LOCUS       NM_182503               6244 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens adenosine deaminase tRNA specific 2 (ADAT2),
            transcript variant 1, mRNA.
ACCESSION   NM_182503
VERSION     NM_182503.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6244)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6244)
  AUTHORS   Ramos,J., Proven,M., Halvardson,J., Hagelskamp,F., Kuchinskaya,E.,
            Phelan,B., Bell,R., Kellner,S.M., Feuk,L., Thuresson,A.C. and Fu,D.
  TITLE     Identification and rescue of a tRNA wobble inosine deficiency
            causing intellectual disability disorder
  JOURNAL   RNA 26 (11), 1654-1666 (2020)
   PUBMED   32763916
  REMARK    GeneRIF: Identification and rescue of a tRNA wobble inosine
            deficiency causing intellectual disability disorder.
REFERENCE   3  (bases 1 to 6244)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 6244)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 6244)
  AUTHORS   Wulff,T.F., Arguello,R.J., Molina Jordan,M., Roura Frigole,H.,
            Hauquier,G., Filonava,L., Camacho,N., Gatti,E., Pierre,P., Ribas de
            Pouplana,L. and Torres,A.G.
  TITLE     Detection of a Subset of Posttranscriptional Transfer RNA
            Modifications in Vivo with a Restriction Fragment Length
            Polymorphism-Based Method
  JOURNAL   Biochemistry 56 (31), 4029-4038 (2017)
   PUBMED   28703578
  REMARK    GeneRIF: Transfer RNAs (tRNAs) are among the most heavily modified
            RNA species. Data confirm that ADAT2 exhibits substrate specificity
            that includes tRNA(Ala-AGC) and tRNA(Thr-AGU), deaminating
            adenosine-34 to inosine-34 as post-transcriptional modifications.
REFERENCE   6  (bases 1 to 6244)
  AUTHORS   Caron,C., Lestrat,C., Marsal,S., Escoffier,E., Curtet,S.,
            Virolle,V., Barbry,P., Debernardi,A., Brambilla,C., Brambilla,E.,
            Rousseaux,S. and Khochbin,S.
  TITLE     Functional characterization of ATAD2 as a new cancer/testis factor
            and a predictor of poor prognosis in breast and lung cancers
  JOURNAL   Oncogene 29 (37), 5171-5181 (2010)
   PUBMED   20581866
  REMARK    GeneRIF: data indicate that ATAD2 overexpression in somatic cells,
            by acting on basic properties of chromatin, may contribute to
            malignant transformation
REFERENCE   7  (bases 1 to 6244)
  AUTHORS   Schaub,M. and Keller,W.
  TITLE     RNA editing by adenosine deaminases generates RNA and protein
            diversity
  JOURNAL   Biochimie 84 (8), 791-803 (2002)
   PUBMED   12457566
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA100320.1, BC037955.1, AL031320.6 and BM680217.1.
            
            On Nov 23, 2018 this sequence version replaced NM_182503.2.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.97971.1,
                                           SRR5189661.146545.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000237283.9/ ENSP00000237283.8
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                DA100320.1         10-52
            44-656              BC037955.1         13-625
            657-5567            AL031320.6         43136-48046         c
            5568-6244           BM680217.1         18-694              c
FEATURES             Location/Qualifiers
     source          1..6244
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q24.2"
     gene            1..6244
                     /gene="ADAT2"
                     /gene_synonym="DEADC1; dJ20N2; dJ20N2.1; TAD2"
                     /note="adenosine deaminase tRNA specific 2"
                     /db_xref="GeneID:134637"
                     /db_xref="HGNC:HGNC:21172"
                     /db_xref="MIM:615388"
     exon            1..133
