LOCUS       NM_001114               6271 bp    mRNA    linear   PRI 29-APR-2025
DEFINITION  Homo sapiens adenylate cyclase 7 (ADCY7), transcript variant 1,
            mRNA.
ACCESSION   NM_001114 XM_017022895
VERSION     NM_001114.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6271)
  AUTHORS   Cai,L., Wang,Y., Wu,J. and Wu,G.
  TITLE     Hsa_circ_0008234 facilitates proliferation of cutaneous squamous
            cell carcinoma through targeting miR-127-5p to regulate ADCY7
  JOURNAL   Arch Dermatol Res 314 (6), 541-551 (2022)
   PUBMED   34143288
  REMARK    GeneRIF: Hsa_circ_0008234 facilitates proliferation of cutaneous
            squamous cell carcinoma through targeting miR-127-5p to regulate
            ADCY7.
REFERENCE   2  (bases 1 to 6271)
  AUTHORS   Alhaidan,Y., Christesen,H.T., Lundberg,E., Balwi,M.A.A. and
            Brusgaard,K.
  TITLE     CRISPR/Cas9 ADCY7 Knockout Stimulates the Insulin Secretion Pathway
            Leading to Excessive Insulin Secretion
  JOURNAL   Front Endocrinol (Lausanne) 12, 657873 (2021)
   PUBMED   34177802
  REMARK    GeneRIF: CRISPR/Cas9 ADCY7 Knockout Stimulates the Insulin
            Secretion Pathway Leading to Excessive Insulin Secretion.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6271)
  AUTHORS   He,B., Chang,Y., Yang,C., Zhang,Z., Xu,G., Feng,X. and Zhuang,L.
  TITLE     Adenylate cyclase 7 regulated by miR-192 promotes ATRA-induced
            differentiation of acute promyelocytic leukemia cells
  JOURNAL   Biochem Biophys Res Commun 506 (3), 543-547 (2018)
   PUBMED   30366671
  REMARK    GeneRIF: AC7 and miR-192 might be new biomarkers and therapeutic
            targets for patients with relapsed acute promyelocytic leukemia.
REFERENCE   4  (bases 1 to 6271)
  AUTHORS   Luo,Y., de Lange,K.M., Jostins,L., Moutsianas,L., Randall,J.,
            Kennedy,N.A., Lamb,C.A., McCarthy,S., Ahmad,T., Edwards,C.,
            Serra,E.G., Hart,A., Hawkey,C., Mansfield,J.C., Mowat,C.,
            Newman,W.G., Nichols,S., Pollard,M., Satsangi,J., Simmons,A.,
            Tremelling,M., Uhlig,H., Wilson,D.C., Lee,J.C., Prescott,N.J.,
            Lees,C.W., Mathew,C.G., Parkes,M., Barrett,J.C. and Anderson,C.A.
  TITLE     Exploring the genetic architecture of inflammatory bowel disease by
            whole-genome sequencing identifies association at ADCY7
  JOURNAL   Nat Genet 49 (2), 186-192 (2017)
   PUBMED   28067910
  REMARK    GeneRIF: We discovered a 0.6% frequency missense variant in ADCY7.
REFERENCE   5  (bases 1 to 6271)
  AUTHORS   Li,C., Xie,J., Lu,Z., Chen,C., Yin,Y., Zhan,R., Fang,Y., Hu,X. and
            Zhang,C.C.
  TITLE     ADCY7 supports development of acute myeloid leukemia
  JOURNAL   Biochem Biophys Res Commun 465 (1), 47-52 (2015)
   PUBMED   26220344
  REMARK    GeneRIF: The ADCY7 deficiency resulted in decreased cell growth,
            elevated apoptosis, and lower c-Myc expression in cultured leukemia
            cells obtained from acute myeloid leukemia patients.
REFERENCE   6  (bases 1 to 6271)
  AUTHORS   Hellevuo,K., Welborn,R., Menninger,J.A. and Tabakoff,B.
  TITLE     Human adenylyl cyclase type 7 contains polymorphic repeats in the
            3' untranslated region: investigations of association with
            alcoholism
  JOURNAL   Am J Med Genet 74 (1), 95-98 (1997)
   PUBMED   9034014
REFERENCE   7  (bases 1 to 6271)
  AUTHORS   Dessauer,C.W. and Gilman,A.G.
