LOCUS       NM_018417               5342 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens adenylate cyclase 10 (ADCY10), transcript variant 1,
            mRNA.
ACCESSION   NM_018417 NM_018673
VERSION     NM_018417.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5342)
  AUTHORS   Ge,Y., Liu,Y., Zhan,R., Zhao,Z., Wang,W. and Tian,Y.
  TITLE     Two novel heterozygous ADCY10 variants identified in Chinese
            pediatric patients with absorptive hypercalciuria: case report and
            literature review
  JOURNAL   J Genet 103 (2024)
   PUBMED   38258300
  REMARK    GeneRIF: Two novel heterozygous ADCY10 variants identified in
            Chinese pediatric patients with absorptive hypercalciuria: case
            report and literature review.
            Review article
REFERENCE   2  (bases 1 to 5342)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 5342)
  AUTHORS   Chang,J.C., Go,S., Gilglioni,E.H., Duijst,S., Panneman,D.M.,
            Rodenburg,R.J., Li,H.L., Huang,H.L., Levin,L.R., Buck,J.,
            Verhoeven,A.J. and Oude Elferink,R.P.J.
  TITLE     Soluble adenylyl cyclase regulates the cytosolic NADH/NAD+ redox
            state and the bioenergetic switch between glycolysis and oxidative
            phosphorylation
  JOURNAL   Biochim Biophys Acta Bioenerg 1862 (4), 148367 (2021)
   PUBMED   33412125
  REMARK    GeneRIF: Soluble adenylyl cyclase regulates the cytosolic
            NADH/NAD(+) redox state and the bioenergetic switch between
            glycolysis and oxidative phosphorylation.
REFERENCE   4  (bases 1 to 5342)
  AUTHORS   Zhang,X., Yu,K., Ma,L., Qian,Z., Tian,X., Miao,Y., Niu,Y., Xu,X.,
            Guo,S., Yang,Y., Wang,Z., Xue,X., Gu,C., Fang,W., Sun,J., Yu,Y. and
            Wang,J.
  TITLE     Endogenous glutamate determines ferroptosis sensitivity via
            ADCY10-dependent YAP suppression in lung adenocarcinoma
  JOURNAL   Theranostics 11 (12), 5650-5674 (2021)
   PUBMED   33897873
  REMARK    GeneRIF: Endogenous glutamate determines ferroptosis sensitivity
            via ADCY10-dependent YAP suppression in lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5342)
  AUTHORS   Geng,W., Wang,Z., Zhang,J., Reed,B.Y., Pak,C.Y. and Moe,O.W.
  TITLE     Cloning and characterization of the human soluble adenylyl cyclase
  JOURNAL   Am J Physiol Cell Physiol 288 (6), C1305-C1316 (2005)
   PUBMED   15659711
REFERENCE   6  (bases 1 to 5342)
  AUTHORS   Reed,B.Y., Gitomer,W.L., Heller,H.J., Hsu,M.C., Lemke,M.,
            Padalino,P. and Pak,C.Y.
  TITLE     Identification and characterization of a gene with base
            substitutions associated with the absorptive hypercalciuria
            phenotype and low spinal bone density
  JOURNAL   J Clin Endocrinol Metab 87 (4), 1476-1485 (2002)
   PUBMED   11932268
REFERENCE   7  (bases 1 to 5342)
  AUTHORS   Chen,Y., Cann,M.J., Litvin,T.N., Iourgenko,V., Sinclair,M.L.,
            Levin,L.R. and Buck,J.
  TITLE     Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate
            sensor
  JOURNAL   Science 289 (5479), 625-628 (2000)
   PUBMED   10915626
REFERENCE   8  (bases 1 to 5342)
  AUTHORS   Sinclair,M.L., Wang,X.Y., Mattia,M., Conti,M., Buck,J.,
            Wolgemuth,D.J. and Levin,L.R.
  TITLE     Specific expression of soluble adenylyl cyclase in male germ cells
  JOURNAL   Mol Reprod Dev 56 (1), 6-11 (2000)
   PUBMED   10737962
REFERENCE   9  (bases 1 to 5342)
  AUTHORS   Reed,B.Y., Heller,H.J., Gitomer,W.L. and Pak,C.Y.
