LOCUS       NM_001354761            4140 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens adducin 1 (ADD1), transcript variant 12, mRNA.
ACCESSION   NM_001354761 XM_005247933
VERSION     NM_001354761.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4140)
  AUTHORS   Sydorchuk,L., Lytvyn,B., Sydorchuk,A., Yarynych,Y., Daruvuri,S.P.,
            Semenenko,S., Hoshovska,A., Sydorchuk,R. and Biryuk,I.
  TITLE     Alpha-adducin 1 (rs4961) gene and its expression associated with
            sodium sensitivity in hypertensive patients: a cohort study in the
            western Ukrainian population
  JOURNAL   Endocr Regul 58 (1), 195-205 (2024)
   PUBMED   39352780
  REMARK    GeneRIF: Alpha-adducin 1 (rs4961) gene and its expression
            associated with sodium sensitivity in hypertensive patients: a
            cohort study in the western Ukrainian population.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4140)
  AUTHORS   Gonzalez-Fernandez,E., Fan,L., Wang,S., Liu,Y., Gao,W.,
            Thomas,K.N., Fan,F. and Roman,R.J.
  TITLE     The adducin saga: pleiotropic genomic targets for precision
            medicine in human hypertension-vascular, renal, and cognitive
            diseases
  JOURNAL   Physiol Genomics 54 (2), 58-70 (2022)
   PUBMED   34859687
  REMARK    GeneRIF: The adducin saga: pleiotropic genomic targets for
            precision medicine in human hypertension-vascular, renal, and
            cognitive diseases.
            Review article
REFERENCE   3  (bases 1 to 4140)
  AUTHORS   Liang,X., Zhou,Y. and Li,S.
  TITLE     Association of TBXA2R, P2Y12 and ADD1 genes polymorphisms with
            ischemic stroke susceptibility: A metaanalysis
  JOURNAL   Clin Invest Med 43 (3), E33-E43 (2020)
   PUBMED   32971583
  REMARK    GeneRIF: Association of TBXA2R, P2Y12 and ADD1 genes polymorphisms
            with ischemic stroke susceptibility: A metaanalysis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4140)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 4140)
  AUTHORS   Luo,C., Wang,G., Ying,H., Shen,J. and Gilligan,D.M.
  TITLE     Increased expression of phosphorylated adducin in tumor cells
  JOURNAL   J Int Med Res 48 (4), 300060520910646 (2020)
   PUBMED   32237935
  REMARK    GeneRIF: Increased expression of phosphorylated adducin in tumor
            cells.
REFERENCE   6  (bases 1 to 4140)
  AUTHORS   Goldberg,Y.P., Lin,B.Y., Andrew,S.E., Nasir,J., Graham,R.,
            Glaves,M.L., Hutchinson,G., Theilmann,J., Ginzinger,D.G.,
            Schappert,K. et al.
  TITLE     Cloning and mapping of the alpha-adducin gene close to D4S95 and
            assessment of its relationship to Huntington disease
  JOURNAL   Hum Mol Genet 1 (9), 669-675 (1992)
   PUBMED   1284592
REFERENCE   7  (bases 1 to 4140)
  AUTHORS   Taylor,S.A., Snell,R.G., Buckler,A., Ambrose,C., Duyao,M.,
            Church,D., Lin,C.S., Altherr,M., Bates,G.P., Groot,N. et al.
  TITLE     Cloning of the alpha-adducin gene from the Huntington's disease
            candidate region of chromosome 4 by exon amplification
  JOURNAL   Nat Genet 2 (3), 223-227 (1992)
   PUBMED   1345173
REFERENCE   8  (bases 1 to 4140)
  AUTHORS   Joshi,R., Gilligan,D.M., Otto,E., McLaughlin,T. and Bennett,V.
  TITLE     Primary structure and domain organization of human alpha and beta
            adducin
  JOURNAL   J Cell Biol 115 (3), 665-675 (1991)
   PUBMED   1840603
REFERENCE   9  (bases 1 to 4140)
  AUTHORS   Mangeat,P.H.
  TITLE     Interaction of biological membranes with the cytoskeletal framework
            of living cells
  JOURNAL   Biol Cell 64 (3), 261-281 (1988)
   PUBMED   2976282
  REMARK    Review article
REFERENCE   10 (bases 1 to 4140)
  AUTHORS   Gardner,K. and Bennett,V.
  TITLE     Modulation of spectrin-actin assembly by erythrocyte adducin
  JOURNAL   Nature 328 (6128), 359-362 (1987)
   PUBMED   3600811
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121750.22, BX465861.7 and
            AL390065.20.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001354761.1.
