LOCUS       NM_001617               9290 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens adducin 2 (ADD2), transcript variant 1, mRNA.
ACCESSION   NM_001617
VERSION     NM_001617.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9290)
  AUTHORS   Yang,C., Sui,Z., Xu,T., Liu,W., Wang,X. and Zeng,X.
  TITLE     Lipid raft-associated beta-adducin participates in neutrophil
            migration
  JOURNAL   Mol Med Rep 18 (2), 1353-1360 (2018)
   PUBMED   29901076
  REMARK    GeneRIF: betaadducin was demonstrated to have a critical role in
            neutrophil migration.
REFERENCE   2  (bases 1 to 9290)
  AUTHORS   Bosia,M., Pigoni,A., Zagato,L., Merlino,L., Casamassima,N.,
            Lorenzi,C., Pirovano,A., Smeraldi,E., Manunta,P. and Cavallaro,R.
  TITLE     ADDing a piece to the puzzle of cognition in schizophrenia
  JOURNAL   Eur J Med Genet 59 (1), 26-31 (2016)
   PUBMED   26723519
  REMARK    GeneRIF: Study evaluated effects of ADD genetic variability on
            cognitive functions in a sample of patients with schizophrenia,
            known to show a wide and heterogeneous neuropsychological deficit
            and found that ADD2 C1797T polymorphism showed diffuse effects on
            almost every cognitive domain.
REFERENCE   3  (bases 1 to 9290)
  AUTHORS   Wei,J., Li,G., Dang,S., Zhou,Y., Zeng,K. and Liu,M.
  TITLE     Discovery and Validation of Hypermethylated Markers for Colorectal
            Cancer
  JOURNAL   Dis Markers 2016, 2192853 (2016)
   PUBMED   27493446
  REMARK    GeneRIF: Aberrant DNA methylation of ADD2 could be potential
            screening markers of colorectal cancer.
REFERENCE   4  (bases 1 to 9290)
  AUTHORS   Ramirez,G.A., Lanzani,C., Bozzolo,E.P., Zagato,L., Citterio,L.,
            Casamassima,N., Canti,V., Sabbadini,M.G., Rovere-Querini,P.,
            Manunta,P. and Manfredi,A.A.
  TITLE     Beta-adducin and sodium-calcium exchanger 1 gene variants are
            associated with systemic lupus erythematosus and lupus nephritis
  JOURNAL   Rheumatol Int 35 (12), 1975-1983 (2015)
   PUBMED   26045217
  REMARK    GeneRIF: ADD2 and NCX1 variants influence the risk and the clinical
            features of systemic lupus erythematosus and lupus nephritis.
REFERENCE   5  (bases 1 to 9290)
  AUTHORS   Citterio,L., Tizzoni,L., Catalano,M., Zerbini,G., Bianchi,G. and
            Barlassina,C.
  TITLE     Expression analysis of the human adducin gene family and evidence
            of ADD2 beta4 multiple splicing variants
  JOURNAL   Biochem Biophys Res Commun 309 (2), 359-367 (2003)
   PUBMED   12951058
REFERENCE   6  (bases 1 to 9290)
  AUTHORS   Hughes,C.A. and Bennett,V.
  TITLE     Adducin: a physical model with implications for function in
            assembly of spectrin-actin complexes
  JOURNAL   J Biol Chem 270 (32), 18990-18996 (1995)
   PUBMED   7642559
REFERENCE   7  (bases 1 to 9290)
  AUTHORS   Gilligan,D.M., Lieman,J. and Bennett,V.
  TITLE     Assignment of the human beta-adducin gene (ADD2) to 2p13-p14 by in
            situ hybridization
  JOURNAL   Genomics 28 (3), 610-612 (1995)
   PUBMED   7490111
REFERENCE   8  (bases 1 to 9290)
  AUTHORS   Miyazaki,M., Kaibuchi,K., Shirataki,H., Kohno,H., Ueyama,T.,
            Nishikawa,J. and Takai,Y.
  TITLE     Rabphilin-3A binds to a M(r) 115,000 polypeptide in a
            phosphatidylserine- and Ca(2+)-dependent manner
  JOURNAL   Brain Res Mol Brain Res 28 (1), 29-36 (1995)
   PUBMED   7707875
REFERENCE   9  (bases 1 to 9290)
  AUTHORS   Joshi,R., Gilligan,D.M., Otto,E., McLaughlin,T. and Bennett,V.
