LOCUS       NM_001324445            5757 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens adenosine deaminase tRNA specific 1 (ADAT1),
            transcript variant 3, mRNA.
ACCESSION   NM_001324445
VERSION     NM_001324445.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5757)
  AUTHORS   Wolpin,B.M., Rizzato,C., Kraft,P., Kooperberg,C., Petersen,G.M.,
            Wang,Z., Arslan,A.A., Beane-Freeman,L., Bracci,P.M., Buring,J.,
            Canzian,F., Duell,E.J., Gallinger,S., Giles,G.G., Goodman,G.E.,
            Goodman,P.J., Jacobs,E.J., Kamineni,A., Klein,A.P., Kolonel,L.N.,
            Kulke,M.H., Li,D., Malats,N., Olson,S.H., Risch,H.A., Sesso,H.D.,
            Visvanathan,K., White,E., Zheng,W., Abnet,C.C., Albanes,D.,
            Andreotti,G., Austin,M.A., Barfield,R., Basso,D., Berndt,S.I.,
            Boutron-Ruault,M.C., Brotzman,M., Buchler,M.W.,
            Bueno-de-Mesquita,H.B., Bugert,P., Burdette,L., Campa,D.,
            Caporaso,N.E., Capurso,G., Chung,C., Cotterchio,M., Costello,E.,
            Elena,J., Funel,N., Gaziano,J.M., Giese,N.A., Giovannucci,E.L.,
            Goggins,M., Gorman,M.J., Gross,M., Haiman,C.A., Hassan,M.,
            Helzlsouer,K.J., Henderson,B.E., Holly,E.A., Hu,N., Hunter,D.J.,
            Innocenti,F., Jenab,M., Kaaks,R., Key,T.J., Khaw,K.T., Klein,E.A.,
            Kogevinas,M., Krogh,V., Kupcinskas,J., Kurtz,R.C., LaCroix,A.,
            Landi,M.T., Landi,S., Le Marchand,L., Mambrini,A., Mannisto,S.,
            Milne,R.L., Nakamura,Y., Oberg,A.L., Owzar,K., Patel,A.V.,
            Peeters,P.H., Peters,U., Pezzilli,R., Piepoli,A., Porta,M.,
            Real,F.X., Riboli,E., Rothman,N., Scarpa,A., Shu,X.O.,
            Silverman,D.T., Soucek,P., Sund,M., Talar-Wojnarowska,R.,
            Taylor,P.R., Theodoropoulos,G.E., Thornquist,M., Tjonneland,A.,
            Tobias,G.S., Trichopoulos,D., Vodicka,P., Wactawski-Wende,J.,
            Wentzensen,N., Wu,C., Yu,H., Yu,K., Zeleniuch-Jacquotte,A.,
            Hoover,R., Hartge,P., Fuchs,C., Chanock,S.J.,
            Stolzenberg-Solomon,R.S. and Amundadottir,L.T.
  TITLE     Genome-wide association study identifies multiple susceptibility
            loci for pancreatic cancer
  JOURNAL   Nat Genet 46 (9), 994-1000 (2014)
   PUBMED   25086665
REFERENCE   2  (bases 1 to 5757)
  AUTHORS   Dastani,Z., Pajukanta,P., Marcil,M., Rudzicz,N., Ruel,I.,
            Bailey,S.D., Lee,J.C., Lemire,M., Faith,J., Platko,J., Rioux,J.,
            Hudson,T.J., Gaudet,D., Engert,J.C. and Genest,J.
  TITLE     Fine mapping and association studies of a high-density lipoprotein
            cholesterol linkage region on chromosome 16 in French-Canadian
            subjects
  JOURNAL   Eur J Hum Genet 18 (3), 342-347 (2010)
   PUBMED   19844255
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 5757)
  AUTHORS   Maas,S., Gerber,A.P. and Rich,A.
