LOCUS       NM_001118               6639 bp    mRNA    linear   PRI 15-DEC-2024
DEFINITION  Homo sapiens ADCYAP receptor type I (ADCYAP1R1), transcript variant
            3, mRNA.
ACCESSION   NM_001118
VERSION     NM_001118.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6639)
  AUTHORS   Toth,D., Simon,G. and Reglodi,D.
  TITLE     Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) and
            Sudden Infant Death Syndrome: A Potential Model for Investigation
  JOURNAL   Int J Mol Sci 24 (20), 15063 (2023)
   PUBMED   37894743
  REMARK    GeneRIF: Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)
            and Sudden Infant Death Syndrome: A Potential Model for
            Investigation.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6639)
  AUTHORS   Rees,T.A., Labastida-Ramirez,A. and Rubio-Beltran,E.
  TITLE     Calcitonin/PAC1 receptor splice variants: a blind spot in migraine
            research
  JOURNAL   Trends Pharmacol Sci 44 (10), 651-663 (2023)
   PUBMED   37543479
  REMARK    GeneRIF: Calcitonin/PAC1 receptor splice variants: a blind spot in
            migraine research.
            Review article
REFERENCE   3  (bases 1 to 6639)
  AUTHORS   Piper,S.J., Deganutti,G., Lu,J., Zhao,P., Liang,Y.L., Lu,Y.,
            Fletcher,M.M., Hossain,M.A., Christopoulos,A., Reynolds,C.A.,
            Danev,R., Sexton,P.M. and Wootten,D.
  TITLE     Understanding VPAC receptor family peptide binding and selectivity
  JOURNAL   Nat Commun 13 (1), 7013 (2022)
   PUBMED   36385145
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6639)
  AUTHORS   Tasma,Z., Siow,A., Harris,P.W.R., Brimble,M.A., O'Carroll,S.J.,
            Hay,D.L. and Walker,C.S.
  TITLE     PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human
            Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor
            Antibodies
  JOURNAL   Int J Mol Sci 23 (22), 13797 (2022)
   PUBMED   36430275
  REMARK    GeneRIF: PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and
            Human Trigeminal Ganglia: Characterization of PACAP-Responsive
            Receptor Antibodies.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6639)
  AUTHORS   Szabo,D., Sarszegi,Z., Polgar,B., Saghy,E., Reglodi,D., Toth,T.,
            Onodi,Z., Leszek,P., Varga,Z.V., Helyes,Z., Kemeny,A.,
            Ferdinandy,P. and Tamas,A.
  TITLE     PACAP-38 and PAC1 Receptor Alterations in Plasma and Cardiac Tissue
            Samples of Heart Failure Patients
  JOURNAL   Int J Mol Sci 23 (7), 3715 (2022)
   PUBMED   35409075
  REMARK    GeneRIF: PACAP-38 and PAC1 Receptor Alterations in Plasma and
            Cardiac Tissue Samples of Heart Failure Patients.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6639)
  AUTHORS   Pantaloni,C., Brabet,P., Bilanges,B., Dumuis,A., Houssami,S.,
            Spengler,D., Bockaert,J. and Journot,L.
  TITLE     Alternative splicing in the N-terminal extracellular domain of the
            pituitary adenylate cyclase-activating polypeptide (PACAP) receptor
            modulates receptor selectivity and relative potencies of PACAP-27
            and PACAP-38 in phospholipase C activation
  JOURNAL   J Biol Chem 271 (36), 22146-22151 (1996)
   PUBMED   8703026
REFERENCE   7  (bases 1 to 6639)
  AUTHORS   Pisegna,J.R. and Wank,S.A.
  TITLE     Cloning and characterization of the signal transduction of four
            splice variants of the human pituitary adenylate cyclase activating
            polypeptide receptor. Evidence for dual coupling to adenylate
            cyclase and phospholipase C
  JOURNAL   J Biol Chem 271 (29), 17267-17274 (1996)
   PUBMED   8663363
REFERENCE   8  (bases 1 to 6639)
  AUTHORS   Stoffel,M., Espinosa,R. 3rd, Trabb,J.B., Le Beau,M.M. and Bell,G.I.