  TITLE     Primary structure and domain organization of human alpha and beta
            adducin
  JOURNAL   J Cell Biol 115 (3), 665-675 (1991)
   PUBMED   1840603
REFERENCE   10 (bases 1 to 9290)
  AUTHORS   Mische,S.M., Mooseker,M.S. and Morrow,J.S.
  TITLE     Erythrocyte adducin: a calmodulin-regulated actin-bundling protein
            that stimulates spectrin-actin binding
  JOURNAL   J Cell Biol 105 (6 Pt 1), 2837-2845 (1987)
   PUBMED   3693401
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA501584.1, BC010237.1,
            BC065525.1, N53078.1 and AC005234.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001617.3.
            
            Summary: Adducins are heteromeric proteins composed of different
            subunits referred to as adducin alpha, beta and gamma. The three
            subunits are encoded by distinct genes and belong to a family of
            membrane skeletal proteins involved in the assembly of
            spectrin-actin network in erythrocytes and at sites of cell-cell
            contact in epithelial tissues. While adducins alpha and gamma are
            ubiquitously expressed, the expression of adducin beta is
            restricted to brain and hematopoietic tissues. Adducin, originally
            purified from human erythrocytes, was found to be a heterodimer of
            adducins alpha and beta. Polymorphisms resulting in amino acid
            substitutions in these two subunits have been associated with the
            regulation of blood pressure in an animal model of hypertension.
            Heterodimers consisting of alpha and gamma subunits have also been
            described. Structurally, each subunit is comprised of two distinct
            domains. The amino-terminal region is protease resistant and
            globular in shape, while the carboxy-terminal region is protease
            sensitive. The latter contains multiple phosphorylation sites for
            protein kinase C, the binding site for calmodulin, and is required
            for association with spectrin and actin. Alternatively spliced
            transcript variants have been described. [provided by RefSeq, Jun
            2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Both variants 1 and 5 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.108685.1,
                                           SRR1803613.254150.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264436.9/ ENSP00000264436.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                DA501584.1         44-66
            24-2582             BC010237.1         1-2559
            2583-3944           BC065525.1         2380-3741
            3945-3990           N53078.1           1-46                c
            3991-9290           AC005234.1         153769-159068       c
FEATURES             Location/Qualifiers
     source          1..9290
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.3"
     gene            1..9290
                     /gene="ADD2"
                     /gene_synonym="ADDB"
                     /note="adducin 2"
                     /db_xref="GeneID:119"
                     /db_xref="HGNC:HGNC:244"
                     /db_xref="MIM:102681"
     exon            1..315
                     /gene="ADD2"
                     /gene_synonym="ADDB"
                     /inference="alignment:Splign:2.1.0"
     exon            316..434
                     /gene="ADD2"
                     /gene_synonym="ADDB"
                     /inference="alignment:Splign:2.1.0"
     exon            435..651
