LOCUS       NM_018702               8475 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens adenosine deaminase RNA specific B2 (inactive)
            (ADARB2), mRNA.
ACCESSION   NM_018702
VERSION     NM_018702.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8475)
  AUTHORS   Olofsson,I.A., Kristjansson,R.P., Callesen,I., Davidsson,O.,
            Winsvold,B., Hjalgrim,H., Ostrowski,S.R., Erikstrup,C., Bruun,M.T.,
            Pedersen,O.B., Burgdorf,K.S., Banasik,K., Sorensen,E.,
            Mikkelsen,C., Didriksen,M., Dinh,K.M., Mikkelsen,S., Brunak,S.,
            Ullum,H., Chalmer,M.A., Olesen,J., Kogelman,L.J.A. and Hansen,T.F.
  CONSRTM   International Headache Genetic Consortium; DBDS Genomic Consortium
  TITLE     Genome-wide association study reveals a locus in ADARB2 for
            complete freedom from headache in Danish Blood Donors
  JOURNAL   Commun Biol 7 (1), 646 (2024)
   PUBMED   38802570
  REMARK    GeneRIF: Genome-wide association study reveals a locus in ADARB2
            for complete freedom from headache in Danish Blood Donors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8475)
  AUTHORS   Li,W., Wang,T., Fu,G., Xu,Y., Zhang,N., Han,L. and Yang,M.
  TITLE     The allelic regulation of tumor suppressor ADARB2 in papillary
            thyroid carcinoma
  JOURNAL   Endocr Relat Cancer 30 (1), e220189 (2022)
   PUBMED   36305508
  REMARK    GeneRIF: The allelic regulation of tumor suppressor ADARB2 in
            papillary thyroid carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8475)
  AUTHORS   Raghava Kurup,R., Oakes,E.K., Manning,A.C., Mukherjee,P.,
            Vadlamani,P. and Hundley,H.A.
  TITLE     RNA binding by ADAR3 inhibits adenosine-to-inosine editing and
            promotes expression of immune response protein MAVS
  JOURNAL   J Biol Chem 298 (9), 102267 (2022)
   PUBMED   35850307
  REMARK    GeneRIF: RNA binding by ADAR3 inhibits adenosine-to-inosine editing
            and promotes expression of immune response protein MAVS.
REFERENCE   4  (bases 1 to 8475)
  AUTHORS   Raghava Kurup,R., Oakes,E.K., Vadlamani,P., Nwosu,O., Danthi,P. and
            Hundley,H.A.
  TITLE     ADAR3 activates NF-kappaB signaling and promotes glioblastoma cell
            resistance to temozolomide
  JOURNAL   Sci Rep 12 (1), 13362 (2022)
   PUBMED   35922651
  REMARK    GeneRIF: ADAR3 activates NF-kappaB signaling and promotes
            glioblastoma cell resistance to temozolomide.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8475)
  AUTHORS   Wang,Y., Chung,D.H., Monteleone,L.R., Li,J., Chiang,Y., Toney,M.D.
            and Beal,P.A.
  TITLE     RNA binding candidates for human ADAR3 from substrates of a gain of
            function mutant expressed in neuronal cells
  JOURNAL   Nucleic Acids Res 47 (20), 10801-10814 (2019)
   PUBMED   31552420
  REMARK    GeneRIF: Novel ADAR3 binding sites discovered include the 3'-UTRs
            of the mRNAs encoding early growth response 1 (EGR1) and dual
            specificity phosphatase 1.
REFERENCE   6  (bases 1 to 8475)
  AUTHORS   Lowe,J.K., Maller,J.B., Pe'er,I., Neale,B.M., Salit,J., Kenny,E.E.,
            Shea,J.L., Burkhardt,R., Smith,J.G., Ji,W., Noel,M., Foo,J.N.,
            Blundell,M.L., Skilling,V., Garcia,L., Sullivan,M.L., Lee,H.E.,
            Labek,A., Ferdowsian,H., Auerbach,S.B., Lifton,R.P.,
            Newton-Cheh,C., Breslow,J.L., Stoffel,M., Daly,M.J., Altshuler,D.M.
            and Friedman,J.M.
