LOCUS       NM_004036               4950 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens adenylate cyclase 3 (ADCY3), transcript variant 2,
            mRNA.
ACCESSION   NM_004036 XM_005264105
VERSION     NM_004036.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4950)
  AUTHORS   Khani,S., Topel,H., Kardinal,R., Tavanez,A.R., Josephrajan,A.,
            Larsen,B.D.M., Gaudry,M.J., Leyendecker,P., Egedal,N.M.,
            Guller,A.S., Stanic,N., Ruppert,P.M.M., Gaziano,I., Hansmeier,N.R.,
            Schmidt,E., Klemm,P., Vagliano,L.M., Stahl,R., Duthie,F.,
            Krause,J.H., Bici,A., Engelhard,C.A., Gohlke,S., Frommolt,P.,
            Gnad,T., Rada-Iglesias,A., Pradas-Juni,M., Schulz,T.J.,
            Wunderlich,F.T., Pfeifer,A., Bartelt,A., Jastroch,M., Wachten,D.
            and Kornfeld,J.W.
  TITLE     Cold-induced expression of a truncated adenylyl cyclase 3 acts as
            rheostat to brown fat function
  JOURNAL   Nat Metab 6 (6), 1053-1075 (2024)
   PUBMED   38684889
  REMARK    GeneRIF: Cold-induced expression of a truncated adenylyl cyclase 3
            acts as rheostat to brown fat function.
REFERENCE   2  (bases 1 to 4950)
  AUTHORS   Brewer,K.K., Brewer,K.M., Terry,T.T., Caspary,T., Vaisse,C. and
            Berbari,N.F.
  TITLE     Postnatal Dynamic Ciliary ARL13B and ADCY3 Localization in the
            Mouse Brain
  JOURNAL   Cells 13 (3), 259 (2024)
   PUBMED   38334651
  REMARK    GeneRIF: Postnatal Dynamic Ciliary ARL13B and ADCY3 Localization in
            the Mouse Brain.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4950)
  AUTHORS   Fitzpatrick,M. and Solberg Woods,L.C.
  TITLE     Adenylate cyclase 3: a potential genetic link between obesity and
            major depressive disorder
  JOURNAL   Physiol Genomics 56 (1), 1-8 (2024)
   PUBMED   37955134
  REMARK    GeneRIF: Adenylate cyclase 3: a potential genetic link between
            obesity and major depressive disorder.
            Review article
REFERENCE   4  (bases 1 to 4950)
  AUTHORS   Ye,C.Y., Xin,J.R., Li,Z., Yin,X.Y., Guo,S.L., Li,J.M., Zhao,T.Y.,
            Wang,L. and Yang,L.
  TITLE     ALDH2, ADCY3 and BCMO1 polymorphisms and lifestyle-induced traits
            are jointly associated with CAD risk in Chinese Han people
  JOURNAL   Gene 807, 145948 (2022)
   PUBMED   34481002
  REMARK    GeneRIF: ALDH2, ADCY3 and BCMO1 polymorphisms and lifestyle-induced
            traits are jointly associated with CAD risk in Chinese Han people.
REFERENCE   5  (bases 1 to 4950)
  AUTHORS   Toumba,M., Fanis,P., Vlachakis,D., Neocleous,V., Phylactou,L.A.,
            Skordis,N., Mantzoros,C.S. and Pantelidou,M.
  TITLE     Molecular modelling of novel ADCY3 variant predicts a molecular
            target for tackling obesity
  JOURNAL   Int J Mol Med 49 (1) (2022)
   PUBMED   34821371
  REMARK    GeneRIF: Molecular modelling of novel ADCY3 variant predicts a
            molecular target for tackling obesity.
REFERENCE   6  (bases 1 to 4950)
  AUTHORS   Gaudin,C., Homcy,C.J. and Ishikawa,Y.
  TITLE     Mammalian adenylyl cyclase family members are randomly located on
            different chromosomes
  JOURNAL   Hum Genet 94 (5), 527-529 (1994)
   PUBMED   7959689
REFERENCE   7  (bases 1 to 4950)
  AUTHORS   Kleuss,C., Raw,A.S., Lee,E., Sprang,S.R. and Gilman,A.G.
