LOCUS       NM_001116               7980 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens adenylate cyclase 9 (ADCY9), mRNA.
ACCESSION   NM_001116
VERSION     NM_001116.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7980)
  AUTHORS   Teixeira,H.M.P., Cruz,A.A., Jesus,T.S., de Santana,M.B.R.,
            Jesus,M.S., Tugores,R., Araujo,W.S., Reis,R.C.C., Pinheiro,G.P.,
            Figueiredo,C.A. and Costa,R.S.
  TITLE     The rs2601796 variant in ADCY9 gene is associated with severe
            asthma and less bronchodilator response
  JOURNAL   Gene 886, 147714 (2023)
   PUBMED   37579959
  REMARK    GeneRIF: The rs2601796 variant in ADCY9 gene is associated with
            severe asthma and less bronchodilator response.
REFERENCE   2  (bases 1 to 7980)
  AUTHORS   Chen,Z. and Antoni,F.A.
  TITLE     Human adenylyl cyclase 9 is auto-stimulated by its isoform-specific
            C-terminal domain
  JOURNAL   Life Sci Alliance 6 (4), e202201791 (2023)
   PUBMED   36657828
  REMARK    GeneRIF: Human adenylyl cyclase 9 is auto-stimulated by its
            isoform-specific C-terminal domain.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7980)
  AUTHORS   Jia,J.J., Wei,B., Li,L.X., Ren,M.Y., Zhang,S.N., Liu,J. and
            Zhang,Y.X.
  TITLE     [Association of the ADCY9 gene and gene-environmental interaction
            with the susceptibility to childhood bronchial asthma]
  JOURNAL   Zhongguo Dang Dai Er Ke Za Zhi 24 (9), 1027-1035 (2022)
   PUBMED   36111722
  REMARK    GeneRIF: [Association of the ADCY9 gene and gene-environmental
            interaction with the susceptibility to childhood bronchial
            asthma].', trans 'ADCY9.
REFERENCE   4  (bases 1 to 7980)
  AUTHORS   Gamache,I., Legault,M.A., Grenier,J.C., Sanchez,R., Rheaume,E.,
            Asgari,S., Barhdadi,A., Zada,Y.F., Trochet,H., Luo,Y., Lecca,L.,
            Murray,M., Raychaudhuri,S., Tardif,J.C., Dube,M.P. and Hussin,J.
  TITLE     A sex-specific evolutionary interaction between ADCY9 and CETP
  JOURNAL   Elife 10, e69198 (2021)
   PUBMED   34609279
  REMARK    GeneRIF: A sex-specific evolutionary interaction between ADCY9 and
            CETP.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7980)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 7980)
  AUTHORS   Paterson,J.M., Smith,S.M., Simpson,J., Grace,O.C., Sosunov,A.A.,
            Bell,J.E. and Antoni,F.A.
  TITLE     Characterisation of human adenylyl cyclase IX reveals inhibition by
            Ca(2+)/Calcineurin and differential mRNA plyadenylation
  JOURNAL   J Neurochem 75 (4), 1358-1367 (2000)
   PUBMED   10987815
REFERENCE   7  (bases 1 to 7980)
  AUTHORS   Hacker,B.M., Tomlinson,J.E., Wayman,G.A., Sultana,R., Chan,G.,
            Villacres,E., Disteche,C. and Storm,D.R.
  TITLE     Cloning, chromosomal mapping, and regulatory properties of the
            human type 9 adenylyl cyclase (ADCY9)
  JOURNAL   Genomics 50 (1), 97-104 (1998)
   PUBMED   9628827
REFERENCE   8  (bases 1 to 7980)
  AUTHORS   Tesmer,J.J., Sunahara,R.K., Gilman,A.G. and Sprang,S.R.
  TITLE     Crystal structure of the catalytic domains of adenylyl cyclase in a
            complex with Gsalpha.GTPgammaS
  JOURNAL   Science 278 (5345), 1907-1916 (1997)
   PUBMED   9417641
REFERENCE   9  (bases 1 to 7980)
  AUTHORS   Dessauer,C.W. and Gilman,A.G.
