LOCUS       NM_016824               4413 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens adducin 3 (ADD3), transcript variant 1, mRNA.
ACCESSION   NM_016824
VERSION     NM_016824.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4413)
  AUTHORS   Cui,M.M., Gong,Y.M., Pan,W.H., Pei,H.Y., Bai,M.R., Song,H.L.,
            Han,X.R., Wu,W.J., Yu,W.W., Gu,B.L., Cai,W., Zhou,Y. and Chu,X.
  TITLE     Contribution of ADD3 and the HLA Genes to Biliary Atresia Risk in
            Chinese
  JOURNAL   Int J Mol Sci 24 (19), 14719 (2023)
   PUBMED   37834180
  REMARK    GeneRIF: Contribution of ADD3 and the HLA Genes to Biliary Atresia
            Risk in Chinese.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4413)
  AUTHORS   Xiong,H., Ren,S., Chen,J., Yang,X., Liu,Y., Xu,Z., Guo,J.,
            Jiang,T., Yuan,M., Liu,Y., Zhang,G., Li,W., Machens,H.G. and
            Chen,Z.
  TITLE     Knockdown of long noncoding RNA SAN rejuvenates aged
            adipose-derived stem cells via miR-143-3p/ADD3 axis
  JOURNAL   Stem Cell Res Ther 14 (1), 213 (2023)
   PUBMED   37605290
  REMARK    GeneRIF: Knockdown of long noncoding RNA SAN rejuvenates aged
            adipose-derived stem cells via miR-143-3p/ADD3 axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4413)
  AUTHORS   Li,T.F., Ke,X.Y., Zhang,Y.R. and Zhan,J.H.
  TITLE     The correlation between rs2501577 gene polymorphism and biliary
            atresia: a systematic review and meta-analysis
  JOURNAL   Pediatr Surg Int 39 (1), 206 (2023)
   PUBMED   37248361
  REMARK    GeneRIF: The correlation between rs2501577 gene polymorphism and
            biliary atresia: a systematic review and meta-analysis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4413)
  AUTHORS   Suo,Z., Ma,X., Ding,Y., Zhou,Y., Duan,X., Fei,L., Song,J. and
            Ding,H.
  TITLE     Posttranscriptional inhibition of gamma-adducin promotes the
            proliferation and migration of osteosarcoma cells
  JOURNAL   Tumori 108 (6), 600-608 (2022)
   PUBMED   34632867
  REMARK    GeneRIF: Posttranscriptional inhibition of gamma-adducin promotes
            the proliferation and migration of osteosarcoma cells.
REFERENCE   5  (bases 1 to 4413)
  AUTHORS   Wang,J.Z., Fu,X., Fang,Z., Liu,H., Zong,F.Y., Zhu,H., Yu,Y.F.,
            Zhang,X.Y., Wang,S.F., Huang,Y. and Hui,J.
  TITLE     QKI-5 regulates the alternative splicing of cytoskeletal gene ADD3
            in lung cancer
  JOURNAL   J Mol Cell Biol 13 (5), 347-360 (2021)
   PUBMED   33196842
  REMARK    GeneRIF: QKI-5 regulates the alternative splicing of cytoskeletal
            gene ADD3 in lung cancer.
REFERENCE   6  (bases 1 to 4413)
  AUTHORS   Gilligan,D.M., Sarid,R. and Weese,J.
  TITLE     Adducin in platelets: activation-induced phosphorylation by PKC and
            proteolysis by calpain
  JOURNAL   Blood 99 (7), 2418-2426 (2002)
   PUBMED   11895774
REFERENCE   7  (bases 1 to 4413)
  AUTHORS   Citterio,L., Azzani,T., Duga,S. and Bianchi,G.
  TITLE     Genomic organization of the human gamma adducin gene
  JOURNAL   Biochem Biophys Res Commun 266 (1), 110-114 (1999)
   PUBMED   10581174
REFERENCE   8  (bases 1 to 4413)
  AUTHORS   Gilligan,D.M., Lozovatsky,L., Gwynn,B., Brugnara,C., Mohandas,N.
            and Peters,L.L.
  TITLE     Targeted disruption of the beta adducin gene (Add2) causes red
            blood cell spherocytosis in mice
  JOURNAL   Proc Natl Acad Sci U S A 96 (19), 10717-10722 (1999)
   PUBMED   10485892
REFERENCE   9  (bases 1 to 4413)
  AUTHORS   Katagiri,T., Ozaki,K., Fujiwara,T., Shimizu,F., Kawai,A., Okuno,S.,
            Suzuki,M., Nakamura,Y., Takahashi,E. and Hirai,Y.