  TITLE     Identification and characterization of a human tRNA-specific
            adenosine deaminase related to the ADAR family of pre-mRNA editing
            enzymes
  JOURNAL   Proc Natl Acad Sci U S A 96 (16), 8895-8900 (1999)
   PUBMED   10430867
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC025287.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001324445.1.
            
            Summary: This gene is a member of the ADAR (adenosine deaminase
            acting on RNA) family. Using site-specific adenosine modification,
            proteins encoded by these genes participate in the pre-mRNA editing
            of nuclear transcripts. The protein encoded by this gene,
            tRNA-specific adenosine deaminase 1, is responsible for the
            deamination of adenosine 37 to inosine in eukaryotic tRNA.
            Alternatively spliced transcript variants have been described.
            [provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (3) and variant 1 both encode the
            same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.4411506.1,
                                           SRR14038193.1950704.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000564657.2/ ENSP00000457501.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-879               AC025287.8         94589-95467
            880-1069            AC025287.8         97050-97239
            1070-1138           AC025287.8         97536-97604
            1139-1193           AC025287.8         99230-99284
            1194-1324           AC025287.8         100598-100728
            1325-1943           AC025287.8         105009-105627
            1944-2089           AC025287.8         108882-109027
            2090-2189           AC025287.8         109547-109646
            2190-2276           AC025287.8         114699-114785
            2277-5757           AC025287.8         117522-121002
FEATURES             Location/Qualifiers
     source          1..5757
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.1"
     gene            1..5757
                     /gene="ADAT1"
                     /gene_synonym="HADAT1"
                     /note="adenosine deaminase tRNA specific 1"
                     /db_xref="GeneID:23536"
                     /db_xref="HGNC:HGNC:228"
                     /db_xref="MIM:604230"
     exon            1..879
                     /gene="ADAT1"
                     /gene_synonym="HADAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1069
                     /gene="ADAT1"
                     /gene_synonym="HADAT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             901..2409
                     /gene="ADAT1"
                     /gene_synonym="HADAT1"
                     /EC_number="3.5.4.34"
                     /note="isoform a is encoded by transcript variant 3;
                     adenosine deaminase acting on tRNA; tRNA-specific
                     adenosine-37 deaminase"
                     /codon_start=1
                     /product="tRNA-specific adenosine deaminase 1 isoform a"
                     /protein_id="NP_001311374.1"
                     /db_xref="CCDS:CCDS10922.1"