  TITLE     Purification and characterization of a soluble form of mammalian
            adenylyl cyclase
  JOURNAL   J Biol Chem 271 (28), 16967-16974 (1996)
   PUBMED   8663304
REFERENCE   10 (bases 1 to 7980)
  AUTHORS   Premont,R.T., Matsuoka,I., Mattei,M.G., Pouille,Y., Defer,N. and
            Hanoune,J.
  TITLE     Identification and characterization of a widely expressed form of
            adenylyl cyclase
  JOURNAL   J Biol Chem 271 (23), 13900-13907 (1996)
   PUBMED   8662814
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005736.1, AJ133123.1 and
            BQ614080.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001116.3.
            
            Summary: Adenylate cyclase is a membrane bound enzyme that
            catalyses the formation of cyclic AMP from ATP. It is regulated by
            a family of G protein-coupled receptors, protein kinases, and
            calcium. The type 9 adenylyl cyclase is a widely distributed
            adenylyl cyclase, and it is stimulated by beta-adrenergic receptor
            activation but is insensitive to forskolin, calcium, and
            somatostatin. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC151229.1, AB011092.3 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294016.8/ ENSP00000294016.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-753               AC005736.1         25405-26157
            754-2489            AC005736.1         26362-28097
            2490-3446           AJ133123.1         2232-3188
            3447-3448           AC005736.1         162703-162704
            3449-3957           AJ133123.1         3191-3699
            3958-7535           AC005736.1         175172-178749
            7536-7980           BQ614080.1         19-463              c
FEATURES             Location/Qualifiers
     source          1..7980
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..7980
                     /gene="ADCY9"
                     /gene_synonym="AC9; ACIX"
                     /note="adenylate cyclase 9"
                     /db_xref="GeneID:115"
                     /db_xref="HGNC:HGNC:240"
                     /db_xref="MIM:603302"
     exon            1..753
                     /gene="ADCY9"
                     /gene_synonym="AC9; ACIX"
                     /inference="alignment:Splign:2.1.0"
     exon            754..2489
                     /gene="ADCY9"
                     /gene_synonym="AC9; ACIX"
                     /inference="alignment:Splign:2.1.0"
     CDS             797..4858
                     /gene="ADCY9"
                     /gene_synonym="AC9; ACIX"
                     /EC_number="4.6.1.1"
                     /note="type IX ATP pyrophosphate-lyase; adenylyl cyclase
                     9; ATP pyrophosphate-lyase 9; adenylate cyclase type IX"
                     /codon_start=1
                     /product="adenylate cyclase type 9"
                     /protein_id="NP_001107.2"
                     /db_xref="CCDS:CCDS32382.1"
                     /db_xref="GeneID:115"
                     /db_xref="HGNC:HGNC:240"
                     /db_xref="MIM:603302"
                     /translation="MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPK
                     HCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSVNLEE
                     ACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFF
                     LFTFTKLYARHYAWTSLALTLLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCL
                     SQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGA
                     LHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMI
                     HSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEE
                     VSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAG
                     CPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFD
                     VWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLGQSVVADQLKGL
                     KTYLISGQRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKTF
                     DNLKTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGLLSPPQE
                     EKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKD
                     YFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFASPTFSSLLDVFLSTTVF
                     LTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLL
                     EWIAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTGSAALIAVVHYCNFCQ
                     LSSWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSERNPCNSSVPRDLR
                     RPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADW
                     LLRNIIPYHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNEL
                     IGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEMM
                     RVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVEC
                     RIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDHRVIPQHQLSISPDI
                     RVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLSPKRPWKEPVKAEE
                     RGRFGKAIEKDDCDETGIEEANELTKLNVSKSV"
     exon            2490..2680
                     /gene="ADCY9"
                     /gene_synonym="AC9; ACIX"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..2785
                     /gene="ADCY9"
                     /gene_synonym="AC9; ACIX"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..3003
                     /gene="ADCY9"
                     /gene_synonym="AC9; ACIX"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3106
                     /gene="ADCY9"
                     /gene_synonym="AC9; ACIX"
                     /inference="alignment:Splign:2.1.0"
     exon            3107..3315
                     /gene="ADCY9"
                     /gene_synonym="AC9; ACIX"
                     /inference="alignment:Splign:2.1.0"
     exon            3316..3475
                     /gene="ADCY9"
                     /gene_synonym="AC9; ACIX"
                     /inference="alignment:Splign:2.1.0"
     exon            3476..3624
                     /gene="ADCY9"
                     /gene_synonym="AC9; ACIX"
                     /inference="alignment:Splign:2.1.0"
     exon            3625..3666
                     /gene="ADCY9"
                     /gene_synonym="AC9; ACIX"
                     /inference="alignment:Splign:2.1.0"
     exon            3667..7980
                     /gene="ADCY9"
                     /gene_synonym="AC9; ACIX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5711..5716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADCY9"
                     /gene_synonym="AC9; ACIX"
                     /note="hexamer: AATAAA"
     polyA_site      5730
                     /gene="ADCY9"
                     /gene_synonym="AC9; ACIX"
                     /note="major polyA site"
