LOCUS       NM_174922               1960 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens aarF domain containing kinase 5 (ADCK5), mRNA.
ACCESSION   NM_174922
VERSION     NM_174922.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1960)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1960)
  AUTHORS   Qiu,M., Li,G., Wang,P., Li,X., Lai,F., Luo,R., Liu,B. and Lin,J.
  TITLE     aarF domain containing kinase 5 gene promotes invasion and
            migration of lung cancer cells through ADCK5-SOX9-PTTG1 pathway
  JOURNAL   Exp Cell Res 392 (1), 112002 (2020)
   PUBMED   32277958
  REMARK    GeneRIF: aarF domain containing kinase 5 gene promotes invasion and
            migration of lung cancer cells through ADCK5-SOX9-PTTG1 pathway.
REFERENCE   3  (bases 1 to 1960)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1960)
  AUTHORS   Nusbaum,C., Mikkelsen,T.S., Zody,M.C., Asakawa,S., Taudien,S.,
            Garber,M., Kodira,C.D., Schueler,M.G., Shimizu,A., Whittaker,C.A.,
            Chang,J.L., Cuomo,C.A., Dewar,K., FitzGerald,M.G., Yang,X.,
            Allen,N.R., Anderson,S., Asakawa,T., Blechschmidt,K., Bloom,T.,
            Borowsky,M.L., Butler,J., Cook,A., Corum,B., DeArellano,K.,
            DeCaprio,D., Dooley,K.T., Dorris,L. 3rd, Engels,R., Glockner,G.,
            Hafez,N., Hagopian,D.S., Hall,J.L., Ishikawa,S.K., Jaffe,D.B.,
            Kamat,A., Kudoh,J., Lehmann,R., Lokitsang,T., Macdonald,P.,
            Major,J.E., Matthews,C.D., Mauceli,E., Menzel,U., Mihalev,A.H.,
            Minoshima,S., Murayama,Y., Naylor,J.W., Nicol,R., Nguyen,C.,
            O'Leary,S.B., O'Neill,K., Parker,S.C., Polley,A., Raymond,C.K.,
            Reichwald,K., Rodriguez,J., Sasaki,T., Schilhabel,M., Siddiqui,R.,
            Smith,C.L., Sneddon,T.P., Talamas,J.A., Tenzin,P., Topham,K.,
            Venkataraman,V., Wen,G., Yamazaki,S., Young,S.K., Zeng,Q.,
            Zimmer,A.R., Rosenthal,A., Birren,B.W., Platzer,M., Shimizu,N. and
            Lander,E.S.
  TITLE     DNA sequence and analysis of human chromosome 8
  JOURNAL   Nature 439 (7074), 331-335 (2006)
   PUBMED   16421571
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY037845.1, BC101659.1 and BC064345.1.
            
            On Nov 22, 2018 this sequence version replaced NM_174922.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.136950.1,
                                           SRR3476690.797297.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308860.11/ ENSP00000310547.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                HY037845.1         33-60
            29-1811             BC101659.1         1-1783
            1812-1960           BC064345.1         795-943
FEATURES             Location/Qualifiers
     source          1..1960
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..1960
                     /gene="ADCK5"
                     /note="aarF domain containing kinase 5"
                     /db_xref="GeneID:203054"
                     /db_xref="HGNC:HGNC:21738"
     exon            1..61
                     /gene="ADCK5"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1792
                     /gene="ADCK5"
                     /codon_start=1
                     /product="uncharacterized aarF domain-containing protein
                     kinase 5"
                     /protein_id="NP_777582.4"
                     /db_xref="CCDS:CCDS34965.2"
                     /db_xref="GeneID:203054"
                     /db_xref="HGNC:HGNC:21738"
                     /translation="MWRPVQLCHFHSALLHSRQKPWPSPAVFFRRNVRGLPPRFSSPT
                     PLWRKVLSTAVVGAPLLLGARYVMAEAREKRRMRLVVDGMGRFGRSLKVGLQISLDYW
                     WCTNVVLRGVEENSPGYLEVMSACHQRAADALVAGAISNGGLYVKLGQGLCSFNHLLP
                     PEYTRTLRVLEDRALKRGFQEVDELFLEDFQALPHELFQEFDYQPIAAASLAQVHRAK
                     LHDGTSVAVKVQYIDLRDRFDGDIHTLELLLRLVEVMHPSFGFSWVLQDLKGTLAQEL
                     DFENEGRNAERCARELAHFPYVVVPRVHWDKSSKRVLTADFCAGCKVNDVEAIRSQGL
                     AVHDIAEKLIKAFAEQIFYTGFIHSDPHPGNVLVRKGPDGKAELVLLDHGLYQFLEEK
                     DRAALCQLWRAIILRDDAAMRAHAAALGVQDYLLFAEMLMQRPVRLGQLWGSHLLSRE