  TITLE     Human type I pituitary adenylate cyclase activating polypeptide
            receptor (ADCYAP1R): localization to chromosome band 7p14 and
            integration into the cytogenetic, physical, and genetic map of
            chromosome 7
  JOURNAL   Genomics 23 (3), 697-699 (1994)
   PUBMED   7851900
REFERENCE   9  (bases 1 to 6639)
  AUTHORS   Ohtaki,T., Masuda,Y., Ishibashi,Y., Kitada,C., Arimura,A. and
            Fujino,M.
  TITLE     Purification and characterization of the receptor for pituitary
            adenylate cyclase-activating polypeptide
  JOURNAL   J Biol Chem 268 (35), 26650-26657 (1993)
   PUBMED   8253796
REFERENCE   10 (bases 1 to 6639)
  AUTHORS   Ogi,K., Miyamoto,Y., Masuda,Y., Habata,Y., Hosoya,M., Ohtaki,T.,
            Masuo,Y., Onda,H. and Fujino,M.
  TITLE     Molecular cloning and functional expression of a cDNA encoding a
            human pituitary adenylate cyclase activating polypeptide receptor
  JOURNAL   Biochem Biophys Res Commun 196 (3), 1511-1521 (1993)
   PUBMED   7902709
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006466.3, DA809763.1,
            AK290046.1 and CA432770.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001118.4.
            
            Summary: This gene encodes type I adenylate cyclase activating
            polypeptide receptor, which is a membrane-associated protein and
            shares significant homology with members of the glucagon/secretin
            receptor family. This receptor mediates diverse biological actions
            of adenylate cyclase activating polypeptide 1 and is positively
            coupled to adenylate cyclase. Multiple alternatively spliced
            transcript variants encoding distinct isoforms have been
            identified. [provided by RefSeq, Dec 2010].
            
            Transcript Variant: This variant (3) lacks an in-frame exon in the
            CDS, as compared to variant 1. The resulting isoform (3) lacks an
            internal segment, as compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.229441.1,
                                           SRR1803613.42409.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304166.9/ ENSP00000306620.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AC006466.3         11830-11982
            154-580             DA809763.1         1-427
            581-2429            AK290046.1         379-2227
            2430-6466           AC006466.3         66786-70822
            6467-6639           CA432770.1         24-196              c
FEATURES             Location/Qualifiers
     source          1..6639
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.3"
     gene            1..6639
                     /gene="ADCYAP1R1"
                     /gene_synonym="PAC1; PAC1R; PACAPR; PACAPRI"
                     /note="ADCYAP receptor type I"
                     /db_xref="GeneID:117"
                     /db_xref="HGNC:HGNC:242"
                     /db_xref="MIM:102981"
     exon            1..371
                     /gene="ADCYAP1R1"
                     /gene_synonym="PAC1; PAC1R; PACAPR; PACAPRI"
                     /inference="alignment:Splign:2.1.0"
     exon            372..493
                     /gene="ADCYAP1R1"
