LOCUS       NM_020546               6645 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens adenylate cyclase 2 (ADCY2), mRNA.
ACCESSION   NM_020546
VERSION     NM_020546.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6645)
  AUTHORS   Wei,W., Pan,J., Wang,J., Mao,S., Qian,Y., Lin,X., Ling,Q., Ye,W.,
            Zhou,Y., Zhao,Y., Huang,J., Huang,X., Ma,Z., Wang,H., Li,C., Sun,J.
            and Jin,J.
  TITLE     circSLC25A13 acts as a ceRNA to regulate AML progression via
            miR-616-3p/ADCY2 axis
  JOURNAL   Mol Carcinog 62 (10), 1546-1562 (2023)
   PUBMED   37493101
  REMARK    GeneRIF: circSLC25A13 acts as a ceRNA to regulate AML progression
            via miR-616-3p/ADCY2 axis.
REFERENCE   2  (bases 1 to 6645)
  AUTHORS   Aghabozorg Afjeh,S.S., Shams,J., Hamednia,S., Boshehri,B., Olfat,A.
            and Omrani,M.D.
  TITLE     Investigation of the impact of an ADCY2 polymorphism as a
            predictive biomarker in bipolar disorder, suicide tendency and
            response to lithium carbonate therapy: the first report from Iran
  JOURNAL   Pharmacogenomics 21 (14), 1011-1020 (2020)
   PUBMED   32893730
  REMARK    GeneRIF: Investigation of the impact of an ADCY2 polymorphism as a
            predictive biomarker in bipolar disorder, suicide tendency and
            response to lithium carbonate therapy: the first report from Iran.
REFERENCE   3  (bases 1 to 6645)
  AUTHORS   Huang,C.B., Shi,W.J., Wang,C.J., Chen,X.F. and Sun,T.P.
  TITLE     Association of adenylate cyclase-2 gene polymorphism with bipolar
            disorder
  JOURNAL   Asian J Psychiatr 52, 102150 (2020)
   PUBMED   32447269
  REMARK    GeneRIF: Association of adenylate cyclase-2 gene polymorphism with
            bipolar disorder.
REFERENCE   4  (bases 1 to 6645)
  AUTHORS   van Huis-Tanja,L.H., Ewing,E., van der Straaten,R.J., Swen,J.J.,
            Baak-Pablo,R.F., Punt,C.J., Gelderblom,A.J. and Guchelaar,H.J.
  TITLE     Clinical validation study of genetic markers for capecitabine
            efficacy in metastatic colorectal cancer patients
  JOURNAL   Pharmacogenet Genomics 25 (6), 279-288 (2015)
   PUBMED   25815774
  REMARK    GeneRIF: In patients receiving capecitabine monotherapy, rs4702484,
            located in ADCY2 and close to MTRR, was associated with slightly
            reduced PFS for homozygous wild-type patients (CC 6.2 vs. CT 8.0
            months; P=0.018).
REFERENCE   5  (bases 1 to 6645)
  AUTHORS   Muhleisen,T.W., Leber,M., Schulze,T.G., Strohmaier,J.,
            Degenhardt,F., Treutlein,J., Mattheisen,M., Forstner,A.J.,
            Schumacher,J., Breuer,R., Meier,S., Herms,S., Hoffmann,P.,
            Lacour,A., Witt,S.H., Reif,A., Muller-Myhsok,B., Lucae,S.,
            Maier,W., Schwarz,M., Vedder,H., Kammerer-Ciernioch,J., Pfennig,A.,
            Bauer,M., Hautzinger,M., Moebus,S., Priebe,L., Czerski,P.M.,
            Hauser,J., Lissowska,J., Szeszenia-Dabrowska,N., Brennan,P.,
            McKay,J.D., Wright,A., Mitchell,P.B., Fullerton,J.M.,
            Schofield,P.R., Montgomery,G.W., Medland,S.E., Gordon,S.D.,
            Martin,N.G., Krasnow,V., Chuchalin,A., Babadjanova,G.,
            Pantelejeva,G., Abramova,L.I., Tiganov,A.S., Polonikov,A.,
            Khusnutdinova,E., Alda,M., Grof,P., Rouleau,G.A., Turecki,G.,
            Laprise,C., Rivas,F., Mayoral,F., Kogevinas,M.,
            Grigoroiu-Serbanescu,M., Propping,P., Becker,T., Rietschel,M.,
            Nothen,M.M. and Cichon,S.