            
            Summary: Adducins are a family of cytoskeletal proteins encoded by
            three genes (alpha, beta, and gamma). Adducin acts as a heterodimer
            of the related alpha, beta, or gamma subunits. The protein encoded
            by this gene represents the alpha subunit. Alpha- and beta-adducin
            include a protease-resistant N-terminal region and a
            protease-sensitive, hydrophilic C-terminal region. Adducin binds
            with high affinity to Ca(2+)/calmodulin and is a substrate for
            protein kinases A and C. [provided by RefSeq, Aug 2017].
            
            Transcript Variant: This variant (12) encodes the longest isoform
            (g).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.255468.1,
                                           SRR1660803.49028.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683351.1/ ENSP00000508142.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               AL121750.22        52978-53158         c
            182-396             AL121750.22        20892-21106         c
            397-559             AL121750.22        14942-15104         c
            560-711             AL121750.22        12336-12487         c
            712-792             AL121750.22        2909-2989           c
            793-942             AL121750.22        2271-2420           c
            943-1086            BX465861.7         19793-19936         c
            1087-1185           BX465861.7         19589-19687         c
            1186-1362           BX465861.7         18685-18861         c
            1363-1707           BX465861.7         13012-13356         c
            1708-1809           BX465861.7         10276-10377         c
            1810-1899           BX465861.7         9516-9605           c
            1900-1992           BX465861.7         8689-8781           c
            1993-2149           BX465861.7         3080-3236           c
            2150-2248           AL390065.20        147130-147228       c
            2249-4140           AL390065.20        143180-145071       c
FEATURES             Location/Qualifiers
     source          1..4140
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..4140
                     /gene="ADD1"
                     /gene_synonym="ADDA"
                     /note="adducin 1"
                     /db_xref="GeneID:118"
                     /db_xref="HGNC:HGNC:243"
                     /db_xref="MIM:102680"
     exon            1..181
                     /gene="ADD1"
                     /gene_synonym="ADDA"
                     /inference="alignment:Splign:2.1.0"
     exon            182..396
                     /gene="ADD1"
                     /gene_synonym="ADDA"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..2601
                     /gene="ADD1"
                     /gene_synonym="ADDA"
                     /note="isoform g is encoded by transcript variant 12;
                     erythrocyte adducin alpha subunit; alpha-adducin; adducin
                     1 (alpha); alpha-adducin 1"
                     /codon_start=1
                     /product="alpha-adducin isoform g"
                     /protein_id="NP_001341690.1"
                     /db_xref="CCDS:CCDS93469.1"
                     /db_xref="GeneID:118"
                     /db_xref="HGNC:HGNC:243"
                     /db_xref="MIM:102680"
                     /translation="MNGDSRAAVVTSPPPTTAPHKERYFDRVDENNPEYLRERNMAPD
                     LRQDFNMMEQKKRVSMILQSPAFCEELESMIQEQFKKGKNPTGLLALQQIADFMTTNV
                     PNVYPAAPQGGMAALNMSLGMVTPVNDLRGSDSIAYDKGEKLLRCKLAAFYRLADLFG
                     WSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVKINLQGDIVDRGSTNLGVNQ
                     AGFTLHSAIYAARPDVKCVVHIHTPAGAAVSAMKCGLLPISPEALSLGEVAYHDYHGI
                     LVDEEEKVLIQKNLGPKSKVLILRNHGLVSVGESVEEAFYYIHNLVVACEIQVRTLAS
                     AGGPDNLVLLNPEKYKAKSRSPGSPVGEGTGSPPKWQIGEQEFEALMRMLDNLGYRTG