  TITLE     Mechanism of GTP hydrolysis by G-protein alpha subunits
  JOURNAL   Proc Natl Acad Sci U S A 91 (21), 9828-9831 (1994)
   PUBMED   7937899
REFERENCE   8  (bases 1 to 4950)
  AUTHORS   Haber,N., Stengel,D., Defer,N., Roeckel,N., Mattei,M.G. and
            Hanoune,J.
  TITLE     Chromosomal mapping of human adenylyl cyclase genes type III, type
            V and type VI
  JOURNAL   Hum Genet 94 (1), 69-73 (1994)
   PUBMED   8034296
REFERENCE   9  (bases 1 to 4950)
  AUTHORS   Hellevuo,K., Yoshimura,M., Kao,M., Hoffman,P.L., Cooper,D.M. and
            Tabakoff,B.
  TITLE     A novel adenylyl cyclase sequence cloned from the human
            erythroleukemia cell line
  JOURNAL   Biochem Biophys Res Commun 192 (1), 311-318 (1993)
   PUBMED   8476432
REFERENCE   10 (bases 1 to 4950)
  AUTHORS   Taylor,S.S., Buechler,J.A. and Yonemoto,W.
  TITLE     cAMP-dependent protein kinase: framework for a diverse family of
            regulatory enzymes
  JOURNAL   Annu Rev Biochem 59, 971-1005 (1990)
   PUBMED   2165385
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012073.9, HY136273.1,
            BM148122.1, BC126235.1 and BC020148.1.
            
            On Jun 2, 2019 this sequence version replaced NM_004036.4.
            
            Summary: This gene encodes adenylyl cyclase 3 which is a
            membrane-associated enzyme and catalyzes the formation of the
            secondary messenger cyclic adenosine monophosphate (cAMP). This
            protein appears to be widely expressed in various human tissues and
            may be involved in a number of physiological and pathophysiological
            metabolic processes. Two transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Feb
            2016].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction compared to variant 1. The resulting isoform (2)
            has the same N- and C-termini but is 1 aa shorter compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.71263.1,
                                           SRR1803615.263447.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000679454.1/ ENSP00000505261.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               AC012073.9         122710-122929       c
            221-609             HY136273.1         6-394
            610-694             BM148122.1         212-296
            695-4362            BC126235.1         1-3668
            4363-4363           AC012073.9         22448-22448         c
            4364-4950           BC020148.1         2770-3356
FEATURES             Location/Qualifiers
     source          1..4950
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..4950
                     /gene="ADCY3"
                     /gene_synonym="AC-III; AC3; BMIQ19"
                     /note="adenylate cyclase 3"
                     /db_xref="GeneID:109"
                     /db_xref="HGNC:HGNC:234"
                     /db_xref="MIM:600291"
     exon            1..555
                     /gene="ADCY3"
                     /gene_synonym="AC-III; AC3; BMIQ19"
                     /inference="alignment:Splign:2.1.0"
     exon            556..1427
                     /gene="ADCY3"
                     /gene_synonym="AC-III; AC3; BMIQ19"
                     /inference="alignment:Splign:2.1.0"
     CDS             753..4187
                     /gene="ADCY3"
                     /gene_synonym="AC-III; AC3; BMIQ19"
                     /EC_number="4.6.1.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     adenylyl cyclase, type III; adenylate cyclase type 3;
                     adenylyl cyclase 3; ATP pyrophosphate-lyase 3; adenylate
                     cyclase type III; adenylate cyclase, olfactive type"
                     /codon_start=1
                     /product="adenylate cyclase type 3 isoform 2"
                     /protein_id="NP_004027.2"
                     /db_xref="CCDS:CCDS1715.1"