  TITLE     Mapping a gene defect in absorptive hypercalciuria to chromosome
            1q23.3-q24
  JOURNAL   J Clin Endocrinol Metab 84 (11), 3907-3913 (1999)
   PUBMED   10566627
REFERENCE   10 (bases 1 to 5342)
  AUTHORS   Buck,J., Sinclair,M.L., Schapal,L., Cann,M.J. and Levin,L.R.
  TITLE     Cytosolic adenylyl cyclase defines a unique signaling molecule in
            mammals
  JOURNAL   Proc Natl Acad Sci U S A 96 (1), 79-84 (1999)
   PUBMED   9874775
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB063660.1, AF299350.1,
            BC117366.1, AK302884.1 and Z99943.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_018417.5.
            
            Summary: The protein encoded by this gene belongs to a distinct
            class of adenylyl cyclases that is soluble and insensitive to G
            protein or forskolin regulation. Activity of this protein is
            regulated by bicarbonate. Variation at this gene has been observed
            in patients with absorptive hypercalciuria. Alternatively spliced
            transcript variants encoding different isoforms have been observed.
            There is a pseudogene of this gene on chromosome 6. [provided by
            RefSeq, Jul 2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF299350.1, GQ472219.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367851.9/ ENSP00000356825.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                DB063660.1         93-124
            33-4266             AF299350.1         1-4234
            4267-5127           BC117366.1         4139-4999
            5128-5340           AK302884.1         4754-4966
            5341-5342           Z99943.1           85683-85684         c
FEATURES             Location/Qualifiers
     source          1..5342
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     gene            1..5342
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /note="adenylate cyclase 10"
                     /db_xref="GeneID:55811"
                     /db_xref="HGNC:HGNC:21285"
                     /db_xref="MIM:605205"
     exon            1..159
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            160..365
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..5050
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /EC_number="4.6.1.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     AH-related protein; ATP pyrophosphate-lyase; 3',5'-cyclic
                     AMP synthetase; adenylate cyclase type 10; testicular
                     soluble adenylyl cyclase (SAC); germ cell soluble adenylyl
                     cyclase; adenylate cyclase 10, soluble; epididymis
                     secretory sperm binding protein Li 7a"
                     /codon_start=1
                     /product="adenylate cyclase type 10 isoform 1"
                     /protein_id="NP_060887.2"
                     /db_xref="CCDS:CCDS1265.1"
                     /db_xref="GeneID:55811"
                     /db_xref="HGNC:HGNC:21285"
                     /db_xref="MIM:605205"
                     /translation="MNTPKEEFQDWPIVRIAAHLPDLIVYGHFSPERPFMDYFDGVLM
                     FVDISGFTAMTEKFSSAMYMDRGAEQLVEILNYHISAIVEKVLIFGGDILKFAGDALL
                     ALWRVERKQLKNIITVVIKCSLEIHGLFETQEWEEGLDIRVKIGLAAGHISMLVFGDE
                     THSHFLVIGQAVDDVRLAQNMAQMNDVILSPNCWQLCDRSMIEIESVPDQRAVKVNFL
                     KPPPNFNFDEFFTKCTTFMHYYPSGEHKNLLRLACTLKPDPELEMSLQKYVMESILKQ
                     IDNKQLQGYLSELRPVTIVFVNLMFEDQDKAEEIGPAIQDAYMHITSVLKIFQGQINK
                     VFMFDKGCSFLCVFGFPGEKVPDELTHALECAMDIFDFCSQVHKIQTVSIGVASGIVF
                     CGIVGHTVRHEYTVIGQKVNLAARMMMYYPGIVTCDSVTYNGSNLPAYFFKELPKKVM