                     YPYRYPALREKSKKYSDVEVPASVTGYSFASDGDSGTCSPLRHSFQKQQREKTRWLNS
                     GRGDEASEEGQNGSSPKSKTKVWTNITHDHVKPLLQSLSSGVCVPSCITNCLWTKEDG
                     HRTSTSAVPNLFVPLNTNPKEVQEMRNKIREQNLQDIKTAGPQSQVLCGVVMDRSLVQ
                     DAPLSDCTETIEGLELTEQTFSPAKSLSFRKGELVTASKAIIEKEYQPHVIVSTTGPN
                     PFTTLTDRELEEYRREVERKQKGSEENLDEAREQKEKSPPDQPAVPHPPPSTPIKLEE
                     DLVPEPTTGDDSDAATFKPTLPDLSPDEPSEALGFPMLEKEEEAHRPPSPTEAPTEAS
                     PEPAPDPAPVAEEAAPSAVEEGAAADPGSDGSPGKSPSKKKKKFRTPSFLKKSKKKSD
                     S"
     exon            397..559
                     /gene="ADD1"
                     /gene_synonym="ADDA"
                     /inference="alignment:Splign:2.1.0"
     exon            560..711
                     /gene="ADD1"
                     /gene_synonym="ADDA"
                     /inference="alignment:Splign:2.1.0"
     exon            712..792
                     /gene="ADD1"
                     /gene_synonym="ADDA"
                     /inference="alignment:Splign:2.1.0"
     exon            793..942
                     /gene="ADD1"
                     /gene_synonym="ADDA"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1086
                     /gene="ADD1"
                     /gene_synonym="ADDA"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1185
                     /gene="ADD1"
                     /gene_synonym="ADDA"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1362
                     /gene="ADD1"
                     /gene_synonym="ADDA"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1707
                     /gene="ADD1"
                     /gene_synonym="ADDA"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1809
                     /gene="ADD1"
                     /gene_synonym="ADDA"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1899
                     /gene="ADD1"
                     /gene_synonym="ADDA"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..1992
                     /gene="ADD1"
                     /gene_synonym="ADDA"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2149
                     /gene="ADD1"
                     /gene_synonym="ADDA"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2248
                     /gene="ADD1"
                     /gene_synonym="ADDA"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..4140
                     /gene="ADD1"
                     /gene_synonym="ADDA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4122..4127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADD1"
                     /gene_synonym="ADDA"
                     /note="hexamer: AATAAA"
     polyA_site      4140
                     /gene="ADD1"
                     /gene_synonym="ADDA"
                     /note="major polyA site"
ORIGIN      
        1 agcgccgcag gccgcaccca ggtcgggcgg tgggggcgag cggaggggct gaggggcgga
       61 gaggcctggc gggccgctgc tgcgggccag gggacggggg cggagccgga gccggagccg
      121 acgggcggtg gccgcactgg gaccccggaa tcccgcgcgc tgcccacgat tcgcttctga
      181 ggaacctaga aagattgtac aatgaatggt gattctcgtg ctgcggtggt gacctcacca
      241 cccccgacca cagcccctca caaggagagg tacttcgacc gagtagatga gaacaaccca
      301 gagtacttga gggagaggaa catggcacca gaccttcgcc aggacttcaa catgatggag
      361 caaaagaaga gggtgtccat gattctgcaa agccctgctt tctgtgaaga attggaatca
      421 atgatacagg agcaatttaa gaaggggaag aaccccacag gcctattggc attacagcag
      481 attgcagatt ttatgaccac gaatgtacca aatgtctacc cagcagctcc gcaaggaggg
      541 atggctgcct taaacatgag tcttggtatg gtgactcctg tgaacgatct tagaggatct
      601 gattctattg cgtatgacaa aggagagaag ttattacggt gtaaattggc agcgttttat
      661 agactagcag atctctttgg gtggtctcag cttatctaca atcatatcac aaccagagtg
      721 aactccgagc aggaacactt cctcattgtc ccttttgggc ttctttacag tgaagtgact
      781 gcatccagtt tggttaagat caatctacaa ggagatatag tagatcgtgg aagcactaat
      841 ctgggagtga atcaggccgg cttcacctta cactctgcaa tttatgctgc acgcccggac
      901 gtgaagtgcg tcgtgcacat tcacacccca gcaggggctg cggtctctgc aatgaaatgt