                     /db_xref="GeneID:109"
                     /db_xref="HGNC:HGNC:234"
                     /db_xref="MIM:600291"
                     /translation="MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSG
                     SCLCLPRFMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSS
                     DKLASLAVAGIGLVLDIILFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFA
                     RAHAASDTVGWQVFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELK
                     GMQLLREILANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQE
                     NLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSA
                     CSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGL
                     AMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGI
                     PGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGL
                     NGSALPNGAPASSKSSSPALIETKEPNGSAHSSGSTSEKPEEQDAQADNPSFPNPRRR
                     LRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLSMRFMDPEMETRY
                     SVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAI
                     FPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMANVVDMLSCLQYYTGPSNATAG
                     METEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPV
                     FDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYF
                     SRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEEL
                     YSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVIT
                     KIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNI
                     NNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEE
                     TQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNGPSVTLPHQVVDNS"
     exon            1428..1577
                     /gene="ADCY3"
                     /gene_synonym="AC-III; AC3; BMIQ19"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1708
                     /gene="ADCY3"
                     /gene_synonym="AC-III; AC3; BMIQ19"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1820
                     /gene="ADCY3"
                     /gene_synonym="AC-III; AC3; BMIQ19"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1948
                     /gene="ADCY3"
                     /gene_synonym="AC-III; AC3; BMIQ19"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2107
                     /gene="ADCY3"
                     /gene_synonym="AC-III; AC3; BMIQ19"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2285
                     /gene="ADCY3"
                     /gene_synonym="AC-III; AC3; BMIQ19"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2414
                     /gene="ADCY3"
                     /gene_synonym="AC-III; AC3; BMIQ19"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2557
                     /gene="ADCY3"
                     /gene_synonym="AC-III; AC3; BMIQ19"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2719
                     /gene="ADCY3"
                     /gene_synonym="AC-III; AC3; BMIQ19"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2807
                     /gene="ADCY3"
                     /gene_synonym="AC-III; AC3; BMIQ19"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..2924
                     /gene="ADCY3"
                     /gene_synonym="AC-III; AC3; BMIQ19"
                     /inference="alignment:Splign:2.1.0"
     exon            2925..3184
                     /gene="ADCY3"
                     /gene_synonym="AC-III; AC3; BMIQ19"
                     /inference="alignment:Splign:2.1.0"
     exon            3185..3247
                     /gene="ADCY3"
                     /gene_synonym="AC-III; AC3; BMIQ19"
                     /inference="alignment:Splign:2.1.0"
     exon            3248..3329