  TITLE     Genome-wide association studies in an isolated founder population
            from the Pacific Island of Kosrae
  JOURNAL   PLoS Genet 5 (2), e1000365 (2009)
   PUBMED   19197348
REFERENCE   7  (bases 1 to 8475)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 8475)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   9  (bases 1 to 8475)
  AUTHORS   Chen,C.X., Cho,D.S., Wang,Q., Lai,F., Carter,K.C. and Nishikura,K.
  TITLE     A third member of the RNA-specific adenosine deaminase gene family,
            ADAR3, contains both single- and double-stranded RNA binding
            domains
  JOURNAL   RNA 6 (5), 755-767 (2000)
   PUBMED   10836796
REFERENCE   10 (bases 1 to 8475)
  AUTHORS   Mittaz,L., Antonarakis,S.E., Higuchi,M. and Scott,H.S.
  TITLE     Localization of a novel human RNA-editing deaminase (hRED2 or
            ADARB2) to chromosome 10p15
  JOURNAL   Hum Genet 100 (3-4), 398-400 (1997)
   PUBMED   9272162
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC026224.6, AF034837.1,
            BC140852.1 and AL392083.17.
            
            On Nov 23, 2018 this sequence version replaced NM_018702.3.
            
            Summary: This gene encodes a member of the double-stranded RNA
            adenosine deaminase family of RNA-editing enzymes and may play a
            regulatory role in RNA editing. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF034837.1, BC137477.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157437, SAMN03465403
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381312.6/ ENSP00000370713.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AC026224.6         148339-148387       c
            50-228              AF034837.1         9-187
            229-2250            BC140852.1         1-2022
            2251-2251           AL392083.17        14945-14945         c
            2252-2718           BC140852.1         2024-2490
            2719-8475           AL392083.17        7230-12986          c
FEATURES             Location/Qualifiers
     source          1..8475
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p15.3"
     gene            1..8475
                     /gene="ADARB2"
                     /gene_synonym="ADAR3; RED2"
                     /note="adenosine deaminase RNA specific B2 (inactive)"
                     /db_xref="GeneID:105"
                     /db_xref="HGNC:HGNC:227"
                     /db_xref="MIM:602065"
     exon            1..475
                     /gene="ADARB2"
                     /gene_synonym="ADAR3; RED2"
                     /inference="alignment:Splign:2.1.0"
     CDS             376..2595
                     /gene="ADARB2"
                     /gene_synonym="ADAR3; RED2"
                     /note="adenosine deaminase, RNA-specific, B2 (RED1 homolog
                     rat); RED2 homolog; adenosine deaminase, RNA-specific, B2
                     (RED2 homolog rat); homolog of rat BLUE; adenosine
