LOCUS       NM_001198568            3710 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens adenylate cyclase 4 (ADCY4), transcript variant 3,
            mRNA.
ACCESSION   NM_001198568
VERSION     NM_001198568.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3710)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3710)
  AUTHORS   Fan,Y., Mu,J., Huang,M., Imani,S., Wang,Y., Lin,S., Fan,J. and
            Wen,Q.
  TITLE     Epigenetic identification of ADCY4 as a biomarker for breast
            cancer: an integrated analysis of adenylate cyclases
  JOURNAL   Epigenomics 11 (14), 1561-1579 (2019)
   PUBMED   31584294
  REMARK    GeneRIF: ADCY4 may be used as an epigenetic biomarker for breast
            cancer, as well as a possible target for therapy.
REFERENCE   3  (bases 1 to 3710)
  AUTHORS   Nudel,R., Simpson,N.H., Baird,G., O'Hare,A., Conti-Ramsden,G.,
            Bolton,P.F., Hennessy,E.R., Ring,S.M., Davey Smith,G., Francks,C.,
            Paracchini,S., Monaco,A.P., Fisher,S.E. and Newbury,D.F.
  CONSRTM   SLI Consortium
  TITLE     Genome-wide association analyses of child genotype effects and
            parent-of-origin effects in specific language impairment
  JOURNAL   Genes Brain Behav 13 (4), 418-429 (2014)
   PUBMED   24571439
REFERENCE   4  (bases 1 to 3710)
  AUTHORS   Bogard,A.S., Xu,C. and Ostrom,R.S.
  TITLE     Human bronchial smooth muscle cells express adenylyl cyclase
            isoforms 2, 4, and 6 in distinct membrane microdomains
  JOURNAL   J Pharmacol Exp Ther 337 (1), 209-217 (2011)
   PUBMED   21228062
  REMARK    GeneRIF: AC4 and AC2, both isoforms stimulated by Gbetagamma, are
            expressed in bronchial nonlipid raft membrane fractions where they
            colocalize with and couple to prostanoid EP2 receptors.
REFERENCE   5  (bases 1 to 3710)
  AUTHORS   Rhim,J.H., Jang,I.S., Yeo,E.J., Song,K.Y. and Park,S.C.
  TITLE     Role of protein kinase C-dependent A-kinase anchoring proteins in
            lysophosphatidic acid-induced cAMP signaling in human diploid
            fibroblasts
  JOURNAL   Aging Cell 5 (6), 451-461 (2006)
   PUBMED   17081159
REFERENCE   6  (bases 1 to 3710)
  AUTHORS   Wong,S.T., Trinh,K., Hacker,B., Chan,G.C., Lowe,G., Gaggar,A.,
            Xia,Z., Gold,G.H. and Storm,D.R.
  TITLE     Disruption of the type III adenylyl cyclase gene leads to
            peripheral and behavioral anosmia in transgenic mice
  JOURNAL   Neuron 27 (3), 487-497 (2000)
   PUBMED   11055432
  REMARK    GeneRIF: This paper reports the presence of adenylyl cyclases 2, 3,
            and 4 in mouse olfactory cilia.
REFERENCE   7  (bases 1 to 3710)
  AUTHORS   Tesmer,J.J., Sunahara,R.K., Gilman,A.G. and Sprang,S.R.
  TITLE     Crystal structure of the catalytic domains of adenylyl cyclase in a
            complex with Gsalpha.GTPgammaS
  JOURNAL   Science 278 (5345), 1907-1916 (1997)
   PUBMED   9417641
REFERENCE   8  (bases 1 to 3710)
  AUTHORS   Dessauer,C.W. and Gilman,A.G.
  TITLE     Purification and characterization of a soluble form of mammalian
            adenylyl cyclase
  JOURNAL   J Biol Chem 271 (28), 16967-16974 (1996)
   PUBMED   8663304
REFERENCE   9  (bases 1 to 3710)
  AUTHORS   Edelhoff,S., Villacres,E.C., Storm,D.R. and Disteche,C.M.