                     /gene="ADAT2"
                     /gene_synonym="DEADC1; dJ20N2; dJ20N2.1; TAD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..613
                     /gene="ADAT2"
                     /gene_synonym="DEADC1; dJ20N2; dJ20N2.1; TAD2"
                     /EC_number="3.5.4.33"
                     /note="isoform a is encoded by transcript variant 1;
                     deaminase domain containing 1; tRNA-specific adenosine
                     deaminase 2 homolog; deaminase domain-containing protein
                     1; tRNA-specific adenosine-34 deaminase subunit ADAT2;
                     adenosine deaminase, tRNA-specific 2, TAD2 homolog"
                     /codon_start=1
                     /product="tRNA-specific adenosine deaminase 2 isoform a"
                     /protein_id="NP_872309.2"
                     /db_xref="CCDS:CCDS43511.1"
                     /db_xref="GeneID:134637"
                     /db_xref="HGNC:HGNC:21172"
                     /db_xref="MIM:615388"
                     /translation="MEAKAAPKPAASGACSVSAEETEKWMEEAMHMAKEALENTEVPV
                     GCLMVYNNEVVGKGRNEVNQTKNATRHAEMVAIDQVLDWCRQSGKSPSEVFEHTVLYV
                     TVEPCIMCAAALRLMKIPLVVYGCQNERFGGCGSVLNIASADLPNTGRPFQCIPGYRA
                     EEAVEMLKTFYKQENPNAPKSKVRKKECQKS"
     exon            134..238
                     /gene="ADAT2"
                     /gene_synonym="DEADC1; dJ20N2; dJ20N2.1; TAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            239..389
                     /gene="ADAT2"
                     /gene_synonym="DEADC1; dJ20N2; dJ20N2.1; TAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            390..496
                     /gene="ADAT2"
                     /gene_synonym="DEADC1; dJ20N2; dJ20N2.1; TAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            497..569
                     /gene="ADAT2"
                     /gene_synonym="DEADC1; dJ20N2; dJ20N2.1; TAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            570..6244
                     /gene="ADAT2"
                     /gene_synonym="DEADC1; dJ20N2; dJ20N2.1; TAD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1839..1844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAT2"
                     /gene_synonym="DEADC1; dJ20N2; dJ20N2.1; TAD2"
                     /note="hexamer: ATTACA"
     polyA_site      1857
                     /gene="ADAT2"
                     /gene_synonym="DEADC1; dJ20N2; dJ20N2.1; TAD2"
     polyA_site      2087
                     /gene="ADAT2"
                     /gene_synonym="DEADC1; dJ20N2; dJ20N2.1; TAD2"
                     /note="major polyA site"
     regulatory      3120..3125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAT2"
                     /gene_synonym="DEADC1; dJ20N2; dJ20N2.1; TAD2"
                     /note="hexamer: GATAAA"
     polyA_site      3141
                     /gene="ADAT2"
                     /gene_synonym="DEADC1; dJ20N2; dJ20N2.1; TAD2"
     regulatory      6217..6222
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAT2"
                     /gene_synonym="DEADC1; dJ20N2; dJ20N2.1; TAD2"
                     /note="hexamer: AATAAA"
     polyA_site      6244
                     /gene="ADAT2"
                     /gene_synonym="DEADC1; dJ20N2; dJ20N2.1; TAD2"
ORIGIN      
        1 ctctgccgcg ggctctgtag ctgagtggtg gctgggtatg gaggcgaagg cggcacccaa
       61 gccagctgca agcggcgcgt gctcggtgtc ggcagaggag accgaaaagt ggatggagga
      121 ggcgatgcac atggccaaag aagccctcga aaatactgaa gttcctgttg gctgtcttat
      181 ggtctacaac aatgaagttg tagggaaggg gagaaatgaa gttaaccaaa ccaaaaatgc
      241 tactcgacat gcagaaatgg tggccatcga tcaggtcctc gattggtgtc gtcaaagtgg