                     deaminase, RNA-specific, B2 (non-functional);
                     RNA-dependent adenosine deaminase 3; dsRNA adenosine
                     deaminase B2; RNA-editing deaminase 2; RNA-editing enzyme
                     2"
                     /codon_start=1
                     /product="double-stranded RNA-specific editase B2"
                     /protein_id="NP_061172.1"
                     /db_xref="CCDS:CCDS7058.1"
                     /db_xref="GeneID:105"
                     /db_xref="HGNC:HGNC:227"
                     /db_xref="MIM:602065"
                     /translation="MASVLGSGRGSGGLSSQLKCKSKRRRRRRSKRKDKVSILSTFLA
                     PFKHLSPGITNTEDDDTLSTSSAEVKENRNVGNLAARPPPSGDRARGGAPGAKRKRPL
                     EEGNGGHLCKLQLVWKKLSWSVAPKNALVQLHELRPGLQYRTVSQTGPVHAPVFAVAV
                     EVNGLTFEGTGPTKKKAKMRAAELALRSFVQFPNACQAHLAMGGGPGPGTDFTSDQAD
                     FPDTLFQEFEPPAPRPGLAGGRPGDAALLSAAYGRRRLLCRALDLVGPTPATPAAPGE
                     RNPVVLLNRLRAGLRYVCLAEPAERRARSFVMAVSVDGRTFEGSGRSKKLARGQAAQA
                     ALQELFDIQMPGHAPGRARRTPMPQEFADSISQLVTQKFREVTTDLTPMHARHKALAG
                     IVMTKGLDARQAQVVALSSGTKCISGEHLSDQGLVVNDCHAEVVARRAFLHFLYTQLE
                     LHLSKRREDSERSIFVRLKEGGYRLRENILFHLYVSTSPCGDARLHSPYEITTDLHSS
                     KHLVRKFRGHLRTKIESGEGTVPVRGPSAVQTWDGVLLGEQLITMSCTDKIARWNVLG
                     LQGALLSHFVEPVYLQSIVVGSLHHTGHLARVMSHRMEGVGQLPASYRHNRPLLSGVS
                     DAEARQPGKSPPFSMNWVVGSADLEIINATTGRRSCGGPSRLCKHVLSARWARLYGRL
                     STRTPSPGDTPSMYCEAKLGAHTYQSVKQQLFKAFQKAGLGTWVRKPPEQQQFLLTL"
     exon            476..562
                     /gene="ADARB2"
                     /gene_synonym="ADAR3; RED2"
                     /inference="alignment:Splign:2.1.0"
     exon            563..1452
                     /gene="ADARB2"
                     /gene_synonym="ADAR3; RED2"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1567
                     /gene="ADARB2"
                     /gene_synonym="ADAR3; RED2"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1736
                     /gene="ADARB2"
                     /gene_synonym="ADAR3; RED2"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1888
                     /gene="ADARB2"
                     /gene_synonym="ADAR3; RED2"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2057
                     /gene="ADARB2"
                     /gene_synonym="ADAR3; RED2"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2239
                     /gene="ADARB2"
                     /gene_synonym="ADAR3; RED2"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2418
                     /gene="ADARB2"
                     /gene_synonym="ADAR3; RED2"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..8475
                     /gene="ADARB2"
                     /gene_synonym="ADAR3; RED2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2753