                     KGVADSGPLYQYWGRTEKVMFGMACLICNRKEDYPLLGRNKEINYFMYTMKKFLISNS
                     SQVLMYEGLPGYGKSQILMKIEYLAQGKNHRIIAISLNKISFHQTFYTIQMFMANVLG
                     LDTCKHYKERQTNLRNKVMTLLDEKFYCLLNDIFHVQFPISREISRMSTLKKQKQLEI
                     LFMKILKLIVKEERIIFIIDEAQFVDSTSWRFMEKLIRTLPIFIIMSLCPFVNIPCAA
                     ARAVIKNRNTTYIVIGAVQPNDISNKICLDLNVSCISKELDSYLGEGSCGIPFYCEEL
                     LKNLEHHEVLVFQQTESEEKTNRTWNNLFKYSIKLTEKLNMVTLHSDKESEEVCHLTS
                     GVRLKNLSPPTSLKEISLIQLDSMRLSHQMLVRCAAIIGLTFTTELLFEILPCWNMKM
                     MIKTLATLVESNIFYCFRNGKELQKALKQNDPSFEVHYRSLSLKPSEGMDHGEEEQLR
                     ELENEVIECHRIRFCNPMMQKTAYELWLKDQRKAMHLKCARFLEEDAHRCDHCRGRDF
                     IPYHHFTVNIRLNALDMDAIKKMAMSHGFKTEEKLILSNSEIPETSAFFPENRSPEEI
                     REKILNFFDHVLTKMKTSDEDIIPLESCQCEEILEIVILPLAHHFLALGENDKALYYF
                     LEIASAYLIFCDNYMAYMYLNEGQKLLKTLKKDKSWSQTFESATFYSLKGEVCFNMGQ
                     IVLAKKMLRKALKLLNRIFPYNLISLFLHIHVEKNRHFHYVNRQAQESPPPGKKRLAQ
                     LYRQTVCLSLLWRIYSYSYLFHCKYYAHLAVMMQMNTALETQNCFQIIKAYLDYSLYH
                     HLAGYKGVWFKYEVMAMEHIFNLPLKGEGIEIVAYVAETLVFNKLIMGHLDLAIELGS
                     RALQMWALLQNPNRHYQSLCRLSRCLLLNSRYPQLIQVLGRLWELSVTQEHIFSKAFF
                     YFVCLDILLYSGFVYRTFEECLEFIHQYENNRILKFHSGLLLGLYSSVAIWYARLQEW
                     DNFYKFSNRAKNLLPRRTMTLTYYDGISRYMEGQVLHLQKQIKEQSENAQASGEELLK
                     NLENLVAQNTTGPVFCPRLYHLMAYVCILMGDGQKCGLFLNTALRLSETQGNILEKCW
                     LNMNKESWYSTSELKEDQWLQTILSLPSWEKIVAGRVNIQDLQKNKFLMRANTVDNHF
                     "
     exon            366..470
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            471..509
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            510..653
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            654..859
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            860..956
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1045
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1237
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1356
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1433
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1623
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1679
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1833
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..2026
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2113
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2388
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2525
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2654
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2933
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..3224
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            3225..3294
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            3295..3526
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            3527..3634
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            3635..3810
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            3811..3967
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            3968..4172
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            4173..4269
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            4270..4385
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            4386..4503
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            4504..4699
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            4700..4888