  TITLE     Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in
            mouse
  JOURNAL   Mamm Genome 6 (2), 111-113 (1995)
   PUBMED   7766992
REFERENCE   10 (bases 1 to 3710)
  AUTHORS   Gaudin,C., Homcy,C.J. and Ishikawa,Y.
  TITLE     Mammalian adenylyl cyclase family members are randomly located on
            different chromosomes
  JOURNAL   Hum Genet 94 (5), 527-529 (1994)
   PUBMED   7959689
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL096870.5, BC117473.1 and
            AK122714.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001198568.1.
            
            Summary: This gene encodes a member of the family of adenylate
            cyclases, which are membrane-associated enzymes that catalyze the
            formation of the secondary messenger cyclic adenosine monophosphate
            (cAMP). Mouse studies show that adenylate cyclase 4, along with
            adenylate cyclases 2 and 3, is expressed in olfactory cilia,
            suggesting that several different adenylate cyclases may couple to
            olfactory receptors and that there may be multiple
            receptor-mediated mechanisms for the generation of cAMP signals.
            Alternative splicing results in transcript variants. [provided by
            RefSeq, Nov 2010].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: The RefSeq transcript was derived from the reference
            genome assembly. The genomic coordinates were determined from
            alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.222309.1,
                                           SRR1803616.61830.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000418030.7/ ENSP00000393177.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-324               AL096870.5         54884-55207
            325-3677            BC117473.1         1-3353
            3678-3710           AK122714.1         3373-3405
FEATURES             Location/Qualifiers
     source          1..3710
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..3710
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /note="adenylate cyclase 4"
                     /db_xref="GeneID:196883"
                     /db_xref="HGNC:HGNC:235"
                     /db_xref="MIM:600292"
     exon            1..578
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             420..3653
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /EC_number="4.6.1.1"
                     /note="adenylate cyclase type IV; adenylyl cyclase 4; ATP
                     pyrophosphate-lyase 4"
                     /codon_start=1
                     /product="adenylate cyclase type 4"
                     /protein_id="NP_001185497.1"
                     /db_xref="CCDS:CCDS9627.1"
                     /db_xref="GeneID:196883"
                     /db_xref="HGNC:HGNC:235"
                     /db_xref="MIM:600292"
                     /translation="MARLFSPRPPPSEDLFYETYYSLSQQYPLLLLLLGIVLCALAAL
                     LAVAWASGRELTSDPSFLTTVLCALGGFSLLLGLASREQRLQRWTRPLSGLVWVALLA
                     LGHAFLFTGGVVSAWDQVSYFLFVIFTAYAMLPLGMRDAAVAGLASSLSHLLVLGLYL
                     GPQPDSRPALLPQLAANAVLFLCGNVAGVYHKALMERALRATFREALSSLHSRRRLDT
                     EKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLY
                     ADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSL
                     PDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHD
                     VTLANHMEAGGVPGRVHITGATLALLAGAYAVEDAGMEHRDPYLRELGEPTYLVIDPR
                     AEEEDEKGTAGGLLSSLEGLKMRPSLLMTRYLESWGAAKPFAHLSHGDSPVSTSTPLP
                     EKTLASFSTQWSLDRSRTPRGLDDELDTGDAKFFQVIEQLNSQKQWKQSKDFNPLTLY