                     /gene="ADARB2"
                     /gene_synonym="ADAR3; RED2"
                     /note="major polyA site"
     regulatory      3628..3633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADARB2"
                     /gene_synonym="ADAR3; RED2"
                     /note="hexamer: AATAAA"
     polyA_site      3655
                     /gene="ADARB2"
                     /gene_synonym="ADAR3; RED2"
                     /note="major polyA site"
     regulatory      4421..4426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADARB2"
                     /gene_synonym="ADAR3; RED2"
                     /note="hexamer: AATGAA"
     polyA_site      4445
                     /gene="ADARB2"
                     /gene_synonym="ADAR3; RED2"
                     /note="major polyA site"
     regulatory      8451..8456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADARB2"
                     /gene_synonym="ADAR3; RED2"
                     /note="hexamer: AATAAA"
     polyA_site      8475
                     /gene="ADARB2"
                     /gene_synonym="ADAR3; RED2"
ORIGIN      
        1 caaagtggct ggtgccaaac aactagcaga ggcgcaaaag tagcctccct gcgctgggag
       61 cccagagcag gaggcagagc ccgcgggaag ctcggagcac tcaggacgcc gcgcgccctt
      121 ccccgccctc cctgaccagg gagcagctcg ctccaggcgc ccagccgagg cccccagccc
      181 agtgggagca agtcatagag aacaattcga gagacagaga gacggagcgc gctttcctgc
      241 tcagtcctga aaagtgagcc gctcccgggt ttgcaacctc aagcttcgca gcagcggcgg
      301 cggcggctgc cgggaaggag gcaggtgcag gtgcaggagg gaggcggctc tgggctccgc
      361 gcctgggtct cggccatggc ctcggtcctg gggagcggca gagggtctgg agggctgagc
      421 agtcaactca aatgcaagtc caagaggagg aggaggcgga ggtccaagcg gaaagataaa
      481 gtaagcatat tgtcaacctt cctcgctcct ttcaagcacc tgagtcctgg catcacaaac
      541 acggaggatg acgacaccct cagtaccagc agcgcggagg tgaaggagaa ccgcaacgtg
      601 ggcaacctgg ccgcgcggcc accgccctcc ggggaccggg cccggggcgg cgcgcccggc
      661 gcgaagagga agcggccgct ggaggagggg aatgggggcc acttgtgcaa actgcagctg
      721 gtctggaaga agctgtcgtg gtcggtggcg cccaagaacg cgctggtgca gctgcacgag
      781 ctgaggccgg gcctgcagta ccggacagtg tcgcagacgg gcccggtgca tgccccggtc
      841 ttcgcggtag cggtggaggt gaacgggctc acgttcgagg gcacaggccc caccaagaag
      901 aaggccaaga tgcgcgcggc ggagctggca ctcaggtcct tcgtgcagtt ccccaacgcc
      961 tgccaggcgc acctggccat gggcgggggc ccgggccccg gcacggactt cacctccgac
     1021 caggccgatt tccccgacac gctcttccag gagttcgagc ccccggcgcc gcgccccgga
     1081 ctcgcgggag gccgccccgg ggacgccgcg cttctgtccg cggcctacgg gcgacggcgg
     1141 ctgctgtgcc gcgcgctgga cctggtgggc ccgacccccg ccacccccgc ggccccgggc
     1201 gagcgcaacc ccgtggtgct gctgaaccgc ctgcgcgccg ggctgcgcta cgtgtgtctg
     1261 gcagaaccgg ccgagcggcg cgcgcggagc ttcgtgatgg ccgtgagcgt ggacggcagg
     1321 acgttcgagg gctcggggcg cagcaagaag ctggcccggg gtcaggccgc gcaggccgca
     1381 ctgcaggagc tgttcgacat ccagatgccc ggccacgcgc ccggcagggc caggaggacg