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            4889..5342
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5058..5063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /note="hexamer: AAGAAA"
     polyA_site      5083
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
     regulatory      5322..5327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /note="hexamer: ATTACA"
     polyA_site      5342
                     /gene="ADCY10"
                     /gene_synonym="HCA2; HEL-S-7a; hsAC; SAC; SACI; Sacy"
                     /note="major polyA site"
ORIGIN      
        1 agacaaaact gtcattttat gggtcagcta tagacagaca tggcgcttca gctgtcttca
       61 gaataatgtc acccggcctc ctctcctgtc ttctgcagtc ttaaaagacc tagtccctaa
      121 ctgaggtctg gcttttcctc agccctggat gaagtggaga agacctattt ggagactgct
      181 tcctgtcacc ataaaatcct gaacatttgt cttgaacatg aacactccaa aagaagaatt
      241 ccaggactgg cccatagtca gaatagcagc tcatttacca gacctcattg tctatggaca
      301 tttctcccca gagcgaccct ttatggatta ttttgacgga gtcctgatgt ttgttgatat
      361 ttcaggtttt actgcaatga ctgagaagtt cagcagtgcc atgtacatgg acagaggggc
      421 tgagcagttg gtggagatcc tcaactacca cataagtgca atagtggaga aagtgttgat
      481 ttttggagga gacatcctga aatttgcagg tgatgcactg ctagccctgt ggagggtgga
      541 gcgaaagcag ctgaaaaaca ttatcacagt ggtaattaaa tgtagcctgg agatccatgg
      601 attgtttgag acccaggagt gggaagaagg cctagacatc cgagtcaaga taggactggc
      661 tgctggccac atcagcatgt tggtctttgg agatgaaaca cacagccact ttctggtgat
      721 tggtcaggca gtggacgatg tgcgccttgc ccagaacatg gctcagatga atgatgttat
      781 tctgtcacca aactgctggc agctctgtga ccggagcatg attgaaattg agagtgttcc
      841 agatcagaga gcagttaagg ttaacttctt aaaaccaccc cccaatttta attttgatga
      901 atttttcaca aagtgtacga ccttcatgca ttattatcct tctggtgagc acaaaaacct
      961 cctgaggctt gcatgcacgc tgaagcctga tcctgaactg gagatgtccc tacaaaagta
     1021 tgtgatggaa agcattttga agcagattga taacaaacag cttcagggct atttatctga
     1081 gcttcgccca gtgacgattg tgtttgtgaa cctgatgttt gaagaccaag acaaagcaga
     1141 agagataggc ccagccatcc aggatgccta tatgcacatc acttctgtcc tgaagatctt
     1201 ccaaggccaa atcaataaag tcttcatgtt tgacaagggc tgctctttcc tctgtgtctt
     1261 tggcttccct ggggaaaagg tacctgacga gctcactcat gctctggaat gtgctatgga
     1321 tatatttgac ttctgctctc aagtccacaa aatccaaact gtatccatcg gtgttgccag
     1381 tgggattgtc ttctgtggga tcgttggaca cactgtgaga cacgagtaca cagtcattgg
     1441 tcaaaaagtc aacttagctg ccaggatgat gatgtactac ccaggaattg tgacctgcga
     1501 ctctgtcacc tacaatggga gcaacctacc agcgtacttt tttaaagagc ttccaaagaa
     1561 agttatgaaa ggtgttgcag attctggacc attgtatcag tattggggcc gtactgagaa
     1621 agtcatgttt ggtatggcgt gcctcatctg caacagaaag gaggattacc ctttgctggg
     1681 acgtaataaa gagatcaact acttcatgta tactatgaag aaatttttga tatctaacag
     1741 cagccaagtc ttaatgtatg agggattacc aggatatgga aaaagccaga tacttatgaa
     1801 aattgagtac ctggcccaag gtaagaatca caggattatt gccatttcat tgaataagat
     1861 cagcttccat caaactttct ataccatcca gatgttcatg gccaatgtcc taggcctaga
     1921 cacttgtaaa cattataaag aacgacagac caaccttcga aataaagtca tgacactgtt
     1981 ggatgaaaag ttctactgtc ttcttaatga cattttccat gttcagttcc ctatttctcg
     2041 ggagatttcc aggatgagca ccttgaaaaa gcaaaaacaa ttggaaatat tgtttatgaa
     2101 gatcttgaag ctgatagtga aagaggaaag gattattttt atcattgatg aggcccagtt
     2161 tgtggattcg acctcctgga gatttatgga gaagcttatc cggactcttc ctatcttcat
     2221 cattatgtcc ctgtgtccct tcgttaacat tccctgtgca gctgccaggg ccgtaataaa
     2281 gaacaggaac accacctaca ttgtcattgg tgcagtacag cctaacgaca tctccaacaa
     2341 gatctgtctt gacctcaatg tgagctgcat ctccaaagaa ctggactcgt acctggggga
     2401 gggaagctgt gggattccat tttactgtga agaattgctt aaaaacctgg aacatcatga
