LOCUS       NM_183357               6643 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens adenylate cyclase 5 (ADCY5), transcript variant 1,
            mRNA.
ACCESSION   NM_183357 XM_351567
VERSION     NM_183357.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6643)
  AUTHORS   Yen,Y.C., Li,Y., Chen,C.L., Klose,T., Watts,V.J., Dessauer,C.W. and
            Tesmer,J.J.G.
  TITLE     Structure of adenylyl cyclase 5 in complex with Gbetagamma offers
            insights into ADCY5-related dyskinesia
  JOURNAL   Nat Struct Mol Biol 31 (8), 1189-1197 (2024)
   PUBMED   38589608
  REMARK    GeneRIF: Structure of adenylyl cyclase 5 in complex with Gbetagamma
            offers insights into ADCY5-related dyskinesia.
REFERENCE   2  (bases 1 to 6643)
  AUTHORS   Cif,L., Demailly,D., Gehin,C., Chan Seng,E., Dornadic,M., Huby,S.,
            Poulen,G., Roubertie,A., Villessot,M., Roujeau,T. and Coubes,P.
  TITLE     Deep brain stimulation effect in genetic dyskinetic cerebral palsy:
            The case of ADCY5- related disease
  JOURNAL   Mol Genet Metab 138 (1), 106970 (2023)
   PUBMED   36610259
  REMARK    GeneRIF: Deep brain stimulation effect in genetic dyskinetic
            cerebral palsy: The case of ADCY5- related disease.
REFERENCE   3  (bases 1 to 6643)
  AUTHORS   Rivera-Paredez,B., Aparicio-Bautista,D.I., Argoty-Pantoja,A.D.,
            Patino,N., Flores Morales,J., Salmeron,J., Leon-Reyes,G. and
            Velazquez-Cruz,R.
  TITLE     Association of MARC1, ADCY5, and BCO1 Variants with the Lipid
            Profile, Suggests an Additive Effect for Hypertriglyceridemia in
            Mexican Adult Men
  JOURNAL   Int J Mol Sci 23 (19), 11815 (2022)
   PUBMED   36233117
  REMARK    GeneRIF: Association of MARC1, ADCY5, and BCO1 Variants with the
            Lipid Profile, Suggests an Additive Effect for Hypertriglyceridemia
            in Mexican Adult Men.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6643)
  AUTHORS   Liu,J., Ding,H. and Liu,R.
  TITLE     Mutation of ADCY5 gene in patients with Meige syndrome
  JOURNAL   Asian J Surg 45 (7), 1487-1488 (2022)
   PUBMED   35288007
  REMARK    GeneRIF: Mutation of ADCY5 gene in patients with Meige syndrome.
REFERENCE   5  (bases 1 to 6643)
  AUTHORS   Ludwig,M.G. and Seuwen,K.
  TITLE     Characterization of the human adenylyl cyclase gene family: cDNA,
            gene structure, and tissue distribution of the nine isoforms
  JOURNAL   J Recept Signal Transduct Res 22 (1-4), 79-110 (2002)
   PUBMED   12503609
REFERENCE   6  (bases 1 to 6643)
  AUTHORS   Cote,M., Guillon,G., Payet,M.D. and Gallo-Payet,N.
  TITLE     Expression and regulation of adenylyl cyclase isoforms in the human
            adrenal gland
  JOURNAL   J Clin Endocrinol Metab 86 (9), 4495-4503 (2001)
   PUBMED   11549699
REFERENCE   7  (bases 1 to 6643)
  AUTHORS   Raimundo,S., Giray,J., Volff,J.N., Schwab,M., Altenbuchner,J.,
            Ratge,D. and Wisser,H.
  TITLE     Cloning and sequence of partial cDNAs encoding the human type V and
            VI adenylyl cyclases and subsequent RNA-quantification in various
            tissues
  JOURNAL   Clin Chim Acta 285 (1-2), 155-161 (1999)
   PUBMED   10481931
REFERENCE   8  (bases 1 to 6643)
  AUTHORS   Dessauer,C.W. and Gilman,A.G.
  TITLE     Purification and characterization of a soluble form of mammalian
            adenylyl cyclase
  JOURNAL   J Biol Chem 271 (28), 16967-16974 (1996)
   PUBMED   8663304
REFERENCE   9  (bases 1 to 6643)
  AUTHORS   Haber,N., Stengel,D., Defer,N., Roeckel,N., Mattei,M.G. and
            Hanoune,J.
