LOCUS       NM_001142545            3064 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens aarF domain containing kinase 1 (ADCK1), transcript
            variant 2, mRNA.
ACCESSION   NM_001142545
VERSION     NM_001142545.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3064)
  AUTHORS   Zhuo,B.B., Zhu,L.Q., Yao,C., Wang,X.H., Li,S.X., Wang,R., Li,Y. and
            Ling,Z.Y.
  TITLE     ADCK1 is a potential therapeutic target of osteosarcoma
  JOURNAL   Cell Death Dis 13 (11), 954 (2022)
   PUBMED   36371387
  REMARK    GeneRIF: ADCK1 is a potential therapeutic target of osteosarcoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3064)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 3064)
  AUTHORS   Zhang,H., Cao,X., Tang,M., Zhong,G., Si,Y., Li,H., Zhu,F., Liao,Q.,
            Li,L., Zhao,J., Feng,J., Li,S., Wang,C., Kaulich,M., Wang,F.,
            Chen,L., Li,L., Xia,Z., Liang,T., Lu,H., Feng,X.H. and Zhao,B.
  TITLE     A subcellular map of the human kinome
  JOURNAL   Elife 10, e64943 (2021)
   PUBMED   33988507
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3064)
  AUTHORS   Ji,Y., Liu,Y., Sun,C., Yu,L., Wang,Z., Du,X., Yang,W., Zhang,C.,
            Tao,C., Wang,J., Yang,X., Di,S. and Huang,Y.
  TITLE     ADCK1 activates the beta-catenin/TCF signaling pathway to promote
            the growth and migration of colon cancer cells
  JOURNAL   Cell Death Dis 12 (4), 354 (2021)
   PUBMED   33824271
  REMARK    GeneRIF: ADCK1 activates the beta-catenin/TCF signaling pathway to
            promote the growth and migration of colon cancer cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3064)
  AUTHORS   Yoon,W., Hwang,S.H., Lee,S.H. and Chung,J.
  TITLE     Drosophila ADCK1 is critical for maintaining mitochondrial
            structures and functions in the muscle
  JOURNAL   PLoS Genet 15 (5), e1008184 (2019)
   PUBMED   31125351
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3064)
  AUTHORS   Floyd,B.J., Wilkerson,E.M., Veling,M.T., Minogue,C.E., Xia,C.,
            Beebe,E.T., Wrobel,R.L., Cho,H., Kremer,L.S., Alston,C.L.,
            Gromek,K.A., Dolan,B.K., Ulbrich,A., Stefely,J.A., Bohl,S.L.,
            Werner,K.M., Jochem,A., Westphall,M.S., Rensvold,J.W., Taylor,R.W.,
            Prokisch,H., Kim,J.P., Coon,J.J. and Pagliarini,D.J.
  TITLE     Mitochondrial Protein Interaction Mapping Identifies Regulators of
            Respiratory Chain Function
  JOURNAL   Mol Cell 63 (4), 621-632 (2016)
   PUBMED   27499296
REFERENCE   7  (bases 1 to 3064)
  AUTHORS   Leger,P.D., Johnson,D.H., Robbins,G.K., Shafer,R.W., Clifford,D.B.,
            Li,J., McLaren,P.J. and Haas,D.W.
  TITLE     Genome-wide association study of peripheral neuropathy with
            D-drug-containing regimens in AIDS Clinical Trials Group protocol
            384
  JOURNAL   J Neurovirol 20 (3), 304-308 (2014)
   PUBMED   24554482
REFERENCE   8  (bases 1 to 3064)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3064)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
REFERENCE   10 (bases 1 to 3064)
  AUTHORS   Manning,G., Whyte,D.B., Martinez,R., Hunter,T. and Sudarsanam,S.
  TITLE     The protein kinase complement of the human genome
  JOURNAL   Science 298 (5600), 1912-1934 (2002)
   PUBMED   12471243
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD630155.1, DN996748.1, BC017459.1, AK096919.1, AI866496.1 and
            AC008372.6.
