LOCUS       NM_020421               3268 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens aarF domain containing kinase 1 (ADCK1), transcript
            variant 1, mRNA.
ACCESSION   NM_020421
VERSION     NM_020421.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3268)
  AUTHORS   Zhuo,B.B., Zhu,L.Q., Yao,C., Wang,X.H., Li,S.X., Wang,R., Li,Y. and
            Ling,Z.Y.
  TITLE     ADCK1 is a potential therapeutic target of osteosarcoma
  JOURNAL   Cell Death Dis 13 (11), 954 (2022)
   PUBMED   36371387
  REMARK    GeneRIF: ADCK1 is a potential therapeutic target of osteosarcoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3268)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 3268)
  AUTHORS   Zhang,H., Cao,X., Tang,M., Zhong,G., Si,Y., Li,H., Zhu,F., Liao,Q.,
            Li,L., Zhao,J., Feng,J., Li,S., Wang,C., Kaulich,M., Wang,F.,
            Chen,L., Li,L., Xia,Z., Liang,T., Lu,H., Feng,X.H. and Zhao,B.
  TITLE     A subcellular map of the human kinome
  JOURNAL   Elife 10, e64943 (2021)
   PUBMED   33988507
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3268)
  AUTHORS   Ji,Y., Liu,Y., Sun,C., Yu,L., Wang,Z., Du,X., Yang,W., Zhang,C.,
            Tao,C., Wang,J., Yang,X., Di,S. and Huang,Y.
  TITLE     ADCK1 activates the beta-catenin/TCF signaling pathway to promote
            the growth and migration of colon cancer cells
  JOURNAL   Cell Death Dis 12 (4), 354 (2021)
   PUBMED   33824271
  REMARK    GeneRIF: ADCK1 activates the beta-catenin/TCF signaling pathway to
            promote the growth and migration of colon cancer cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3268)
  AUTHORS   Yoon,W., Hwang,S.H., Lee,S.H. and Chung,J.
  TITLE     Drosophila ADCK1 is critical for maintaining mitochondrial
            structures and functions in the muscle
  JOURNAL   PLoS Genet 15 (5), e1008184 (2019)
   PUBMED   31125351
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3268)
  AUTHORS   Floyd,B.J., Wilkerson,E.M., Veling,M.T., Minogue,C.E., Xia,C.,
            Beebe,E.T., Wrobel,R.L., Cho,H., Kremer,L.S., Alston,C.L.,
            Gromek,K.A., Dolan,B.K., Ulbrich,A., Stefely,J.A., Bohl,S.L.,
            Werner,K.M., Jochem,A., Westphall,M.S., Rensvold,J.W., Taylor,R.W.,
            Prokisch,H., Kim,J.P., Coon,J.J. and Pagliarini,D.J.
  TITLE     Mitochondrial Protein Interaction Mapping Identifies Regulators of
            Respiratory Chain Function
  JOURNAL   Mol Cell 63 (4), 621-632 (2016)
   PUBMED   27499296
REFERENCE   7  (bases 1 to 3268)
  AUTHORS   Leger,P.D., Johnson,D.H., Robbins,G.K., Shafer,R.W., Clifford,D.B.,
            Li,J., McLaren,P.J. and Haas,D.W.
  TITLE     Genome-wide association study of peripheral neuropathy with
            D-drug-containing regimens in AIDS Clinical Trials Group protocol
            384
  JOURNAL   J Neurovirol 20 (3), 304-308 (2014)
   PUBMED   24554482
REFERENCE   8  (bases 1 to 3268)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3268)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
REFERENCE   10 (bases 1 to 3268)
  AUTHORS   Manning,G., Whyte,D.B., Martinez,R., Hunter,T. and Sudarsanam,S.
  TITLE     The protein kinase complement of the human genome
  JOURNAL   Science 298 (5600), 1912-1934 (2002)
   PUBMED   12471243
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD630155.1, BC058906.1, AI866496.1 and AC008372.6.
