LOCUS       NM_015270               6092 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens adenylate cyclase 6 (ADCY6), transcript variant 1,
            mRNA.
ACCESSION   NM_015270 XM_005268605
VERSION     NM_015270.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6092)
  AUTHORS   Li,W., Sang,M., Hao,X., Jia,L., Wang,Y. and Shan,B.
  TITLE     Gene expression and DNA methylation analyses suggest that immune
            process-related ADCY6 is a prognostic factor of luminal-like breast
            cancer
  JOURNAL   J Cell Biochem 121 (7), 3537-3546 (2020)
   PUBMED   31886586
  REMARK    GeneRIF: Gene expression and DNA methylation analyses suggest that
            immune process-related ADCY6 is a prognostic factor of luminal-like
            breast cancer.
REFERENCE   2  (bases 1 to 6092)
  AUTHORS   Agolini,E., Cherchi,C., Bellacchio,E., Martinelli,D.,
            Cocciadiferro,D., Cutrera,R., Chiarini Testa,M.B., Barone,C.,
            Bianca,S. and Novelli,A.
  TITLE     Expanding the clinical and molecular spectrum of lethal congenital
            contracture syndrome 8 associated with biallelic variants of ADCY6
  JOURNAL   Clin Genet 97 (4), 649-654 (2020)
   PUBMED   31846058
  REMARK    GeneRIF: Expanding the clinical and molecular spectrum of lethal
            congenital contracture syndrome 8 associated with biallelic
            variants of ADCY6.
REFERENCE   3  (bases 1 to 6092)
  AUTHORS   Saito,M., Cui,L., Hirano,M., Li,G., Yanagisawa,T., Sato,T. and
            Sukegawa,J.
  TITLE     Activity of Adenylyl Cyclase Type 6 Is Suppressed by Direct Binding
            of the Cytoskeletal Protein 4.1G
  JOURNAL   Mol Pharmacol 96 (4), 441-451 (2019)
   PUBMED   31383768
  REMARK    GeneRIF: Data found that direct binding of 4.1G to the N-terminus
            of AC6 (AC6-N) contributes to the plasma membrane association of
            AC6-N and the resulting suppression of AC6 cyclase activity.
REFERENCE   4  (bases 1 to 6092)
  AUTHORS   Laquerriere,A., Maluenda,J., Camus,A., Fontenas,L., Dieterich,K.,
            Nolent,F., Zhou,J., Monnier,N., Latour,P., Gentil,D., Heron,D.,
            Desguerres,I., Landrieu,P., Beneteau,C., Delaporte,B., Bellesme,C.,
            Baumann,C., Capri,Y., Goldenberg,A., Lyonnet,S., Bonneau,D.,
            Estournet,B., Quijano-Roy,S., Francannet,C., Odent,S.,
            Saint-Frison,M.H., Sigaudy,S., Figarella-Branger,D., Gelot,A.,
            Mussini,J.M., Lacroix,C., Drouin-Garraud,V., Malinge,M.C.,
            Attie-Bitach,T., Bessieres,B., Bonniere,M., Encha-Razavi,F.,
            Beaufrere,A.M., Khung-Savatovsky,S., Perez,M.J., Vasiljevic,A.,
            Mercier,S., Roume,J., Trestard,L., Saugier-Veber,P., Cordier,M.P.,
            Layet,V., Legendre,M., Vigouroux-Castera,A., Lunardi,J., Bayes,M.,
            Jouk,P.S., Rigonnot,L., Granier,M., Sternberg,D., Warszawski,J.,
            Gut,I., Gonzales,M., Tawk,M. and Melki,J.
  TITLE     Mutations in CNTNAP1 and ADCY6 are responsible for severe
            arthrogryposis multiplex congenita with axoglial defects
  JOURNAL   Hum Mol Genet 23 (9), 2279-2289 (2014)
   PUBMED   24319099
  REMARK    GeneRIF: Mutations in CNTNAP1 and ADCY6 are responsible for severe
            arthrogryposis multiplex congenita with axoglial defects
REFERENCE   5  (bases 1 to 6092)
  AUTHORS   Wicker,R., Catalan,A.G., Cailleux,A., Starenki,D., Stengel,D.,
            Sarasin,A. and Suarez,H.G.