                     /gene="ADCY3"
                     /gene_synonym="AC-III; AC3; BMIQ19"
                     /inference="alignment:Splign:2.1.0"
     exon            3330..3488
                     /gene="ADCY3"
                     /gene_synonym="AC-III; AC3; BMIQ19"
                     /inference="alignment:Splign:2.1.0"
     exon            3489..3635
                     /gene="ADCY3"
                     /gene_synonym="AC-III; AC3; BMIQ19"
                     /inference="alignment:Splign:2.1.0"
     exon            3636..3755
                     /gene="ADCY3"
                     /gene_synonym="AC-III; AC3; BMIQ19"
                     /inference="alignment:Splign:2.1.0"
     exon            3756..3879
                     /gene="ADCY3"
                     /gene_synonym="AC-III; AC3; BMIQ19"
                     /inference="alignment:Splign:2.1.0"
     exon            3880..4004
                     /gene="ADCY3"
                     /gene_synonym="AC-III; AC3; BMIQ19"
                     /inference="alignment:Splign:2.1.0"
     exon            4005..4950
                     /gene="ADCY3"
                     /gene_synonym="AC-III; AC3; BMIQ19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4926..4931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADCY3"
                     /gene_synonym="AC-III; AC3; BMIQ19"
                     /note="hexamer: ATTAAA"
     polyA_site      4950
                     /gene="ADCY3"
                     /gene_synonym="AC-III; AC3; BMIQ19"
                     /note="major polyA site"
ORIGIN      
        1 gagcgcgcgt ggccccggag ccgccggcgc cgcgcgggga atagctgtgc agcacgccga
       61 gcccggactc ggctggctcg gctcggcgcg ggcgggcgag aggatgctgg cgggcttccc
      121 cgggctcggc ccgcgctccc gccggggagg gccccgcgcg cgcccctagc agccgccgcc
      181 gccgcgggtg caggggaggg gtccggagag ccgcgctcgc cgccgcccgc gcctgccggc
      241 ccccgcacgg cccctgcccc tgagcctcag ccccagggcg ggcgcgctgg gccggcgccc
      301 acggatctcc cagccctcgt cgccgcctcc tccttccccc tgcggccggg cgcccgcgga
      361 tgctgagggg cagccctgcg cctctcccgg tcggatcccg ggcctgacgg cgggagatcg
      421 cgctccggcc gggccccgag gcgctgccgg ggcggcgcgg ctctgcgggg agcagccctc
      481 gggcgcgccg agctctcccg ccccagcccg cgcggggacc gtcccggagc acgcggtggc
      541 cgagttcccg cacagttcta gctgatcagt gctacctgtg ctctggaaac ccgctctgcg
      601 ttcctgctgg aggtggcctc ccctccgccc cagacaagaa gaggccctca gccctccccc
      661 ggtctcagag agccctgaga ggaggcccag tccagagctc ttcctccgtt cccagtccac
      721 ttctctaggg ccagtagcag acaccagcca gtatgccgag gaaccagggc ttctccgagc
      781 ccgaatactc ggccgagtac tcagccgagt actccgtcag cctgccctcc gaccctgacc
      841 gcggggtggg ccggacccat gaaatctcgg tccggaactc gggctcctgc ctgtgcctgc
      901 ctcgcttcat gcggctgact ttcgtgccgg agtccttgga gaacctctac cagacctact
      961 tcaaaaggca gcgccacgag accctgctgg tgctggtggt ctttgcagcc ctctttgact
     1021 gctacgtggt ggtcatgtgt gctgtggtct tctccagcga caagctggct tccctcgccg
     1081 tggctggaat tggactggtg ttggacatca tcctcttcgt gctctgcaaa aaggggctgc
     1141 tcccggaccg ggtcacccgc agagtgctgc cctacgtgct gtggctgctc ataaccgccc
     1201 agatcttctc ctacctgggc ctgaacttcg cgcgtgccca cgcggctagt gacacggtgg
     1261 gctggcaggt cttctttgtc ttctccttct tcatcacgct gcccctcagc ctcagcccca
     1321 tcgtgatcat ctccgtggtc tcctgtgtgg tgcacacgtt ggtcctgggg gtcaccgtgg
     1381 cccagcagca gcaggaggag ctcaagggga tgcagctgct gcgggagatc ctggccaacg
     1441 tcttcctcta cctgtgcgcc atcgctgtgg gcatcatgtc ctactacatg gctgaccgca
     1501 agcaccgcaa ggccttcctg gaggcccgcc agtcgctgga ggtgaagatg aacctggaag
     1561 agcagagcca gcagcaggag aacctcatgc tttccatcct gcccaagcac gtggctgacg
     1621 agatgctgaa agacatgaag aaagacgaga gccagaagga ccagcagcag ttcaacacca
     1681 tgtacatgta ccgtcacgag aacgtcagca tcctctttgc cgacatcgtg ggctttaccc
     1741 agctgtcttc tgcctgcagt gcccaggagc ttgtgaagct gctcaacgag ctctttgccc
     1801 gctttgacaa gctggcagct aaataccacc agctgcggat taagatcctg ggcgactgct