     1441 ccaatgccgc aggaattcgc agactccata tcccagctgg tcacacagaa gttccgcgag
     1501 gtgacgacgg acctcacgcc catgcacgcc cgccataaag cgctggcagg aatcgtcatg
     1561 accaaaggcc tggatgctcg gcaggcgcag gtcgtggccc tgtcctcggg gaccaagtgc
     1621 atcagcggcg agcacctcag tgaccagggg ctggtggtga atgactgcca cgcggaggtc
     1681 gtggcccggc gggcgttcct gcacttcctc tacacgcagc tggagctgca cctgagcaag
     1741 cggcgcgagg actcagagcg atcgatattc gtgcggttaa aagaaggtgg ctaccggctg
     1801 cgagagaaca tcctcttcca tctctacgtg agcacctccc cctgtggaga cgcaagactc
     1861 cactctccct acgagatcac cacagacctg cacagcagca aacacctcgt caggaagttc
     1921 cgcgggcacc tgcgcaccaa gatcgagtcc ggggaaggga cggtccccgt gcgtggcccc
     1981 agcgcagtgc agacctggga cggcgtcctg ctgggggagc agctgatcac catgtcctgc
     2041 acggacaaga tcgccaggtg gaacgtcctg gggctgcagg gcgcgctcct gtcccacttc
     2101 gtggagcccg tgtacctgca gagcatcgtg gtgggcagcc tgcaccacac gggccacctc
     2161 gcacgcgtca tgagccaccg catggagggt gtcggccagc tgcccgcctc ctaccggcac
     2221 aaccggcctc tcctcagcgg cgtgagtgac gccgaggcgc gccagccggg gaagtcgccc
     2281 cccttcagca tgaactgggt cgtgggcagc gcggacctgg agattatcaa cgccaccact
     2341 gggcggagga gctgtggggg cccatcccgg ctctgcaagc acgtgctgtc tgcacggtgg
     2401 gcgcggctgt atggcaggct gagcacacgg acacccagcc ctggagacac gccctccatg
     2461 tactgtgagg ccaagctggg ggcgcacacc taccagtctg tgaaacagca gctgttcaag
     2521 gcctttcaga aggctggcct gggcacctgg gtgaggaaac caccggagca gcagcagttt
     2581 ctactgactc tctaggctgc gggctcctgg ctgctggagc tgagcgggac gctggaggga
     2641 tgggaccgtg tctggggggc gacgtggcgg gtcggccggt tccctgcatt cgttttactt
     2701 tggtgtccca gaaacacgcg agtgtgcaat gtttggacga gcaacaacac aaattcagaa
     2761 cgtgcctctt tccagatcgc tggccccaga accctgtccc ccacacccag gggcacatgc
     2821 actgttgagt tagcgccgac tcttcctgtg gagtctgagg gaggggctcc attcaggcaa
     2881 aggggtttta gctgcagcct tggaaggagg caccgacacg acaccaggca ggagtgagcc
     2941 tcaggccccg tccctgcacc ccacccctgc gtgcgcctct tggtgatgct ggggtctcac
     3001 tagcttgagg gggcacatga agataagcca caaatgaaga gaaaagccat gcccacccca
     3061 gccccagaga aaccaataag aatcctctat tattttcact attcatttag gtttttatac
     3121 tccacctcct ttcaaaaaag atttaagatg tacgacatta ccgaacacct aaaatagaac
     3181 cagagaaacg aaagccattc ccacaaagtg aaggaacagt ttccaaaacc cctgcgaggc
     3241 agagttaaga cctgtgacgt ggggagcctg gaaacacccg gcccacgcgt gctgcagatg
     3301 tggggagcct ggaaacaccc ggcccacgcg tgctgcagat gtggggagcc tggaaacacc
     3361 cggcccacgc gtgctgcaga tgtggggagt ctggaaacac ccggcccacg cgtgctgcag
     3421 atgtggggag cccggaaaca cctggcccat gcctgttcag tccgtcatgg cgtttggttt
     3481 atggtggccg atactaagag ccactgaggt ctgggttgtg taagggttag ctaccaccct
     3541 ataacctccc taccaggtaa taaggagacc aagtctttga tcaaattctg attttttaac
     3601 taaattttca ttagaaagca agcacaaaat aaaatcaaaa caacctttac cttcagcttg
     3661 agaggctacc agctctctat tctttcagat tctccaatca acaccttgca ggacaagacc
     3721 ccaaaaaagt tcagctgtca aaaaatgtaa gaggcaggat tctgtgaccc tcagagcagg