     regulatory      7958..7963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADCY9"
                     /gene_synonym="AC9; ACIX"
                     /note="hexamer: ATTAAA"
     polyA_site      7980
                     /gene="ADCY9"
                     /gene_synonym="AC9; ACIX"
                     /note="major polyA site"
ORIGIN      
        1 agtgacagcg ggcggggcag gggccggaga tggtggcggc ggcagctctt ccgacatgag
       61 gcagcggccg cgggggacac ggcggcgggc gcggcggcgg ccgcatctct agctcgggga
      121 ggcggccccc ggcgtgggcg cgggcgggcg ggcgtcccgg ccggcgtcgc gggagcccgg
      181 ctctgcggca gcgtctgcac cgccgcccgg cgaggggccc gcgtccgtgg ttccacgcgc
      241 tcggtcccgg gacagctgcg gccgcggcgg gagcggcggc gcactcgggg ggaagcaggc
      301 cccactagac gggccgcgcc gacgggctcc gcgcactcgc agcccggggc gcccccaccc
      361 ccagcgcccg ccgccgcggg cagggccggc ccggagcgcg gggggcggcc ggggagcgcg
      421 agccgggggc gcccgccgaa gctcgctgct ccgggtcggg gtccgggccc ggggccggcc
      481 gcgcgccgcc tttgacgcat cggagcgcgg ctcctgcagg atggagggct ccgcgccgcc
      541 agcggagttg tttgtgcgca ggcggctcgc ggggctggga gcgctcaagg tctgaacttc
      601 cctccggagc cgcagctgga ggaggcgagc gcgcgaggag gagaagccgc gcggcgcgga
      661 ggccaccctc ggggcgagag gcgcggaagg cgagcgagca aagcggtccc ggagccacgg
      721 cggccacgcg gcggggaccc ccgggcgttc taggtactgg tgaccccggc cggggcaggc
      781 cccgggactc gacaacatgg cttccccacc ccaccagcag ctgctgcatc accacagcac
      841 cgaggtgagc tgcgactcca gcggggacag caacagcgtg cgcgtcaaga tcaaccccaa
      901 gcagctgtcc tccaacagcc accccaagca ctgcaaatac agcatctcct ctagctgcag
      961 cagctctggg gactccgggg gcgtcccccg gcgagtgggc ggcggaggcc ggctgcgcag
     1021 gcagaagaag ctgccccagc tgttcgagag ggcctccagc cgctggtggg accccaagtt
     1081 cgactcggtg aacctggagg aggcctgcct ggagcgctgc ttcccgcaga cccagcgccg
     1141 gttccggtat gcgctcttct acatcggctt cgcctgcctt ctgtggagca tctattttgc
     1201 ggtccacatg agatccagac tgatcgtcat ggtcgccccc gcgctgtgct tcctcctggt
     1261 gtgtgtgggc ttctttctgt ttaccttcac caagctgtac gcccggcatt acgcgtggac
     1321 ctcgctggct ctcaccctgc tggtgttcgc cctgaccctg gctgcgcagt tccaggtctt
     1381 gacgcctgtc tcaggacgcg gcgacagctc caaccttacg gccacagccc ggcccacaga
     1441 tacttgctta tctcaagtgg ggagcttctc catgtgcatc gaagtgctct ttttgctcta
     1501 taccgtcatg cacttacctt tgtacctgag tttgtgtctg ggggtggcct actctgtcct
     1561 tttcgagacc tttggctacc atttccggga tgaagcctgc ttcccctcgc ccggagccgg
     1621 ggccctgcac tgggagctgc tgagcagggg gctgctccac ggctgcatcc acgccatcgg
     1681 ggtccacctg ttcgtcatgt cccaggtgag gtccaggagc accttcctca aggtggggca
     1741 atccattatg cacgggaagg acctggaagt ggaaaaagcc ctcaaagaga ggatgattca
     1801 ttccgtgatg ccaagaatca tagccgatga cttaatgaag cagggagatg aggagagtga
     1861 gaattctgtc aagaggcatg ccacctcgag ccccaagaac aggaagaaaa agtcttccat
     1921 ccaaaaagct cctatagcct tccgcccttt taagatgcag cagatcgaag aagtcagtat
     1981 tttatttgca gatatcgtgg gcttcaccaa gatgagtgcc aacaagtctg cccacgccct
     2041 ggtgggtctc ctgaacgatc tgttcggtcg cttcgaccgc ctgtgtgagg agaccaagtg
     2101 tgagaaaatc agcaccctgg gagactgtta ctactgcgtg gcgggctgtc ccgagccccg
     2161 ggccgaccat gcctactgct gcatcgagat gggcctgggc atgatcaagg ccatcgagca
     2221 gttctgccag gagaagaagg agatggtgaa catgagagtc ggggtgcaca cgggcaccgt
     2281 cctttgcggc atcctgggca tgaggaggtt taaatttgac gtgtggtcca acgatgtgaa
     2341 cctggccaat ctcatggagc agctgggagt ggccggcaaa gttcacattt ctgaggccac
     2401 cgcaaaatac ttagatgacc ggtacgaaat ggaagatggg aaagttattg aacggctggg
     2461 ccagagcgtg gttgctgacc agttgaaagg tttgaagaca tacctgatat cgggtcagag