            
            On Nov 22, 2018 this sequence version replaced NM_020421.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.35033.1,
                                           SRR1803615.151045.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000238561.10/ ENSP00000238561.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                CD630155.1         32-53
            23-1777             BC058906.1         1-1755
            1778-2208           AI866496.1         16-446              c
            2209-3268           AC008372.6         225066-226125
FEATURES             Location/Qualifiers
     source          1..3268
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..3268
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /note="aarF domain containing kinase 1"
                     /db_xref="GeneID:57143"
                     /db_xref="HGNC:HGNC:19038"
                     /db_xref="MIM:620399"
     exon            1..62
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            63..208
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1645
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /note="isoform a is encoded by transcript variant 1; aarF
                     domain-containing protein kinase 1"
                     /codon_start=1
                     /product="aarF domain-containing protein kinase 1 isoform
                     a"
                     /protein_id="NP_065154.2"
                     /db_xref="CCDS:CCDS9869.1"
                     /db_xref="GeneID:57143"
                     /db_xref="HGNC:HGNC:19038"
                     /db_xref="MIM:620399"
                     /translation="MARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVA
                     TTAVISYDYLTSLKSVPYGSEEYLQLRSKVHLRSARRLCELCCANRGTFIKVGQHLGA
                     LDYLLPEEYTSTLKVLHSQAPQSSMQEIRQVIREDLGKEIHDLFQSFDDTPLGTASLA
                     QVHKAVLHDGRTVAVKVQHPKVRAQSSKDILLMEVLVLAVKQLFPEFEFMWLVDEAKK
                     NLPLELDFLNEGRNAEKVSQMLRHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDY
                     MERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGL
                     YQMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRLGAGDLYPLFACMLTARSWDSVNRG
                     ISQAPVTATEDLEIRNNAANYLPQISHLLNHVPRQMLLILKTNDLLRGIEAALGTRAS
                     ASSFLNMSRCCIRALAEHKKKNTCSFFRRTQISFSEAFNLWQINLHELILRVKGLKLA
                     DRVLALICWLFPAPL"
     exon            209..292
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            293..496
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            497..655
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            656..814
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            815..931
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1081
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1279
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1473
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..3268
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2185..2190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /note="hexamer: AATAAA"
     polyA_site      2206
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /note="major polyA site"
     regulatory      3247..3252
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /note="hexamer: TATAAA"
     polyA_site      3268
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
ORIGIN      
        1 gctaattccc cgctaccggg ttgcggccgg aagccgggcg ccgcggctct gcttccctcg
       61 gggatctggc gacatggcca gaaaggctct caagcttgct tcgtggacca gcatggctct
      121 tgctgcctct ggcatctact tctacagtaa caagtacttg gaccctaatg actttggcgc
      181 tgtcagggtg ggcagagcag ttgctacgac ggctgtcatc agttacgact acctcacttc
      241 cctgaagagt gtcccttatg gctcagagga gtacttgcag ctgagatcta aggtgcacct