     3781 cttccaacac cagagacctt cagctcacag tggagatggg acatgggggc tttagcccac
     3841 agcatcatcc ctgagagcca aggcgctgta ttcatacggg gtcaggctct tttccaagta
     3901 tctttacgta atccatgtac ctcgagctgc tgtcatctca cctccgagaa ctcatttcta
     3961 acattcatca tgctagatag ccagtctctc atttctccaa cttaaaaaat ccatctctga
     4021 aattcatgac agtgatggca gacggcaaag catggtggtg tccacctctg gggtgtgggc
     4081 ttcccggaaa gaatcccagc tgaccacccc agaaagtgca agaataacat tgtgctgtac
     4141 atagtcaagt gctataaatt acagttatca taatgagaag gcagaaatga aactgagttg
     4201 tagctatttg ttacaagata ataagaagta gagatattag tatggaaaaa gaaacttttc
     4261 ctgggattta aaatcaggcc aaatttatca ctcgagttct tttagaaaag aaaacaggta
     4321 ctggagtaga caacttcttc cagataaagt ttcaaaagat acgagaacat tttttcaaat
     4381 aaaggactca cattaatctt ttataaaaat cacaaaaata aatgaaatct taattcagtg
     4441 caaaagctaa gctcaaacga ccagtttcta ttaagttctg gtaacttgac atcactagga
     4501 tgaagcttag agaacttaga gtcgagaggt gatgggtggc tcagacattc gcagcagtca
     4561 gaagtgagcg ctcccctgaa tgcgtgggag cacggccagc tcctggctga agtctcccac
     4621 ccaggcctca aatcaccttc atctgagatg ttggctagag aagcatataa tgctttgtcc
     4681 cagtgggctc caaatcacgc tgtttctgca gcgagggggc ctgtgttgta agcagatttc
     4741 actgtcacag ggaagacgca gggtctgatt cacgggactc ggaaagcgct cggccaccca
     4801 gtggccagca tcatgaagcc acagctgggg ggttgggatt cgttttgtct caggcattga
     4861 ccttccagaa acaactcaga ctttactgaa atatcaacat ccacatctgg agaaagccac
     4921 acattaattc catgctaccc attagtacaa gtgtatggat tcgtgtatta agtccacagg
     4981 agactccatg gaaggagaga ttaaagctct tcagagaagg ccgatagcga cagaagagtt
     5041 tccaatgcag ccagagtgag gttgaggtgc cggagccttt ccgtggaggg atctgtcaga
     5101 ggggatgtgg gctgcagagg ggaccccacg taaggaaagg agggtcccag gccctgggta
     5161 gtgaaaggag aaggtagtcg aggcagtcaa gggtgaccct acacgcagga ggcacgccac
     5221 accagatcac gccacacgca ggctgctccc aactggcagg gcctgaccca gccaggaagg
     5281 gccaggtcct aggattccac agtgccagga gtgcccgaag gggccaggtc ccaggattcc
     5341 cacagcccca ggtgtgcctg gaagacccgg gtcccaggat tcccacagcc ccagctatgc
     5401 ttgggggggc cgagtcccag gattcccaca gccccaggtg tgcctggaag acccgggtcc
     5461 caggattccc acagccccaa gagttcccgg aagagctggg tcccaggatt cccacagccc
     5521 cagctatgct tgggggggcc gggtcccagg attcccacag ccccaggtgt gcctggaaga
     5581 cccaggtccc aggattccca cagccctgga tgtgcctgga ggggctgtgc cacctctgca
     5641 gagatggaag ggctcgtgtt gaagcctgag gatttcgccc tcaggtccag gtcagaacat
     5701 cccagcacca ctttcaggcc atgtctgccc tgcagttttg accactgaat tggtcttaag
     5761 agtggccacc cattcccctc caagtgaggg ggcaagacac aagtagggga cgggtcactt
     5821 tctgtcaccc tgaaaatacg ctgggcacga cacaagtagg ggatgggtca ctttctgtca
     5881 ccctgaaaat acgctgggca cgacacaagg ggggctgatg aagtcaggcc cgcccctcca
     5941 agtccacctc gaaatcaccg tctggcttcc tcgcacttcc caccacctga caccgccaag
     6001 ccccttgctt cagattttct gtggtctgta ttcataccct tgcttcagat tttctgtagt
     6061 ctatattcat gcctgcttag gcccctacaa aagtcctcat aaaaccagca ccacctttat