  TITLE     Cloning, expression and chromosome mapping of adducin-like 70
            (ADDL), a human cDNA highly homologous to human erythrocyte adducin
  JOURNAL   Cytogenet Cell Genet 74 (1-2), 90-95 (1996)
   PUBMED   8893809
REFERENCE   10 (bases 1 to 4413)
  AUTHORS   Kaiser,H.W., O'Keefe,E. and Bennett,V.
  TITLE     Adducin: Ca++-dependent association with sites of cell-cell contact
  JOURNAL   J Cell Biol 109 (2), 557-569 (1989)
   PUBMED   2503523
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC062559.1, BC057285.1 and
            BC021694.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_016824.4.
            
            Summary: Adducins are heteromeric proteins composed of different
            subunits referred to as adducin alpha, beta and gamma. The three
            subunits are encoded by distinct genes and belong to a family of
            membrane skeletal proteins involved in the assembly of
            spectrin-actin network in erythrocytes and at sites of cell-cell
            contact in epithelial tissues. While adducins alpha and gamma are
            ubiquitously expressed, the expression of adducin beta is
            restricted to brain and hematopoietic tissues. Adducin, originally
            purified from human erythrocytes, was found to be a heterodimer of
            adducins alpha and beta. Polymorphisms resulting in amino acid
            substitutions in these two subunits have been associated with the
            regulation of blood pressure in an animal model of hypertension.
            Heterodimers consisting of alpha and gamma subunits have also been
            described. Structurally, each subunit is comprised of two distinct
            domains. The amino-terminal region is protease resistant and
            globular in shape, while the carboxy-terminal region is protease
            sensitive. The latter contains multiple phosphorylation sites for
            protein kinase C, the binding site for calmodulin, and is required
            for association with spectrin and actin. Alternatively spliced
            adducin gamma transcripts encoding different isoforms have been
            described. The functions of the different isoforms are not known.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1 and 4-6 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043143.1, SRR1660809.40114.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356080.9/ ENSP00000348381.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-336               BC062559.1         22-357
            337-338             BC057285.1         95-96
            339-3195            BC062559.1         360-3216
            3196-4413           BC021694.1         409-1626
FEATURES             Location/Qualifiers
     source          1..4413
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.1-q25.2"
     gene            1..4413
                     /gene="ADD3"
                     /gene_synonym="ADDL; CPSQ3"
                     /note="adducin 3"
                     /db_xref="GeneID:120"
                     /db_xref="HGNC:HGNC:245"
                     /db_xref="MIM:601568"
     exon            1..316
                     /gene="ADD3"
                     /gene_synonym="ADDL; CPSQ3"
                     /inference="alignment:Splign:2.1.0"
     exon            317..540
                     /gene="ADD3"
                     /gene_synonym="ADDL; CPSQ3"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..2466
                     /gene="ADD3"
                     /gene_synonym="ADDL; CPSQ3"
                     /note="isoform a is encoded by transcript variant 1;
                     adducin-like protein 70; gamma-adducin; adducin 3 (gamma)"
                     /codon_start=1
                     /product="gamma-adducin isoform a"
                     /protein_id="NP_058432.1"
                     /db_xref="CCDS:CCDS7561.1"
                     /db_xref="GeneID:120"
                     /db_xref="HGNC:HGNC:245"
                     /db_xref="MIM:601568"
                     /translation="MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPD
                     LRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLALQQIADYIMANS
                     FSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTY
                     ISVRISKEQDHIIIIPRGLSFSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAA
                     IYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLEEQEERI
                     QLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLH
                     VLDFQKYKAFTYTVAASGGGGVNMGSHQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHP
                     LIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVN
                     VPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKI
                     REQNRYDLKTAGPQSQLLAGIVVDKPPSTMQFEDDDHGPPAPPNPFSHLTEGELEEYK
                     RTIERKQQGLEDAEQELLSDDASSVSQIQSQTQSPQNVPEKLEENHELFSKSFISMEV
                     PVMVVNGKDDMHDVEDELAKRVSRLSTSTTIENIEITIKSPEKIEEVLSPEGSPSKSP
                     SKKKKKFRTPSFLKKNKKKEKVEA"
     exon            541..679
                     /gene="ADD3"
                     /gene_synonym="ADDL; CPSQ3"
                     /inference="alignment:Splign:2.1.0"
     exon            680..831
                     /gene="ADD3"
                     /gene_synonym="ADDL; CPSQ3"
                     /inference="alignment:Splign:2.1.0"
     exon            832..912
                     /gene="ADD3"
                     /gene_synonym="ADDL; CPSQ3"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1062
                     /gene="ADD3"
                     /gene_synonym="ADDL; CPSQ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1206
                     /gene="ADD3"
                     /gene_synonym="ADDL; CPSQ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1305
                     /gene="ADD3"
                     /gene_synonym="ADDL; CPSQ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1488
                     /gene="ADD3"
                     /gene_synonym="ADDL; CPSQ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1746
                     /gene="ADD3"
                     /gene_synonym="ADDL; CPSQ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1866
                     /gene="ADD3"
                     /gene_synonym="ADDL; CPSQ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1953
                     /gene="ADD3"
                     /gene_synonym="ADDL; CPSQ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2077
                     /gene="ADD3"
                     /gene_synonym="ADDL; CPSQ3"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2173
                     /gene="ADD3"
                     /gene_synonym="ADDL; CPSQ3"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..4413
                     /gene="ADD3"
                     /gene_synonym="ADDL; CPSQ3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4392..4397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADD3"
                     /gene_synonym="ADDL; CPSQ3"
                     /note="hexamer: AATAAA"
     polyA_site      4413
                     /gene="ADD3"
                     /gene_synonym="ADDL; CPSQ3"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcgag ccgccagccc gtaacggtcg ccagtgtgag gggcgggagg gaaagaagag
       61 gggtttaaat tagatttttt aaaacacaga gcaagcgcca gaggcgtcgg catcccaggt
      121 gtcgccgctt cctgctgcac agggctcggc gtacaggtcc ctccctcctc aagccccctc
      181 cccttctccc gccctaccct ctggggctct gcggcgctta agaggcggcc gcagcggcgg
      241 atccggcggc tgctgcagcc cgggcggctg ccgagaagga gggaggggaa acacaaagcc
      301 ggctacgcgc tgcgagataa caagagtaat ccacagactt aaaacatgag ctcagatgcc
      361 agccaaggcg tgattaccac tcctcctcct cccagcatgc ctcacaaaga gagatatttt
      421 gaccgcatca atgaaaatga cccagaatac attagggaga ggaacatgtc tcctgatcta
      481 cgacaagact tcaacatgat ggagcagagg aaacgagtta ctcagatcct gcaaagtcct
      541 gcctttcggg aagacttgga atgccttatt caagaacaga tgaagaaagg ccacaaccca
      601 actggattac tagcattaca gcagattgca gattacatca tggccaattc tttctcgggt
      661 ttttcttcac ctcctctcag tcttggcatg gtcacaccta tcaatgacct tcctggtgca
      721 gatacatcct catatgtgaa gggagaaaaa cttactcgct gtaaacttgc cagcctgtac
      781 agacttgtag acttgtttgg atgggcacac ctggcaaata cctatatctc agtaagaata
      841 agtaaggagc aagaccacat tataataatt cccagaggcc tatctttttc tgaagctaca
      901 gcctccaatt tggtgaaagt caatataata ggagaagtgg ttgaccaggg aagtaccaat
      961 ttgaaaattg accatacagg attcagtccc catgctgcaa tctattcaac acgtcctgat