      301 tcgctctgcc aggcgtctct gtgagctctg ctgtgccaac cggggcacct tcatcaaggt
      361 gggccagcac ctgggggctc tggactacct gttgccagag gagtacacca gcacgctgaa
      421 ggtactgcac agccaggctc cacagagcag catgcaagag atccgccagg tcatccgaga
      481 agatctgggc aaggagatcc atgatttgtt ccagagcttc gatgacaccc ctctggggac
      541 ggcctccctg gcccaggtcc acaaggcagt gctgcatgat gggcggacgg tggccgtgaa
      601 ggtccagcac ccaaaggtgc gggctcagag ctcgaaggac attctcctga tggaggtgct
      661 cgttctggct gtgaagcagc tgttcccaga gtttgagttt atgtggcttg tggatgaagc
      721 caagaagaac ctgcctttgg agctggattt cctcaatgaa gggaggaatg ctgagaaggt
      781 gtcccagatg ctcaggcatt ttgacttctt gaaggtcccc cgaatccact gggacctgtc
      841 cacggagcgg gtcctcctga tggagtttgt ggatggcggg caggtcaatg acagagacta
      901 catggagagg aacaagatcg acgtcaatga gatctcacgc cacctgggca agatgtatag
      961 tgagatgatc ttcgtcaatg gcttcgtgca ctgcgatccc caccccggca atgtactggt
     1021 gcggaagcac cccggcacgg gaaaggcgga gattgtcctg ttggaccatg ggctttacca
     1081 gatgctcacg gaagaattcc gcctgaatta ctgccacctc tggcagtctc tgatctggac
     1141 tgacatgaag agagtgaagg agtacagcca gcgactggga gccggggatc tctacccctt
     1201 gtttgcctgc atgctgacgg cgcgatcgtg ggactcggtc aacagaggca tcagccaagc
     1261 tcccgtcact gccactgagg acttagagat tcgcaacaac gcggccaact acctccccca
     1321 gatcagccat ctcctcaacc acgtgccgcg ccagatgctg ctcatcttga agaccaacga
     1381 cctgctgcgt ggcattgagg ccgccctggg cacccgcgcc agcgccagct cctttctcaa
     1441 catgtcacgt tgctgcatca gagcgctagc tgagcacaag aagaagaata cctgttcatt
     1501 cttcagaagg acccagatct ctttcagcga ggccttcaac ttatggcaga tcaacctcca
     1561 tgagctcatc ctgcgtgtga aggggttgaa gctggctgac cgggtcttgg ccctaatatg
     1621 ctggctgttc cctgctccac tctgagtgga attgctctcc ctgccccatt ctggtgtctt
     1681 tccactcctc agcccctcat cttgcctcca cccagctgct ccatttttgc cacatcgtgg
     1741 cccgcagccc cagagtcact gtccatgtca ccatccttct cctcctttgg aatcctctcc
     1801 gcacactgtg gcccttgtct cagggcccac aagctgaact gtggcatagc tctctcttct
     1861 tctccaagaa gactcagcag cctacattcc cattcctggt atgtgccatt gggttggatg
     1921 tccccactac ttccgttaac ccttcccatt gtcaagatgt gccacgggtg ccactggggg
     1981 cacactgaac ttgtagggag tgtgattttg ttggaggtgc acatggtctc tgaatttgac
     2041 agagaacacc ttccctttcc ttgccatgtc accctccaga ggaagtcaca cctcagcgag
     2101 gtggtttggc atctggggcc aactccatta cagctatgag ctcactgctg tcagtgacgt
     2161 ttggtgtttt ctgtactgtg tttcaataaa aactccttca aggttgcagg atttgtccat
     2221 cataactcac tggcctccca cctgacccca ggcacgtgcc cttccagaat gtgctcatgg
     2281 tcctcgccaa gggcttatgg ttcctcttgg ttgctgcttc ctcagggttt cccagggaga
     2341 tctagggaac agaaggccag gggctgtttg gtgggatttt ccttataggt tgggagttca
     2401 cctacaatgc ccattaggtc agagtggacc tgaatcgagt attggtgtga tcttctgctt
     2461 ggcttcttgc tcctgtaatc cttccaacct gtggggccac ttccactatg gggccacttc
     2521 ctgcttcttg ggggtttctc ttaccttcca agactcagac tctggttgga ggagttaaga
     2581 agcccaaggc caggaactca gaggctcagc tgaaaccttg gaccttgttt ttctgtgacc
     2641 tgggtaccaa ccttgttcta ctgtttcctg acttatccct ttggttctca ttcagtggcc
     2701 ccagttttag gcctggaatt ctacttgtct ccccccagtc cttctggaga ccttagtcct
     2761 cttgctgaaa cctccgtcac tgtggctggg ttttcactgg gaaacttctg tgtttctacc
     2821 ccattgcttg ctgccagcac tgcctctccc cccagcctgg ttgtctgctt ctgtttcttg
     2881 gacatcccta agctcctgct ctaattccca tgtctttgtc tttggcaggt cctactgtct
     2941 gctttcacgg acagtaattg tatttgagcc tctctgatct tacttcaccc aattcacaag
     3001 ggcagaaaaa atcctgaatt tgagcctaat tttctgtact ctttattcat agtacagcaa
     3061 gcagattttt cagtgatcag tgacaattca caatcctttt atttcccaaa agaattaatt
     3121 gttcttagtg accagttgga tgcacccagg gacctgagag tataatttgc aatatctgat
     3181 tattaatctt gaggatgtgt gctgcatagt atattttatg gtgtctttta tagccactga
     3241 agtaaatata aatgtccttt ctgttcaa
//