  TITLE     Cloning and expression of human adenylyl cyclase type VI in normal
            thyroid tissues
  JOURNAL   Biochim Biophys Acta 1493 (1-2), 279-283 (2000)
   PUBMED   10978539
REFERENCE   6  (bases 1 to 6092)
  AUTHORS   Raimundo,S., Giray,J., Volff,J.N., Schwab,M., Altenbuchner,J.,
            Ratge,D. and Wisser,H.
  TITLE     Cloning and sequence of partial cDNAs encoding the human type V and
            VI adenylyl cyclases and subsequent RNA-quantification in various
            tissues
  JOURNAL   Clin Chim Acta 285 (1-2), 155-161 (1999)
   PUBMED   10481931
REFERENCE   7  (bases 1 to 6092)
  AUTHORS   Gaudin,C., Homcy,C.J. and Ishikawa,Y.
  TITLE     Mammalian adenylyl cyclase family members are randomly located on
            different chromosomes
  JOURNAL   Hum Genet 94 (5), 527-529 (1994)
   PUBMED   7959689
REFERENCE   8  (bases 1 to 6092)
  AUTHORS   Kleuss,C., Raw,A.S., Lee,E., Sprang,S.R. and Gilman,A.G.
  TITLE     Mechanism of GTP hydrolysis by G-protein alpha subunits
  JOURNAL   Proc Natl Acad Sci U S A 91 (21), 9828-9831 (1994)
   PUBMED   7937899
REFERENCE   9  (bases 1 to 6092)
  AUTHORS   Haber,N., Stengel,D., Defer,N., Roeckel,N., Mattei,M.G. and
            Hanoune,J.
  TITLE     Chromosomal mapping of human adenylyl cyclase genes type III, type
            V and type VI
  JOURNAL   Hum Genet 94 (1), 69-73 (1994)
   PUBMED   8034296
REFERENCE   10 (bases 1 to 6092)
  AUTHORS   Taylor,S.S., Buechler,J.A. and Yonemoto,W.
  TITLE     cAMP-dependent protein kinase: framework for a diverse family of
            regulatory enzymes
  JOURNAL   Annu Rev Biochem 59, 971-1005 (1990)
   PUBMED   2165385
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC064923.1, AC117498.6 and
            AF250226.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_015270.4.
            
            Summary: This gene encodes a member of the adenylyl cyclase family
            of proteins, which are required for the synthesis of cyclic AMP.
            All members of this family have an intracellular N-terminus, a
            tandem repeat of six transmembrane domains separated by a
            cytoplasmic loop, and a C-terminal cytoplasmic domain. The two
            cytoplasmic regions bind ATP and form the catalytic core of the
            protein. Adenylyl cyclases are important effectors of transmembrane
            signaling pathways and are regulated by the activity of G protein
            coupled receptor signaling. This protein belongs to a small
            subclass of adenylyl cyclase proteins that are functionally related
            and are inhibited by protein kinase A, calcium ions and nitric
            oxide. A mutation in this gene is associated with arthrogryposis
            multiplex congenita. [provided by RefSeq, May 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.3364392.1,
                                           SRR14038193.2693211.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357869.8/ ENSP00000350536.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                BC064923.1         8-82
            76-153              AC117498.6         100679-100756
            154-823             BC064923.1         83-752
            824-824             AF250226.1         1330-1330
            825-6092            BC064923.1         754-6021
FEATURES             Location/Qualifiers
     source          1..6092
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..6092