  TITLE     Genome-wide association study reveals two new risk loci for bipolar
            disorder
  JOURNAL   Nat Commun 5, 3339 (2014)
   PUBMED   24618891
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6645)
  AUTHORS   Dessauer,C.W. and Gilman,A.G.
  TITLE     Purification and characterization of a soluble form of mammalian
            adenylyl cyclase
  JOURNAL   J Biol Chem 271 (28), 16967-16974 (1996)
   PUBMED   8663304
REFERENCE   7  (bases 1 to 6645)
  AUTHORS   Gaudin,C., Homcy,C.J. and Ishikawa,Y.
  TITLE     Mammalian adenylyl cyclase family members are randomly located on
            different chromosomes
  JOURNAL   Hum Genet 94 (5), 527-529 (1994)
   PUBMED   7959689
REFERENCE   8  (bases 1 to 6645)
  AUTHORS   Kleuss,C., Raw,A.S., Lee,E., Sprang,S.R. and Gilman,A.G.
  TITLE     Mechanism of GTP hydrolysis by G-protein alpha subunits
  JOURNAL   Proc Natl Acad Sci U S A 91 (21), 9828-9831 (1994)
   PUBMED   7937899
REFERENCE   9  (bases 1 to 6645)
  AUTHORS   Stengel,D., Parma,J., Gannage,M.H., Roeckel,N., Mattei,M.G.,
            Barouki,R. and Hanoune,J.
  TITLE     Different chromosomal localization of two adenylyl cyclase genes
            expressed in human brain
  JOURNAL   Hum Genet 90 (1-2), 126-130 (1992)
   PUBMED   1427768
REFERENCE   10 (bases 1 to 6645)
  AUTHORS   Taylor,S.S., Buechler,J.A. and Yonemoto,W.
  TITLE     cAMP-dependent protein kinase: framework for a diverse family of
            regulatory enzymes
  JOURNAL   Annu Rev Biochem 59, 971-1005 (1990)
   PUBMED   2165385
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC024577.5, DB481853.2,
            BE677757.1, BC111743.1, DB029098.1, AF070583.1 and AC010346.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_020546.2.
            
            Summary: This gene encodes a member of the family of adenylate
            cyclases, which are membrane-associated enzymes that catalyze the
            formation of the secondary messenger cyclic adenosine monophosphate
            (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is
            stimulated by the G protein beta and gamma subunit complex.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.93886.1,
                                           SRR1660803.36055.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338316.9/ ENSP00000342952.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AC024577.5         80844-80935         c
            93-567              DB481853.2         1-475
            568-655             BE677757.1         474-561
            656-2036            BC111743.1         502-1882
            2037-2525           DB029098.1         69-557
            2526-2819           BC111743.1         2372-2665
            2820-4096           AF070583.1         489-1765
            4097-4983           BC111743.1         3943-4829
            4984-6645           AC010346.6         39048-40709
FEATURES             Location/Qualifiers
     source          1..6645
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.31"
     gene            1..6645
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /note="adenylate cyclase 2"
                     /db_xref="GeneID:108"
                     /db_xref="HGNC:HGNC:233"
                     /db_xref="MIM:103071"
     exon            1..369
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..3435
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /EC_number="4.6.1.1"
                     /note="type II adenylate cyclase; 3',5'-cyclic AMP
                     synthetase; adenylyl cyclase 2; adenylate cyclase II; ATP
                     pyrophosphate-lyase 2; adenylate cyclase type II;
                     adenylate cyclase 2 (brain)"
                     /codon_start=1
                     /product="adenylate cyclase type 2"
                     /protein_id="NP_065433.2"
                     /db_xref="CCDS:CCDS3872.2"
                     /db_xref="GeneID:108"
