacacat tgttaataat
     3181 gacacaatgg agcaagtgcc aaaggtgttc caaaaagtgg tgccttatct ttataccaag
     3241 aataagaagg gatacacttt tgtggcggaa gcatttacag gcgacacata tgtagcagcc
     3301 tcacgatgga aactgcgtct catcggttct tctgctccac tgccatgcct ctctcgagac
     3361 tctccatgca attcctttgc cataaaggaa atccgagatt actacatacc caatgataag
     3421 aaaattttat tcaggtattc ggttaaagtt ctaacaccac aacctgctac aatacaggta
     3481 cgcacatcca aaccagatgc attcatcaag ctgcaggtcc tagaaaatga agaaactatg
     3541 gtgagctcca ctggaaaagg ccaagctata atcccagcat ttcacttctt gaagagtgag
     3601 aaaggtttga gctcccagtc tagcaagcac attctttcat ttcactctgc atccaagaaa
     3661 gagcaagaag tgtatgttaa gaagaaagct gctcagggaa ttcagaaatc ccccaagggt
     3721 agagctgtaa gtgcaataca agacattggt ctaccccttg tggaggagga aactaccagt
     3781 acacccacta gagaagacag ttccagcaca ccactgcaga attacaagta tattatacag
     3841 tgttcggtgt tgtataacag ttggcctctc actgaaagcc agctgacatt tgttcaagca
     3901 ctgaaagact taaagaaaag taataccaaa gcttatggtg aaagacacga ggagttaatt
     3961 aacttaggaa gcccagactc ccacactatt agtgagggac aaaaatcttc agtaacttcc
     4021 aaaacaacaa ggaaaggcaa agaaaagtct tctgagaaag aaaagacagc caaagaaaaa
     4081 caagcacctc gctttgagcc tcagatatcc actgttcacc ctcaacaaga agacccaaat
     4141 aaaccctact ggattttgag gttggtcact gaacacaatg aatcagaatt atttgaagtg
     4201 aaaaaggata cagaaagggc agatgaaatc cgagccatga aacaagcctg ggagacaact
     4261 gagccaggaa gagcaatcaa ggcttctcag gctcgtttgc attaccttag cgggttcatt
     4321 aagaaaacat ctgatgctga gagtccgcct atatctgaaa gccaaactaa accaaaagaa
     4381 gaagtagaaa cagctgcacg tggcgtaaaa gaaccaaact caaagaattc tgcaggttca
     4441 gagagcaaag agatgacaca aacaggatca gggagtgcgg tgtggaagaa gtggcaattg
     4501 accaaaggct tgagggatgt ggcaaaatcc acgagtagcg aaagtggagg agtgtcttca
     4561 ccagggaaag aagagcgcga gcagagcaca cggaaggaaa acattcaaac aggacctcgt
     4621 acacgatctc caacaatttt ggaaacatct ccacgactta ttcgaaaagc actagaattt
     4681 atggatttaa gtcaatatgt tcggaaaaca gatacagatc ctctgctgca aacagatgaa
     4741 ttgaatcagc agcaggcaat gcaaaaggcg gaagaaattc atcagtttcg acagcatagg
     4801 accagagtcc ttagcattcg aaacattgac caagaagagc ggttgaagtt aaaggatgaa
     4861 gtcctggata tgtataagga aatgcaggac tccttagatg aagcccgaca gaaaattttc
     4921 gacatccggg aagagtacag aaacaaattg ctggaagctg agcacctaaa gctggaaact
     4981 ctggctgctc aggaagcagc catgaagctg gagacagaaa agatgacccc agctcctgac
     5041 acacagaaaa aaaagaaagg aaagaaaaag taaccagggg atgtccaata ctaccctgct
     5101 tctggagaga aaaaatctat ttgtaatgat ctttaactgc ctgctgttaa gatattaggc
     5161 caaatgaaaa tagaaatttc tctttcttag aaatatttta atgctaactt gttagttttc
     5221 ctcagaaagc tagtatttga agccatttga gtttaagatg ctctaatttc aataaaatag
     5281 cttccaaata tttaataaaa tatgtttgac actctaaa
//