                     /gene="ADD2"
                     /gene_synonym="ADDB"
                     /inference="alignment:Splign:2.1.0"
     exon            652..790
                     /gene="ADD2"
                     /gene_synonym="ADDB"
                     /inference="alignment:Splign:2.1.0"
     exon            791..942
                     /gene="ADD2"
                     /gene_synonym="ADDB"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1023
                     /gene="ADD2"
                     /gene_synonym="ADDB"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1173
                     /gene="ADD2"
                     /gene_synonym="ADDB"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1317
                     /gene="ADD2"
                     /gene_synonym="ADDB"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1416
                     /gene="ADD2"
                     /gene_synonym="ADDB"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1593
                     /gene="ADD2"
                     /gene_synonym="ADDB"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1851
                     /gene="ADD2"
                     /gene_synonym="ADDB"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1971
                     /gene="ADD2"
                     /gene_synonym="ADDB"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2061
                     /gene="ADD2"
                     /gene_synonym="ADDB"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2209
                     /gene="ADD2"
                     /gene_synonym="ADDB"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2338
                     /gene="ADD2"
                     /gene_synonym="ADDB"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..9290
                     /gene="ADD2"
                     /gene_synonym="ADDB"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3944
                     /gene="ADD2"
                     /gene_synonym="ADDB"
                     /note="major polyA site"
     regulatory      4823..4828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADD2"
                     /gene_synonym="ADDB"
                     /note="hexamer: AATAAG"
     polyA_site      4872
                     /gene="ADD2"
                     /gene_synonym="ADDB"
     regulatory      9264..9269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADD2"
                     /gene_synonym="ADDB"
                     /note="hexamer: AGTAAA"
     polyA_site      9290
                     /gene="ADD2"
                     /gene_synonym="ADDB"
                     /note="major polyA site"
ORIGIN      
        1 ctcatttcct cccagcctcg tgcgggaaat ggctttaatt ctgacggcag ggctgtgagg
       61 gactagcggg aacccgagcc ttttgtcaag gaactgcggc gtcggtggcc agtcatcccc
      121 gccgccgcgg agccgctgca ctgctggggg atctcccagc agctctgacg agcgcgggct
      181 gcagcatggg cagaaaacgc tgccctgcag attagctggg tggatttttt aagcgcaccc
      241 caccccccaa acccataaaa taacaaaacc aacccgcagt ggccgaccgg agatagctaa
      301 gatgccgcgc aggagtttcc acctggatgt ttgaggttgt gtagatgtgg ccggcaccct
      361 tgagagtgga gctagggggt gcagactgag cagtgaacag aaggagcctt ggacagggct
      421 gggccagcct cccgagttcc aggagcgaat tgcaaaccca ccgggaaaat gagcgaagag
      481 acggtccccg aggctgcctc gccgccgccc ccgcaggggc agccttactt tgaccgcttc
      541 tcagaggacg accccgagta catgcgcctt cgcaaccggg cggcggacct gcggcaggac
      601 ttcaacctga tggagcagaa gaagcgcgtc accatgatcc tgcagagtcc ctctttcagg
      661 gaggagctgg aaggcctcat ccaggagcag atgaagaagg ggaacaactc ctccaacatc
      721 tgggccctgc gacagatcgc ggacttcatg gccagcacct cccacgcagt cttcccgaca