  TITLE     Purification and characterization of a soluble form of mammalian
            adenylyl cyclase
  JOURNAL   J Biol Chem 271 (28), 16967-16974 (1996)
   PUBMED   8663304
REFERENCE   8  (bases 1 to 6271)
  AUTHORS   Hellevuo,K., Berry,R., Sikela,J.M. and Tabakoff,B.
  TITLE     Localization of the gene for a novel human adenylyl cyclase (ADCY7)
            to chromosome 16
  JOURNAL   Hum Genet 95 (2), 197-200 (1995)
   PUBMED   7860067
REFERENCE   9  (bases 1 to 6271)
  AUTHORS   Kleuss,C., Raw,A.S., Lee,E., Sprang,S.R. and Gilman,A.G.
  TITLE     Mechanism of GTP hydrolysis by G-protein alpha subunits
  JOURNAL   Proc Natl Acad Sci U S A 91 (21), 9828-9831 (1994)
   PUBMED   7937899
REFERENCE   10 (bases 1 to 6271)
  AUTHORS   Taylor,S.S., Buechler,J.A. and Yonemoto,W.
  TITLE     cAMP-dependent protein kinase: framework for a diverse family of
            regulatory enzymes
  JOURNAL   Annu Rev Biochem 59, 971-1005 (1990)
   PUBMED   2165385
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY102720.1, BC039891.1,
            AC007597.3, BC126271.1, D25538.1 and AA740624.1.
            
            On or before Jul 3, 2019 this sequence version replaced
            XM_017022895.1, NM_001114.4.
            
            Summary: This gene encodes a membrane-bound adenylate cyclase that
            catalyses the formation of cyclic AMP from ATP and is inhibitable
            by calcium. The product of this gene is a member of the adenylyl
            cyclase class-4/guanylyl cyclase enzyme family that is
            characterized by the presence of twelve membrane-spanning domains
            in its sequences. Several transcript variants have been observed
            for this gene, but the full-length natures of only two have been
            determined so far. [provided by RefSeq, Oct 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.799783.1,
                                           SRR11853563.12539.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000673801.1/ ENSP00000501053.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               HY102720.1         13-142
            131-1009            BC039891.1         38-916
            1010-1010           AC007597.3         33308-33308         c
            1011-1673           BC039891.1         918-1580
            1674-4522           BC126271.1         1356-4204
            4523-5493           D25538.1           4390-5360
            5494-6256           D25538.1           5422-6184
            6257-6271           AA740624.1         14-28               c
FEATURES             Location/Qualifiers
     source          1..6271
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q12.1"
     gene            1..6271
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /note="adenylate cyclase 7"
                     /db_xref="GeneID:113"
                     /db_xref="HGNC:HGNC:238"
                     /db_xref="MIM:600385"
     exon            1..130
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /inference="alignment:Splign:2.1.0"
     exon            131..569
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /inference="alignment:Splign:2.1.0"
     CDS             399..3641
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /EC_number="4.6.1.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     adenylate cyclase type 7; adenylyl cyclase 7; ATP
                     pyrophosphate-lyase 7; adenylate cyclase type VII"
                     /codon_start=1
                     /product="adenylate cyclase type 7 isoform 1"
                     /protein_id="NP_001105.1"
                     /db_xref="CCDS:CCDS10741.1"
                     /db_xref="GeneID:113"
                     /db_xref="HGNC:HGNC:238"
                     /db_xref="MIM:600385"