  TITLE     Chromosomal mapping of human adenylyl cyclase genes type III, type
            V and type VI
  JOURNAL   Hum Genet 94 (1), 69-73 (1994)
   PUBMED   8034296
REFERENCE   10 (bases 1 to 6643)
  AUTHORS   Hisama,F.M., Friedman,J., Raskind,W.H. and Bird,T.D.
  TITLE     ADCY5 Dyskinesia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   25521004
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC025571.20, AF497517.1 and
            AC112503.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 5, 2020 this sequence version replaced NM_183357.2.
            
            Summary: This gene encodes a member of the membrane-bound adenylyl
            cyclase enzymes. Adenylyl cyclases mediate G protein-coupled
            receptor signaling through the synthesis of the second messenger
            cAMP. Activity of the encoded protein is stimulated by the Gs alpha
            subunit of G protein-coupled receptors and is inhibited by protein
            kinase A, calcium and Gi alpha subunits. Single nucleotide
            polymorphisms in this gene may be associated with low birth weight
            and type 2 diabetes. Alternatively spliced transcript variants that
            encode different isoforms have been observed for this gene.
            [provided by RefSeq, Dec 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ891503.1, SRR14038193.3993331.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000462833.6/ ENSP00000419361.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1644              AC025571.20        94154-95797         c
            1645-4387           AF497517.1         1-2743
            4388-6643           AC112503.7         70742-72997
FEATURES             Location/Qualifiers
     source          1..6643
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.1"
     gene            1..6643
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
                     /note="adenylate cyclase 5"
                     /db_xref="GeneID:111"
                     /db_xref="HGNC:HGNC:236"
                     /db_xref="MIM:600293"
     exon            1..1679
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
                     /inference="alignment:Splign:2.1.0"
     CDS             546..4331
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
                     /EC_number="4.6.1.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     adenylate cyclase type 5; adenylyl cyclase 5; adenylate
                     cyclase type V; ATP pyrophosphate-lyase 5; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="adenylate cyclase type 5 isoform 1"
                     /protein_id="NP_899200.1"
                     /db_xref="CCDS:CCDS3022.1"
                     /db_xref="GeneID:111"
                     /db_xref="HGNC:HGNC:236"
                     /db_xref="MIM:600293"
                     /translation="MSGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPH
                     APGGSARGSTKKPGGAVTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSA
                     WQERGGDDCGRGSRRQRRGAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGL
                     EERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAGPGAVLSLGACCLALLQIFRS
                     KKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAA
                     AVGVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVF
                     FIYTIYTLLPVRMRAAVLSGVLLSALHLAIALRTNAQDQFLLKQLVSNVLIFSCTNIV
                     GVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINA
                     KQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAEN
                     HCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIH
                     SGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGC
                     GGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYN
                     HLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKF
                     LLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSL
                     LLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTC
                     NSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSV
                     LLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNN
                     GTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEME
                     ELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELE
                     ANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKT
                     HIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVN
                     VASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS"
     exon            1680..1829
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1951
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2063
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2191
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2350
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2492
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2633
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2656
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2801
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
                     /inference="alignment:Splign:2.1.0"
     exon            2802..2899
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..2987
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..3104
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3269
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
                     /inference="alignment:Splign:2.1.0"
     exon            3270..3445
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
                     /inference="alignment:Splign:2.1.0"
     exon            3446..3475
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
                     /inference="alignment:Splign:2.1.0"
     exon            3476..3608
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
                     /inference="alignment:Splign:2.1.0"
     exon            3609..3872
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
                     /inference="alignment:Splign:2.1.0"
     exon            3873..4077
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
                     /inference="alignment:Splign:2.1.0"
     exon            4078..4202
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
                     /inference="alignment:Splign:2.1.0"
     exon            4203..6643
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4983..4988
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
                     /note="hexamer: AATAAA"
     polyA_site      4997
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
     regulatory      6623..6628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
                     /note="hexamer: ATTAAA"
     polyA_site      6643
                     /gene="ADCY5"
                     /gene_synonym="AC5; DSKOD; FDFM"
                     /note="major polyA site"
ORIGIN      
        1 agtcgctccc agtccgctgc gaggaaagcg cacccgcagt gtctcttcgc cgggaccccc
       61 gccgagccgc cctcgccgcc gccgagcccc gagagcagct gggctccgct taggcggaat
      121 cagcgagcgc cgcgcccggg cactgccggc ccgaggaggc accgcccgca aggacaccac
      181 tccgtcccgt ctcgtccgca actccggccc tcgtcgagct cgacgcgagc caggatcccg
      241 gacgtctctc cgcgtgcggc gcagcagcag ccagaccagt ccctgcgacc ccacctcgga
      301 ggcaactcca tttcggacct gggacttctg acgcggatcc tcagctactt ctcacctcgg
      361 ggctgtgccc tcctcctccg ctcaggacgg gggtgccaag atgccccgct gcagcgcagg
      421 gccccgggcc gcccccgacg tgtgacccta gcctggtccc cctgctcggc cgtccgccct
      481 ccccttggag acccccggcc cggcttccgg gggaggagga aggagacgac gaggccgagg