                     /db_xref="GeneID:23536"
                     /db_xref="HGNC:HGNC:228"
                     /db_xref="MIM:604230"
                     /translation="MWTADEIAQLCYEHYGIRLPKKGKPEPNHEWTLLAAVVKIQSPA
                     DKACDTPDKPVQVTKEVVSMGTGTKCIGQSKMRKNGDILNDSHAEVIARRSFQRYLLH
                     QLQLAATLKEDSIFVPGTQKGVWKLRRDLIFVFFSSHTPCGDASIIPMLEFEDQPCCP
                     VFRNWAHNSSVEASSNLEAPGNERKCEDPDSPVTKKMRLEPGTAAREVTNGAAHHQSF
                     GKQKSGPISPGIHSCDLTVEGLATVTRIAPGSAKVIDVYRTGAKCVPGEAGDSGKPGA
                     AFHQVGLLRVKPGRGDRTRSMSCSDKMARWNVLGCQGALLMHLLEEPIYLSAVVIGKC
                     PYSQEAMQRALIGRCQNVSALPKGFGVQELKILQSDLLFEQSRSAVQAKRADSPGRLV
                     PCGAAISWSAVPEQPLDVTANGFPQGTTKKTIGSLQARSQISKVELFRSFQKLLSRIA
                     RDKWPHSLRVQKLDTYQEYKEAASSYQEAWSTLRKQVFGSWIRNPPDYHQFK"
     exon            1070..1138
                     /gene="ADAT1"
                     /gene_synonym="HADAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1193
                     /gene="ADAT1"
                     /gene_synonym="HADAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1324
                     /gene="ADAT1"
                     /gene_synonym="HADAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1943
                     /gene="ADAT1"
                     /gene_synonym="HADAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2089
                     /gene="ADAT1"
                     /gene_synonym="HADAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2189
                     /gene="ADAT1"
                     /gene_synonym="HADAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2276
                     /gene="ADAT1"
                     /gene_synonym="HADAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..5757
                     /gene="ADAT1"
                     /gene_synonym="HADAT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5737..5742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAT1"
                     /gene_synonym="HADAT1"
                     /note="hexamer: AATAAA"
     polyA_site      5757
                     /gene="ADAT1"
                     /gene_synonym="HADAT1"
                     /note="major polyA site"
ORIGIN      
        1 accggcggat taagctcgct ttcttctagg cgcgtttcct gaaggtggga ggggagcgtc
       61 cgcgaggcgc tggggcgacg gggcaggttt atccgggcta actttgccga gtctgttttt
      121 gagggaagag gttgtgagga tcgtatcttc cgggacgcgt ttcacgtggg aaggcgctcc
      181 acgcctggaa ctgtcagcag ccggcgcctg aagagctcct ggcgcggggc ctctggcctg
      241 gcagccgcag gacccaatgg atcaggcgct cacgctgttc tcactgcatg gcttcagtgc
      301 cttgcctggc acctcctatc ctgtaactgg ccgactcggg gtcccaccca ggcttctcca
      361 gcggccggga aggggctctg cttccggaag tgtttaggaa gggagccagc gtaaaccaga
      421 gtcccttcct ccaagcatcg ctgaagcctt ttctcccctg gcagccgact tccttttctt
      481 tggaaaggac gtcagttttt ttagcttgtt gaaactgttc agagatgcgg tcttgtgggc
      541 aaataaatgc ctgtttagct gagctgttat tttcagctaa gaagttcttc aagttttcaa
      601 gatctaggag ggggtgtagg ctcgaattat aatggaccca gtgtagcaaa acatttattc
      661 atttaaacaa ttgtgcatgc tcattcagac gcactacctg agtgagatga tgccgttctg