                     /translation="MPAKGRYFLNEGEEGPDQDALYEKYQLTSQHGPLLLTLLLVAAT
                     ACVALIIIAFSQGDPSRHQAILGMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWA
                     CLVALGYVLVFDAWTKAACAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLL
                     VLGSLMGGFTTPSVRVGLQLLANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQI
                     RRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQ
                     NVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVS
                     GLPVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQY
                     DVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKAYEVEDGHGQQRDPYLKEMNIRTY
                     LVIDPRSQQPPPPSQHLPRPKGDAALKMRASVRMTRYLESWGAARPFAHLNHRESVSS
                     GETHVPNGRRPKSVPQRHRRTPDRSMSPKGRSEDDSYDDEMLSAIEGLSSTRPCCSKS
                     DDFYTFGSIFLEKGFEREYRLAPIPRARHDFACASLIFVCILLVHVLLMPRTAALGVS
                     FGLVACVLGLVLGLCFATKFSRCCPARGTLCTISERVETQPLLRLTLAVLTIGSLLTV
                     AIINLPLMPFQVPELPVGNETGLLAASSKTRALCEPLPYYTCSCVLGFIACSVFLRMS
                     LEPKVVLLTVALVAYLVLFNLSPCWQWDCCGQGLGNLTKPNGTTSGTPSCSWKDLKTM
                     TNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAH
                     VAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIAD
                     FDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAHIGVMVEFSIALM
                     SKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGK
                     IQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCTDTAKFQGLGLN"
     exon            570..773
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /inference="alignment:Splign:2.1.0"
     exon            774..935
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1085
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1234
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1346
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1474
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1633
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1766
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1958
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..1993
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2077
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2150
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2248
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2333
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2459
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2558
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2752
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2846
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..3002
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3149
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..3254
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..3369
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3370..3494
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3495..6271
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6244..6249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /note="hexamer: ATTAAA"
     polyA_site      6271
                     /gene="ADCY7"
                     /gene_synonym="AC7"
                     /note="major polyA site"
ORIGIN      
        1 actctcatta ggtagcgtgg aaggagcctt cggatgggtg agcctgggcg cgtctgagga
       61 agggcaggcg ggggccgggc cacctccctg cagaccctgg ccggctgctg gggccgggga
      121 ggagagccag agctgaggaa ctgcgtgtgg agtcagccca gtctggatgc acaggaggat
      181 gctggcggca cagtgagtga ggcctggtgc cagagctgtg cggacccctt gttggccatg
      241 gagcagcagg cccagaggcc ctctccccag ccctgcttgc ctgcctcgga gaggacagag