      301 caagagtccc tctgaagtat ttgaacacac tgtgttgtat gtcactgtgg agccgtgcat
      361 tatgtgtgca gctgctctcc gcctgatgaa aatcccgctg gttgtatatg gctgtcagaa
      421 tgaacgattt ggtggttgtg gctctgttct aaatattgcc tctgctgacc taccaaacac
      481 tgggagacca tttcagtgta tccctggata tcgggctgag gaagcagtgg aaatgttaaa
      541 gaccttctac aaacaagaaa atccaaatgc accaaaatcg aaagttcgga aaaaggaatg
      601 tcagaaatct tgaacatgtt ctgatgaaag aaccaagtga cccaaagtga cctggacaag
      661 attcatagac tgaaagctgt tgacatcgtt gaatcatatg tttatatatt gtttttaatc
      721 tgcaggaaaa tggtgtctct catcatttgc tctgttaagg gaacaaatta gcacttttta
      781 gaagtctgac aattgtaaac agttattagc ttttccagaa gctgattccc attttaagat
      841 gggggaaaat taaggtttga ggttttagaa attagcaagt agtgcatacc cttctagcca
      901 caagtgccca gtccaggcaa gtgctgactt cttagagaat gtgtggccag acccagggac
      961 ctggagtgtg tttggactgc agtttgccac cctgagaaca ccttctccag gactggcatt
     1021 tcagaatcag attcttcatt ttttgcagct acgatgttct tccagggcac tgggggctgt
     1081 gacttctctc taaattgtat ataagttgtg tatatagaga ccataattat atggtcctta
     1141 gaaaagactt tgcttttata aagcatttag aaaaaatgca tacttttaaa acaagtgctt
     1201 gagttgtcac ttaaaaatta tagcatattg ctataataaa accttattta tgtcttattt
     1261 gaagatgaat agtcttaaaa gataaagaca taaatgggac aattgttatt gagcaaaaaa
     1321 ccaaattatc ccaccctcat ggagcttata ttctagcaag gggagatgga tatgatagat
     1381 tacacagttt attggaggac aataagagtt atggcaaaaa gcaaaaggaa cacagggtaa
     1441 aggggatagg tgccatttgg tggtgagaat gctgactgaa aaatagaatg atcaatttaa
     1501 tctgaaacaa atggttattt cttttataat ccatataata aatttaaaat ctaaaatgta
     1561 aaattttgaa cacaacactg gaaagggtat ccacagcagg aagtccccag ttcacctcca
     1621 tgactacagg gcagctttgc acagccctct gggcgcactg tgtgcctctg cccagaaggg
     1681 ggcctcgccg ttccaccaga agctcagctc caggccctgg aggggctgct gctcctcagt
     1741 tgcatttctt cagtagattc atttccttga tgcaaagcat ctgtatttgt tggttctgtc
     1801 atttgagcga tgtctctgac ttgtttgttt tgaattacat tacaggctgg aatgtaattg
     1861 tggtgaaagt atttttatat tgctgagagt agcagctaat cacagttaca tgcttcagag
     1921 gacttataat tgcttggttt tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtt
     1981 taactgcatt tgaaaagttt tatggagaat atgcatgatt ttaaatctgt gataatgtta
     2041 catgcacctt caatttcatc cactttaaaa attatcttct cattgaattt tagtgcttct
     2101 actagtttgt tcctttttgc agttggtcgt aattcatttc tggcttctta tgctttcctg
     2161 caagcagatt tcattgcatt tattgtgttc atatcatttt cttggggatt atttgtagga
     2221 caaccaacct ggagttttgc ctctctagag taccacccag taagtctggc tgagcatctt
     2281 atgtccagta ggttcttggt aaacatttgc taaatgaaat tactgattga aatttgggga
     2341 aaagtgaata agaagactat ctaggacaaa aagccaaagc cgaaaatagt atatgagcat
     2401 tctagcccag agactgtcgc tactaaaaga atgaaggaaa taataaagtg atagacaggg
     2461 aaggatagaa aagacttaac aatatacata tgttccgtct ttgctgtttt ggagaatgat
     2521 ggataagtag tgtttcctga ttctgaagca tagctgaaca atttaattgt ggtttaccat
     2581 ctttttggtt ccctcttcag taattaacct atcgaaaatc tgtcctaaat gtttggactg
     2641 gggcacagtt ccctccatcg ctttgggaga aaatcattaa tatggcatac tgcagattgg
     2701 agggcaggac cactgagggt gtcatagaca ttagctctat ggaattctgc tagcaatttc
     2761 caagtgacag tgaggaatta tggatatatg ttgaggtcat tcagcttcct gagtaccaca
     2821 ttccccagct acttagacac gggttaaaat attaagatgt cctagttcaa cagcttgaat
     2881 tccattgatt gatactgata gtgcctgtcc aagacaccag ctgaaagact tgttttgtgt
     2941 acaaaatagt tctgaaagtg gtgagataca aaaaggtttt agaatcactg ccctgttgag
     3001 agaaattagg gggaaatgat tacatttaga agctgctaga gttatccagt gtttgctggt
     3061 ctttgcaaca aactgtggag aatgggtggt atgtaatgct ttggtaggct tcaatcactg
     3121 ataaaagatc atgttaaaat atctttgtgc tttcttgtta cttggcacaa ccatctcttc
     3181 ctgtgttgta tttggagtat catggagaga aaatagatgg ccaagagctt cagtgtaggc
     3241 aagaactctt aatttttctt taaacttttt actgggaaaa gtatatatat ataaaataca