     1021 gttaagtgtg tgatacacat ccataccctt gcaacagcag ctgtatcctc catgaaatgt
     1081 gggatccttc caatttctca agagtctctt cttctgggag atgttgccta ttatgactac
     1141 caagggtcac ttgaagaaca ggaggagaga attcaactgc agaaggttct gggaccaagt
     1201 tgtaaggtgc tggtactcag gaatcatggt gtggttgcac ttggagaaac attagaggag
     1261 gcttttcatt atatttttaa tgtgcaacta gcctgtgaga ttcaggtgca ggccctagca
     1321 ggtgcaggtg gagtagacaa tctccatgta ctggactttc agaagtataa agctttcact
     1381 tacactgtag cagcgtctgg tggaggaggt gtgaatatgg gttcccatca aaaatggaag
     1441 gttggcgaaa ttgagtttga agggcttatg aggactctgg acaacttggg gtatagaaca
     1501 ggctatgctt acaggcatcc tctcattcga gagaagccta ggcacaagag tgatgtggaa
     1561 atcccagcaa ctgtgactgc tttttccttt gaagacgata cagtgccact ctctcctctc
     1621 aaatacatgg cacagaggca acagcgtgaa aaaacaagat ggctgaactc accaaatact
     1681 tacatgaaag tgaatgtgcc tgaggagtct cggaacggag aaaccagtcc ccgaaccaaa
     1741 atcacgtgga tgaaagcaga agactcatct aaagttagtg gtggaacacc tatcaaaatt
     1801 gaagatccaa atcagtttgt tcctttaaac acaaacccga atgaggtact agaaaagaga
     1861 aataagattc gggaacaaaa tcgatatgac ttgaaaacag caggaccaca atctcagttg
     1921 cttgctggaa ttgttgtgga taagccacct tctactatgc aatttgaaga tgatgatcat
     1981 ggcccaccag ctcctcctaa cccatttagt catctcacag aaggagaact tgaagagtat
     2041 aagaggacaa tcgaacgtaa acaacaaggc ctagaagatg ctgagcagga attactctca
     2101 gatgacgctt catctgtttc acaaattcag tctcaaactc agtcaccgca aaatgtccct
     2161 gaaaaattag aagaaaacca tgagctgttt tccaagagct tcatctccat ggaagtgcct
     2221 gtcatggtag taaatggcaa ggatgatatg catgatgttg aagatgagct tgctaagcga
     2281 gtgagtaggt taagcacaag tacaaccata gaaaacatcg agattactat taagtctcca
     2341 gagaaaatcg aagaagtcct gtcacctgaa ggctcccctt caaaatcgcc atccaagaaa
     2401 aagaagaaat tccgcactcc ttcttttctg aaaaagaaca aaaaaaagga gaaagttgag
     2461 gcctaaataa agtcttttta taattattat tataacaatg tgacattgca catctaaata
     2521 ccacatttaa gttgatcatt aatatgcaat ggtagatcag attgggggat gtagcaaact
     2581 ggactttaag aactggaaag aggttttaca aaagaaaaac tttcagattc atctctcatt
     2641 ttatatgtcc agaaatggct ttgaatttta agcaattact agttttaatt agctctgccc
     2701 tcatgaagta ttattataat tcaccataaa cagctatctg tctgaattac ttcaggcctt
     2761 ctccataata tctgttagaa agaaattgcc agtgagcaag tgagaatttt tatttctcaa
     2821 tacctgcttc acttgataat catattataa ttttttatca tgattattga ctatattttt
     2881 ggagtcccat tgtttcagtg ggcattaaca gaatgcttta aaaacttcta agacaagaat
     2941 ctatagcatt agtatacact ggcacataat tttttaaaaa gttttaagaa aagattcatt
     3001 tggaatttta ttcacagtat aaaatttcct cacctgaagt aactttgttt gccaaaaaag
     3061 ttgttttaat aaactataat ttttgaaaac ttcctttttt attagtttag aaagcccctt
     3121 atttttcaac aaaggggatt ttgtacacat aacatgggtt atttagttta actctggcaa
     3181 aaaaaaaaaa aaaaattttg tatgttgatg tttgtatacc gttcagtata aaagtgtcct
     3241 aagcatatta gccaatcttt tcacagtaga gcatacttaa ggctgcttgg tactgagtat
     3301 acttaaatat aactccagaa tccagggact tggtgttaaa acaggattag agcatgtaaa
     3361 ggtacatcta gattcatatt tgaatcttaa actgtatttt tctcttagta ttgctaatga
     3421 gtaaagaaaa gtctcataag gtagccaaat gaaaaagaat gaaagggaaa gtgaaaaatt
     3481 aaggggacaa aagatgggat gtgaaaagaa gaattctagt ttgatggtga ctcatattca
     3541 cgataggata caaagtgtga tttgttggaa acatgtccca aatttctaaa attctgcttc
     3601 tctgccaaaa gcaatgtctt tcttggttga tatttgagtt ttaaaagggt caaatctttc
     3661 taattttttg tatctttaga gggcagcact agaagaaatc agcaggtcta atcccaccag
     3721 taagaaaact accacttctt gatttttaca gatttaaaaa aatcttttca gtgacctttc
     3781 tttttaatgt aaatacaaat ttaaacctag gcttaatata ggcgtttccc ctttcaccca
     3841 agtgatgtca cagttcgatg caaaatcaat gatccagaat gatcgtgggt aaaaataact
     3901 caaagtgttt cttaagggtg agttggcatg caaaaaatta cattgattac agtgtgtttt
     3961 ggagctggct ctgtttgtgt gcatatgata atgcagagtt gagccagagc ctggaaatgt
     4021 cattctagat ctcactaact actggaatca gtgttttaat ctcttggtgg aaactttcag
     4081 ttgcttaact ctctattgga agattttttt aatgttctac atcatttatg ttgtattaca
     4141 atgtatgtag aaatagtaac ctgtgaacta tgcttttcca taacttttta aaaatatata
     4201 tatctaaatg aatgcaatgt gcataaatat tttttaaaca taacagtgaa ctattgcacc
     4261 ttttgctaat gcctctattt acttgctttg gcataaagaa tgagccaatg aacctctgtg
     4321 tcctgtggaa aaatgtataa atgttatctg atattgctct tagatgtaat gctaattaat
     4381 gttaaatcac aaataaacag tattttaaat ata
//