      301 gcctaggccc acgggggagg gtgttggcag acagatgccc tccaggccct ggggcctcct
      361 taacggcccc ttaacgacac gcgtgccaag ggtggaggat gccagccaag gggcgctact
      421 tcctcaacga gggcgaggag ggccctgacc aagatgcgct ctacgagaag taccagctca
      481 ccagccagca tgggccgctg ctgctcacgc tcctgctggt ggccgccact gcctgcgtgg
      541 ccctcatcat cattgccttc agccaggggg acccctccag acaccaggcc attctgggca
      601 tggcgttcct ggtgctggcg gtgtttgcgg ccctctctgt gctgatgtac gtcgagtgtc
      661 tcctgcggcg ctggctcagg gccttggcgc tgctcacctg ggcctgcttg gtggcgctgg
      721 gctatgtgct ggtgttcgac gcatggacaa aggcggcctg tgcgtgggag caggtgccct
      781 tcttcctgtt cattgtcttc gtggtgtaca cactactgcc cttcagcatg cggggcgctg
      841 tcgccgttgg ggccgtctcc actgcctccc acctcctggt gctcggttct ttgatgggag
      901 gcttcacgac acccagtgtc cgggtggggc tgcagctgct ggccaacgca gtcatcttcc
      961 tgtgtgggaa cctgacaggc gccttccaca agcaccaaat gcaggatgca tcccgggacc
     1021 tcttcaccta cactgtgaag tgcatccaga tccgccggaa gctgcgcatc gagaagcgcc
     1081 agcaggagaa cctgctgctg tcagtgcttc cggcccacat ctccatgggc atgaagctgg
     1141 ccatcatcga acggctcaag gagcatggtg accgtcgctg catgcctgac aacaacttcc
     1201 acagcctcta cgtcaagagg caccagaatg tcagcatcct ctatgcggac atcgtgggct
     1261 tcacgcagct ggccagcgac tgttctccca aggagctggt ggtggtgctg aatgagctct
     1321 ttggcaagtt cgaccagatc gccaaggcca acgagtgcat gcgaatcaag atcctcggcg
     1381 actgctacta ctgtgtatcg ggcctgcccg tgtcgctgcc tacccacgcc cggaactgcg
     1441 tgaagatggg gctggacatg tgccaggcca tcaagcaggt gcgggaggcc acgggcgtgg
     1501 acatcaacat gcgtgtgggc atacactcgg ggaatgtgct gtgcggggtc atcgggctgc
     1561 gcaagtggca gtatgacgtg tggtcccacg acgtgtccct ggccaaccgg atggaggcag
     1621 ccggagtacc cggccgggtg cacatcacgg aggccacgct aaagcacctg gacaaggcgt
     1681 acgaggtgga ggatgggcac gggcagcagc gggaccccta cctcaaggag atgaacatcc
     1741 gcacctacct ggtcatcgac ccccggagcc agcagccacc cccgcccagc caacacctcc
     1801 ccaggcccaa gggggacgcg gccctgaaga tgcgggcgtc agtgcgcatg acccggtacc
     1861 tcgagtcctg gggggcggca cggccctttg cacatctcaa ccaccgtgag agcgtgagca
     1921 gtggtgagac ccacgtcccc aacgggcgga ggcctaagag cgttccccag cgccaccgcc
     1981 ggaccccaga cagaagcatg tcccccaagg ggcggtcgga ggatgactcg tacgatgacg
     2041 agatgctgtc agccattgag gggctcagct ccacgaggcc ctgctgctcc aagtccgatg
     2101 acttctacac ctttgggtcc atcttcctgg agaagggctt tgagcgcgag taccgcctgg
     2161 cacccatccc ccgggcccgc cacgactttg cctgcgccag cctgatcttc gtctgcatcc
     2221 tgctcgtcca tgtcctgctc atgcccagga cggcggcact gggtgtgtcc ttcgggctgg
     2281 tggcctgtgt actggggctg gtgctgggcc tgtgctttgc caccaagttc tcgaggtgct
     2341 gcccagctcg ggggacgctc tgcactatct ctgagagggt ggagacacag cccctgctga
     2401 ggctgaccct ggccgtcctg accatcggca gcctgctcac tgtggccatc atcaacctgc
     2461 ccctgatgcc tttccaagtt ccagagctgc ctgttggcaa tgagacaggc ctactggccg
     2521 cgagcagcaa gacaagagcc ctgtgtgagc ccctcccgta ctacacctgc agctgtgtcc
     2581 tgggcttcat cgcctgctcg gtcttcctga ggatgagcct ggagccaaag gttgtgctgc
     2641 tgacagtggc cctggtggcc tacctggtgc tcttcaacct ctccccatgc tggcagtggg
     2701 actgctgcgg ccaaggcctg ggcaacctca ccaagcccaa cggcaccacc agtggcaccc
     2761 ctagctgttc ctggaaggac ctgaagacca tgaccaattt ctacctggtc ctgttctaca
     2821 tcaccctgct tacactctcc agacagattg actattactg ccgcttggac tgcctatgga
     2881 agaagaagtt caagaaggag cacgaggagt ttgagaccat ggagaacgtg aaccgccttc
     2941 ttctggagaa cgtcctgcca gcccacgtgg ctgcccactt tatcggtgac aagttaaacg
     3001 aggactggta ccatcagtcc tatgactgcg tctgtgtcat gtttgcctcc gtgccggact
     3061 tcaaagtgtt ctacacagag tgcgatgtca acaaagaagg gctggagtgc ctacgcctgc
     3121 tcaatgagat cattgccgac ttcgacgagc tcctactgaa gcccaagttc agcggcgtgg
     3181 agaagatcaa gaccatcggc agcacgtaca tggcagctgc agggctcagc gtcgcctcag
     3241 ggcacgagaa ccaggagctg gagcggcagc atgcccacat tggtgtcatg gtggagttca