                     /db_xref="HGNC:HGNC:233"
                     /db_xref="MIM:103071"
                     /translation="MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQH
                     PLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVF
                     KKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAII
                     ASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQ
                     TYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTN
                     NFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRI
                     KILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVL
                     CGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRD
                     PYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFA
                     HLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGINA
                     QKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPK
                     TSVLGISFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISL
                     TIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFSASNNQVAILRAQNLFFLPYF
                     IYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGDYSQVLFERPGI
                     WKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLL
                     ENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLR
                     LLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGT
                     MVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASR
                     MDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRSLSQSN
                     VAS"
     exon            370..567
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            568..729
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            730..879
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1028
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1140
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1268
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1427
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1560
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1737
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1781
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1862
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1932
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2030
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2115
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2253
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2373
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2543
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2628
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2787
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2934
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2935..3042
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..3157
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3158..3282
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..6645
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4074..4079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /note="hexamer: ATTAAA"
     polyA_site      4096
                     /gene="ADCY2"
                     /gene_synonym="AC2; HBAC2"
                     /note="major polyA site"
ORIGIN      
        1 ggggcgccga gctccgcccg cgccggaggc ccctgcgcgc agctccgggt gccggcagcc
       61 gggccggccg aggcggcgcg ggggtgggac gcgggcggcc gcggcgagcg gcgctgcccg
      121 ggccgggcgc gcacggcggg cgccctgtga gcggccccga tgtggcagga ggcgatgcgg
      181 cgccgccgct acctgcggga ccgctccgag gaggcggcgg gcggcggaga cgggctgccg
      241 cggtcccggg actggctcta cgagtcctac tactgcatga gccagcagca cccgctcatc
      301 gtcttcctgc tgctcatcgt catgggctcc tgcctcgccc tgctcgccgt cttcttcgcg
      361 ctcgggctgg aagttgaaga ccatgtggcg tttctaataa cagttccaac tgccctggcg