     2461 ggtactcgtt ttccaacaaa cggagtctga ggaaaagaca aataggacct ggaataacct
     2521 gttcaagtat tccattaagc taacagagaa gttaaacatg gttactctcc atagtgataa
     2581 ggaaagtgaa gaagtctgtc acctcacaag tggtgtcaga ctgaaaaacc tgtcacctcc
     2641 aacgtcatta aaagaaatct ctctgatcca gctggatagc atgagacttt cccaccaaat
     2701 gctggtgaga tgtgctgcca tcattggcct gaccttcacc actgagttgt tgtttgagat
     2761 tctcccctgt tggaatatga agatgatgat caagaccctg gcaaccctag tggaatctaa
     2821 cattttttat tgtttccgga atggcaagga gcttcaaaag gccctgaaac agaatgatcc
     2881 ctcatttgag gtgcactatc gttccttgtc tctgaagccc agtgaaggga tggatcacgg
     2941 tgaagaggaa cagcttcgtg aactggagaa tgaggtgatc gagtgccaca ggattcgatt
     3001 ctgtaaccct atgatgcaga aaacagccta cgagctgtgg ctcaaggacc agagaaaagc
     3061 catgcacttg aaatgtgccc gctttttaga agaagatgcc cacagatgtg accactgccg
     3121 aggcagggac ttcattccct atcatcactt cacagtgaat attcggctca acgctttaga
     3181 catggatgcc attaaaaaga tggctatgtc tcatggattt aaaactgaag aaaagcttat
     3241 cttgtccaac tcagagattc ctgagacatc tgcatttttt cctgaaaatc gcagtcctga
     3301 agaaataaga gaaaagatct tgaatttctt tgaccacgtt ttaacaaaaa tgaagacatc
     3361 tgacgaagac attatccctc tggaatcttg ccagtgtgaa gaaatcctag agattgtcat
     3421 cttgcctctg gcccaccatt ttctggcttt gggagaaaat gacaaagcct tatattactt
     3481 cttagaaatt gcatctgctt atctcatctt ttgtgataac tacatggcat acatgtattt
     3541 gaatgaagga cagaagttgc taaaaactct caagaaggac aaatcttgga gccagacatt
     3601 tgagtctgcc accttttaca gcctcaaagg tgaggtctgt ttcaatatgg gccagatagt
     3661 gcttgccaag aaaatgctga ggaaggcact gaagctcctc aaccgaatct ttccttacaa
     3721 cttaatctcc ttgtttctcc atatccatgt cgagaaaaac agacactttc attatgtgaa
     3781 tcggcaggcc caagagagcc cacctccagg gaagaagagg ctggcacaac tttaccggca
     3841 aactgtctgc ctttccttgc tgtggcgcat ctatagctac agttatcttt ttcactgcaa
     3901 gtattatgcc cacctggcag ttatgatgca aatgaatact gcactggaaa ctcaaaattg
     3961 tttccagatc attaaggctt acctagacta ttcgctatac caccacctgg ctggctacaa
     4021 aggtgtgtgg ttcaaatatg aagtcatggc catggagcac atcttcaacc tccccctgaa
     4081 aggcgagggc attgaaatcg tggcatacgt ggctgagaca ctggtcttca acaagctcat
     4141 aatgggacac ctggatttgg ccattgagtt aggctcccga gcccttcaga tgtgggcact
     4201 gctccagaat cccaaccgac attatcagtc cctctgcaga cttagcagat gtctccttct
     4261 gaacagcaga tacccgcaat tgatccaggt gctggggcgg ctgtgggagc tttctgtaac
     4321 acaggaacac atcttcagca aggcattttt ctattttgtc tgcttggaca tcctgcttta
     4381 ttctggtttt gtttatagaa catttgaaga atgtttggaa ttcatacacc aatacgaaaa
     4441 caacagaatc ctcaagttcc acagtggact cctcctggga ctttattcct ctgtagctat
     4501 ctggtatgcc agacttcagg aatgggacaa cttttacaaa ttttccaata gagctaaaaa
     4561 tcttttgcca agaagaacca tgacacttac ttactatgac ggaatatcta ggtacatgga
     4621 ggggcaagtt cttcaccttc aaaaacaaat caaagaacag tcagagaatg cccaagccag
     4681 tggggaggag ctactcaaga acttggagaa tctggtggct caaaatacca ctggccctgt
     4741 cttttgccca aggctctacc acctgatggc ttacgtctgt atattaatgg gagatgggca
     4801 gaaatgtggc ctcttcctga acacagcctt gcggctctct gaaacacagg ggaatatact
     4861 ggagaaatgc tggctgaaca tgaacaaaga atcatggtac tcaacctctg agttaaaaga
     4921 agaccaatgg cttcagacga tcttgagtct cccatcatgg gaaaaaattg tagcaggcag
     4981 ggtaaacatt caggatcttc aaaaaaacaa attcctgatg agagctaata ccgtggacaa
     5041 tcatttctaa catgtcaaag aaaaaagatt ttaataagca ctatgtcctt gtgattatct
     5101 attattgacc tttctccgtg gctggcccac tccaggttcc tacataatct cttctgttcc
     5161 agacacagaa acagacatgt tgatttcttc tctttctgga gggcctacaa gggtcaggag
     5221 tgtcatggtt tacttcttcc taatgttaca aaaaattgct tttaccattc atgttgtttt
     5281 agcttgacct gtttatttca gcccatgcaa aactgtatca tattacaaat tattaatctc
     5341 aa
//