                     /gene_synonym="PAC1; PAC1R; PACAPR; PACAPRI"
                     /inference="alignment:Splign:2.1.0"
     CDS             443..1849
                     /gene="ADCYAP1R1"
                     /gene_synonym="PAC1; PAC1R; PACAPR; PACAPRI"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; pituitary adenylate cyclase activating
                     polypeptide 1 receptor type I Hiphop; PACAP-R1; PACAP type
                     I receptor; PACAP receptor 1; adenylate cyclase activating
                     polypeptide 1 (pituitary) receptor type I; pituitary
                     adenylate cyclase-activating polypeptide type 1 receptor;
                     PAC1 receptor"
                     /codon_start=1
                     /product="pituitary adenylate cyclase-activating
                     polypeptide type I receptor isoform 3 precursor"
                     /protein_id="NP_001109.2"
                     /db_xref="CCDS:CCDS5433.1"
                     /db_xref="GeneID:117"
                     /db_xref="HGNC:HGNC:242"
                     /db_xref="MIM:102981"
                     /translation="MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANEL
                     MGFNDSSPGCPGMWDNITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGD
                     SNSLDLSDMGVVSRNCTEDGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVG
                     YSTSLVTLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNH
                     CFISTVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGT
                     PTVCVTVWATLRLYFDDTGCWDMNDSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQK
                     LQSPDMGGNESSIYLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQ
                     GFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILS
                     KSSSQIRMSGLPADNLAT"
     exon            494..599
                     /gene="ADCYAP1R1"
                     /gene_synonym="PAC1; PAC1R; PACAPR; PACAPRI"
                     /inference="alignment:Splign:2.1.0"
     exon            600..707
                     /gene="ADCYAP1R1"
                     /gene_synonym="PAC1; PAC1R; PACAPR; PACAPRI"
                     /inference="alignment:Splign:2.1.0"
     exon            708..728
                     /gene="ADCYAP1R1"
                     /gene_synonym="PAC1; PAC1R; PACAPR; PACAPRI"
                     /inference="alignment:Splign:2.1.0"
     exon            729..770
                     /gene="ADCYAP1R1"
                     /gene_synonym="PAC1; PAC1R; PACAPR; PACAPRI"
                     /inference="alignment:Splign:2.1.0"
     exon            771..880
                     /gene="ADCYAP1R1"
                     /gene_synonym="PAC1; PAC1R; PACAPR; PACAPRI"
                     /inference="alignment:Splign:2.1.0"
     exon            881..978
                     /gene="ADCYAP1R1"
                     /gene_synonym="PAC1; PAC1R; PACAPR; PACAPRI"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1111
                     /gene="ADCYAP1R1"
                     /gene_synonym="PAC1; PAC1R; PACAPR; PACAPRI"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1265
                     /gene="ADCYAP1R1"
                     /gene_synonym="PAC1; PAC1R; PACAPR; PACAPRI"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1326
