LOCUS       NM_001099733            3259 bp    mRNA    linear   PRI 20-MAY-2024
DEFINITION  Homo sapiens adenylate cyclase activating polypeptide 1 (ADCYAP1),
            transcript variant 1, mRNA.
ACCESSION   NM_001099733
VERSION     NM_001099733.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3259)
  AUTHORS   Bdeir,R., Al-Keilani,M.S. and Khamaiseh,K.
  TITLE     Effects of the Neuropeptides Pituitary Adenylate Cyclase Activating
            Polypeptide and Vasoactive Intestinal Peptide in Male Fertility
  JOURNAL   Medicina (Kaunas) 60 (4), 652 (2024)
   PUBMED   38674298
  REMARK    GeneRIF: Effects of the Neuropeptides Pituitary Adenylate Cyclase
            Activating Polypeptide and Vasoactive Intestinal Peptide in Male
            Fertility.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3259)
  AUTHORS   Toth,D., Simon,G. and Reglodi,D.
  TITLE     Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) and
            Sudden Infant Death Syndrome: A Potential Model for Investigation
  JOURNAL   Int J Mol Sci 24 (20), 15063 (2023)
   PUBMED   37894743
  REMARK    GeneRIF: Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)
            and Sudden Infant Death Syndrome: A Potential Model for
            Investigation.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3259)
  AUTHORS   Tominaga,A., Sugawara,H., Futagawa,T., Inoue,K., Sasaki,K.,
            Minamino,N., Hatakeyama,M., Handa,H. and Miyata,A.
  TITLE     Characterization of the testis-specific promoter region in the
            human pituitary adenylate cyclase-activating polypeptide (PACAP)
            gene
  JOURNAL   Genes Cells 15 (6), 595-606 (2010)
   PUBMED   20500521
  REMARK    GeneRIF: Data suggest that promoter activity of the 80-bp fragment
            might be involved in the testis-specific gene expression of PACAP.
REFERENCE   4  (bases 1 to 3259)
  AUTHORS   Vaudry,D., Falluel-Morel,A., Bourgault,S., Basille,M., Burel,D.,
            Wurtz,O., Fournier,A., Chow,B.K., Hashimoto,H., Galas,L. and
            Vaudry,H.
  TITLE     Pituitary adenylate cyclase-activating polypeptide and its
            receptors: 20 years after the discovery
  JOURNAL   Pharmacol Rev 61 (3), 283-357 (2009)
   PUBMED   19805477
  REMARK    Review article
REFERENCE   5  (bases 1 to 3259)
  AUTHORS   Felley,C.P., Qian,J.M., Mantey,S., Pradhan,T. and Jensen,R.T.
  TITLE     Chief cells possess a receptor with high affinity for PACAP and VIP
            that stimulates pepsinogen release
  JOURNAL   Am J Physiol 263 (6 Pt 1), G901-G907 (1992)
   PUBMED   1335692
REFERENCE   6  (bases 1 to 3259)
  AUTHORS   Inooka,H., Endo,S., Kitada,C., Mizuta,E. and Fujino,M.
  TITLE     Pituitary adenylate cyclase activating polypeptide (PACAP) with 27
            residues. Conformation determined by 1H NMR and CD spectroscopies
            and distance geometry in 25% methanol solution
  JOURNAL   Int J Pept Protein Res 40 (5), 456-464 (1992)
   PUBMED   1483839
REFERENCE   7  (bases 1 to 3259)
  AUTHORS   Okazaki,K., Kimura,C., Kosaka,T., Watanabe,T., Ohkubo,S., Ogi,K.,
            Kitada,C., Onda,H. and Fujino,M.
  TITLE     Expression of human pituitary adenylate cyclase activating
            polypeptide (PACAP) cDNA in CHO cells and characterization of the
            products
  JOURNAL   FEBS Lett 298 (1), 49-56 (1992)
   PUBMED   1544422
REFERENCE   8  (bases 1 to 3259)
  AUTHORS   Hosoya,M., Kimura,C., Ogi,K., Ohkubo,S., Miyamoto,Y., Kugoh,H.,
            Shimizu,M., Onda,H., Oshimura,M., Arimura,A. et al.
  TITLE     Structure of the human pituitary adenylate cyclase activating
            polypeptide (PACAP) gene
  JOURNAL   Biochim Biophys Acta 1129 (2), 199-206 (1992)
   PUBMED   1730060
REFERENCE   9  (bases 1 to 3259)
  AUTHORS   Ohkubo,S., Kimura,C., Ogi,K., Okazaki,K., Hosoya,M., Onda,H.,
            Miyata,A., Arimura,A. and Fujino,M.
  TITLE     Primary structure and characterization of the precursor to human
            pituitary adenylate cyclase activating polypeptide
  JOURNAL   DNA Cell Biol 11 (1), 21-30 (1992)
   PUBMED   1739432
REFERENCE   10 (bases 1 to 3259)
  AUTHORS   Kimura,C., Ohkubo,S., Ogi,K., Hosoya,M., Itoh,Y., Onda,H.,
            Miyata,A., Jiang,L., Dahl,R.R., Stibbs,H.H. et al.