                     FREKEMEKEYRLSAIPAFKYYEACTFLVFLSNFIIQMLVTNRPPALAITYSITFLLFL
                     LILFVCFSEDLMRCVLKGPKMLHWLPALSGLVATRPGLRIALGTATILLVFAMAITSL
                     FFFPTSSDCPFQAPNVSSMISNLSWELPGSLPLISVPYSMHCCTLGFLSCSLFLHMSF
                     ELKLLLLLLWLAASCSLFLHSHAWLSECLIVRLYLGPLDSRPGVLKEPKLMGAISFFI
                     FFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIG
                     QNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLS
                     KPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDV
                     INKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTE
                     ETAWALQSLGYTCYSRGVIKVKGKGQLCTYFLNTDLTRTGPPSATLG"
     exon            579..776
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /inference="alignment:Splign:2.1.0"
     exon            777..938
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1088
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1237
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1349
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1477
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1636
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1769
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1943
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..1987
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2074
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2144
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2242
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2327
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2465
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2576
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2761
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2762..2846
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..3005
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3152
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /inference="alignment:Splign:2.1.0"
     exon            3153..3260
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /inference="alignment:Splign:2.1.0"
     exon            3261..3375
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /inference="alignment:Splign:2.1.0"
     exon            3376..3500
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /inference="alignment:Splign:2.1.0"
     exon            3501..3710
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3680..3685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /note="hexamer: AATAAA"
     polyA_site      3710
                     /gene="ADCY4"
                     /gene_synonym="AC4"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcagc ggcgagcgtg actccgccat caggtccccg gctccctccc cggacctagc
       61 ccactccgct gcgccagcgc cgcgggcagt gagttcgggg atcaggggaa cccggggctc
      121 cctcgcacca accccaaatc ctgccctcct ggcgatgagg cttttctagg gcacctctac
      181 aatccgggtt tgagggagga ggaggaaagg actgagggat cccctcatcg ccagctggga
      241 gcgggctggg aggccgcagg gagggcctga aaaaggagac gggattgcca cgaggttggg
      301 ggcgcggggt ggtagcggct ttgagcgggt gagaaaagct caggtggggc ccgccgggcc
      361 gaaggaggta acccggcgcc cggccctagc cagccccggg gctcggggct ggggagatca
      421 tggcccgcct cttcagcccc cggccgcccc ccagcgaaga cctcttctac gagacctact
      481 acagcctgag ccagcagtac ccgctgctgc tgctgctgct ggggatcgtg ctctgtgcgc
      541 tcgcggcgct gctcgcagtg gcctgggcca gcggcaggga gctgacctca gacccgagct
      601 tcctgaccac tgtgctgtgc gcgctgggcg gcttctcgct gctgctgggc ctcgcttccc
      661 gggagcagcg actgcagcgc tggacgcgtc ccctgtccgg cttggtatgg gtcgcgctgc
      721 tagcgctagg ccacgccttc ctgttcaccg ggggcgtggt gagcgcctgg gaccaggtgt