     3301 cacacacaca cacacacaca cacacacaca cacacacaca caaacacaac acaccatggc
     3361 cctttacccc gaaatgcttc agtatagtta ttgacttaag taaatttaac attgatatac
     3421 ttgaatctat catttgtatt acagttttgt cagctgaccc aataatgtcc tgtaaagaag
     3481 ttctcccact accctataat cccaggtcca gtctagggtc cagcattaca tttacttgtc
     3541 ttgaatccag ctttttcttt tttttttttt tttttgagat aggtctcact ctgtcgtcca
     3601 gtggcatgat cacagctcac tgcagcctca acctggctca agcaatcctt cctcctcagc
     3661 ctcctgagta gctgggacca cagactcatg tcaccacacc taattttttt tttttttttt
     3721 ttttgtagag acaaggtctc actatgttgc ccaggctggt cttgaactcc taggctgaag
     3781 caatcctcct tccttggcct cccaaagcac tgggattata gacgtgagcc actgcaccgg
     3841 tctgccttta gcttctttta gtctagaaca ttttcactgg ctttctttgt cttttatgac
     3901 attgacattt ttaaataata cagtcatttt gcctcctttc tgttttcttc ttcttttttt
     3961 aaataataga atggtccttg ttttaaattt atttgatatt ttcttgtgat tagattcagg
     4021 tgctggttga tgttaagttc ctcacaggat atcacatctg gaggcacaca aaggccgtca
     4081 caccaaggtg atgtcaattt tggtcatctg gtcaaggtgt tgtcctattc cttcactata
     4141 tagttacctt ttttctctgt tgcaatgaat aagcagtctg tgggaagagg agctgttaca
     4201 ttttaaacag aaaatgtatt tgacactgat ggaaaggaga ggaggaaaat taatgacata
     4261 aatttcaaag caactattaa attatttgat tgcattcttc ctcttttact gtctgccaaa
     4321 attgataaaa aaaatttttc taataagaat gttttaaata gtgatatctt aataagcatc
     4381 aaaattaagc ctgagaaata aattctttcc ttcctaattt cctcctcagc aaaagtaata
     4441 attatataaa tttcattatg cctgataaga tagggttttg gaaaatagac ctaagatgtt
     4501 tctgatactg cagatgacct atggtgatcc aatgggataa acactctagg taggttgtca
     4561 tttggtcata aaatatgagt tatcttgggt ttccatagag acatctagac ttaaaatgtt
     4621 gtaagcactg ctactttcaa aatgtcagta aaaatagcaa aagccaaagc tcttgaaaaa
     4681 attacttaaa tcttttttaa aagtagtata gcgccttgtt aaaaatctgt ggtgatgcca
     4741 aagcttgtct ttcccagtgg tcctacgtga actggcctta tagccccagg gaaaccagac
     4801 accaggaatt ggtttctctg ccttttggca aaggaataag actacattga cttcatctat
     4861 gaagacaact gccaactatt tcctttgtaa attgctaatt ttgtgtagtg aggaaaggag
     4921 cgatgggcga cgtgattttt atggattaga ctggtgagtt ctgctgaaag tttgacatct
     4981 ttaggatctt acattttctt caagttgagc taatgaaaac aggctcgtga ctatttatca
     5041 cctgatttct aagtggatat tgggttgaac accacatatc catgactatt aaggaggctt
     5101 catggtgtag tttgacaaag gctctctcct tgaccaaact tcagtcaggc cctaagtcct
     5161 ctttttaacc aggcctccac cttggccccc attcttgatg ggcctataca gcccagcttt
     5221 agcaagaatc ctgctaagct agtttagaga gaatcccaca tccccaatat ctatgaaatt
     5281 tctcatcccc tacttttgat gtgtaagtcc ttggcctccc ttcaacgaga agcctgttaa
     5341 gttcattttg caagaactct actcttgata tctcctctta gtaatttcct aatcactgac
     5401 cccctcactc tgcccattag ttataaaccc ccacatgttc tggttgtatt cagagctgag
     5461 cctgatctct tcctcttgtt gggatagttt taaaacctgc gatagtttta aaacctatca
     5521 ctgtagtcct gaattaagtc ttccttacct taacaagtgt caaaataaat ttttctttaa
     5581 catgttgaag catgaacttg agaatctaga gcaggagtcc acaaagtatg gcccatgggc
     5641 catatccagc ccgctgccgg tttcggtacc actcatgact taaaaatggg tcttacaatt
     5701 ctgagtgatt gaaaaaaaat caaaagaagg ataatattta gtgacccatg aaccttatat
     5761 ggcaatcaaa tttcagtgtc cataaataaa gttacattgg atgacagcca tgcccatttg
     5821 tttctgtgtt gtctgtggct gctcgtgtgc tacaatggca gagttgagca gtggtgacaa
     5881 accatgcgac tcacaaaggc ctaaaatatt tagcgtctgg cccttcgaga aaatgttagc
     5941 tgcccctggt ctagagtagg taaaaggctg agattggaag ctgcttgttc aaattctgtg
     6001 attggaaccg aatgatgtgg ctcattgtac agctcatggt gaattgcttc agtaccatgg
     6061 ttttgttttt tccttttgaa aagttggtct ataaatgtaa aggaaaaatc taagatacca
     6121 aaatatgttt tctggcttag aatgttttat ttccttgtat acattttaag agagtggcaa
     6181 ggagaaaaga taatgtatca ttttatttgg gtttagaata aataatacat tttatttatg
     6241 atca
//