            
            On May 31, 2019 this sequence version replaced NM_001142545.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon, compared to variant 1, resulting in a shorter protein
            (isoform b), compared to isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096919.1, SRR5189658.222408.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                CD630155.1         32-59
            29-607              DN996748.1         9-587
            608-637             BC017459.1         794-823
            638-1573            AK096919.1         610-1545
            1574-2004           AI866496.1         16-446              c
            2005-3064           AC008372.6         225066-226125
FEATURES             Location/Qualifiers
     source          1..3064
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..3064
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /note="aarF domain containing kinase 1"
                     /db_xref="GeneID:57143"
                     /db_xref="HGNC:HGNC:19038"
                     /db_xref="MIM:620399"
     exon            1..62
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            63..208
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1441
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /note="isoform b is encoded by transcript variant 2; aarF
                     domain-containing protein kinase 1"
                     /codon_start=1
                     /product="aarF domain-containing protein kinase 1 isoform
                     b"
                     /protein_id="NP_001136017.1"
                     /db_xref="CCDS:CCDS45144.1"
                     /db_xref="GeneID:57143"
                     /db_xref="HGNC:HGNC:19038"
                     /db_xref="MIM:620399"
                     /translation="MARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVA
                     TTAVISYDYLTSLKSVPYGSEEYLQLRSKIHDLFQSFDDTPLGTASLAQVHKAVLHDG
                     RTVAVKVQHPKVRAQSSKDILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLN
                     EGRNAEKVSQMLRHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNE
                     ISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTEEFRL
                     NYCHLWQSLIWTDMKRVKEYSQRLGAGDLYPLFACMLTARSWDSVNRGISQAPVTATE
                     DLEIRNNAANYLPQISHLLNHVPRQMLLILKTNDLLRGIEAALGTRASASSFLNMSRC
                     CIRALAEHKKKNTCSFFRRTQISFSEAFNLWQINLHELILRVKGLKLADRVLALICWL
                     FPAPL"
     exon            209..292
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            293..451
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            452..610
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            611..727
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            728..877
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1075
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1269
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..3064
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1981..1986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /note="hexamer: AATAAA"
     polyA_site      2002
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /note="major polyA site"
     regulatory      3043..3048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /note="hexamer: TATAAA"
     polyA_site      3064
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
ORIGIN      
        1 gctaattccc cgctaccggg ttgcggccgg aagccgggcg ccgcggctct gcttccctcg
       61 gggatctggc gacatggcca gaaaggctct caagcttgct tcgtggacca gcatggctct
      121 tgctgcctct ggcatctact tctacagtaa caagtacttg gaccctaatg actttggcgc