                     /gene="ADCYAP1R1"
                     /gene_synonym="PAC1; PAC1R; PACAPR; PACAPRI"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1396
                     /gene="ADCYAP1R1"
                     /gene_synonym="PAC1; PAC1R; PACAPR; PACAPRI"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1488
                     /gene="ADCYAP1R1"
                     /gene_synonym="PAC1; PAC1R; PACAPR; PACAPRI"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1618
                     /gene="ADCYAP1R1"
                     /gene_synonym="PAC1; PAC1R; PACAPR; PACAPRI"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1660
                     /gene="ADCYAP1R1"
                     /gene_synonym="PAC1; PAC1R; PACAPR; PACAPRI"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..6639
                     /gene="ADCYAP1R1"
                     /gene_synonym="PAC1; PAC1R; PACAPR; PACAPRI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6619..6624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADCYAP1R1"
                     /gene_synonym="PAC1; PAC1R; PACAPR; PACAPRI"
                     /note="hexamer: AATAAA"
     polyA_site      6639
                     /gene="ADCYAP1R1"
                     /gene_synonym="PAC1; PAC1R; PACAPR; PACAPRI"
                     /note="major polyA site"
ORIGIN      
        1 gcctccctcc agcgcccagc ctggcttcgc ggcggaggcg gcgcctctcc cgcaggacgg
       61 agccaagctg gactgccgcg ccgcgcgggg cgggcaaagg gggcgctgcg ctcggccccg
      121 ggcagggagt gacggcggcg gcggcggctc cgggcgagcg tggtccccgc gtgcgcacac
      181 gcacacgccg ccgcgcaggg acacacggac cccggccgcc agccggccac acaggcgcgg
      241 agacccggct cggcgcgcgc tcctcggcgc acacgctccc catccccgcg ccgcgcgggc
      301 cgcggacttg caggctgcgc gtcctttgcg gagtctgccc cggccccacg gacaggcccc
      361 gcagtgagca gcccagagac acattggggc tgacctgccg ctgctgtcag tgggaggcca
      421 gtggtgctgg ccaagaagtg tcatggctgg tgtcgtgcac gtttccctgg ctgctctcct
      481 cctgctgcct atggcccctg ccatgcattc tgactgcatc ttcaagaagg agcaagccat
      541 gtgcctggag aagatccaga gggccaatga gctgatgggc ttcaatgatt cctctccagg
      601 ctgtcctggg atgtgggaca acatcacgtg ttggaagccc gcccatgtgg gtgagatggt
      661 cctggtcagc tgccctgagc tcttccgaat cttcaaccca gaccaagtct gggagaccga
      721 aaccattgga gagtctgatt ttggtgacag taactcctta gatctctcag acatgggagt
      781 ggtgagccgg aactgcacgg aggatggctg gtcggaaccc ttccctcatt actttgatgc
      841 ctgtgggttt gatgaatatg aatctgagac tggggaccag gattattact acctgtcagt
      901 gaaggccctc tacacggttg gctacagcac atccctcgtc accctcacca ctgccatggt
      961 catcctttgt cgcttccgga agctgcactg cacacgcaac ttcatccaca tgaacctgtt
     1021 tgtgtcgttc atgctgaggg cgatctccgt cttcatcaaa gactggattc tgtatgcgga
     1081 gcaggacagc aaccactgct tcatctccac tgtggaatgt aaggccgtca tggttttctt
     1141 ccactactgt gttgtgtcca actacttctg gctgttcatc gagggcctgt acctcttcac
     1201 tctgctggtg gagaccttct tccctgaaag gagatacttc tactggtaca ccatcattgg
     1261 ctgggggacc ccaactgtgt gtgtgacagt gtgggctacg ctgagactct actttgatga
     1321 cacaggctgc tgggatatga atgacagcac agctctgtgg tgggtgatca aaggccctgt
     1381 ggttggctct atcatggtta actttgtgct ttttattggc attatcgtca tccttgtgca
     1441 gaaacttcag tctccagaca tgggaggcaa tgagtccagc atctacttgc gactggcccg