      421 attttctttg cgatatttat cctggtctgc atcgagtctg tgtttaagaa gctgctgcgc
      481 ctcttctcgt tggtgatatg gatatgcctt gttgccatgg gatacctgtt catgtgtttt
      541 ggaggcaccg tctctccctg ggaccaggta tcgttcttcc tcttcatcat cttcgtggtg
      601 tacaccatgc tgcccttcaa catgcgagac gccatcattg ccagcgtcct cacctcctcc
      661 tcccacacca tcgtgcttag cgtctgcctg tctgcaacac cgggaggcaa ggagcacctg
      721 gtctggcaga tcctggccaa tgtgatcatt ttcatctgtg ggaacctggc gggagcctac
      781 cataagcacc tcatggaact cgctcttcag caaacatatc aggacacctg taattgcatc
      841 aagtcgcgga tcaagttgga atttgaaaaa cgtcaacagg agcggcttct gctctccctg
      901 ctgccggccc acatcgccat ggagatgaaa gcggagatca tccagaggct gcagggcccc
      961 aaggcgggcc agatggagaa cacaaataac ttccacaacc tgtatgtgaa gcggcataca
     1021 aacgtgagca tcttatacgc tgacatcgtt ggctttaccc ggctggcaag tgactgctcc
     1081 ccgggagaac tagtccacat gctgaatgag ctctttggaa agtttgatca aattgcaaag
     1141 gagaatgaat gcatgagaat taaaatttta ggagactgct actactgtgt atctggactc
     1201 cctatatctc tccctaacca tgccaagaac tgtgtgaaaa tggggctgga catgtgtgaa
     1261 gccataaaga aagtgaggga tgctactgga gttgatatca acatgcgcgt gggcgtgcat
     1321 tctgggaatg tcctgtgtgg cgtgattggt ctgcagaagt ggcaatatga tgtgtggtca
     1381 catgatgtga ccttggccaa ccacatggaa gctggagggg tccctggacg tgttcacatt
     1441 tcttctgtca ccctggagca cttgaatggc gcttataaag tggaggaggg agatggtgac
     1501 attagggacc catatttaaa acagcacctg gtgaaaacct actttgtgat caaccccaag
     1561 ggagaacgac ggagccccca gcatctcttc agacctcgcc acacccttga tggagccaaa
     1621 atgagggcct cggtccgcat gacccggtac ttggagtcct ggggggcagc caagcccttt
     1681 gcacacctac atcacaggga cagcatgacc acagagaacg gcaagatcag caccacggat
     1741 gtacccatgg gtcagcataa ttttcaaaat cgcaccttaa gaaccaagtc acaaaagaag
     1801 agatttgaag aagaattgaa tgaaaggatg attcaagcaa ttgatgggat taatgcacag
     1861 aagcaatggc tcaagtctga agacattcag agaatctcac tgcttttcta taacaaagta
     1921 ctagaaaaag agtaccgggc cacggcactg ccagcgttca agtattatgt gacttgtgcc
     1981 tgtctcatat tcttctgcat cttcattgtg cagattctcg tgctgccaaa aacgtccgtc
     2041 ctgggcatct cctttggggc tgcgtttctc ttgctggcct tcatcctctt cgtctgcttt
     2101 gctggacagc ttctgcaatg cagcaaaaaa gcctctcccc tgctcatgtg gcttttgaag
     2161 tcctcgggca tcattgccaa ccgcccctgg ccacggatct ctctcacgat catcaccaca
     2221 gccatcatat taatgatggc cgtgttcaac atgtttttcc tgagtgactc agaggaaaca
     2281 atccctccaa ctgccaacac aacaaacaca agcttttcag cctcaaataa tcaggtggcg
     2341 attctgcgtg cgcagaattt atttttcctc ccgtacttta tctacagctg cattctggga
     2401 ctgatatcct gttccgtgtt cctgcgggta aactatgagc tgaagatgtt gatcatgatg
     2461 gtggccttgg tgggctacaa caccatccta ctccacaccc acgcccacgt cctgggcgac
     2521 tacagccagg tcttatttga gagaccaggc atttggaaag acctgaagac catgggctct
     2581 gtgtctctct ctatattctt catcacactg cttgttctgg gtagacagaa tgaatattac
     2641 tgtaggttag acttcttatg gaagaacaaa ttcaaaaaag agcgggagga gatagagacc
     2701 atggagaacc tgaaccgcgt gctgctggag aacgtgcttc ccgcgcacgt ggctgagcac
     2761 ttcctggcca ggagcctgaa gaatgaggag ctataccacc agtcctatga ctgcgtctgc
     2821 gtcatgtttg cctccattcc ggatttcaaa gaattttata cagaatccga cgtgaacaag
     2881 gagggcttgg aatgccttcg gctcctgaac gagatcatcg ctgactttga tgatcttctt
     2941 tccaagccaa aattcagtgg agttgaaaag attaagacca ttggcagcac atacatggca
     3001 gcaacaggtc tgagcgctgt gcccagccag gagcactccc aggagcccga gcggcagtac
     3061 atgcacattg gcaccatggt ggagtttgct tttgccctgg tagggaagct ggatgccatc
     3121 aacaagcact ccttcaacga cttcaaattg cgagtgggta ttaaccatgg acctgtgata
     3181 gctggtgtga ttggagctca gaagccacaa tatgatatct ggggcaacac tgtcaatgtg
     3241 gccagtagga tggacagcac cggagtcctg gacaaaatac aggttaccga ggagacgagc
     3301 ctcgtcctgc agaccctcgg atacacgtgc acctgtcgag gaataatcaa cgtgaaagga
     3361 aagggggacc tgaagacgta ctttgtaaac acagaaatgt caaggtccct ttcccagagc
     3421 aacgtggcat cctgaagagt caccttcatt ttggcaagaa gactgtattt tcaggaaggt
     3481 atcacacact ttctgactgc aacttctgtc ccttgttttt gatgtgcgtg ctgtctgtcc