                     /gene="ADCY6"
                     /gene_synonym="AC6; LCCS8"
                     /note="adenylate cyclase 6"
                     /db_xref="GeneID:112"
                     /db_xref="HGNC:HGNC:237"
                     /db_xref="MIM:600294"
     exon            1..184
                     /gene="ADCY6"
                     /gene_synonym="AC6; LCCS8"
                     /inference="alignment:Splign:2.1.0"
     exon            185..1052
                     /gene="ADCY6"
                     /gene_synonym="AC6; LCCS8"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..3695
                     /gene="ADCY6"
                     /gene_synonym="AC6; LCCS8"
                     /EC_number="4.6.1.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     adenylate cyclase type 6; ATP pyrophosphate-lyase 6;
                     adenylate cyclase type VI; ca(2+)-inhibitable adenylyl
                     cyclase"
                     /codon_start=1
                     /product="adenylate cyclase type 6 isoform 1"
                     /protein_id="NP_056085.1"
                     /db_xref="CCDS:CCDS8767.1"
                     /db_xref="GeneID:112"
                     /db_xref="HGNC:HGNC:237"
                     /db_xref="MIM:600294"
                     /translation="MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYM
                     SCLRDAEPPSPTPAGPPRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGG
                     TAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLV
                     LLTAVLLAFHAAPARPQPAYVALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGI
                     LAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAW
                     QLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHE
                     NRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLA
                     SQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM
                     GVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAG
                     GRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRKEEKAML
                     AKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDNRGTQDALNPEDEV
                     DEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCF
                     ICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQRLSRSIVRSRA
                     HSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQLNYSLGL
                     DAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLG
                     PPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQ
                     QVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYY
                     QSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKI
                     KTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLN
                     MGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECR
                     GVVKVKGKGEMTTYFLNGGPSS"
     exon            1053..1202
                     /gene="ADCY6"
                     /gene_synonym="AC6; LCCS8"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1324
                     /gene="ADCY6"
                     /gene_synonym="AC6; LCCS8"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1436
                     /gene="ADCY6"
                     /gene_synonym="AC6; LCCS8"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1564
                     /gene="ADCY6"