  TITLE     A novel peptide which stimulates adenylate cyclase: molecular
            cloning and characterization of the ovine and human cDNAs
  JOURNAL   Biochem Biophys Res Commun 166 (1), 81-89 (1990)
   PUBMED   2302217
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000894.6, DC320719.1 and
            BC093837.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001099733.1.
            
            Summary: This gene encodes a secreted proprotein that is further
            processed into multiple mature peptides. These peptides stimulate
            adenylate cyclase and increase cyclic adenosine monophosphate
            (cAMP) levels, resulting in the transcriptional activation of
            target genes. The products of this gene are key mediators of
            neuroendocrine stress responses. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Feb 2013].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX333515.2, BX353189.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670, SAMEA2152568
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000450565.8/ ENSP00000411658.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AP000894.6         109675-109746
            73-351              DC320719.1         1-279
            352-771             BC093837.1         232-651
            772-3259            AP000894.6         114489-116976
FEATURES             Location/Qualifiers
     source          1..3259
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.32"
     gene            1..3259
                     /gene="ADCYAP1"
                     /gene_synonym="PACAP"
                     /note="adenylate cyclase activating polypeptide 1"
                     /db_xref="GeneID:116"
                     /db_xref="HGNC:HGNC:241"
                     /db_xref="MIM:102980"
     exon            1..190
                     /gene="ADCYAP1"
                     /gene_synonym="PACAP"
                     /inference="alignment:Splign:2.1.0"
     exon            191..301
                     /gene="ADCYAP1"
                     /gene_synonym="PACAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..722
                     /gene="ADCYAP1"
                     /gene_synonym="PACAP"
                     /note="pituitary adenylate cyclase-activating polypeptide;
                     prepro-PACAP; adenylate cyclase activating polypeptide 1
                     (pituitary)"
                     /codon_start=1
                     /product="pituitary adenylate cyclase-activating
                     polypeptide preproprotein"
                     /protein_id="NP_001093203.1"
                     /db_xref="CCDS:CCDS11825.1"
                     /db_xref="GeneID:116"
                     /db_xref="HGNC:HGNC:241"
                     /db_xref="MIM:102980"
                     /translation="MTMCSGARLALLVYGIIMHSSVYSSPAAAGLRFPGIRPEEEAYG
                     EDGNPLPDFDGSEPPGAGSPASAPRAAAAWYRPAGRRDVAHGILNEAYRKVLDQLSAG
                     KHLQSLVARGVGGSLGGGAGDDAEPLSKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGK
                     RYKQRVKNKGRRIAYL"
     exon            302..433
                     /gene="ADCYAP1"
                     /gene_synonym="PACAP"
                     /inference="alignment:Splign:2.1.0"
     exon            434..532
                     /gene="ADCYAP1"
                     /gene_synonym="PACAP"
                     /inference="alignment:Splign:2.1.0"
     exon            533..3259
                     /gene="ADCYAP1"
                     /gene_synonym="PACAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      839..844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADCYAP1"
                     /gene_synonym="PACAP"
                     /note="hexamer: AGTAAA"
     polyA_site      857
                     /gene="ADCYAP1"
                     /gene_synonym="PACAP"
     regulatory      2120..2125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADCYAP1"
                     /gene_synonym="PACAP"
                     /note="hexamer: AGTAAA"
     polyA_site      2144
                     /gene="ADCYAP1"
                     /gene_synonym="PACAP"
                     /note="major polyA site"
     regulatory      3236..3241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADCYAP1"