      541 gggggatgtc cggctccaaa agcgtgagcc ccccgggcta cgcggcgcag aagactgcgg
      601 cgccggcgcc ccggggaggc cccgaacacc gctctgcgtg gggcgaggcc gattcccgcg
      661 cgaatggcta cccccatgcc cccgggggct ctgcccgcgg ctccaccaag aaacccgggg
      721 gggcggtgac cccgcagcag cagcagcgcc tggccagccg ctggcgcagc gacgacgacg
      781 acgatcctcc gctgagcggt gacgaccccc tggccggggg cttcggcttc agcttccgct
      841 ccaagtccgc ctggcaggag cgcggcggcg acgactgcgg tcgcggcagc cgccggcagc
      901 ggcggggcgc ggccagcggg ggcagcaccc gggcgccccc tgcgggcggc ggcggcggct
      961 cggcggcggc ggctgcctcg gcgggcggga cggaggtgcg ccctcgctcg gtggaggtgg
     1021 gtctggagga gcggcggggc aaggggcgcg cggccgacga gctggaggcc ggcgccgtcg
     1081 agggcggcga ggggtccggg gatggcggca gctcggcgga ctcgggctcg ggcgcggggc
     1141 ccggcgcggt gctgtccctg ggcgcctgct gcctggcgtt gctgcagata ttccgctcca
     1201 agaagttccc gtcggacaaa ctggagcggc tgtaccagcg ctacttcttc cgcctgaacc
     1261 agagcagcct caccatgctc atggccgtgc tggtgctcgt gtgcctggtc atgttggcct
     1321 tccacgcggc gcggcccccg ctccagctgc cctacctggc cgtgctggcg gccgccgtcg
     1381 gcgtgatcct catcatggct gtgctttgca accgcgccgc cttccaccag gaccacatgg
     1441 gcctggcctg ctatgcgctc atcgccgtgg tgctggccgt ccaggtggtg ggcctgctgc
     1501 tgccgcagcc acgcagcgcc tctgagggca tctggtggac cgtgttcttc atctacacca
     1561 tctacacgct gctgcccgtg cgcatgcggg ccgcagtgct cagcggggtg ctcctgtccg
     1621 ccctccacct ggccatcgcc ctgcgcacca acgcccagga ccagttcctg ctgaagcagc
     1681 ttgtctccaa tgttctcatt ttctcctgca ccaacatcgt gggtgtctgc acccactatc
     1741 cggctgaggt ctcccagaga caggctttcc aggagacccg agagtgcatc caggcgcggc
     1801 tccactcgca gcgggagaac cagcagcagg aacggctcct gctgtctgtc cttccccgtc
     1861 atgttgccat ggagatgaaa gcagacatca acgccaagca ggaggatatg atgttccata
     1921 agatttacat ccagaaacat gacaacgtga gcatcctgtt tgctgacatc gagggcttca
     1981 ccagcctggc gtcccagtgc actgcacagg aactggtcat gaccctcaac gagctcttcg
     2041 cccgctttga caagctggcc gcagagaatc actgtttacg tattaagatc cttggggatt
     2101 gttattactg cgtctcgggg ctgcctgaag caagggctga ccacgcccac tgctgtgtgg
     2161 agatgggcat ggacatgatc gaggccatct cgttggtccg ggaggtgaca ggggtgaacg
     2221 tgaacatgcg tgtgggaatt cacagcgggc gagtacactg cggtgtcctt ggtctcagga
     2281 agtggcagtt cgacgtctgg tctaacgatg tcacgctagc caaccacatg gaggctggcg
     2341 gcaaggcagg acgcatccac atcaccaagg ctacactcaa ctacctgaat ggggactacg
     2401 aggtggagcc aggctgtggg ggcgagcgca acgcctacct caaggagcac agtatcgaga
     2461 ccttcctcat cctgcgctgc acccagaagc ggaaagaaga gaaggccatg atcgccaaga
     2521 tgaaccgcca gagaaccaac tccatcgggc acaacccacc acactggggg gctgagcgcc
     2581 ccttctacaa ccacctgggt ggcaaccagg tgtccaagga gatgaagcgg atgggctttg
     2641 aagaccccaa ggacaagaac gcccaggaga gtgcgaaccc tgaggatgaa gtggatgagt
     2701 ttctgggccg tgccattgac gccaggagca ttgataggct tcggtctgag cacgtccgca
     2761 agttcctcct gaccttcagg gagcctgact tagagaagaa gtactccaag caggtagacg
     2821 accgatttgg tgcctatgtg gcgtgtgcct cgctcgtctt cctcttcatc tgctttgtcc
     2881 agatcaccat cgtgccccac tccatattca tgctcagctt ctacctgacc tgttccctgc
     2941 tgctgacctt ggtggtgttt gtgtctgtga tctactcctg cgtaaagctc ttcccctccc
     3001 cactgcagac cctctccagg aagatcgtgc ggtccaagat gaacagcacc ctggttgggg
     3061 tgttcaccat caccctggtg ttcctggcgg cttttgtcaa catgttcacg tgcaactcca
     3121 gggacctgct gggctgcttg gcacaggagc acaacatcag cgcgagccag gtcaacgcgt
     3181 gtcacgtggc ggagtcggcc gtcaactaca gcctgggcga tgagcagggc ttctgtggca
     3241 gcccctggcc caactgcaac ttccccgagt acttcaccta cagcgtgctg ctcagcctgc
     3301 tggcctgctc cgtgttcctg cagatcagct gcatcgggaa gctggtgctc atgctggcca
     3361 tcgagctcat ctacgtgctc atcgtggagg tgccaggtgt cacgctcttc gacaacgccg
     3421 acctgctggt caccgccaac gccatagact tcttcaacaa cgggacctcc cagtgccctg
     3481 agcatgcaac caaggtggca ttgaaggtgg tgacgcccat catcatctca gtctttgtgc
     3541 tggccctgta cctgcacgcc cagcaggtgg agtccactgc ccgcctcgac ttcctctgga