     6121 ctgcctccaa aacacacact gctttcccat caggaagatc agcaatgtgg tttccggcct
     6181 ggttcttagt caaaaagtta gtgtctggtg gtttctggcc tttttgcagg acggggcgca
     6241 gggaacggct gcgcggccag gcagcctccg ctgtccacct ccagccccgg ttttgcagcc
     6301 gtgtgtgata tcaagggata gagttagggt ttctgtgggt tttgtttttg ctgaggaaag
     6361 gatgtgcagg tcgatagcta ttgtttcctt tccattcctg tgattctctt tacatctgta
     6421 tatatctatc acaccatgct gactttgtga tgagtcctgt tcctcagaaa catcaagctg
     6481 ggttcctttt caaagaaaca cacagatcat atttctccat ctcattttgt tttcacaggg
     6541 agcttttctt atcaacaaag tcgcatgctt ttttttttgg atataatgtt tatcacgtct
     6601 ggagagccat aaacagtaaa tacagaggat atcaatgccc agaatagtta ttttgatgaa
     6661 atcctatttt tagataataa atttcaagat gtgtctatag tgtattgttt aaaacaactg
     6721 aagacatttg agacgtacat aaagtagaca tttttaattt agggaaactt atatgccctt
     6781 ttttaagaag ccattctaat aaaataatct gactaattgg cccaaaatac aataagtatc
     6841 actttctaac agagaccaaa gggaagctga gaggctttcc ttttatgtac taccgttgga
     6901 tcgctgcagc cgcctctcat aacacccaac agaacccggt gaggctctgt gggcttcccg
     6961 cggccctcag ggaggctgca gagtccccta gtccatgtca gggagccgcc atcccacata
     7021 cctccaaagc ctgtcctcgc ctgcagtttt tgcagagctc gcggttggag gtggaaattt
     7081 agaagccctg tgttgcagga gaggcagtag cacccccagg cagctcttag cagggacaga
     7141 ccaccccccg cctcgctggt attttagggt cttttggtat tttgccactg tgtggggcta
     7201 ggcgggtggc tggaggacac ggtgtaggcc ttgccgctgt ctgggttcct cgccactgca
     7261 ggagcagggc tgtttctgga aacactgggc tgctggtgac ccgtcaaact tctcccacaa
     7321 attctgaatc cgagaaagtg aaggaaggat ggtggggaag tgaggaggca ggagcagagg
     7381 ccacagggac caaccagaga tgcggtggag acagaggagc ttccttctca ggctgtttct
     7441 gggaagcctg agaggcggcc agcaccaccc tccgctcact ctcccctcag cctcttcgct
     7501 tcccttctca accctttctc tcctcctcgc ctcttccctt tcttgctgtc ttgttagtcc
     7561 ctgtcccaaa actcctggct cctttgttct gctgccgtgg cccccaccca ggaggaggtc
     7621 tcaggcacca tccccccacg agggatccac acaacaggtt catgctgggg ctgggggagc
     7681 cccgctgggt tcctgatgcc ttgtgcacag ggagttgctg cagtcatttt tggactctcc
     7741 tgaatgtgtc cacatgttct gacctcccac cagaaggaac gctggtggcc acatctctag
     7801 agatctattt acttttttga gaccggctta tgagattggc taatttttgt atttttggta
     7861 gagatggggt ctcaccatgt tgcccaggct agtctcgaac tcctggcctc aagtgatctg
     7921 cccacctcgg cctcccagag tgctgggatt acaggcatga gccaccgcgc tggcctctag
     7981 agattcacac caaacaatat cactcctgcg ggaaccgcag acagatcaaa ccctggtgag
     8041 aggaacactt tatttcccaa ctcatcatcc taagccaagg ttggagggat gagcattccc
     8101 taaacaccaa ggcgagatca cctggtccca gtgcctcttt tcacacaggc cctagatttc
     8161 tatctctctg cagtttatgc atcggtaaaa aaaaaaaaat ctctcccagt gtgccccgtt
     8221 agttttcagc attttgtaag caaaatgaac ttaacacata gtaattctaa ttgaaggtat
     8281 gtacataaaa agcatgatag aatggcaata ttgtatcaat ggatgtacat ttgtaatatt
     8341 tgtaaaaaaa aatccaaaac cttaaaatat gaatttacat gttaatttgc ctctaagttc
     8401 tataaattgc acttcagtga tatctaataa gtgaatgttt ctgttaagta aataaaaata
     8461 ttcagtaaaa ttgtt
//