     1501 gtccaccctg ctgctcatcc cactattcgg aatccactac acagtatttg ccttctcccc
     1561 agagaatgtc agcaaaaggg aaagactcgt gtttgagctg gggctgggct ccttccaggg
     1621 ctttgtggtg gctgttctct actgttttct gaatggtgag gtacaagcgg agatcaagcg
     1681 aaaatggcga agctggaagg tgaaccgtta cttcgctgtg gacttcaagc accgacaccc
     1741 gtctctggcc agcagtgggg tgaatggggg cacccagctc tccatcctga gcaagagcag
     1801 ctcccaaatc cgcatgtctg gcctccctgc tgacaatctg gccacctgag ccatgctccc
     1861 ctcctcctcc tctcctccat ccacaggctg ggaccgcagg caggtgccag cccacgcatg
     1921 tttgcgcctc ttccctcccc ttgggcaggc cctgggctgg aagcttggct cctgaggggg
     1981 gagaaggagg cagggcacag actggaattg tcccctcctt gttttggtac tggtcccacc
     2041 cactgtggtc ccctgggccc tgaccccaga catgtaaata ctcctcaaat ttggaaaagt
     2101 tgtcccatcc cttccccctt tgccccagtg tccctgctca cttccagtca ggtctcagct
     2161 ccaccccact gtttcttggt cagcctcagt gatggcctga ccccagctgt gaggccttgt
     2221 gagctaaggc tgaagagacc ttgcctgtgg gagctggggt ggtacctgcc ccaacagccc
     2281 cccatcatct gattttgggt gtgacccctc gagtgtgcat gccaccctgg ggctcttctc
     2341 agtcctgggc ccaagtccct gaagcctagc agagggccag ctcgggtggc cagaacaccc
     2401 cttggtgcag gcctcctggc actcgcctgg catcttggtg tccgggtgct cagctcctgg
     2461 gtcccagggc agtgggacag ctcccaggct cttctcatca gagacttcag tttgggtggg
     2521 gagtctgcag gtcagggaag gttctggtgc ttttcgtttg atccaaaagg agctgagagc
     2581 cagaaatgtg gctgtgattg cgaaagagac ggagtttggg agacccatgg aagaaaacct
     2641 tcgccatctc cattgtttta cccccagctc aagatggaca gggttcttct ggtcatctcc
     2701 cttccacctc ttccaccctc atggatgcct tccagaagct gtctccaacc atgcacacca
     2761 cagagagccc ttaagccctc ccctccccat ttcccctaag tcaaagccat gactaggatg
     2821 taccagccac ctgcctctga tgtcggcgaa tcctgaagca cctgcacccg aatctggggc
     2881 ccagggctgc ccgaccccca ctcccatgga tgatgaggag ccccagacac cagctcctct
     2941 ggcctggact caactattga aatctctctg agacctctgc aaagatgtcc cttttatgcc
     3001 cttgaccttg actcaccatg ggctgctggg gtgtcgggag aagccacacc caacatgccc
     3061 attagcagag gctgctgctg atgtggcagc tgctccctac cacccgccct ggctccccag
     3121 ctgcaggttg cacaccctca gcctgagaat gtaaaatagg gcagtgccca gctggggagg
     3181 tagaggaaag tgctagagta catggtccgt gtgtggccta gctcattcca tgtcagcatt
     3241 tggtgttact cctgtccaaa ttctgtttgc agacttgttt catgatgatg ctctggaatg
     3301 cttggggact ttgggtggag gaggatgtta cttcatttta taaagaggaa ggggcctggg
     3361 agacttggga aaatgtttct ggagaggctt tcagagtggc tggaaaaggc tcttgttgct
     3421 gtaatttaga gaggagctct gtgtccttgg ccagtcaagt aagttcctgg atctttggca
     3481 aagccagagg aagaaaggag ctacctgccc tttcctgggc atgcttggtg actcagattg
     3541 atcttggagt gtgcagtggc ccttctaccc tgcacctgac ctcatgatcc cctccacctg
     3601 cactggtgtg cattactgaa gcaagggtcc tgtggacatc ttgcattttg ggcactgcta
     3661 gggggtctgg gctgcttgga aggagccatg gcctagggtt cagggaacta gactctatcc
     3721 cagttgggtt cagactgctg tgactgtgga cacgatgctc cttgttctgg gctccagttt
     3781 tcccatttgt gagatgaggc aacttccaat gcttctctag gccctgcacg taagtgattt
     3841 ttccagttca aagtcaagac aggtaaaagg gcattcatca ttgtgcctca tatcaggttt
     3901 tgatgaatat atgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtagag ggatggacag
     3961 gatgctgttt attttccctt tcttggaaat ggaccttctg tcccttccat ttggacacca
     4021 cagtggaagc tggtggcctg gaaggaagga ttaggtcatg gacatttgaa caggtgcctt