     2521 agccaaggag tctcgctgca gctgtgcaga ggccttgctt tctggctttg aggtcattga
     2581 cggctcacag gtgtcctcag gccctagggg acaggggaca gcgtcatcag ggaatgtcag
     2641 tgacttggcg cagactgtca aaacctttga taaccttaag acctgccctt cgtgcggaat
     2701 cacatttgct cccaaatctg aagccggcgc cgagggagga gcacctcaaa acggctgcca
     2761 agacgagcat aaaaacagca ccaaggcttc tggaggacct aatcccaaaa ctcagaacgg
     2821 gctcctcagc cctccccaag aggagaagct caccaacagt cagacttctc tgtgtgagat
     2881 cttgcaggag aagggaaggt gggcaggggt gagcctggac cagtcggctc tccttccgct
     2941 gaggttcaag aacatccggg agaaaacgga cgcccacttt gtggacgtta tcaaagaaga
     3001 cagcctgatg aaagattact tttttaagcc gcccattaat cagttcagcc tgaacttcct
     3061 ggatcaggag ctggagcgat cctacaggac cagctatcag gaagaggtca taaagaactc
     3121 ccccgtgaag acgtttgcta gtcccacctt cagctccctc ctggatgtgt ttctgtcgac
     3181 cacagtgttt ctgacgctgt ccaccacctg cttcctgaag tacgaggcgg ccaccgtgcc
     3241 tcccccgccc gccgccctgg cggtcttcag tgcagccctg ctgctggagg tgctgtccct
     3301 cgcggtgtcc atcaggatgg tgttcttcct ggaggacgtc atggcctgca ccaagcgcct
     3361 gctggagtgg atcgccggct ggctaccacg tcactgcatc ggggccatcc tggtgtcgct
     3421 tcccgcactg gccgtctact cccatgtcac ctccgaatat gagaccaaca tacacttccc
     3481 agtgttcaca ggctcggccg cgctgattgc cgtcgtgcac tactgtaact tctgccagct
     3541 cagctcctgg atgaggtcct ccctcgccac cgtcgtgggg gccgggccgc tgctcctgct
     3601 ctacgtctcc ctgtgcccag acagttctgt attaacttcg ccccttgacg cagtacagaa
     3661 tttcagttcc gagaggaacc cgtgcaatag ttcggtgccg cgtgacctcc ggcggcccgc
     3721 cagcctcatc ggccaggagg tggttctcgt cttctttctc ctgctcttgt tggtctggtt
     3781 cctgaatcgc gaatttgaag tcagctaccg cctccactac cacggagacg tggaagcgga
     3841 tcttcaccgc accaagatcc agagcatgcg ggaccaggca gactggctgc tgaggaacat
     3901 catcccctac cacgtggctg agcagctgaa ggtgtcccag acctactcca agaaccatga
     3961 cagcggaggg gtgatcttcg ccagcatcgt caacttcagc gagttctacg aggagaacta
     4021 cgagggcggc aaggagtgct accgggtcct caacgagctc atcggggact ttgacgagct
     4081 cctaagcaag ccggactaca gcagcatcga gaagatcaag accatcggag ccacgtacat
     4141 ggcggcgtca gggctgaaca ccgcgcaggc ccaggacggc agccacccgc aggagcacct
     4201 gcagatcctg ttcgagttcg ccaaggagat gatgcgcgtg gtggacgact tcaacaacaa
     4261 catgctgtgg ttcaacttca agctccgcgt cggcttcaac catgggcccc tcacggccgg
     4321 ggtcatcggc accaccaagc tgctgtacga catctgggga gacaccgtca acatcgccag
     4381 caggatggac accaccggcg tggagtgccg catccaggtg agcgaagaga gctaccgcgt
     4441 cttgagcaag atgggctatg acttcgacta cagagggacc gtgaatgtca aggggaaagg
     4501 ccagatgaag acctacctgt acccaaagtg cacggatcac agggtcatcc cacagcacca
     4561 gctgtccatc tccccagaca tccgcgtcca ggtggatggc agcatcggac ggtctcccac
     4621 agacgagatt gccaacctgg tgccttctgt ccagtatgtg gacaagacat ctctgggttc
     4681 tgacagcagc acgcaggcca aggatgccca cctgtccccc aagagaccgt ggaaggagcc
     4741 cgtcaaagcc gaagaaaggg gtcgatttgg caaagccata gagaaagacg actgtgacga
     4801 aacaggaata gaagaagcca acgaactcac caagctcaac gtttcaaaga gtgtgtgagg
     4861 cggcgcccac ccgctgcccg aggtgctctg tttgtcgaaa cacagtaata tttgtatttg
     4921 gctgttgtgc tttccaagcg ccacagttgc cctccccgga cgtggtgtta tgtggtcatt
     4981 tcagccctaa cttctgtgtg gatcacagtt attcagggtt cattttcatc cattcttccc
     5041 tttcgctccc ttccctggaa accccgctgc ctctgggtca tccgttcagc acgtggtgga
     5101 gaacaagtgc cttcagggct ggcctcggcc tcgagtctcg ggacagaggc cgccagtgga
     5161 gatcatggct ttgggtatta tttgactttt agaacaaaag ctgtggttaa gatctcattt