                     /gene_synonym="AC6; LCCS8"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1723
                     /gene="ADCY6"
                     /gene_synonym="AC6; LCCS8"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1865
                     /gene="ADCY6"
                     /gene_synonym="AC6; LCCS8"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1994
                     /gene="ADCY6"
                     /gene_synonym="AC6; LCCS8"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2020
                     /gene="ADCY6"
                     /gene_synonym="AC6; LCCS8"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2168
                     /gene="ADCY6"
                     /gene_synonym="AC6; LCCS8"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2266
                     /gene="ADCY6"
                     /gene_synonym="AC6; LCCS8"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2354
                     /gene="ADCY6"
                     /gene_synonym="AC6; LCCS8"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2471
                     /gene="ADCY6"
                     /gene_synonym="AC6; LCCS8"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2630
                     /gene="ADCY6"
                     /gene_synonym="AC6; LCCS8"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2809
                     /gene="ADCY6"
                     /gene_synonym="AC6; LCCS8"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..2845
                     /gene="ADCY6"
                     /gene_synonym="AC6; LCCS8"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..2975
                     /gene="ADCY6"
                     /gene_synonym="AC6; LCCS8"
                     /inference="alignment:Splign:2.1.0"
     exon            2976..3239
                     /gene="ADCY6"
                     /gene_synonym="AC6; LCCS8"
                     /inference="alignment:Splign:2.1.0"
     exon            3240..3444
                     /gene="ADCY6"
                     /gene_synonym="AC6; LCCS8"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..3569
                     /gene="ADCY6"
                     /gene_synonym="AC6; LCCS8"
                     /inference="alignment:Splign:2.1.0"
     exon            3570..6092
                     /gene="ADCY6"
                     /gene_synonym="AC6; LCCS8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6069..6074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADCY6"
                     /gene_synonym="AC6; LCCS8"
                     /note="hexamer: AATAAA"
     polyA_site      6092
                     /gene="ADCY6"
                     /gene_synonym="AC6; LCCS8"
                     /note="major polyA site"
ORIGIN      
        1 agagggcggc tgcgctggac agctcgggag ggggcgaggg ccgggcggac ggcggacggc
       61 ggacggcggg cgggacggcc aggacgcgcg ggctcggagg accgcgggac ggccggccgg
      121 ccggccggag cccgcggggg cggcggggcg ggggcccagg gcaggcgcgg agccgggccg
      181 gcagcaacat gtcatggttt agtggcctcc tggtccctaa agtggatgaa cggaaaacag
      241 cctggggtga acgcaatggg cagaagcgtt cgcggcgccg tggcactcgg gcaggtggct
      301 tctgcacgcc ccgctatatg agctgcctcc gggatgcaga gccacccagc cccacccctg
      361 cgggcccccc tcggtgcccc tggcaggatg acgccttcat ccggaggggc ggcccaggca
      421 agggcaagga gctggggctg cgggcagtgg ccctgggctt cgaggatacc gaggtgacaa
      481 cgacagcggg cgggacggct gaggtggcgc ccgacgcggt gcccaggagt gggcgatcct
      541 gctggcgccg tctggtgcag gtgttccagt cgaagcagtt ccgttcggcc aagctggagc