     3541 tatggagcct ctgcagactc gttctcgtga cccagtggca taccgtttgg tgtctgatgt
     3601 gtgcccagat cgttctgcca cttgcactgt gcttgctcct aagcaaaagg gaaaaggagc
     3661 gcgcgtgata gaagaaaagc actgggagaa ctaacagagg agaaaggtga aacacacaca
     3721 cattcttaag gcaataaaac tagggggtgt atattatctt ctggtgcatg ttcttttctg
     3781 gaaaatatgg tagctcgcca accgcatctg ctcatctgat attcaaacac acagtattcg
     3841 tgaataagtt gattctgtcc cccacgtgga ctctgtgctc acccattgtc tcattgccag
     3901 tggtgtccaa gggcccccgt tgggacccac ggctctcgtc cctctgctcc gtgtgtctca
     3961 tgccagcagc acgtcgccat ccgtcaccag aattagtcct cacagcctag gaccagtttt
     4021 gtatcaaact cgtctgatgt tttgatgcca tttgtctttt gtaaagttaa ttcattaaaa
     4081 gttttatgta ctttgattta cagtgcctgt atcttttatt ttcctgtctt ctttctcctg
     4141 tggtttgctc cagaattaag gtttgttttc catccattct cccttttgac acagttgttt
     4201 cagaaagagc tctccagaag ccaatattga gatgtaattc agattaggac acagtgtgtg
     4261 acgcagataa ctggttactc agctccctgg aaagcaggca agcatgttga atgtatctag
     4321 tggtctgatt ttaatttggg catctctaga gaacgctttc agggaaaaat actttaatag
     4381 taaaaagatt ctctgcgagc aacagtgccc cctccgtcca ctacgctcct gtctccaaga
     4441 atgttttgct agagctaaca gacatagact gcaaaagaat aatttggaat cagctatgca
     4501 aatcagtctc acaatagcgt gagctaactg agagaagtac taagacccac aaactgcctg
     4561 ttaagtctga gaaggctaaa gaagacacac agccaacgtt catgcatttt taaagacaga
     4621 aggccttgaa gaatttgttc ttgtaaatcc aacacaagtt gtttggtact tttaacataa
     4681 agaaatcata ctttgccaaa tagtgaaaag tagagcaatc gtgtataagc taatgtttaa
     4741 aagcaaaact gcaaattgta gcccagttgg tcaaacttgt tttcttttta taactcatgg
     4801 caggcatctg taagaagtag agaacccaga tgatctctta ggaagccttt tattcgtggg
     4861 aactcgaact tgaagcacaa gttcctggtt tgaatcctgg ctctgatttt ttactggctg
     4921 tgtgactttg aacacatctc ttagtccctc ttaggagtac tttccttatt ggcaacttat
     4981 ggactcgcta gtgattaaac gaggcaatga ctgtgagcga gcctggcagg tgccccgtgg
     5041 tacattcaca gcacgggcac agctgctgtg ccaggactgt gactcattcc cagtaaaagg
     5101 cacttatcga agctgataac cgtccttcat caccgaagtg tgagtagagc atgacttatt
     5161 tagtattctg cctcaatggg gaattttttg atcctgtaat cacaactcag cattggcctt
     5221 aatataccta aatctccaaa aacagtgatt aaagcaagag aattattaca agggcttttc
     5281 tctttcctct aactcattct tcacggatgc cgtagcgttt ccgtgagctc aaactggcct
     5341 tggtgtaaaa tgtgtaagga tgagcagcag gcgtgcctcg tgggttcttc ctctgttaca
     5401 tcctgctaca ctcatccgca ggtcacctta gttcacctac cctgagtgaa cacccccagc
     5461 tgggtggtcc accaagttct cataaacaga gtccctccca ttcccccacg gggtgcaccg
     5521 aacttgggtt tgcgctaaaa agaactcaaa aggagaactg tgctctccca aagccatatc
     5581 accagtctta ccaaacaata ggcttttaaa agcattgagt cattgtcaga atccactatg
     5641 ggaagctctg tgtgtacctg gtcccttcta ggtgtggtcc cataggagca gccttagcat
     5701 cccctgtgaa cttatcaaaa atgcaaattc tcaggcccca acctgaagga ggaccctgaa
     5761 tttgagatcc ccggggctgg ggcccagcac aactgctgtt tagtgaacag gttctccagg
     5821 tgattctgat ccctgatcaa gcttcagacc tccctccctc cccagtgttt ttgcaggtga
     5881 ggaaacaggg gcagagtaat tcaggcacat gtgttcagag ttccacagtt gattagcagt
     5941 tgaggccagg ctagaatgga aaactgcctg ttccttgaat ctgaaagagc attattcctg
     6001 gtcaaagctc cttaaagttc tgggcagcta aaagcatccc tgtgagcaaa aatgccaggc
     6061 agaaaactgg cagtgcacct ctcatcagcc caggtcccag tgccattggc ttcaagaaaa
     6121 aaaaaaaatc tctccccaat gctctcctta acctttaagt cttacaggaa gcctctcata
     6181 gaaattgcct ccagtccagt ttcccaaaaa ccccagtgtt ttacatatct gtttaggagt
     6241 gtctaagttt tgtcatcaat ccaggatgtt attcttcctt cccaactcac tgtgctccta
     6301 aaggcagcaa ccattcatct ttcctttgct ctggatacac cgaatgacca ggtaacatca
     6361 tcaggccggg tgcagtggct cctataatcc caatattttg ggaggccgag gagagaggat
     6421 cacttaagcc caggagtctg agaccagcct gggcaacata gcaagacccc catctctgca
     6481 aaaaaataag aaaattagct tggcatggtg gcacgtgcct gtagtcccag ctacatggga
     6541 ggctgaggtg ggaggatcac ttgagcccag gaagtccaga acgtagtgag ccttgattat
     6601 accactgcac tccagcctgg gtgacagagc gagactctgt ctcag
//