      961 ggcctcttgc caatctcccc ggaggcgctt tcccttggag aagtggctta tcatgactac
     1021 catggcattc tggttgatga agaggaaaaa gttttgattc agaaaaatct ggggcctaaa
     1081 agcaaggttc ttattctccg gaaccatggg ctcgtgtcag ttggagagag cgttgaggag
     1141 gccttctatt acatccataa ccttgtggtt gcctgtgaga tccaggttcg aactctggcc
     1201 agtgcaggag gaccagacaa cttagtcctg ctgaatcctg agaagtacaa agccaagtcc
     1261 cgttccccag ggtctccggt aggggaaggc actggatcgc ctcccaagtg gcagattggt
     1321 gagcaggaat ttgaagccct catgcggatg ctcgataatc tgggctacag aactggctac
     1381 ccttatcgat accctgctct gagagagaag tctaaaaaat acagcgatgt ggaggttcct
     1441 gctagtgtca caggttactc ctttgctagt gacggtgatt cgggcacttg ctccccactc
     1501 agacacagtt ttcagaagca gcagcgggag aagacaagat ggctgaactc tggccggggc
     1561 gacgaagctt ccgaggaagg gcagaatgga agcagtccca agtcgaagac taaggtgtgg
     1621 acgaacatta cacacgatca cgtgaaaccc ttgctgcagt ctctctcgtc cggtgtctgc
     1681 gtgccaagct gtattaccaa ctgcttgtgg actaaagagg atggacatag aacttccacc
     1741 tctgctgtcc ctaacctgtt tgttccattg aacactaacc caaaagaggt ccaggagatg
     1801 aggaacaaga tccgagagca gaatttacag gacattaaga cggctggccc tcagtcccag
     1861 gttttgtgtg gtgtagtgat ggacaggagc ctcgtccagg atgcacctct ctctgactgt
     1921 acggaaacta tcgaagggct cgagcttaca gagcagacct ttagtcccgc taaatctctc
     1981 tcttttagaa agggagagct ggtgacggcc tccaaggcca tcattgaaaa ggagtaccag
     2041 ccccacgtca ttgtgagcac cacgggcccc aaccccttca ccacactcac agaccgtgag
     2101 ctggaggagt accgcaggga ggtggagagg aagcagaagg gctctgaaga gaatctggac
     2161 gaggctagag aacagaaaga aaagagtcct ccagaccagc ctgcggtccc ccacccgcct
     2221 cccagcactc ccatcaagct ggaggaagac cttgtgccgg agccgactac tggagatgac
     2281 agtgatgctg ccacctttaa gccaactctc cccgatctgt cccctgatga accttcagaa
     2341 gcactcggct tcccaatgtt agagaaggag gaggaagccc atagaccccc aagccccact
     2401 gaggccccta ctgaggccag ccccgagcca gccccagacc cagccccggt ggctgaagag
     2461 gctgccccct cagctgtcga ggagggggcc gccgcggacc ctggcagcga tgggtctcca
     2521 ggcaagtccc cgtccaaaaa gaagaagaag ttccgtaccc cgtcctttct gaagaagagc
     2581 aagaagaaga gtgactcctg aaagccctgc gctaacactg tcctgtccgg agcgaccctg
     2641 gctctgccag cgtccccggc cacgtctgtg ctctgtcctt gtgtaatgga atgcaaaaaa
     2701 gccaagccct ccgcctagag gtcccctcac gtgaccagcc ccgtgtagcc ccgggctgac
     2761 ccagtgtgtg ctcagcagcc ccaccccacc ctgccccttg tcctctcaga gcctcagctt
     2821 ctgggggaga catgctctcc ccacaggggg gaggcactaa gtcatggtcc tggctggaag
     2881 gtactgaagg cttctgcagc tttggctgca cgtcaccctc ctgagcctca cctttcctgc
     2941 cgtccctcct gttgtgaaat caccacattc tgtctctgct tggcttcccc tccaccctaa
     3001 agtctcaggt gacggactca gactcctggc ttcatgtggc attctctctg ctcagtgatc
     3061 tcacttaaat ctatatacaa agccttggtc ccgtgaaaac actcgtgtgc ccaccagcgg
     3121 ccttgaagag gcaggtctgg gccagatgct gggcaggaaa ccccagcggc agatgggcct
     3181 gtgtgcaccc aacgtgatgc tatgcatgtc tgaccgacga tccctcgacc agaatcagat
     3241 tcaggagctc agtttctttt tcacttgggt ctctggattc ctgtcatagg gaaggtatat
     3301 caggagggga agaggccttt ctagaatttt ctttgagcag gtttacaatt tagcttacat
     3361 ttttcgactg tgaacgtgaa taggctgctt tttgctttct tctttccaga ccccacagta
     3421 gagcactttt cacttatttg ggggaggctt caggggactg ttctcacctt aactcagcca
     3481 gaaagatgcc ctagttgtga tcaaaggtaa ctcgaggtgg agggtagccc tggggcccct
     3541 cgacatcacc gtcattgatg gagcctgaac cgtgtgctcc tcggcagatg ctgttgttgt
     3601 tacttccctc caagaggctg gaaaagggct cagagctgct gagcaggaac cggagggtga
     3661 cccatttcag gaggtgccgg taccagcctg actaggtaca ggcaagcttg tgtgggccca
     3721 acaggccctt ggtagagctg gtgccagatg tgggctcaga tcctgggcat gatgggccga
     3781 gccacctcgg atcccactga ttggccagcc gagcgagaac caggctgctg catggcactg
     3841 accgccgctt ccagcttcct ctgagccgca gggcctgcta cgcgggcaag cgtgctgcct
     3901 ctcttctgtg tcgttttgtt gccaaggcag aatgaaaagt ccttaaccgt ggactcttcc
     3961 tttatcccct cctttacccc acatatgcaa tgacttttaa ttttcacttt tgtagtttaa
     4021 tcctttgtat tacaacatga aatatagttg catatatgga caccgacttg ggaggacagg
     4081 tcctgaatgt cctttctcca gtgtaacatg ttttactcac aaataaaatt ctttcagcaa
//