      601 gcctgtacca gcggtacttc ttccagatga accagagcag cctgacgctg ctgatggcgg
      661 tgctggtgct gctcacagcg gtgctgctgg ctttccacgc cgcacccgcc cgccctcagc
      721 ctgcctatgt ggcactgttg gcctgtgccg ccgccctgtt cgtggggctc atggtggtgt
      781 gtaaccggca tagcttccgc caggactcca tgtgggtggt gagctacgtg gtgctgggca
      841 tcctggcggc agtgcaggtc gggggcgctc tcgcagcaga cccgcgcagc ccctctgcgg
      901 gcctctggtg ccctgtgttc tttgtctaca tcgcctacac gctcctcccc atccgcatgc
      961 gggctgccgt cctcagcggc ctgggcctct ccaccttgca tttgatcttg gcctggcaac
     1021 ttaaccgtgg tgatgccttc ctctggaagc agctcggtgc caatgtgctg ctgttcctct
     1081 gcaccaacgt cattggcatc tgcacacact atccagcaga ggtgtctcag cgccaggcct
     1141 ttcaggagac ccgcggttac atccaggccc ggctccacct gcagcatgag aatcggcagc
     1201 aggagcggct gctgctgtcg gtattgcccc agcacgttgc catggagatg aaagaagaca
     1261 tcaacacaaa aaaagaagac atgatgttcc acaagatcta catacagaag catgacaatg
     1321 tcagcatcct gtttgcagac attgagggct tcaccagcct ggcatcccag tgcactgcgc
     1381 aggagctggt catgaccctg aatgagctct ttgcccggtt tgacaagctg gctgcggaga
     1441 atcactgcct gaggatcaag atcttggggg actgttacta ctgtgtgtca gggctgccgg
     1501 aggcccgggc cgaccatgcc cactgctgtg tggagatggg ggtagacatg attgaggcca
     1561 tctcgctggt acgtgaggtg acaggtgtga atgtgaacat gcgcgtgggc atccacagcg
     1621 ggcgcgtgca ctgcggcgtc cttggcttgc ggaaatggca gttcgatgtg tggtccaatg
     1681 atgtgaccct ggccaaccac atggaggcag gaggccgggc tggccgcatc cacatcactc
     1741 gggcaacact gcagtacctg aacggggact acgaggtgga gccaggccgt ggtggcgagc
     1801 gcaacgcgta cctcaaggag cagcacattg agactttcct catcctgggc gccagccaga
     1861 aacggaaaga ggagaaggcc atgctggcca agctgcagcg gactcgggcc aactccatgg
     1921 aagggctgat gccgcgctgg gttcctgatc gtgccttctc ccggaccaag gactccaagg
     1981 ccttccgcca gatgggcatt gatgattcca gcaaagacaa ccggggcacc caagatgccc
     2041 tgaaccctga ggatgaggtg gatgagttcc tgagccgtgc catcgatgcc cgcagcattg
     2101 atcagctgcg gaaggaccat gtgcgccggt ttctgctcac cttccagaga gaggatcttg
     2161 agaagaagta ctcccggaag gtggatcccc gcttcggagc ctacgttgcc tgtgccctgt
     2221 tggtcttctg cttcatctgc ttcatccagc ttctcatctt cccacactcc accctgatgc
     2281 ttgggatcta tgccagcatc ttcctgctgc tgctaatcac cgtgctgatc tgtgctgtgt
     2341 actcctgtgg ttctctgttc cctaaggccc tgcaacgtct gtcccgcagc attgtccgct
     2401 cacgggcaca tagcaccgca gttggcatct tttccgtcct gcttgtgttt acttctgcca
     2461 ttgccaacat gttcacctgt aaccacaccc ccatacggag ctgtgcagcc cggatgctga
     2521 atttaacacc tgctgacatc actgcctgcc acctgcagca gctcaattac tctctgggcc
     2581 tggatgctcc cctgtgtgag ggcaccatgc ccacctgcag ctttcctgag tacttcatcg
     2641 ggaacatgct gctgagtctc ttggccagct ctgtcttcct gcacatcagc agcatcggga
     2701 agttggccat gatctttgtc ttggggctca tctatttggt gctgcttctg ctgggtcccc
     2761 cagccaccat ctttgacaac tatgacctac tgcttggcgt ccatggcttg gcttcttcca
     2821 atgagacctt tgatgggctg gactgtccag ctgcagggag ggtggccctc aaatatatga
     2881 cccctgtgat tctgctggtg tttgcgctgg cgctgtatct gcatgctcag caggtggagt
     2941 cgactgcccg cctagacttc ctctggaaac tacaggcaac aggggagaag gaggagatgg
     3001 aggagctaca ggcatacaac cggaggctgc tgcataacat tctgcccaag gacgtggcgg
     3061 cccacttcct ggcccgggag cgccgcaatg atgaactcta ctatcagtcg tgtgagtgtg
     3121 tggctgttat gtttgcctcc attgccaact tctctgagtt ctatgtggag ctggaggcaa
     3181 acaatgaggg tgtcgagtgc ctgcggctgc tcaacgagat catcgctgac tttgatgaga
     3241 ttatcagcga ggagcggttc cggcagctgg aaaagatcaa gacgattggt agcacctaca
     3301 tggctgcctc agggctgaac gccagcacct acgatcaggt gggccgctcc cacatcactg