      781 tcttccatga atgtctccat gatgacgcct atcaatgacc tccacacagc tgactccctg
      841 aacctggcca aaggggagcg gctcatgcgg tgcaagatca gcagtgtcta ccgactcctg
      901 gacctctatg gctgggccca gctgagtgac acctatgtca cgttgagagt cagcaaggag
      961 caggaccact tcctgatcag ccctaaggga gtttcttgca gtgaagtcac agcgtccagc
     1021 ctgatcaagg tgaacattct gggagaggtg gtggagaagg gcagcagctg cttcccagtg
     1081 gacaccacag gcttctgtct gcactcggcc atctatgcag cgaggcccga cgtgcgctgc
     1141 atcatccacc tgcacacacc ggccacagca gcggtgtcgg ccatgaagtg gggcctcctg
     1201 cctgtctccc acaatgccct gctggtgggg gacatggcct attatgactt caatggggaa
     1261 atggagcagg aagccgatcg gatcaacctg cagaagtgcc ttggacccac ctgcaagatc
     1321 ctggtgctaa gaaaccatgg agtggttgct ctgggtgaca cggtagagga ggcattttac
     1381 aagatcttcc acctgcaggc tgcatgtgag atacaggtgt cggctctgtc cagtgccggg
     1441 ggagtggaga acctcatcct cctggagcag gagaagcacc ggccccatga ggtgggctcc
     1501 gtgcagtggg ccgggagcac ctttgggcct atgcagaaga gtcggctggg ggagcatgag
     1561 tttgaggccc tcatgaggat gctggacaac ctgggctaca gaacaggtta cacgtatcgc
     1621 cacccctttg ttcaagagaa aaccaaacac aaaagtgagg tggagattcc agccacggtc
     1681 acagccttcg tgtttgagga ggacggtgcc ccggtgcccg ccctgcgaca gcatgcccag
     1741 aagcagcaga aggagaagac ccgctggctc aatacgccca acacctacct gcgggtcaat
     1801 gtggccgatg aggtccagag gagcatgggc agcccccgac ccaagaccac gtggatgaag
     1861 gctgacgagg tggagaaatc cagcagtggc atgccgattc gcatcgaaaa cccaaaccaa
     1921 tttgtgcctc tctatactga cccccaggaa gtactggaga tgaggaacaa gattcgagaa
     1981 caaaaccgac aagatgtgaa gtcagcgggg cctcagtccc agctcctggc gagcgtcatt
     2041 gccgagaaga gccgaagccc gtctacagag agccagctga tgtccaaggg agacgaggat
     2101 accaaagacg attcagagga gacggtgccc aaccccttca gccaactcac tgaccaggag
     2161 ttggaggagt acaagaaaga ggtggagagg aagaaactag aacttgatgg agagaaagaa
     2221 actgccccag aagagcctgg ctcacctgca aagtctgcac ctgcttctcc agtgcagagc
     2281 ccagcgaagg aggcagagac aaagagccct ttagtctctc cttccaagtc tttagaggaa
     2341 ggtactaaga agacagaaac aagcaaagcc gccaccacag agcccgaaac aacccagccg
     2401 gaaggggtgg tggtcaacgg gagggaggag gagcagacgg cagaggaaat cctcagcaaa
     2461 ggcctgagcc agatgaccac cagtgctgac acggatgttg atacctctaa ggacaaaacc
     2521 gagtcggtca ccagcggccc catgtcccca gagggctcac cttccaagtc tccctcaaag
     2581 aagaaaaaga aattccgaac cccctccttc ctgaaaaaga gcaaaaagaa ggagaaagtg
     2641 gagtcctgat tcatgacacc cttgggctcc ctcctgcctc ctctctctcc tccccttccc
     2701 ttctcccatc tctgtccctg caagcacagg gctaaggagg gatagagtag gaccctggac
     2761 cacattcgga aggggaactt agagatcacc cgaccaaccc ttcgttttac agttgcccaa
     2821 gagaaatcag gtgacttgcc caaggtcaca cagctagtta gcggcagagc ctgcactcga
     2881 attcaggtct cctgacttcc agtccagtgc tccttctact acacaacact gcctagttgt
     2941 gggctgcctt tgtttggatg ctgtccacca atctgagcct agggcaagaa ggccagaaat
     3001 gggccgtgag ctctcacagg ctcagactaa atcagaggtc aaggcttccc ctgagtaagg
     3061 tccatttctt cccaggaatc caatctcctg tggatggagc tatctctaca tttaaaaatc
     3121 tcttctcttt tccactttgg gtccctgccc tgctgctcaa agtgactagc caaattgacc
     3181 cctccaacag aaagtaatct ttgttcccaa gggctgatgg cttagcttgt actaccccaa
     3241 acattaaccc tgagctttct tcatggaacc tcttgaatga tggatggaag agctataaga
     3301 ggtggtaggc ataggggcaa gccatgtaag ctgaggattg gggatggttt catcaacata
     3361 agaggccagg aacttgaccc ctttgaattg tgcatctcag gcacttcaaa actaaaacca
     3421 aatttagcat aggaaaaagt tgtttaatgc tcagggcaga aatttgggga agttgaaatc
     3481 ctctgttggc tttgggttgt ataaggagga tcaaaacaac agaggaaatg ctgactttct
     3541 agctttgcat gacacctgga gcaatgcact gtacctgcct cactcctgtc cagtggtcag