     1861 actactgcat ctgcggcttg cccgactacc gggaggacca cgccgtctgc tccatcctca
     1921 tggggctggc catggtggag gccatctcgt atgtgcggga gaagaccaag actggggtgg
     1981 acatgcgtgt gggggtgcac acgggcaccg tgctgggggg cgtcctgggc cagaagcgct
     2041 ggcagtacga cgtgtggtcg actgatgtca ctgtagccaa caagatggag gccggcggca
     2101 tccctgggcg cgtgcacatc tcccagagca ccatggactg cctgaaaggg gagtttgatg
     2161 tggagccagg cgatgggggc agccgctgtg attacctaga agagaagggt attgaaacct
     2221 acctcatcat tgcctccaag ccagaggtga agaaaacagc cacccagaat ggcctcaatg
     2281 gctcggccct gcccaatgga gcaccagctt cctcaaagtc cagctcccct gccctcattg
     2341 agaccaagga gcccaacggg agtgcccaca gcagtgggtc cacgtcggag aagcccgagg
     2401 agcaggatgc ccaggccgac aacccctcat tccccaaccc acgccggagg ctgcgcctgc
     2461 aggacctggc tgaccgagtg gtggatgcct ctgaagatga gcacgagctc aaccagctgc
     2521 tcaacgaggc cctgcttgag cgagagtccg cccaagtagt aaagaagaga aacaccttcc
     2581 tcttgtccat gcggttcatg gaccccgaga tggaaacccg ctactcggtg gagaaggaga
     2641 agcagagtgg ggctgccttc agctgctcct gcgtcgtcct gctctgcacg gccctggtcg
     2701 agatactcat cgacccctgg ctaatgacaa actatgtgac cttcatggtg ggggagattc
     2761 tgctcctcat cctgaccatc tgctccctgg ctgccatctt tccccgggcc tttcctaaga
     2821 agcttgtggc cttctcaact tggattgacc ggacccgctg ggccaggaac acctgggcca
     2881 tgctcgccat cttcatcctg gtgatggcaa atgtcgtgga catgctcagc tgtctccagt
     2941 actacacggg acccagcaat gcaacggcag ggatggaaac ggagggcagc tgcctggaga
     3001 accccaagta ttacaactat gtggccgtgc tgtccctcat cgccaccatc atgctggtgc
     3061 aggtcagcca catggtgaag ctcacgctca tgctgctcgt cgcaggcgcc gtggccacca
     3121 tcaacctcta tgcctggcgt cccgtctttg atgaatacga ccacaagcgt tttcgggagc
     3181 acgacttacc tatggtggcc ttagagcaga tgcaaggatt caaccctggg ctcaatggca
     3241 ctgacaggct gcccctggtg ccttccaagt actctatgac ggtgatggtg ttcctcatga
     3301 tgctcagctt ctactacttc tcccgccacg tagaaaaact ggcacggaca cttttcttgt
     3361 ggaagattga ggtccacgac cagaaggaac gtgtctatga gatgcgacgc tggaacgagg
     3421 ccttggtcac caacatgttg cctgagcacg tggcacgcca tttcctgggg tccaagaaga
     3481 gagatgagga gctgtatagc cagacgtatg atgagattgg agtcatgttt gcctccctgc
     3541 ccaactttgc tgacttctac acagaggaga gcatcaacaa tggtggtatt gagtgtctgc
     3601 gtttcctcaa tgaaatcatc tcagattttg actctctcct ggacaatccc aagttccggg
     3661 tgatcaccaa gatcaaaacc attggcagca cgtatatggc ggcttcagga gtcacccccg
     3721 atgtcaacac caatggcttt gccagctcca acaaggaaga caagtccgag agagagcgct
     3781 ggcagcacct ggctgacctg gccgacttcg cgctggccat gaaggatacg ctcaccaaca
     3841 tcaacaacca gtccttcaat aacttcatgc tgcgcatagg catgaacaaa ggcggggttc
     3901 tggctggggt catcggagcc cggaaaccac actacgacat ctggggcaat acagtcaatg
     3961 tagccagcag gatggagtcc acgggggtca tgggcaacat tcaggtggta gaagaaaccc
     4021 aagtcatcct ccgagagtac ggcttccgct ttgtgaggcg aggccccatc tttgtgaagg
     4081 ggaaggggga gctgctgacc ttcttcttga aggggcggga taagctagcc accttcccca
     4141 atggcccctc tgtcacactg ccccaccagg tggtggacaa ctcctgaatg gcctcgagcc
     4201 tgcaacagtc caaaccggaa gggagaattt attttttgaa actgaaggaa gtcccgacct
     4261 tcctggattg aagtgcacac tcatggactt taggtttaga aacctcctca gccttcattt
     4321 gttcgtggat gtgtgagctc tgagggtggc cctgctattc ctgtgtgtgc ctgtagtgtc
     4381 cccagcatag gggtcttagg catagggctg aacagtcctt ccagagccct cgttccaatc
     4441 cctgccgtcc ttgcccctga ggggccctga ccactgtgag caggagggtg gcagagctgg
     4501 gacaaagctg cctttgccgc tgggctttcc gggactgtgg agggagcaca ggcggggaag
     4561 ctccacttca gacagggctt ggtggggcag gacatggctc ccattttgaa gggaggtctc
     4621 catgtggtcc gagtgaggtg agacggccct cgtcctggtg ttcctgatca tcttgaaagg
     4681 ttcttctgga actcctgtcc ccttagtcat gagaacagaa agtgcaatat ttcctttcac
     4741 ctggcagggg aggggggatt tatttctgaa agaaaaatat ataaacagat cttctacatt
     4801 tatattttta atcttctgtt aaatacactt tccgatattg ccttgccttt tgagctcttg
     4861 ctacagtcgc ctttgctact gctttaagag aatttacagg tattgataaa gaacaagact
     4921 gttttattaa aagctttatt caacttgaaa
//