      721 ggctgcttca tcttaaagag agtcactgtt tcttctggca acttctacct gccttgccta
      781 tcgaggtttg tgaattgcac ctctggttta atttcaggtc gatggccagg tggtcttcat
      841 aaactatact gccttgtgat gcctccctag aaatgagagg tctcaatacc agctcagacc
      901 atgtggaccg cggatgagat tgctcagcta tgctatgaac actatgggat caggctgccc
      961 aagaagggga agcctgagcc aaaccatgag tggacattat tggcagcggt ggtgaagata
     1021 caatctccag ctgacaaggc ctgcgacacc cctgataagc cggtgcaagt gacaaaggaa
     1081 gttgtgtcaa tgggaacagg aacaaaatgc ataggacagt ccaaaatgag gaagaacgga
     1141 gacatcctca atgatagcca tgctgaggtc atagccagaa ggagtttcca aaggtacctt
     1201 ctccaccaac tccagttggc agccaccctg aaagaggata gcatctttgt cccaggaact
     1261 caaaaaggag tgtggaaact tagacgagac ctcatttttg tgtttttctc cagccataca
     1321 ccctgtgggg atgcctccat cattccgatg cttgagtttg aagatcagcc ttgctgtcct
     1381 gtcttcagaa attgggccca caactcatca gtagaagcca gtagtaacct ggaagctcct
     1441 ggaaatgaaa gaaaatgtga agaccctgac agtcctgtaa ccaaaaagat gaggcttgag
     1501 cctgggactg cagccaggga ggtcaccaac ggagcagctc accatcagag ttttggcaag
     1561 cagaaaagtg gcccaatctc accaggcatc cacagctgtg atctcactgt agagggactg
     1621 gctactgtca ccagaatagc ccctggtagt gccaaagtga tagacgttta tagaactgga
     1681 gccaagtgtg tacctggaga agctggagac tccggaaagc cgggtgctgc gtttcaccag
     1741 gtggggctgc tccgagtgaa gccaggccgt ggagacagaa cacgctccat gtcctgtagt
     1801 gacaagatgg cccgatggaa cgtcctcgga tgccaagggg cactgttgat gcacttgctg
     1861 gaagagccca tctacctgtc agctgtggtc attgggaagt gcccatacag ccaggaagcc
     1921 atgcagagag cactgattgg aaggtgtcag aatgtgtctg ctttaccaaa aggcttcgga
     1981 gttcaagaat taaaaatact gcagtcagat ttactatttg aacagagccg cagtgcggtg
     2041 caggcaaaaa gggctgatag cccaggtcga cttgttcctt gtggggcagc catcagctgg
     2101 agtgcagttc ctgagcagcc tttggatgtt actgccaatg gctttccaca gggaacaaca
     2161 aagaaaacaa ttggaagcct tcaggcaaga tcccaaatca gcaaagtgga actcttcaga
     2221 tcattccaga agctgctaag cagaattgca agggacaagt ggccacactc cctcagggtg
     2281 cagaagctgg atacctacca ggagtacaag gaggctgcgt cctcttacca ggaagcctgg
     2341 agcacactcc ggaagcaggt gtttggatcc tggatcagaa acccaccgga ttatcaccag
     2401 ttcaagtgag aaggaaatgt ttgctctggt agcaggaccc ttcatcctga actgccttcc
     2461 tccacgcagg acaagtctta gcttttttgg tagttaaatc agggaacatt ctttctgagc
     2521 tttgcatctc tgttgtgtaa tacagatgga atctggaact tagagcaagc tatacttgat
     2581 tgaagtagct ctctgctaaa atggcatctc actaatgacc tcactatctg acttccattg
     2641 tgttttattg cttctctaaa atatgaaatc agagtttgga acatgatgct ttgaaagtac
     2701 tctgcagcag ctctgtttta tgggttccta cattgattca gcaaatattt attgagctga
     2761 aatgatgttt gacgctctgc aagttttaca gctttgccta gcatagcgaa tatatatttt
     2821 gtattcccag cctttctttc ttcagggagc cattcttttc ccattcttca gtgatcctgc
     2881 tctgtgcctc agacttggct gaagctaacc ttactccctg gctctaggaa tagcctgtga
     2941 gccagccctg gactgccctg gacttgttct cagaggtatc aggaaaggct ttctgttttg
     3001 atctggagct gtaagggtca cataatcatg ggactgccgg tggccatctt ttcctactac
     3061 ctagagaaag ccagcaaaga atgaaggcaa caaaggaaac agccaagaga atcaaagatc
     3121 tagtaacact gtttagatgt ctcaattatg tgagacagat tcctgttgtt attttgatta
     3181 agcctgtttg tgttggtttt ctgacttaca attgaaagag ttctgtccaa aaagccaaaa