     3601 gtttcccctg accttccctc acccccagaa acacttgctt acagaccgaa actggcatct
     3661 tactcttggc accttgactt gcaccctctg aggttccaac tcagtcattc tttgtccagc
     3721 agaggagaat cagaaatgag cccttcagga ttaatcctct tgcaccagct ctcagagaaa
     3781 tgctgggtat ccctgtcctt gtccctatct gtccatcctg gggcctggta atggccacag
     3841 ttattgtttt aaatgccaac actgtcttct catgttcttc cgtggggcat tgattaatga
     3901 gcatttgttg gctcctaaaa attagacaat ccattctctt gaaagcaccg tgtcttgaaa
     3961 gaatattttt ccttttgatc tgactatcgt gaaaatattt ttgaaagttc ttaatcatag
     4021 ttttccactt ttgagcactt gctatctata gacactgtgc aggcttcaca tacattacat
     4081 tctttaaccc tcacagtaat cctttgaggg gggtaagatc attcccattt tgtgggtgag
     4141 gaaattgacc ccctaaaatg ataattgact tgtcccagct gacttggcta gaaagatctg
     4201 gatcctggat ttgaatccag gtcagtctga gtccagagcc cttgctctta acagctatgg
     4261 tgaacagaca actttaatcc ccaggggtgg tggttttcat ccaggatttg tctctatgac
     4321 tgttctccat tgcataatgt tagcacgtga agcaaaggta gggaacaccc tgtgctcatc
     4381 ctcatcactg cacgtgaagt tcctggtcaa tgtggactgt ggtgatgcta ctgtgtgcct
     4441 ctgacaaagg agaggcaaga gccttctggt tggggcggga aataccatcc atagttggct
     4501 atttcttgag aaggaaggaa actgacctag gaccaaggta aacctgacac tgtgtctctc
     4561 tagtgcagat tcctaactgc taccccaggc tccatctctg ttctacttcc tgattgggtc
     4621 aaattttagg agggacaacc cactcatgcc tcagaaaaat ctgtcatatg ggaaatgcct
     4681 ttaaaagcca atcccttgat gccttctttt aaaaagtaga tttcacactt attcatttat
     4741 ccttacatgg tatttgttaa ggatccactg agcaccaggc attatgctga cgttgaaaga
     4801 gagccatcat tatgactaga ataataagtg gcaaacgatg ttgtgagaat ggtgaacacg
     4861 acctctgatg cagccttttg tgtgcgagtt gttctacttc gggggtgatg ttgattgcct
     4921 ctgcattcaa cacactctat tcccttgaca atgaggcctc acttaggcct cattgggtgg
     4981 agtcttgctg cagcattatt ctgggaattt atgccatggg cccactttct attgatagat
     5041 gaacctgtca gttggttcat tcctcatgca ttccaaaaac atgcattgag cttgggtcaa
     5101 gggccaggca tgaggatagg catagttcct gccctcaaga agttcatgag cataggaggt
     5161 gtatagacaa attgcaaaac aggcaagggt accaaggtgg cataagaaag catcaattaa
     5221 ctatcttggg gaccagagaa accctgagag aagcaatggc tgctaaggtt ttaaaacaaa
     5281 gagtaaattt ccagtagaat gaaaggattg gcagggcatg ccacaatgag ggaagaatgt
     5341 gcaaaggtgt ggacgcatga aatgccatga tgggttccgc tgagcaacgt ggcattgcca
     5401 gagcatgatg tggaagctca ggggttgagg ggtcccttca taggtaggca gggctgaatc
     5461 ctaaggaaac tggtaggaag tgtggaggag ctagacttgt catggaaggg gtttggagcc
     5521 actggagcct ttaaatcagg atagagtcat gatcagaatt gcattttagg aaaatccctt
     5581 tggtggctga atggagactg tggactggat gggcgtggga tggtggcatg ggagctatga
     5641 ggcctttttg aaatgtcaat actaaaacat agttgatggc ctgctttaca cgatgtttcc
     5701 tctacagcag atagtgagtt tccaacacaa aatttatttc cataaaagtc tttggataaa
     5761 gcaccttaag agggattttc aacaaggaga ggggagcatt caaagagcta atgtttccag
     5821 ttttattttg tcttggtgta gaattgctgg gagaggtgtc cagccatcct gccatttctt
     5881 cttcccttgc acagaatgtg gcacatttag ctccaggctt gaggacatgc accaaatgct
     5941 acagaaacag acatgtggtc caaacaaatc tacaggctat tagaaaggaa aggccatttt
     6001 ctttggctgt ggataaaagt tggctgaaaa ctttgaccaa tatctgactg gagaaaatgt
     6061 gtattcaaga gctcagattt ggtgggcagt aggttcatgt ctggttgagc tactgtgctt
     6121 ggatgtgcca gagaaaaggg taacatttga accaatgtgc tgctctgtgg ctggctgagc
     6181 tgggaagtgg agaggtttct gagcttattt ccatcgcaag gcaggcagga ggagagagga
     6241 caagaaggat tagtggtttc gcagagacag gcttggctcc aacggctcct tgcgtagtgt
     6301 tggctgcacc caacagtggt gtgagagaac cgtccatacc atgtgacctt cctcccaaac
     6361 tgcagaaaga gacaccttct agcccagatc tggactccct aagagcctcc tggcctgcat