     3601 aactgcaggc cacagaggag aaagaggaga tggaggagct gcaggcctac aaccggcggc
     3661 tgctgcacaa catcctgccc aaggacgtgg ccgctcactt cctggcccgc gagcggcgca
     3721 atgatgagct ctactatcag tcctgtgagt gtgtggcggt catgttcgcc tccatcgcca
     3781 acttctccga gttctacgtt gagctggagg ccaacaacga gggtgtcgag tgcctgcggc
     3841 tactcaatga gatcatcgct gactttgatg agatcatcag cgaggatcgg ttccggcagc
     3901 tggagaagat caagaccatc ggcagcacct acatggctgc ctccggcctc aacgactcta
     3961 cctacgacaa ggtgggcaag acccacatca aggcactggc cgactttgcc atgaagctga
     4021 tggaccagat gaagtacatc aatgagcact ccttcaacaa cttccagatg aagatcgggc
     4081 tcaacatcgg ccccgtggtg gccggggtga taggggcacg aaagcctcag tacgacatct
     4141 ggggcaatac cgtgaacgtg gccagccgca tggacagcac cggtgtaccc gaccgcatcc
     4201 aggtcaccac agacatgtac caggtgctgg ctgccaacac gtaccagctg gagtgccggg
     4261 gcgtggtcaa ggtcaagggc aaaggcgaga tgatgaccta cttcctcaat ggagggcccc
     4321 cgctcagtta gcagctgttg gccaatggtg ccaggcagcc tggcctccag aggcatggaa
     4381 gcagcttctc tgtgtgccgg gggtggcggg gaagccatgc tccagcccgc agggctgcgc
     4441 tgctgagatt ttccacttgg actccagagc agcttctgcc tttgctggtg ggcagcggcc
     4501 tctgtcccag gccccggggt gccagcgtcc tgcgagcacc cagctgacca aagatgtttc
     4561 cctctgtaga agactctgct agactgggtc tgaagcttga gttttctaac aggtgctgct
     4621 gcacaggtgg aaaggagccg tgggaatgtg tgtgtggcac ggcccagaca agggcagggc
     4681 tgaggggcct ccgactcagc tgggggtaga cgggctcgaa tgtggcctgg gagagcctag
     4741 ggggccccag gggtctgctt ttctatgtga gcctttaaac ttcagacagg ccaccaccct
     4801 gcacctgcag gggctttggc acaggagtgc tggctttgga gggactgtgg ccttcatcgt
     4861 ggtcctctgc ccacacctcc acgcacacag acagtgccct aggagggaaa cagaactaat
     4921 tacgaggggg aggcaagagg acgccaagca aggagtggtg attctgagaa aaatatttat
     4981 taaataaaac aaaacaagtt ctccgtgccc ttctttagac tatgctagtt gtatgcgtgt
     5041 aagagacaca caagcaaacg aggacgccac tcggggggag ggcggggatc cccacttgtc
     5101 ttttttgtat tttttatttt gtattattga aagccttgga gatctcacag atagatatgc
     5161 caaattctat attttgtaaa ttctctatat tagaaaacag ctgtgcacag cagggcgggt
     5221 gtgctcattt gtactgtgtg tatgtcggtg tatgtactgg tgtatatgtg tgtgtgttca
     5281 tgctgtggaa ctggtctcac acaggatgtg tttccctcat ttcagatttg gcagttttgg
     5341 gttttccaag gtaccaccag agcagtgggt gtgtgctttt ggggtaccat atgctcagat
     5401 taagtaggag gatgcatgga cacactgccc catcttttct gacacacgca cacgtatgta
     5461 cacacatgca cacaccctcc ttcccctaag caaaacgcag atggaataag aaaacaaaaa
     5521 gctgctttcc catcccaggc cgagctggaa ccaagggaag caatctcatc ctgcgacagg
     5581 cagtgtggtg ccctccacac cctgagattt cagacgtttg cggcttacag aggcagcgcc
     5641 cacagattcc agagtgctta cagaaggcca ggtgctttgc aggctgggac gaggaagcca
     5701 agcctccctg gcctactcag ttggccaagg tgcaggtggc tcttcctgga gatgttcact
     5761 cagactgggg gatgcaatgt gcagccttca ggtttgcgga aagggagtgg ccttgacctc
     5821 caccggcaaa ccaggcagag gaatgggtag agcccagctt tagagtccac agggaaagct
     5881 agcaggaatt ttgttttagt gggagggggc agttaaacat accaagaaaa aaatactatt
     5941 tttataacct atgaggaaga catttggaaa atgatactct agcacagaat tcagtggaat
     6001 ccttagggcc catgcccaaa tctttccatt gcttctcagg ttagaatgat cttcacctcc
     6061 aacatgagct tggaggtgat gaggcagtgg ctctgtgcca gctgccacaa tgtgactttg
     6121 atgtccacct gtaccacctc tcactgggct ctagcaccac cctcccctcc ccgcacacca
     6181 actgaacaca gctctgagaa gcaaagtgtg tggacccaaa actgccaagc ctgagtctgt
     6241 cccgtgcttc tgctgctcca tcctttgagt tctgcattgc catcctgacg tcggccacag
     6301 gaggcctgct ttcttccagc tgttgttctc aagttccctg cccctccaca tcgcccgcca
     6361 gtggtgttgg gttttcgttc tgcttccaac ctgagtaaag tgtgtgtgct gagttcatcc
     6421 catgttctcc catggtcatg gcttcccggc cccatgggga cccctctccc atcccagcag
     6481 tgactggtga cagtgtgcag gtgcagtgct agctcttcgt tccctctaaa gggtgtgcac
     6541 tctttttatt cctactcttg caaaaacaga tacgattatg atttcccatg gaaattgaaa
     6601 agtctattta aataatttaa ctattaaaca ctttcactgg taa
//