     3241 ggtggccagg cttggtggct caggcctgta atcccagcac tttgggaagc ccaggcaggc
     3301 agatcacttg aggtcaggag ttcaagacca gcctggccaa cctggtgaaa ccctgtctct
     3361 actaaaaatg caaaaactag ccgggcatgg tggcgcacac ctgtaatcct agctactcgg
     3421 gaggctgagg caggagaatt gcttgaaccc aggaggcgga ggtagtggtg agcaaagatc
     3481 gtaccgctgc actccagcct gggtgataga gcaagaccct atctcaaaaa aaaaaaaaaa
     3541 aaaaaaaaaa gaagccaaaa ggccctgcag caaatcagca atagacccag cagccaatcc
     3601 tgttttaaca tcgaatgttt aacactcaac ttcagacctt gaatgattga ctgaaaatgg
     3661 aagctcccat gttggggtta ctcaaggtcc ttattggttc ttcagcattt tgtggctata
     3721 aatattttta aataacagtt gtattgagat ataattcaca gaccataaaa ttcacccaac
     3781 taaagtatac attttaaaag tttttaggcc gggcacggtg gcttacgcct gtaattccaa
     3841 cactttggga ggctgaggca ggcagatcac ctgaggtcag gagttcgaga ccagtctggc
     3901 caacatgatg aaaccccgtc tctgctaaaa atacaaaaat tagccgggca tggtggtgca
     3961 cgcctgtagt cccagctact tgggaggctg aggcaggaga atcacttgaa cctgggaggc
     4021 ggaggttgca gtgagtcaag atcatgccat tgcactccag cctgggtgac agagtgagat
     4081 cctgtctcaa aaaaaaaaaa aaaaaatttt tttagtatat ccacagagtt gtgcaaccat
     4141 caattttaga acattttcat cacaaatttt gtgcctgtaa tagtttccta gagctgtttc
     4201 ttaacgaagt accacaagct gggtggctta agacaacaga aatgtattcc tggccgggtg
     4261 cagtggctca cgcctgtaat cccaacactt taggaggccg aggtgggcag atcacgacgt
     4321 caggagatca agaccatcct ggccaacatg gtgaagcccc tttctactaa aaatacaaaa
     4381 attagccagg tgtattggcg cacgcctata gtcccaacta ctcaggaggc tgaggcagaa
     4441 gaatctctca aacccaggag gtggaggttg cagtgagcca ggatcgtgcc actgcactct
     4501 agcctgggtg acagagcaag actccatctc aaaaaataag aagaaaagac tgtatcccct
     4561 ttcagttctg gaggctagaa gtccaaacag gttgttggtg gggcttctgc ttcctctaaa
     4621 agctttaggg caggggcccc cagccccaga gccacagacc attacttgtc tgtggcctgt
     4681 caggaacaag gtcacacagc aggagataag taacaggtga gcacttgaag tttcatctgt
     4741 atttatggct gccccccatc gctcacattt ctgccgtagc tcctcctcct gtcataccag
     4801 cagtggcatt agattctcat aggagcgtga atcctattgt gaactgtgca tgcaagggat
     4861 ctaggttgca cactccttat gagaatataa tgcctgatga tctgtcagtg tcttccataa
     4921 cccccatatg ggactgtcta gttgcaggaa aacaagctca gggctcctac tgattctacc
     4981 ttatggtgag ttgtataatt atttcatcat gtattacgat gtaataataa tagaaataca
     5041 gtgcacagta aatgtaattc acttcagtca tcccgaaact atccccctat ccccaccccg
     5101 gatctgtgga aaaattatct tccatgaaac cagtccctgg tgccaaaaag gttggggact
     5161 gctgctctaa ggaagacttt ttcgtgcctt ggggactgct gctctgaaga agactctttc
     5221 atgcttcctc cttagcttct gatggctcct ggcagtcctt ggcttgtggc tgcatcactt
     5281 cagtttctcc ctccgtcttc acatggcctt ctgtgtctgt gtctcgcatg gccttcttcc
     5341 ctgtgtctgt gtctttccat ggcctactta taaggacccc agtaattgga tttagggcct
     5401 gccctaatcc agtctgattt catcttaact aactagatct gcaaagactc tatttccaac
     5461 taaagtcaca ttctgaggtt tcaggtagac atgaagtttt gggggacacc actcaaccca
     5521 ttgcagaacc cattagcagt cacttcccgt tcctcaacgc cccctacccc agggcaatca
     5581 gtaatctact ttctgtctgt ttggatttgt ctattctgaa catttcatat aaatggaatc
     5641 atagaatatg tggtcttttg tgactggctt ctttcactta acatgttttc aagatttatg
     5701 ttgtagcatg aatcagtact ttattactat ttatggaata aaaatcagtt gtatgga
//