     5221 ttattgcttt ttcccacgtc ccacgagaca ctattttcgg ttctctggct aataccctgt
     5281 ttttgagttt attttgtttc tgtctatgtc acagtgttcc tctacgaccc gacctctcta
     5341 tgtaagcaca catgcgcaca cacacttgca ttcatgaatc tgatataaag tgccagtaat
     5401 ccgccaagag ggggtgcgaa gggggcatgt cacgacagct ccgccacccc ccattgccca
     5461 cccgcacttt cccgagcacc gcgccccgtg ggctgtgggt gagccgcgct ccctgcactg
     5521 agcgggttta ggggctcgcc cacatgcatg caggccaaga cagcaaatgc cagccgggca
     5581 cgacgcccgt gtgcccaggc ctcgggggtc tcagagccgc ctctcacccc cgaccctcca
     5641 cccaggggtc tccccatcgg gagtggaggt gttggtcctg gaagctgact catcggagag
     5701 ggaaatacca aataaacatc cgaggttgca tttatttatt tatttattta cccggaagca
     5761 tgtgcgctcc cgggaggggt gctgggtcct cagggtgggg ggtcatagcc acaggggagg
     5821 gcagttccca ggaaggtaac cagatgtctc ttttgtgttt tggccacctg gggccgcccc
     5881 caacctcccc accccaagag gggtctgagt gggacctcaa agcatggcca gtgcaattct
     5941 gaggctaggg gaataggaga agcccaccag ctgcccctgc cacccacggg ggctcctccc
     6001 tgccggggtc cagctcagaa ccacgggggt ctgtgccggc agcaccggtg ccatcttggc
     6061 ttccacaaat tccagaagtt tcttggctgc ctcccgctct cagatggcac agggcctatc
     6121 agtggcagga tttaatctgg ggagcaaatt ccagctctga aatggagttc tcacaccgta
     6181 tctagggaca gaggcatctg gatgcaaacg cggggtttgt taggggcgga atcccgaggg
     6241 tggtgtgggg gagctccgtc cgggcagttg gctgctggtc ctgtctgatt atgttttgcc
     6301 atattgagtc tgaagtttgt gtggaagtga gctcgcccga gttgtccggt cggagttgta
     6361 gccagtcttt caggggaccc cgggacgctg atgaggccca gggtgcactc cttgtcagtc
     6421 ttgcccgttg tccctgtgca ttttgctttc cgctgtcaaa tctcactgtc tcgttttcac
     6481 accgcatcag tccccatcat cactactcct ccccagagac atacagattg ccctccccgg
     6541 catgaagaag tcacaattct gacccgccac ctctccaggg gcggtgcctg ggatggccac
     6601 ccatcaggac agccagagcc agggtcccgg cgtcctgaga gtccagggca cctcccccca
     6661 ttagctgtaa ggtttcctgt caggtgtgac tgtcagtttg ctggtcttcc aataccgaag
     6721 aaagggtggt tgtgacaata cctcttgctt ctaaagaatg tattataaaa caccgcagat
     6781 tttttttttt ccttaaaaaa cactacctga tgctttcctt gttcgtgggg attgtggtca
     6841 catgaagctc tttctgcatc agtattaagg tgtatatttg aatgtcctcc cctccccttt
     6901 cccctccagg ctgtgtagct ttgaggggct gggcgtttgc tcacgacctt gctgtctcgc
     6961 tcagaacatg ctccgcaaag ttctccgcac acacttcttc cccatcaagc ccatttcctt
     7021 ccccaaccac aaaggtgttt gtgattcctc accccgggaa accaaggagc tgcaaagtgg
     7081 agtctggttc agccccgtgc agactcaccc agagcttaac gttgtctttc aaacaccctg
     7141 agccttccta aacagccagt gcagacgttc tctctgggcc acgaagcccc tcgggtcctc
     7201 cccgtcccct gctccgatgc atacctcagt gcagaaccac agaatctctg cagcggaaac
     7261 gccgtgcatc tcttgtctgt tggcagcgag cacatcgtgc tggagacacg agtttctaag
     7321 cagctggcac gagggctgct gacggcatgg gtcgtgcttc agggtggcaa tacctcttag
     7381 gaacttaggg caggaagcaa tacttcagca ttgaatgtgt gtaaatagtt gctttgagtt
     7441 gcaattgcta ttttcttctc agtcccagct cagatcgaat tatatatcca tatatatata
     7501 tatatatata tatatatata tatatatata tatatggtaa acaagcacac acaattttat
     7561 ccaatgcaaa caaatgtaga gcatcagtta caaaaccctc gaatagcttg agagccccac
     7621 aggctctgcc acacccgtga cttcatccac actgacgtca cccgcggggg ctccccctgc
     7681 acatttgcac acgatccgga gagccgaagg ccgcgtgctt cctgtcacat gggctgtaat
     7741 catttgtagt ttccaaagac acgtctgcat ttgaatttct agattttcga ggtaaggagt
     7801 tttttttaat tggttgtttg gaaaatcaca tcatgcctag aatctgaaat tgaattagca
     7861 agaaccgact gtttgcattt tccatatatc cttttatctg ctctttttaa attgttaatt
     7921 ctaataattt caaaatgcat tcactgaaga aatggacatt aaaatattct aaaatttaaa
//