                     /gene_synonym="PACAP"
                     /note="hexamer: AATAAA"
     polyA_site      3259
                     /gene="ADCYAP1"
                     /gene_synonym="PACAP"
ORIGIN      
        1 agaacacgag cctcggcaaa cgagtcccgc agctcctcct gctgctcccg ctggttcctg
       61 cggcttctgc tcagacacca acgccagacg gcgatgcctc tcgggtggtg actccagcgc
      121 aggaacttga agaagcgctt tgcccgccgt cctacctggc agctctcctg gcagcgggag
      181 gagttgaagg aatgaccatg tgtagcggag cgaggctggc cctgctggtc tatgggataa
      241 tcatgcacag cagcgtctac agctcacctg ccgccgccgg actccggttc cccgggatca
      301 ggccagagga agaggcgtac ggcgaggacg gaaacccgct gccagacttc gatggctcgg
      361 agccgccggg cgcagggagc cccgcctccg cgccgcgcgc cgccgccgcc tggtaccgcc
      421 cggccgggag aagagatgtc gcccacggga tccttaacga ggcctaccgc aaagtgctgg
      481 accagctgtc cgccgggaag cacctgcagt cgctcgtggc ccggggcgtg ggtgggagcc
      541 tcggcggcgg cgcgggggac gacgcggagc cgctctccaa gcgccactcg gacgggatct
      601 tcacggacag ctacagccgc taccggaaac aaatggctgt caagaaatac ttggcggccg
      661 tcctagggaa gaggtataaa caaagggtta aaaacaaagg acgccgaata gcttatttgt
      721 agcgatgggt taccagctac cctgtgtata cagccctgac gcaatgaaaa gtcgttttcc
      781 aaactgactc aacagtcatc gctcgtgtgt tctatccaaa catgtattta tgtaatgaag
      841 taaagccatt aaatgaatat tttgataata atattgtttt tctttctaca aagcactaga
      901 gaatgcacag atatactttg tggaccaatt attgatatat attataaata tatataaaga
      961 atatatatat atatatatat atatatatat ataaagtata gagagaagtt catacaaagc
     1021 gtgcacaagg attgaaaatt cgcccgagct gtttatgttt ttataaaaat aaatagaaaa
     1081 gtagacaatc attgttttga atattactcc tatttttgta aactggaatt aaaaggatag
     1141 tatttttatc catgacaggc ctgaagatat tactacttac catttgctac tgtacataaa
     1201 caatgatgcc ctgctccagg gagattttga ggtaaagata tggagaattg ctgaagggca
     1261 ttctttccca gtgagtctct ggggcaggct gcttcaatcc cagcctaact caactgggct
     1321 ctgtccccct ggttgggtgg caattccaat atttctgctt tctttgattc tccttttatg
     1381 tgtagttgtc tctcttcaga ctctcagccc agaagaaaat tctcctgata aaacaacagc
     1441 tcgatccaaa ttgtgcttct ccccagaatt cacgcctctc cctaggagaa gagttgagga
     1501 actgtacaga aaagggcggc ttcgttagac cgctctcttt tctgtacttc ctgagtggcc
     1561 agggaatcta atatccccaa attagggcaa ttggaacaaa gtgaaggaca tagaggtata
     1621 ttggaagagg cagagcctga ggtggtagga ggaggaccct ggaaatggac tggtttgaga
     1681 ttgccccagg tctgggaagc tgagggcaaa tccagtccca atggtcctga ctttgggcgc
     1741 tgggtattgg aaatggatgc aaagtacaat gtgtttttct ccagtgctgt ccatgcttct
     1801 catcttgtga aatggccagg atcctctcct ttgaaacctg ctctgtagga gctacccttt
     1861 tcctttgtgg ttttatggag acctctcctt cctaccctcc tgcactgttt aagtactgtt
     1921 taccattttt cattcacttc tcttaaactt gtgaatgctt ctcacttttt ttttttgttt
     1981 gatgcaggca cttattgtaa attttagaaa cccctctgta gccactagta agtaattatg
     2041 cactaaatat gaaccctttg tttcttgttt attgagtttg taggtaaaat gtatttttct
     2101 acattattgc ttattgctta gtaaaattta tttcataaaa ccaacctttg tcatattaga
     2161 atgtgtagtg ttcacatgtt gctcagtttt gctaactgat aaatcattta atcctcttct
     2221 tcatatgtat gagtactatc ttatatctgt ggtcaagagt gaggtaagca agctccaaca
     2281 gaccctgaga acctacgctt gtatcctttc tttggctaaa gaaagcatgt ctgtttcctg
     2341 tcaattcttt gaacatacag agtaatcttt ataaacaaaa gaaccttcac ccagcaatca
     2401 gatcgagcag caacagacaa accagccagc caatctccca aatttcaggc acaagtttat
     2461 ttatttattt ttttatgttt tgaaaaaaga agatgaagaa gaagaaaaaa aaaagaacaa
     2521 ggaaagatta aacgttagct tgtaaagttt aaaggacctt tccttttcct ttacggattt
     2581 gatcagtatg aagtcataaa tcaaagaaaa cagaattgga tttgcattcc caggcgggat
     2641 ggatgctgcc aggagatcac attgcaaata gtgaaaacag aggcattcgg tctatgcctg
     2701 agtcctgtgt ataggatcaa tcttccttta attccgcagt ctcctcaggc aatgtgacac
     2761 gggatgcagt ttgcagcttt agtgcctttc ttcgcctttt aaattgccac gaatcacaga
     2821 tggctattta gtggccctac aatgctgcaa cacatcagct tgcattttag tcttaattat
     2881 ttgtttcttg gataatgggc agagttttct gtatttgtat cagctgttag tggtgaaata
     2941 gggctctagt taacctttta tttatgaagt ctaatttagt gttcccgtgg ctagttgcaa
     3001 gcattttaca gtgatcaccc agtttaatct tttgtatact ttttagaaat gccaagagcc
     3061 ttactaaact gaagcagatt tatgatatag tgataattta ggtagatgtt agtcttgaag
     3121 ctcttatttt gtgtgcaact gattataaaa acaccttaac caagtattat tacacacatg
     3181 atatctataa ctaggacttt gataactgtt atataaagtg tgtaaaattt gtatgaataa
     3241 atttttgtaa acaatgcaa
//