     6421 gcaacccaag taactgtcct actttggcca gttgaccccc tccactctcc tataactaaa
     6481 acagggttct tcctctgtga acagataagt tctttttaaa ggacttgggg gaaattggat
     6541 gaagagcagt aagttcttac agtaagaacc ccactgtaaa gcactgccct ctgccactga
     6601 tccatgtaga ctgaatttga atcccattcc ctgtggatga taccgtcact tgctcatggt
     6661 gacatggcaa gacagtcatt cagatgtttg gcattgttgt agcagggcta ctgctagtgt
     6721 gggggaaaat gctataaatc cacttctttg attgccatgg atttgaaaga accatttgcc
     6781 caacagcatg attcgcctct gaaagtctaa aaataatttt caatttttcc atgaaggtat
     6841 gtggagggta aacacacagc ctacgcatag gtctgcatga catgtttttt ctttttcttt
     6901 cttttttttt tttttttttt ttttttttag acggagcttt gctctttgtt gcccaggctg
     6961 gagtgcagtg gtgcaatctt agctcactgc aacctctgcc tcccggtttt tcaagcgatt
     7021 cttctgtctc agcctcccaa gtagctggaa ttacaggagc ccgccacctt gcccagctaa
     7081 tttttgtatt tttagtagag acggggtttc accatgttgg ccaggctggt cttgaactcc
     7141 tgacctcgtg atccacctgc ctcggcttcc caaagtgctg ggattacagg aatgagccac
     7201 tgtgccagct gacacgtttt ttcttttgtg tgaattttat gttctagttt tgggacaagg
     7261 gtaatcagtt cttgactagt gaacaaatga gagaacattt accccttact cattttacac
     7321 atgcaggtca gcagaagccc tagagttggt tggcacagtc gcagttgact gagcatagag
     7381 gaaacaggtc tttttacatt ctctctcatc actggagctc agttgaactc taagacctta
     7441 gcactcaaag agtctgaaaa gaaatgaggg agaggctaaa tttaagctct ccactcccac
     7501 agaaaggaca gggcacccta caatctaaaa gccagtgagg cagcctatca tctgtttcac
     7561 atctgttctg aaagggatag tttaatgcaa gaagtaagag gcctgtagtg actgtaaact
     7621 catgaaatgt gcacattggt tatctgtgca catttccact tgcaccataa cataagaaag
     7681 cgtacatgga gtgtaattac ttccagaagc cccgtctaac caacctattc agatgtggca
     7741 cactttctgt cataaatgag agaccacacg tagagctcgg tcaccaagga atgcccaaca
     7801 tccctttacc tctcacaatg agcagccacg ctcaccggga agcagtgtgg ggacttcagt
     7861 ggggtgtccc ttagtggaga acacctttca tcatttttat agagacaatt cccttgagaa
     7921 tgtaggcttt tcatcttagg aacaattagg aagaatctcc agctgggagt gttcttatgt
     7981 atacagaaac aatgggtcgc attggttcat acttaggtga tattaggttt ggctatattg
     8041 atgtttggtg ccacttacct tctagatttt cccaaaagtt gggtcattgc tatgggaaat
     8101 tggggcctgc agatggggga gaaatgatca ttattggtgc agggaagggg ttcaggcaga
     8161 gctggagtct gaggctcagt gtgagaaagc actggcagtt ttctagtaga gtcaggtcct
     8221 gggctcctct cctcacccac tgtgtcccga actgaggcca gctgtgatcg gcaaattgct
     8281 tatctctagg tagtttaaag aaaacgtaag agtttggggg gtggtgggag aataactgta
     8341 gaaagaccct aaactcttct ctcccccagc aaattatctt gtataatgtt taaaaaccca
     8401 aaggccagat ctcccctttt aacgtgaatc agaaggagga tggcaattgg accaagggca
     8461 gagtggccac acttgaaaca cattataaaa tgggaatata tttcagggaa ccccaccccc
     8521 acacttccac tccacctcac acctgttggt cctgctttgt gggtgattga ttgataccca
     8581 aggactgccc cacctttaaa ttcctgcaat ttatgctgca accaacatct tagtgtttgc
     8641 tctctccggg aagaggccag gtgggggaga acatacggtc cagagcctga gatcgcctgg
     8701 ctggggtgca ggcaagcagg aacccagtct agatagaatg cagtgttctc taaagctatg
     8761 gatggtttca gtgaaatgtc tgtgtctgac aatcgtcacg caagagtact tactgtcttc
     8821 ccttgtacat acattgtctg tgtttagctt ttcctagtat tgtgaggttt caaatagggg
     8881 ttccatgtaa atactctttc tgctactgaa atgccggccc ccttgagtat gcatcacccc
     8941 cacagatggt tttgcctttc tctatgctaa cactttttga gccactgacg tgcagatcgg
     9001 tggttagttt cttgggcttt tattttgcaa ttttatatat atacacatat tatatatata
     9061 tatatattta tgggttggtt ttgtatagtt ttctgtttga atctctgagc accaaagctg
     9121 ccctttgatt ttcacgagaa ctttccaaag ccacttcctg agccctcctg ctgctttggt
     9181 gtctgacggt gatgctgcgg tggcatctct gcccgtgaat ttctgtatgt gtgtgctgtt
     9241 acctcacctg cagacatgac cctagtaaat ctaacgtgct tggcttccca
//