     3361 ccctggctga ctacgccatg cggctcatgg agcagatgaa gcacatcaat gagcactcct
     3421 tcaacaattt ccagatgaag attgggctga acatgggccc agtcgtggca ggtgtcatcg
     3481 gggctcggaa gccacagtat gacatctggg ggaacacagt gaatgtctct agtcgtatgg
     3541 acagcacggg ggtccccgac cgaatccagg tgaccacgga cctgtaccag gttctagctg
     3601 ccaagggcta ccagctggag tgtcgagggg tggtcaaggt gaagggcaag ggggagatga
     3661 ccacctactt cctcaatggg ggccccagca gttaacaggg cccagccaca aattcagctg
     3721 aagggaccaa ggtgggcatt gagtggactc tgtgctcact gggtggagct gtggcagggg
     3781 gcactgagcc tccagaccct gctaaccaca aaagggaaca tcccagcagg ctgtgcttgg
     3841 atcatgctcg tctgccctca agctggaaaa caaggggcta cctaccgaga ggattatgca
     3901 agtgactttc tttcttactt ggggtagggc tgttccctct ccaatcttcc agcctttggg
     3961 agcaggggag gggtcagtag cagaagcaga gggaggcctc ttgcctgagg gattaaaatg
     4021 gcagcttgcc atgcctaccc ttccctgtct gtctgggcag caggttcagg gctgagccct
     4081 tcttttccct cttttttcct gggaatattt tgtacaatat tttgtacaaa gacaggcatg
     4141 aggagtgcct attccatgct tgcctttgca atacctgcat ccccagcact ggtcctgggc
     4201 acttccccac cccagccagg tgtccctcct atgcacagag cagaggaggg agaagctctg
     4261 gggagccagc tttggccata tttcaggaga atgtttccat gtgccaaatc ttagtcccat
     4321 gatctgtccc caaaggggaa caaagggacc tctgacagct tagatttagc cccagttcct
     4381 gcacgctcca gggaacgggg tgtctggcct cactggtact gtgaaaaatg ctcagagagc
     4441 aagcctgtgt gtggggatgt caggtcagga gctggaagtt cacctgcagg tgccaaagag
     4501 caggccggcc agggctgggg cagtgccaga ctctgatctg aggaccccgt cggggtccag
     4561 atcaggtcac tctgccccag tgctctcttg ctgtctgctg acaagggggc atggagcatc
     4621 tcttcctctt ctgttgccaa atagaaaagg gtcagggcat ggagaaaggt gaccctgatc
     4681 ccaaacctgc cctcccaagt ctctggtgtt ggggagggcc cgtgtgtttg tgtaactgtg
     4741 tgtgcatgtt ggtctttgtg tgcatatctg ttttccaggt ctatgtgagt ccttgtgctc
     4801 ctgctcctca gctctccacc ccaggttgcc tctctcctgt gggcctctgt cttctgggaa
     4861 taaagcaggg tttcctactt caggggatgt agagagatgc ccaggttgca caggagtggg
     4921 atggggtgtg gtagcaaaag gagggagagg agtccttttt gtgccaaatc cctaagtgcc
     4981 gttcgggggc catgtgtgca gcatgactct ccctgtctgt ggcagggacc caagcgcttg
     5041 cttaagcccc agtgctccat gccagcactt gaactgtctg gggtttgatg gacagaggct
     5101 gaggaatttc ctggcttccc cagatagtgt cctgggacat ggtatgcttt ggggctgggg
     5161 tagcatggaa tccctctgag gacctggata ctggtactac ggggtgggga agaggaacct
     5221 taaacttggc tttccccagc cttcagcctg agtctagcat gtttctagct ccccagtccc
     5281 ttgtgaagcc ttgagggctg gcagaagggt taggaggttg aactctagat tcccttcctg
     5341 tctttgcctt ccttttaccc ctttccctgc aacctccttg actctggcct gaatttgttg
     5401 gtgcctcagt ttctctgtct gtacctattt aagccaaagg cactagcctg aattttgctt
     5461 gaagatcact ttgtcttgga aatgactaga gaggcagagg agaagggttt ccagagttgc
     5521 taggtttggg agtggaaggg gcaggcagtg cacttgcccc tcctcatgcc ccttctgaca
     5581 ccagctccct gtggaggcct ggtttctggg taatgcctcc cttgggcatc ttcatgcatc
     5641 aaccaaatgg gccatcaggt acttcattag tcatggcaga aggaggggaa aagacttgtt
     5701 ttccagacag aaaatctact cccctgtccc cagccatatc cctggatagg aagggatagg
     5761 aagagactac ttggtgccat ggggtagggg tgagggtata agtagatcag agtgggaaga
     5821 cctcagcctt gggtggcttg tctctgcttc ttgccaggtg ggagggcctg tccacaccct
     5881 ggatccccgt accacagtgc cagccatgcc cttcccctgg gctaccattg tccctttcct
     5941 cacccagttg gtagaggagt caggaggtgg gaggccgtgg gctttggttt tataatgtaa
     6001 ccactgtggg ggtgggggag gatggtgaac catgtatttc agtgaaatat ttaatatatt
     6061 taaatatcaa taaaatcaaa ctctttgtaa aa
//