                     EAAYMVDMARERFEAVMAVLRELPRPMLLVLRNINTVRAINVALGAPVDRYFLMAKRA
                     VRGWSRLAGATYRGVYGTSLLRHAKVVWEMLKFEVALRLETLAMRLTALLARALVHLS
                     LVPPAEELYQYLET"
     exon            62..165
                     /gene="ADCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            166..315
                     /gene="ADCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            316..391
                     /gene="ADCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            392..592
                     /gene="ADCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            593..733
                     /gene="ADCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            734..847
                     /gene="ADCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            848..979
                     /gene="ADCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1063
                     /gene="ADCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1145
                     /gene="ADCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1224
                     /gene="ADCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1316
                     /gene="ADCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1569
                     /gene="ADCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1686
                     /gene="ADCK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1960
                     /gene="ADCK5"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1960
                     /gene="ADCK5"
                     /note="major polyA site"
ORIGIN      
        1 gagacgctaa gcggcgccgg gcgggagaag agcggagcag tggtcggaga tgtggcgacc
       61 ggtgcagctc tgtcatttcc actctgctct gctgcacagc aggcagaagc cctggccgtc
      121 ccctgctgtg ttcttcagga gaaacgtcag gggccttcct ccaaggttct ccagccccac
      181 acccctgtgg aggaaggtgc tctccaccgc ggtagtgggg gcgcccctgc tcctcggagc
      241 ccgctatgtc atggcagagg cacgggagaa gaggaggatg cggctcgtgg tggatggcat
      301 ggggcgcttt ggcaggtctc tgaaggtcgg cctgcagatc tccctggact actggtggtg
      361 caccaatgtt gtccttcgag gggtggaaga gaacagccca ggctacttgg aggtgatgtc
      421 tgcgtgtcac cagcgggcgg ctgatgccct ggtggcaggg gccatcagca acgggggcct
      481 ctacgtgaag ctgggccagg ggctgtgctc cttcaaccac ctgcttcccc ccgagtatac
      541 ccggaccctg cgcgtgctag aggacagggc cctcaagcgg ggcttccagg aggtggatga
      601 gttgttcctt gaggacttcc aggccctccc ccacgagctc ttccaggagt ttgactacca
      661 gccaattgct gccgccagcc tggcacaggt gcacagagcc aagctgcacg atggcaccag
      721 cgtggctgtg aaggtgcagt acatcgacct gcgggaccgc tttgatgggg acatccacac
      781 cctggagctc ctgctgcggc tcgttgaggt catgcacccc agctttggct tcagctgggt
      841 cctccaggac ctgaagggga ccctggccca ggagctggac ttcgagaatg agggccgcaa
      901 cgcagagcgc tgtgcgcggg agctggcgca cttcccctac gtcgtggtgc cccgcgtgca
      961 ctgggacaag tccagcaagc gcgtgctcac tgccgacttc tgcgccggct gcaaggtcaa
     1021 cgatgtggag gccatcagga gccaggggct ggcagtgcat gacatagcag aaaagctcat
     1081 caaggccttt gctgagcaga tattttacac cggcttcatc cactcggacc cacatcctgg
     1141 caacgttctg gtgcggaaag gcccggacgg gaaagcggag ctggtgctgc tggaccacgg
     1201 gctctaccag ttcctggagg agaaggaccg cgcagccctc tgccagctgt ggcgggccat
     1261 catcctgcgg gacgacgccg ccatgagggc gcacgcagcc gcactggggg tgcaagacta
     1321 cctcctgttc gccgagatgc tcatgcagcg ccccgtgcgc ctggggcagc tgtggggctc
     1381 gcacctactg agccgcgaag aggcggccta catggtggac atggcccgcg agcgcttcga
     1441 ggccgtcatg gcggtgctca gggagctgcc gcggcccatg ctgctggtgc tgcgcaacat
     1501 caacaccgtg cgcgctatca acgtggccct cggcgccccc gtggaccgct acttccttat
     1561 ggctaaaagg gctgtccggg gctggagccg cctggcgggc gccacgtatc ggggtgtcta
     1621 cggcaccagc ctcctgcgcc acgccaaggt cgtctgggag atgctcaagt ttgaagtggc
     1681 gctcaggctg gagaccttgg ccatgcggct gaccgccctc ctggctcgtg ctctggtcca
     1741 cctgagcctc gtgcccccag cggaggagct ctaccagtac ctggagacct agggtgcagc
     1801 cgcccagggc cggcggggcc cttttcacct tgggctgacg gaggtggcgg ggctagaggt
     1861 gtagacaccc cgagccccgt gggcactcgc actggggggc tgtgacagca gctgggccag
     1921 gaggccgtgt aatgaccaca cactcctctc aagcaaaaaa
//