     3301 gcatcgccct gatgagtaag ctggacggca tcaacaggca ctccttcaac tccttccgcc
     3361 tccgcgtcgg cataaaccat gggcctgtga ttgctggagt gattggggcc cgaaaacctc
     3421 agtatgacat ctggggaaac actgtcaatg tggccagccg aatggaaagc actggagaac
     3481 ttgggaaaat ccaggttacc gaggagacct gcaccatcct ccagggcctc gggtactctt
     3541 gtgaatgccg tggcctgatc aacgtcaaag gcaaaggcga gctgaggact tactttgtct
     3601 gtacggacac tgccaagttt caggggctgg ggctgaactg agggctcctg ctggattccg
     3661 aaaaggccgg gaagccagtc tccttccctg aagcaagccc aggagaagac tctccgcccc
     3721 acgccaatcc caaaggcatg cagatggctg tgcatgttgg cttctttgga cctgcactgg
     3781 aggatttctc agacacatgc accagattct ggctcgaagc agccactgag ccataatgcg
     3841 caggggaggc cagaagctct gtgcctggtc tgtaacagtt tccaggccag ctggagaatg
     3901 ttcactggtt cggggctgac tttgagatct ttgttccctg aggtgccagg caggcaactt
     3961 tagcacatga tgaaaacaga cttccacctc agtggcctgt gggcacgcac aagtgaggtc
     4021 tgtttttcta gacaccaagg gggagtaagc tgagctgtct agcacggatt ggagactccc
     4081 tctccctggt gggcctggca atgacagcat ttctcacaga ggcattctgg taaatgaagc
     4141 tgaaaggggt gttttacatc tgtaaacggt ttcaaacagg tagagagaaa aacaccacaa
     4201 ttaacactgt tactttttgc cttgtctggc atgtttgttt taaatgaata cattaatggg
     4261 gtttttatcc ttttgaatga cttttcagac actagacata aatctcttcc ctccagtgta
     4321 tgctctgcct ttttaaccac tgacatgtaa ggaggactac tgtctagcat cagcttatgg
     4381 ggtcagctgg ctgtggggat agagtcctga ggaatgtggt cacagcaaga aggcggggag
     4441 cagcagagcc ttgcctttga atgaggcagc ttgtgaggca agcattctgg agagaggtgc
     4501 tttgaaagta aggtgcggcc tttcacctct tccttgatta ctcacacatc tttgcgttct
     4561 cccctgccgt ccttcaactg tatcttactt ttcttaccag aaaggaatgg agtctgttta
     4621 gagacaactt ggacaacctg tgagtgcatc tcttctttcc tttagtcttc acagctaact
     4681 ctggagagct tcaaaactag aaggatctac tccgcatggg tgcatgcaga ggctcctgga
     4741 tctgggaagc ccgccccctc acaaatgctg agccgttctt gctctgaaac tgcgtgagtc
     4801 aaggcaaatg caaaaagcca ggttttgggg atgtgtctta ctgtgcttca acttcccaag
     4861 gaattgaaag tcaacctaac tgtaacaaca gggtgagaaa tgaccaaact gcccgtgact
     4921 ttttctgaat ggacttcata accggaagac ttaaccggtg gcctcatcac cagagcatcg
     4981 ccaggatttc taatgcactc agtttcccta catagcaggg attcttagct aggtgtcccc
     5041 atgaaccccg taaagttcta cacaaagtct tgcatacagg agcctttaca agatgattat
     5101 acagggttgc agattgggtg actgaccaga cttgttgggg tcctgggatg agttgccccg
     5161 ggctgcaaat taagagtaca gctaagtgcg ggggtggcgg tggagggaac gaaaattgaa
     5221 cctgtctgcc tgtgctgtgt cgtgtggctt tatcagcccg aggaagggca ggtgtattct
     5281 aatttgcaca aaggtgctgg gtagactagt ggcagctctc atgtgctgca cataagtgga
     5341 atcagtatga atagaagaac ttgctgtata aaggaatttc atggcaacaa tgctggtaag
     5401 ggcaattagc ctcgcttaag ttgccttttt tacacaccaa aactttttac atgaagggct
     5461 ggtttcacat gaatactata ctgaaatctg tgctctcaag atctagcagt gaccagggct
     5521 gcccggcggg ggctctcctg gcaagtcagg aaggtttctg ttgctaatat aacatagaaa
     5581 cacattagtg cactgggcct ctctgaggtc agcatatttg tactcttgga atatttgttt
     5641 ttttcttcag taacaacaga aaccccagtt gggagtttaa caaataactg actaccactc
     5701 actcatgcat ttttatttcc aattaaagca aagcactgtg ctgtgctcag ataataatag
     5761 tttgtaagta aaagttttta gttttcagtg ttcaggttat agaatataac tgaccataaa
     5821 aattacctgc aggtattttc tttttatgaa cttgttttta aattaccaag taattactgg
     5881 tgtcattttg ttttatgaca gacacacgta tctaacaaac aaacaaacag tgaccttctc
     5941 catgggtcaa ggacttcctt acaatttctc ctgagttaac ttttgtgaaa ataataccta
     6001 aggttttctg gcttattgag gaaatttcct aacaaacaaa caaacaaaca aacagaagag
     6061 aagatcatta accactgtat actttgtgta tataataggt cagtgtaaag aaatatgatt
     6121 tgaggtggtg catgcaagta actagggttt attctatata atgaatattt atagatctgt
     6181 aacatttgtt tcaaaatgct gtttcatttt tataaagtac cagtgtttag ctgcttttta
     6241 tacattaaat tagcaatttg aaaaactcaa a
//