     4081 gggcatgatg tatagatgca gtcatatata ccttgctggg gtggggtgcc acctccagtg
     4141 gccagctcca gatccaagga gcagccccct ggggatggac cccattcatt catcatgact
     4201 cccaacagtt ttcattgtgg aagaagaaac tttggcatta tagagacatc atcacaaaac
     4261 agtaaaaaca aaatcaaccc tgaaccccat gcactgtgct gcttcctgag cctggccctg
     4321 catcctcata gaggtgccgg gttcctattg gttagttggt tgtttttccg tctgagtgaa
     4381 tttttgccag tcttgtgagc agatgtacct gatgtattct caatgttcca agaggttctg
     4441 gccttcaggg tcacaggcag tagggggaca gcataaggtc tatgtaaaac ccttccctct
     4501 ctgaccctct gttttcaaat ctgtaaaatg ggcaataaga ctagatgatt tgtatatagc
     4561 ccaatgcatc tctggaactc tgtctaaaca ccagccatct acttggaatg ggccccagga
     4621 ctgtggtatt tgcctgggcc aggaaaggat aagaaatcct gtcatgtgaa gacagcttga
     4681 gaggcttgag aaaagtgggg ctggggagaa gcaggcttgt cagactccac ccctgttgat
     4741 gatcattcct gggaaggggt ttctcgttct atgcaatcct aaaggacgaa actcacccat
     4801 gggaggccga attctccttg ggatgaagaa atttctcttt ccctgtcatg agtgtccagc
     4861 cagggagcag ggaggcagtg tcagggaggg actctcatcc tggaggaaat gggattccaa
     4921 gtcaaggatg ctgaggctgt cagggagcca gagagggggg tccaagtgcg ggatgtgggt
     4981 ggctctgtgg ttcagtggct ctgtggtagt tcctagcact gcagacttca tgactcccca
     5041 cttaagtcca agtcacattg tctatcccag tgtgtagctc tgtcaccctg cttgacacat
     5101 ccagtggcct acagcgactc ttctctaacc ccaccccctc caagctgggt tctttgtgga
     5161 agaaggacag ggagctagag ccaagcccta ggcttgagag acacctgcat ctataatccc
     5221 cgccaaggat gcccactcac ctctctcatc tgatcctcac tctttgtgga agggaaagct
     5281 caaagggact ctctctctct ctctcttttt tttttttttt gagtagtacc cttgccctct
     5341 tcatggccac ttcaaagtga agccagcaaa gtgataatac tttatcattt agtattatca
     5401 taaagtatta atactttgtc ataaagtcct ccttgagccc agggaccatg gaagtcagct
     5461 agaagagccc tgagcaagga gcaaggactt gggcttctcc acgctttgct cctggcttgt
     5521 ttgaccttga ctcattcccc atatgtcttt gaggaggctc acaaaatact aaagctggga
     5581 ggaaacttgg agatctatag gtcaaacctc cccattgggc tgatgagaaa atacacgcag
     5641 gcctagcatg gtgcctgcca ccatggtggg atccagtatg ttttataaat ctgaatgagt
     5701 aaatggctca ccaatttatg catagccctg cacatgagca gaatgtgaca ctcaaagcat
     5761 ccatgcagta cgcatgtaac cttgcacagg agtggggctc tggtgaccga aggttgtcca
     5821 ggactcttgc aggagaagca atggagtcag tgtggtgtgg ggagacctac tttttaacct
     5881 gggcttagcc acctgctctg tgatccaggg cttaccttct ttgggcctcg gcctcctaat
     5941 ctgggtaatg gggaggactt cattggcatt gttagtccca caggccaagg ataaggttga
     6001 aatgagacgg cttgtgtgtg aaaagatttt ggaaattaca cagatgtggg cttgttattg
     6061 ggatgaagac tgctggaagg gactccttgc tgtttatcta ctgctttgag ccctcctaag
     6121 ttaacctgtg cctcatttgt aaaaccacca gcatcaggag taagggggag gccagagggc
     6181 tcagatggac acagaattct agctttacct gcatccgctg attcagtttt ctgttgggat
     6241 cagagtgagg atacttccat atgggtgata gcagccatgc ccctgggagt caacttcaag
     6301 gatctgggac attttggtgt gcccattcct tcttttcctg aactcacagt cttggggtgt
     6361 ttctgcactt ggctatgtgt gtcttgtctg atgtctgtct tctgtagctt tgcctctatc
     6421 agggctggag tggtgcagcc cctggcatct cagacatggt tcctgcctca cttgtgggag
     6481 ctggaccagc ctgggtttca tctcccacag taaagctaag taagccccac agaccttact
     6541 gctactgctg ctgccattaa tgctgtgctc actatcttgt ccaggatttt aaggatgtca
     6601 gactgctgta gatgactcaa taaatgtttt gccattttt
//