      181 tgtcagggtg ggcagagcag ttgctacgac ggctgtcatc agttacgact acctcacttc
      241 cctgaagagt gtcccttatg gctcagagga gtacttgcag ctgagatcta agatccatga
      301 tttgttccag agcttcgatg acacccctct ggggacggcc tccctggccc aggtccacaa
      361 ggcagtgctg catgatgggc ggacggtggc cgtgaaggtc cagcacccaa aggtgcgggc
      421 tcagagctcg aaggacattc tcctgatgga ggtgctcgtt ctggctgtga agcagctgtt
      481 cccagagttt gagtttatgt ggcttgtgga tgaagccaag aagaacctgc ctttggagct
      541 ggatttcctc aatgaaggga ggaatgctga gaaggtgtcc cagatgctca ggcattttga
      601 cttcttgaag gtcccccgaa tccactggga cctgtccacg gagcgggtcc tcctgatgga
      661 gtttgtggat ggcgggcagg tcaatgacag agactacatg gagaggaaca agatcgacgt
      721 caatgagatc tcacgccacc tgggcaagat gtatagtgag atgatcttcg tcaatggctt
      781 cgtgcactgc gatccccacc ccggcaatgt actggtgcgg aagcaccccg gcacgggaaa
      841 ggcggagatt gtcctgttgg accatgggct ttaccagatg ctcacggaag aattccgcct
      901 gaattactgc cacctctggc agtctctgat ctggactgac atgaagagag tgaaggagta
      961 cagccagcga ctgggagccg gggatctcta ccccttgttt gcctgcatgc tgacggcgcg
     1021 atcgtgggac tcggtcaaca gaggcatcag ccaagctccc gtcactgcca ctgaggactt
     1081 agagattcgc aacaacgcgg ccaactacct cccccagatc agccatctcc tcaaccacgt
     1141 gccgcgccag atgctgctca tcttgaagac caacgacctg ctgcgtggca ttgaggccgc
     1201 cctgggcacc cgcgccagcg ccagctcctt tctcaacatg tcacgttgct gcatcagagc
     1261 gctagctgag cacaagaaga agaatacctg ttcattcttc agaaggaccc agatctcttt
     1321 cagcgaggcc ttcaacttat ggcagatcaa cctccatgag ctcatcctgc gtgtgaaggg
     1381 gttgaagctg gctgaccggg tcttggccct aatatgctgg ctgttccctg ctccactctg
     1441 agtggaattg ctctccctgc cccattctgg tgtctttcca ctcctcagcc cctcatcttg
     1501 cctccaccca gctgctccat ttttgccaca tcgtggcccg cagccccaga gtcactgtcc
     1561 atgtcaccat ccttctcctc ctttggaatc ctctccgcac actgtggccc ttgtctcagg
     1621 gcccacaagc tgaactgtgg catagctctc tcttcttctc caagaagact cagcagccta
     1681 cattcccatt cctggtatgt gccattgggt tggatgtccc cactacttcc gttaaccctt
     1741 cccattgtca agatgtgcca cgggtgccac tgggggcaca ctgaacttgt agggagtgtg
     1801 attttgttgg aggtgcacat ggtctctgaa tttgacagag aacaccttcc ctttccttgc
     1861 catgtcaccc tccagaggaa gtcacacctc agcgaggtgg tttggcatct ggggccaact
     1921 ccattacagc tatgagctca ctgctgtcag tgacgtttgg tgttttctgt actgtgtttc
     1981 aataaaaact ccttcaaggt tgcaggattt gtccatcata actcactggc ctcccacctg
     2041 accccaggca cgtgcccttc cagaatgtgc tcatggtcct cgccaagggc ttatggttcc
     2101 tcttggttgc tgcttcctca gggtttccca gggagatcta gggaacagaa ggccaggggc
     2161 tgtttggtgg gattttcctt ataggttggg agttcaccta caatgcccat taggtcagag
     2221 tggacctgaa tcgagtattg gtgtgatctt ctgcttggct tcttgctcct gtaatccttc
     2281 caacctgtgg ggccacttcc actatggggc cacttcctgc ttcttggggg tttctcttac
     2341 cttccaagac tcagactctg gttggaggag ttaagaagcc caaggccagg aactcagagg
     2401 ctcagctgaa accttggacc ttgtttttct gtgacctggg taccaacctt gttctactgt
     2461 ttcctgactt atccctttgg ttctcattca gtggccccag ttttaggcct ggaattctac
     2521 ttgtctcccc ccagtccttc tggagacctt agtcctcttg ctgaaacctc cgtcactgtg
     2581 gctgggtttt cactgggaaa cttctgtgtt tctaccccat tgcttgctgc cagcactgcc
     2641 tctcccccca gcctggttgt ctgcttctgt ttcttggaca tccctaagct cctgctctaa
     2701 ttcccatgtc tttgtctttg gcaggtccta ctgtctgctt tcacggacag taattgtatt
     2761 tgagcctctc tgatcttact tcacccaatt cacaagggca gaaaaaatcc tgaatttgag
     2821 cctaattttc tgtactcttt attcatagta cagcaagcag atttttcagt gatcagtgac
     2881 aattcacaat ccttttattt cccaaaagaa ttaattgttc ttagtgacca gttggatgca
     2941 cccagggacc tgagagtata atttgcaata tctgattatt aatcttgagg atgtgtgctg
     3001 catagtatat tttatggtgt cttttatagc cactgaagta aatataaatg tcctttctgt
     3061 tcaa
//