      781 cctattttct cttcgtcatc ttcacggcgt atgccatgct gcccttgggc atgcgggacg
      841 ccgccgtcgc gggcctcgcc tcctcactct cgcatctgct ggtcctcggg ctgtatcttg
      901 ggccacagcc ggactcacgg cctgcactgc tgccgcagtt ggcagcaaac gcagtgctgt
      961 tcctgtgcgg gaacgtggca ggagtgtacc acaaggcgct gatggagcgc gccctgcggg
     1021 ccacgttccg ggaggcactc agctccctgc actcacgccg gcggctggac accgagaaga
     1081 agcaccagga acaccttctc ttgtccatcc ttcctgccta cctggcccga gagatgaagg
     1141 cagagatcat ggcacggctg caggcaggac aggggtcacg gccagagagc actaacaatt
     1201 tccacagcct ctatgtcaag aggcaccagg gagtcagcgt gctgtatgct gacatcgtgg
     1261 gcttcacgcg gctggccagc gagtgttccc ctaaggagct ggtgctcatg ctcaatgagc
     1321 tctttggcaa gttcgaccag attgccaagg agcatgaatg catgcggatc aagatcctgg
     1381 gggactgtta ctactgtgtc tctgggctgc cactctcact gccagaccat gccatcaact
     1441 gcgtgcgcat gggcctggac atgtgccggg ccatcaggaa actgcgggca gccactggcg
     1501 tggacatcaa catgcgtgtg ggcgtgcact caggcagcgt actgtgtgga gtcatcgggc
     1561 tgcagaagtg gcagtacgac gtttggtcac atgatgtcac actggctaac cacatggagg
     1621 caggcggtgt accagggcga gtgcacatca caggggctac cctggccctg ctggcagggg
     1681 cttatgctgt ggaggacgca ggcatggagc atcgggaccc ctaccttcgg gagctagggg
     1741 agcctaccta tctggtcatc gatccacggg cagaggagga ggatgagaag ggcactgcag
     1801 gaggcttgct gtcctcgctt gagggcctca agatgcgtcc atcactgctg atgacccgtt
     1861 acctggagtc ctggggcgca gccaagcctt ttgcccacct gagccacgga gacagccctg
     1921 tgtccacctc cacccctctc ccggagaaga ccctggcttc cttcagcacc cagtggagcc
     1981 tggatcggag ccgtaccccc cggggactag atgatgaact ggacaccggg gatgccaagt
     2041 tcttccaggt cattgagcag ctcaactcgc agaaacagtg gaagcagtcg aaggacttca
     2101 acccactgac actgtacttc agagagaagg agatggagaa agagtaccga ctctctgcaa
     2161 tccccgcctt caaatactat gaagcctgca ccttcctggt ttttctctcc aacttcatca
     2221 tccagatgct agtgacaaac aggcccccag ctctggccat cacgtatagc atcaccttcc
     2281 tcctcttcct cctcatcctt tttgtctgct tctcagagga cctgatgagg tgtgtcctga
     2341 aaggccccaa gatgctgcac tggctgcctg cactgtctgg cctggtggcc acacgaccag
     2401 gactgagaat agccttgggc accgccacca tcctccttgt ctttgccatg gccattacca
     2461 gcctgttctt cttcccaaca tcatcagact gccctttcca agctcccaat gtgtcctcca
     2521 tgatttccaa cctctcctgg gagctccctg ggtctctgcc tctcatcagt gtcccatact
     2581 ccatgcactg ctgcacgctg ggcttcctct cctgctccct ctttctgcac atgagcttcg
     2641 agctgaagct gctgctgctc ctgctgtggc tggcggcatc ctgctccctc ttcctgcact
     2701 cccatgcctg gctgtcggaa tgcctcatcg tccgcctcta tctgggcccc ttggactcca
     2761 ggcccggagt gctgaaggag cccaaactga tgggtgctat ctccttcttc atcttcttct
     2821 tcaccctcct tgtcctggct cgccagaatg agtactactg ccgcctggac ttcctgtgga
     2881 agaagaagct gaggcaggag agggaggaga cagagacgat ggagaacctg actcggctgc
     2941 tcttggagaa cgtgctccct gcacacgtgg ccccccagtt cattggccag aaccggcgca
     3001 acgaggatct ctaccaccag tcctatgaat gcgtttgtgt cctcttcgcc tcagtcccag
     3061 acttcaagga gttctactct gaatccaaca tcaatcatga gggcctagag tgtctgaggc
     3121 tgctcaatga gataattgct gattttgatg agctgctctc caagcccaag ttcagtgggg
     3181 tggagaagat caagaccatc ggcagcacct acatggcagc cacaggctta aatgccacct
     3241 ctggacagga tgcacaacag gatgctgaac ggagctgcag ccaccttggc actatggtgg
     3301 aatttgccgt ggccctgggg tctaagctgg acgtcatcaa caagcattca ttcaacaact
     3361 tccgcctgcg agtggggttg aaccatggac ccgtagtagc tggagttatt ggggcccaga
     3421 agccgcaata tgacatttgg ggcaacacag tgaacgtggc cagccgcatg gagagtacag
     3481 gagtccttgg caaaatccaa gtgactgagg agacagcatg ggccctacag tccctgggct
     3541 acacctgcta cagccggggt gtcatcaagg tgaaaggcaa agggcagctc tgcacctact
     3601 tcctgaacac agacttgaca cgaactggac ctccttcagc taccctaggc tgagattgca
     3661 ctcgccttct aagaacctca ataaagagac tctggggtgt ctggagccca
//
